U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Benign phyllodes tumor

MedGen UID:
87254
•Concept ID:
C0334501
•
Neoplastic Process
Synonyms: Benign Cystosarcoma Phyllodes; Benign cystosarcoma phyllodes; benign cystosarcoma phyllodes; Benign Phyllodes Neoplasm; benign phyllodes neoplasm; Benign Phyllodes Tumor; benign phyllodes tumor; Cystosarcoma phyllodes, benign; Phyllodes tumor, benign; phyllodes tumor, benign
SNOMED CT: Benign phyllodes tumor (16566002); Benign cystosarcoma phyllodes (16566002); Phyllodes tumor, benign (16566002); Cystosarcoma phyllodes, benign (16566002)
 
Monarch Initiative: MONDO:0037002

Definition

A benign, circumscribed fibroepithelial neoplasm arising from the breast and rarely the prostate gland. It is characterized by the presence of epithelial structures which are arranged in clefts and by a hypercellular mesenchymal stroma which is organized in leaf-like structures. There is no evidence of cellular atypia or sarcomatous features. [from NCI]

Professional guidelines

PubMed

Re-Classification with Outcome Correlation of Previously Diagnosed Malignant Phyllodes Tumors Applying the 2016 Consensus Guidelines.
Duckworth LA, Hoda R, Komforti MK, Rowe JJ, Downs-Kelly E, McIntire PJ
Int J Surg Pathol 2023 Aug;31(5):557-563. Epub 2022 Jul 3 doi: 10.1177/10668969221106105. PMID: 35786083
Diagnosis, characteristics, and treatment of breast carcinomas within benign fibroepithelial tumors.
Saimura M, Koga K, Anan K, Mitsuyama S, Tamiya S
Breast Cancer 2018 Jul;25(4):470-478. Epub 2018 Feb 19 doi: 10.1007/s12282-018-0847-7. PMID: 29460095
Biopsy versus conservative management of sonographically benign-appearing solid breast masses in adolescents.
Jawahar A, Vade A, Ward K, Okur G, Subbaiah P
J Ultrasound Med 2015 Apr;34(4):617-25. doi: 10.7863/ultra.34.4.617. PMID: 25792577

Recent clinical studies

Etiology

High-Risk Breast Lesions Diagnosed by Ultrasound-Guided Vacuum-Assisted Excision.
He P, Lei YT, Zhao HM, Chen W, Shen WW, Fu P, Cui LG
World J Surg 2023 May;47(5):1247-1252. Epub 2023 Feb 8 doi: 10.1007/s00268-023-06930-9. PMID: 36752860
Factors effective on recurrence and metastasis in phyllodes tumors.
Altiok M, Kurt F
Niger J Clin Pract 2022 Apr;25(4):425-431. doi: 10.4103/njcp.njcp_1374_21. PMID: 35439900
Logistic regression analysis of ultrasound findings in predicting the malignant and benign phyllodes tumor of breast.
Li T, Li Y, Yang Y, Li J, Hu Z, Wang L, Pu W, Wei T, Lu M
PLoS One 2022;17(3):e0265952. Epub 2022 Mar 24 doi: 10.1371/journal.pone.0265952. PMID: 35325009Free PMC Article
Benign Phyllodes Tumor in Children: A Study of 8 Cases and Review of the Literature.
Hafeez S, Balarezo F, Ricci A Jr
J Pediatr Hematol Oncol 2020 Jul;42(5):e388-e391. doi: 10.1097/MPH.0000000000001501. PMID: 31107366
Fibroepithelial lesions; The WHO spectrum.
Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536

Diagnosis

High-Risk Breast Lesions Diagnosed by Ultrasound-Guided Vacuum-Assisted Excision.
He P, Lei YT, Zhao HM, Chen W, Shen WW, Fu P, Cui LG
World J Surg 2023 May;47(5):1247-1252. Epub 2023 Feb 8 doi: 10.1007/s00268-023-06930-9. PMID: 36752860
Factors effective on recurrence and metastasis in phyllodes tumors.
Altiok M, Kurt F
Niger J Clin Pract 2022 Apr;25(4):425-431. doi: 10.4103/njcp.njcp_1374_21. PMID: 35439900
Benign Phyllodes Tumor in Children: A Study of 8 Cases and Review of the Literature.
Hafeez S, Balarezo F, Ricci A Jr
J Pediatr Hematol Oncol 2020 Jul;42(5):e388-e391. doi: 10.1097/MPH.0000000000001501. PMID: 31107366
Diagnosis, characteristics, and treatment of breast carcinomas within benign fibroepithelial tumors.
Saimura M, Koga K, Anan K, Mitsuyama S, Tamiya S
Breast Cancer 2018 Jul;25(4):470-478. Epub 2018 Feb 19 doi: 10.1007/s12282-018-0847-7. PMID: 29460095
Fibroepithelial lesions; The WHO spectrum.
Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536

Therapy

Stromal Ki67 Expression Might be a Useful Marker for Distinguishing Fibroadenoma From Benign Phyllodes Tumor of the Breast.
Yuan M, Saeki H, Horimoto Y, Ishizuka Y, Onagi H, Saito M, Hayashi T, Arakawa A, Yao T
Int J Surg Pathol 2024 Apr;32(2):223-229. Epub 2023 May 8 doi: 10.1177/10668969231171132. PMID: 37157807
Cellular fibroepithelial lesions of the breast: A long term follow up study.
Yasir S, Nassar A, Jimenez RE, Jenkins SM, Hartmann LC, Degnim AC, Frost M, Visscher DW
Ann Diagn Pathol 2018 Aug;35:85-91. Epub 2018 Jan 10 doi: 10.1016/j.anndiagpath.2018.01.005. PMID: 30029048
A Case of Benign Phyllodes Tumor in a Transgender Woman Receiving Cross-Sex Hormones.
Richards SM, Pine-Twaddell ED, Ioffe OB, Bellavance EC
Int J Surg Pathol 2018 Jun;26(4):356-359. Epub 2017 Nov 23 doi: 10.1177/1066896917743011. PMID: 29169272
Benign Phyllodes Tumor of the Breast Diagnosed After Ultrasound-Guided Vacuum-Assisted Biopsy: Surgical Excision or Wait-and-Watch?
Ouyang Q, Li S, Tan C, Zeng Y, Zhu L, Song E, Chen K, Su F
Ann Surg Oncol 2016 Apr;23(4):1129-34. Epub 2015 Nov 17 doi: 10.1245/s10434-015-4990-5. PMID: 26577125
Interobserver variability by pathologists in the distinction between cellular fibroadenomas and phyllodes tumors.
Lawton TJ, Acs G, Argani P, Farshid G, Gilcrease M, Goldstein N, Koerner F, Rowe JJ, Sanders M, Shah SS, Reynolds C
Int J Surg Pathol 2014 Dec;22(8):695-8. Epub 2014 Aug 26 doi: 10.1177/1066896914548763. PMID: 25161205Free PMC Article

Prognosis

Factors effective on recurrence and metastasis in phyllodes tumors.
Altiok M, Kurt F
Niger J Clin Pract 2022 Apr;25(4):425-431. doi: 10.4103/njcp.njcp_1374_21. PMID: 35439900
Logistic regression analysis of ultrasound findings in predicting the malignant and benign phyllodes tumor of breast.
Li T, Li Y, Yang Y, Li J, Hu Z, Wang L, Pu W, Wei T, Lu M
PLoS One 2022;17(3):e0265952. Epub 2022 Mar 24 doi: 10.1371/journal.pone.0265952. PMID: 35325009Free PMC Article
Benign Phyllodes Tumor in Children: A Study of 8 Cases and Review of the Literature.
Hafeez S, Balarezo F, Ricci A Jr
J Pediatr Hematol Oncol 2020 Jul;42(5):e388-e391. doi: 10.1097/MPH.0000000000001501. PMID: 31107366
Fibroepithelial lesions; The WHO spectrum.
Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536
Benign Phyllodes Tumor of the Breast Diagnosed After Ultrasound-Guided Vacuum-Assisted Biopsy: Surgical Excision or Wait-and-Watch?
Ouyang Q, Li S, Tan C, Zeng Y, Zhu L, Song E, Chen K, Su F
Ann Surg Oncol 2016 Apr;23(4):1129-34. Epub 2015 Nov 17 doi: 10.1245/s10434-015-4990-5. PMID: 26577125

Clinical prediction guides

Clinical presentation and radiologic imaging findings of phyllodes tumors: benign and borderline/malignant phyllodes tumors.
Lohitvisate W, Rodjanakonkiat K, Kwankua A
F1000Res 2024;13:210. Epub 2024 May 28 doi: 10.12688/f1000research.145872.2. PMID: 38845824Free PMC Article
Machine Learning-Based Ultrasound Texture Analysis in Differentiation of Benign Phyllodes Tumors from Borderline-Malignant Phyllodes Tumors.
Basara Akin I, Ozgul HA, Altay C, Guray Durak M, Aksoy SO, Sevinc AI, Secil M, Gulmez H, Balci P
Ultraschall Med 2023 Jun;44(3):318-326. Epub 2021 Oct 21 doi: 10.1055/a-1640-9508. PMID: 34674218
Logistic regression analysis of ultrasound findings in predicting the malignant and benign phyllodes tumor of breast.
Li T, Li Y, Yang Y, Li J, Hu Z, Wang L, Pu W, Wei T, Lu M
PLoS One 2022;17(3):e0265952. Epub 2022 Mar 24 doi: 10.1371/journal.pone.0265952. PMID: 35325009Free PMC Article
Benign Phyllodes Tumor in Children: A Study of 8 Cases and Review of the Literature.
Hafeez S, Balarezo F, Ricci A Jr
J Pediatr Hematol Oncol 2020 Jul;42(5):e388-e391. doi: 10.1097/MPH.0000000000001501. PMID: 31107366
Fibroepithelial lesions; The WHO spectrum.
Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...