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Malignant neoplastic disease

MedGen UID:
14297
Concept ID:
C0006826
Neoplastic Process
Synonym: Cancer
SNOMED CT: Malignant neoplastic disease (363346000); Cancer (363346000); CA - Cancer (363346000); Malignant neoplasm (363346000); Malignant tumor (363346000); Malignant neoplasm morphology (1240414004); Malignancy (1240414004); Malignant tumor (1240414004); Blastoma (1240414004); Malignant neoplasm (1240414004); Cancer (1240414004); Unclassified malignant tumor (1240414004)
 
Monarch Initiative: MONDO:0004992

Definition

A neoplasm composed of atypical neoplastic, often pleomorphic cells that invade other tissues. Malignant neoplasms often metastasize to distant anatomic sites and may recur after excision. The most common malignant neoplasms are carcinomas, Hodgkin and non-Hodgkin lymphomas, leukemias, melanomas, and sarcomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Malignant neoplastic disease

Professional guidelines

PubMed

Kumar P, Kadakol A, Shasthrula PK, Mundhe NA, Jamdade VS, Barua CC, Gaikwad AB
Anticancer Agents Med Chem 2015;15(5):647-56. doi: 10.2174/1871520615666150101125918. PMID: 25553436
Beauchesne P
Lancet Oncol 2010 Sep;11(9):871-9. Epub 2010 Jul 2 doi: 10.1016/S1470-2045(10)70034-6. PMID: 20598636

Curated

UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023

Suggested Reading

Recent clinical studies

Etiology

Warner BM, Baer AN, Lipson EJ, Allen C, Hinrichs C, Rajan A, Pelayo E, Beach M, Gulley JL, Madan RA, Feliciano J, Grisius M, Long L, Powers A, Kleiner DE, Cappelli L, Alevizos I
Oncologist 2019 Sep;24(9):1259-1269. Epub 2019 Apr 17 doi: 10.1634/theoncologist.2018-0823. PMID: 30996010Free PMC Article
Qin X, Zhang MY, Liu WJ
Eur Rev Med Pharmacol Sci 2018 Oct;22(20):6885-6895. doi: 10.26355/eurrev_201810_16158. PMID: 30402854
Szudy-Szczyrek A, Szczyrek M, Soroka-Wojtaszko M, Hus M
Postepy Hig Med Dosw (Online) 2016 Jan 4;70(0):811-9. doi: 10.5604/17322693.1211183. PMID: 27463592
Kaiser HE, Krenn M, Bodey B Jr, Bodey B
In Vivo 2000 Jan-Feb;14(1):189-98. PMID: 10757077
Bengtsson C
Maturitas 1989 Mar;11(1):35-41. doi: 10.1016/0378-5122(89)90118-7. PMID: 2657344

Diagnosis

Avella P, Vaschetti R, Cappuccio M, Gambale F, DE Meis L, Rafanelli F, Brunese MC, Guerra G, Scacchi A, Rocca A
Minerva Surg 2022 Dec;77(6):582-590. doi: 10.23736/S2724-5691.22.09716-7. PMID: 36409039
Ye K, Li L, Wu B, Wang D
Genes Genomics 2022 Nov;44(11):1311-1322. Epub 2022 Sep 8 doi: 10.1007/s13258-022-01309-x. PMID: 36074324
Qin X, Zhang MY, Liu WJ
Eur Rev Med Pharmacol Sci 2018 Oct;22(20):6885-6895. doi: 10.26355/eurrev_201810_16158. PMID: 30402854
Szudy-Szczyrek A, Szczyrek M, Soroka-Wojtaszko M, Hus M
Postepy Hig Med Dosw (Online) 2016 Jan 4;70(0):811-9. doi: 10.5604/17322693.1211183. PMID: 27463592
Masur H, Rosen PP, Armstrong D
Am J Med 1977 Dec;63(6):914-25. doi: 10.1016/0002-9343(77)90546-0. PMID: 343588

Therapy

Avella P, Vaschetti R, Cappuccio M, Gambale F, DE Meis L, Rafanelli F, Brunese MC, Guerra G, Scacchi A, Rocca A
Minerva Surg 2022 Dec;77(6):582-590. doi: 10.23736/S2724-5691.22.09716-7. PMID: 36409039
Warner BM, Baer AN, Lipson EJ, Allen C, Hinrichs C, Rajan A, Pelayo E, Beach M, Gulley JL, Madan RA, Feliciano J, Grisius M, Long L, Powers A, Kleiner DE, Cappelli L, Alevizos I
Oncologist 2019 Sep;24(9):1259-1269. Epub 2019 Apr 17 doi: 10.1634/theoncologist.2018-0823. PMID: 30996010Free PMC Article
Szudy-Szczyrek A, Szczyrek M, Soroka-Wojtaszko M, Hus M
Postepy Hig Med Dosw (Online) 2016 Jan 4;70(0):811-9. doi: 10.5604/17322693.1211183. PMID: 27463592
Kumar P, Kadakol A, Shasthrula PK, Mundhe NA, Jamdade VS, Barua CC, Gaikwad AB
Anticancer Agents Med Chem 2015;15(5):647-56. doi: 10.2174/1871520615666150101125918. PMID: 25553436
Castiglione M, Gelber RD, Goldhirsch A
J Clin Oncol 1990 Mar;8(3):519-26. doi: 10.1200/JCO.1990.8.3.519. PMID: 2407812

Prognosis

Qureshi A, Michel M, Lerner J, Dasanu CA
Expert Opin Pharmacother 2021 Dec;22(18):2495-2506. Epub 2021 Jul 15 doi: 10.1080/14656566.2021.1953473. PMID: 34252328
Kim C, You SC, Reps JM, Cheong JY, Park RW
J Am Med Inform Assoc 2021 Jun 12;28(6):1098-1107. doi: 10.1093/jamia/ocaa277. PMID: 33211841Free PMC Article
Wu J, Li Z, Zeng K, Wu K, Xu D, Zhou J, Xu L
Mol Med Rep 2019 Aug;20(2):1343-1352. Epub 2019 Jun 3 doi: 10.3892/mmr.2019.10321. PMID: 31173193
Qin X, Zhang MY, Liu WJ
Eur Rev Med Pharmacol Sci 2018 Oct;22(20):6885-6895. doi: 10.26355/eurrev_201810_16158. PMID: 30402854
Szudy-Szczyrek A, Szczyrek M, Soroka-Wojtaszko M, Hus M
Postepy Hig Med Dosw (Online) 2016 Jan 4;70(0):811-9. doi: 10.5604/17322693.1211183. PMID: 27463592

Clinical prediction guides

Soria S, Buckberry J
Int J Paleopathol 2022 Sep;38:32-40. Epub 2022 Jun 23 doi: 10.1016/j.ijpp.2022.05.007. PMID: 35753114
Qureshi A, Michel M, Lerner J, Dasanu CA
Expert Opin Pharmacother 2021 Dec;22(18):2495-2506. Epub 2021 Jul 15 doi: 10.1080/14656566.2021.1953473. PMID: 34252328
Kim C, You SC, Reps JM, Cheong JY, Park RW
J Am Med Inform Assoc 2021 Jun 12;28(6):1098-1107. doi: 10.1093/jamia/ocaa277. PMID: 33211841Free PMC Article
Qin X, Zhang MY, Liu WJ
Eur Rev Med Pharmacol Sci 2018 Oct;22(20):6885-6895. doi: 10.26355/eurrev_201810_16158. PMID: 30402854
Maugeri R, Graziano F, Basile L, Gulì C, Giugno A, Giammalva GR, Visocchi M, Iacopino DG
Acta Neurochir Suppl 2017;124:81-86. doi: 10.1007/978-3-319-39546-3_13. PMID: 28120057

Recent systematic reviews

Zou Y, Li B, Wang X, Mao J, Zhang Y
Medicine (Baltimore) 2022 Dec 2;101(48):e31991. doi: 10.1097/MD.0000000000031991. PMID: 36482589Free PMC Article
Hunt KJ, Roberts C, Kirkpatrick C
Int J Paleopathol 2018 Jun;21:12-26. doi: 10.1016/j.ijpp.2018.03.002. PMID: 29773338

Supplemental Content

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    Clinical resources

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    • PubMed
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023

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