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Refractory Malignant Bone Neoplasm

MedGen UID:
1668876
•Concept ID:
C4725802
•
Neoplastic Process

Definition

Malignant bone neoplasm that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Malignant Bone Neoplasm

Professional guidelines

PubMed

Prophylaxis and management of graft-versus-host disease after stem-cell transplantation for haematological malignancies: updated consensus recommendations of the European Society for Blood and Marrow Transplantation.
Penack O, Marchetti M, Aljurf M, Arat M, Bonifazi F, Duarte RF, Giebel S, Greinix H, Hazenberg MD, Kröger N, Mielke S, Mohty M, Nagler A, Passweg J, Patriarca F, Ruutu T, Schoemans H, Solano C, Vrhovac R, Wolff D, Zeiser R, Sureda A, Peric Z
Lancet Haematol 2024 Feb;11(2):e147-e159. Epub 2024 Jan 3 doi: 10.1016/S2352-3026(23)00342-3. PMID: 38184001
Myelodysplastic syndromes: 2023 update on diagnosis, risk-stratification, and management.
Garcia-Manero G
Am J Hematol 2023 Aug;98(8):1307-1325. Epub 2023 Jun 8 doi: 10.1002/ajh.26984. PMID: 37288607
Prophylaxis and management of graft versus host disease after stem-cell transplantation for haematological malignancies: updated consensus recommendations of the European Society for Blood and Marrow Transplantation.
Penack O, Marchetti M, Ruutu T, Aljurf M, Bacigalupo A, Bonifazi F, Ciceri F, Cornelissen J, Malladi R, Duarte RF, Giebel S, Greinix H, Holler E, Lawitschka A, Mielke S, Mohty M, Arat M, Nagler A, Passweg J, Schoemans H, Socié G, Solano C, Vrhovac R, Zeiser R, Kröger N, Basak GW
Lancet Haematol 2020 Feb;7(2):e157-e167. doi: 10.1016/S2352-3026(19)30256-X. PMID: 32004485

Recent clinical studies

Etiology

Treatment of hypercalcaemia of malignancy in adults.
Mc Donald D, Drake MT, Crowley RK
Clin Med (Lond) 2023 Sep;23(5):503-507. Epub 2023 Sep 29 doi: 10.7861/clinmed.2023-0227. PMID: 37775175Free PMC Article
Cancer-related hypercalcemia and potential treatments.
Almuradova E, Cicin I
Front Endocrinol (Lausanne) 2023;14:1039490. Epub 2023 Mar 22 doi: 10.3389/fendo.2023.1039490. PMID: 37033238Free PMC Article
Treatment of Hypercalcemia of Malignancy.
Chakhtoura M, El-Hajj Fuleihan G
Endocrinol Metab Clin North Am 2021 Dec;50(4):781-792. doi: 10.1016/j.ecl.2021.08.002. PMID: 34774248
Current treatment of non-metastatic castration-refractory prostate cancer.
Büchler T
Klin Onkol 2021 Spring;34(3):185-191. doi: 10.48095/ccko2021185. PMID: 34362254
Current treatment options for meningioma.
Apra C, Peyre M, Kalamarides M
Expert Rev Neurother 2018 Mar;18(3):241-249. Epub 2018 Jan 22 doi: 10.1080/14737175.2018.1429920. PMID: 29338455

Diagnosis

Childhood Myelodysplastic Syndrome.
Chisholm KM, Bohling SD
Clin Lab Med 2023 Dec;43(4):639-655. Epub 2023 Aug 7 doi: 10.1016/j.cll.2023.06.005. PMID: 37865508
Cancer-related hypercalcemia and potential treatments.
Almuradova E, Cicin I
Front Endocrinol (Lausanne) 2023;14:1039490. Epub 2023 Mar 22 doi: 10.3389/fendo.2023.1039490. PMID: 37033238Free PMC Article
Primary Central Nervous System Lymphoma.
Sinicrope K, Batchelor T
Neurol Clin 2018 Aug;36(3):517-532. doi: 10.1016/j.ncl.2018.04.008. PMID: 30072069
Snapping scapula syndrome.
Lazar MA, Kwon YW, Rokito AS
J Bone Joint Surg Am 2009 Sep;91(9):2251-62. doi: 10.2106/JBJS.H.01347. PMID: 19724005
Onycholemmal carcinoma.
Inaoki M, Makino E, Adachi M, Fujimoto W
J Cutan Pathol 2006 Aug;33(8):577-80. doi: 10.1111/j.1600-0560.2006.00482.x. PMID: 16919033

Therapy

Palliative treatment of germ cell cancer.
Oing C, Giannatempo P, Honecker F, Oechsle K, Bokemeyer C, Beyer J
Cancer Treat Rev 2018 Dec;71:102-107. Epub 2018 Oct 22 doi: 10.1016/j.ctrv.2018.10.007. PMID: 30415106
Future directions in the treatment of osteosarcoma.
Bishop MW, Janeway KA, Gorlick R
Curr Opin Pediatr 2016 Feb;28(1):26-33. doi: 10.1097/MOP.0000000000000298. PMID: 26626558Free PMC Article
RANKL, denosumab, and giant cell tumor of bone.
Thomas DM
Curr Opin Oncol 2012 Jul;24(4):397-403. doi: 10.1097/CCO.0b013e328354c129. PMID: 22581354
Management of androgen-independent prostate cancer.
Diaz M, Patterson SG
Cancer Control 2004 Nov-Dec;11(6):364-73. doi: 10.1177/107327480401100604. PMID: 15625524
Pamidronate (Aredia, Ciba).
Strong KM, McPherson ML
Am J Hosp Palliat Care 1998 Jan-Feb;15(1):54-5. doi: 10.1177/104990919801500111. PMID: 9468980

Prognosis

Strategies to Overcome Resistance to Immune-Based Therapies in Osteosarcoma.
Hattinger CM, Salaroglio IC, Fantoni L, Godel M, Casotti C, Kopecka J, Scotlandi K, Ibrahim T, Riganti C, Serra M
Int J Mol Sci 2023 Jan 2;24(1) doi: 10.3390/ijms24010799. PMID: 36614241Free PMC Article
Current treatment options for meningioma.
Apra C, Peyre M, Kalamarides M
Expert Rev Neurother 2018 Mar;18(3):241-249. Epub 2018 Jan 22 doi: 10.1080/14737175.2018.1429920. PMID: 29338455
Future directions in the treatment of osteosarcoma.
Bishop MW, Janeway KA, Gorlick R
Curr Opin Pediatr 2016 Feb;28(1):26-33. doi: 10.1097/MOP.0000000000000298. PMID: 26626558Free PMC Article
NK/T-cell lymphomas: pathobiology, prognosis and treatment paradigm.
Suzuki R
Curr Oncol Rep 2012 Oct;14(5):395-402. doi: 10.1007/s11912-012-0245-9. PMID: 22639106
Androgen-independent prostate cancer.
Schrijvers D
Recent Results Cancer Res 2007;175:239-49. doi: 10.1007/978-3-540-40901-4_14. PMID: 17432563

Clinical prediction guides

177Lu-DOTA-IBA Therapy in Prostate Cancer With Bone Metastases.
Li H, Xu T, Hua Q, Wang L, Chen Y
Clin Nucl Med 2023 Aug 1;48(8):740-742. Epub 2023 May 26 doi: 10.1097/RLU.0000000000004717. PMID: 37390021
Myelodysplastic syndromes: 2023 update on diagnosis, risk-stratification, and management.
Garcia-Manero G
Am J Hematol 2023 Aug;98(8):1307-1325. Epub 2023 Jun 8 doi: 10.1002/ajh.26984. PMID: 37288607
New developments in diagnosis, prognostication, and treatment of advanced systemic mastocytosis.
Reiter A, George TI, Gotlib J
Blood 2020 Apr 16;135(16):1365-1376. doi: 10.1182/blood.2019000932. PMID: 32106312
Current treatment options for meningioma.
Apra C, Peyre M, Kalamarides M
Expert Rev Neurother 2018 Mar;18(3):241-249. Epub 2018 Jan 22 doi: 10.1080/14737175.2018.1429920. PMID: 29338455
The histiocytosis Erdheim-Chester disease is an inflammatory myeloid neoplasm.
Haroche J, Cohen-Aubart F, Charlotte F, Maksud P, Grenier PA, Cluzel P, Mathian A, Emile JF, Amoura Z
Expert Rev Clin Immunol 2015;11(9):1033-42. Epub 2015 Jul 21 doi: 10.1586/1744666X.2015.1060857. PMID: 26197238

Recent systematic reviews

Treatment of hypercalcaemia of malignancy in adults.
Mc Donald D, Drake MT, Crowley RK
Clin Med (Lond) 2023 Sep;23(5):503-507. Epub 2023 Sep 29 doi: 10.7861/clinmed.2023-0227. PMID: 37775175Free PMC Article
Treatment of Hypercalcemia of Malignancy in Adults: An Endocrine Society Clinical Practice Guideline.
El-Hajj Fuleihan G, Clines GA, Hu MI, Marcocci C, Murad MH, Piggott T, Van Poznak C, Wu JY, Drake MT
J Clin Endocrinol Metab 2023 Feb 15;108(3):507-528. doi: 10.1210/clinem/dgac621. PMID: 36545746
Brachytherapy in Spinal Tumors: A Systematic Review.
Zuckerman SL, Lim J, Yamada Y, Bilsky MH, Laufer I
World Neurosurg 2018 Oct;118:e235-e244. Epub 2018 Jun 30 doi: 10.1016/j.wneu.2018.06.166. PMID: 29966796
Role of one, two and three doses of high-dose chemotherapy with autologous transplantation in the treatment of high-risk or relapsed testicular cancer: a systematic review.
Bin Riaz I, Umar M, Zahid U, Husnain M, Iftikhar A, McBride A, Bilal J, Javed A, Akbar S, Singh P, Ali Z, Sipra QUAR, Gondal FR, Ahman F, Anwer F
Bone Marrow Transplant 2018 Oct;53(10):1242-1254. Epub 2018 Apr 27 doi: 10.1038/s41409-018-0188-3. PMID: 29703969
Management of Locally Recurrent Chordoma of the Mobile Spine and Sacrum: A Systematic Review.
Ailon T, Torabi R, Fisher CG, Rhines LD, Clarke MJ, Bettegowda C, Boriani S, Yamada YJ, Kawahara N, Varga PP, Shin JH, Saghal A, Gokaslan ZL
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20(Suppl 20):S193-S198. doi: 10.1097/BRS.0000000000001812. PMID: 27753782Free PMC Article

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