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Borrelia Burgdoferi-Associated Primary Cutaneous Marginal Zone Lymphoproliferative Disorder

MedGen UID:
317419
•Concept ID:
C1706987
•
Neoplastic Process
Synonyms: Borrelia Burgdoferi-Associated Cutaneous Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue; Borrelia Burgdoferi-Associated Cutaneous Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue

Definition

Primary cutaneous marginal zone lymphoproliferative disorder that arises from chronically stimulated lymphoid tissue in the skin in response to Borrelia burgdoferi infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBorrelia Burgdoferi-Associated Primary Cutaneous Marginal Zone Lymphoproliferative Disorder

Professional guidelines

PubMed

Diagnosis and Management of Cutaneous B-Cell Lymphomas.
Malachowski SJ, Sun J, Chen PL, Seminario-Vidal L
Dermatol Clin 2019 Oct;37(4):443-454. Epub 2019 Jul 30 doi: 10.1016/j.det.2019.05.004. PMID: 31466585
The role of infectious agents, antibiotics, and antiviral therapy in the treatment of extranodal marginal zone lymphoma and other low-grade lymphomas.
Foster LH, Portell CA
Curr Treat Options Oncol 2015 Jun;16(6):28. doi: 10.1007/s11864-015-0344-6. PMID: 25975444
Diagnostic criteria of primary cutaneous B-cell lymphomas and pseudolymphomas.
Kerl H, Fink-Puches R, Cerroni L
Keio J Med 2001 Dec;50(4):269-73. doi: 10.2302/kjm.50.269. PMID: 11806505

Recent clinical studies

Etiology

Pediatric Primary Cutaneous Marginal Zone Lymphoma Treated With Doxycycline.
Chan GC, Kamath S
Cutis 2023 Nov;112(5):E1-E4. doi: 10.12788/cutis.0881. PMID: 38091439
Diagnosis and Management of Cutaneous B-Cell Lymphomas.
Malachowski SJ, Sun J, Chen PL, Seminario-Vidal L
Dermatol Clin 2019 Oct;37(4):443-454. Epub 2019 Jul 30 doi: 10.1016/j.det.2019.05.004. PMID: 31466585
Primary cutaneous marginal zone lymphoma.
Dalle S, Thomas L, Balme B, Dumontet C, Thieblemont C
Crit Rev Oncol Hematol 2010 Jun;74(3):156-62. Epub 2009 Oct 12 doi: 10.1016/j.critrevonc.2009.09.003. PMID: 19819717
Primary cutaneous B-cell lymphoma.
Bogle MA, Riddle CC, Triana EM, Jones D, Duvic M
J Am Acad Dermatol 2005 Sep;53(3):479-84. doi: 10.1016/j.jaad.2005.04.043. PMID: 16112357
Primary cutaneous B-cell lymphoma and Borrelia burgdorferi infection in patients from the Highlands of Scotland.
Goodlad JR, Davidson MM, Hollowood K, Ling C, MacKenzie C, Christie I, Batstone PJ, Ho-Yen DO
Am J Surg Pathol 2000 Sep;24(9):1279-85. doi: 10.1097/00000478-200009000-00012. PMID: 10976703

Diagnosis

Pediatric Primary Cutaneous Marginal Zone Lymphoma Treated With Doxycycline.
Chan GC, Kamath S
Cutis 2023 Nov;112(5):E1-E4. doi: 10.12788/cutis.0881. PMID: 38091439
Borrelia burgdorferi in primary cutaneous lymphomas: a systematic review and meta-analysis.
Travaglino A, Varricchio S, Pace M, Russo D, Picardi M, Baldo A, Staibano S, Mascolo M
J Dtsch Dermatol Ges 2020 Dec;18(12):1379-1384. Epub 2020 Oct 8 doi: 10.1111/ddg.14289. PMID: 33029842
Diagnosis and Management of Cutaneous B-Cell Lymphomas.
Malachowski SJ, Sun J, Chen PL, Seminario-Vidal L
Dermatol Clin 2019 Oct;37(4):443-454. Epub 2019 Jul 30 doi: 10.1016/j.det.2019.05.004. PMID: 31466585
Primary cutaneous marginal zone B-cell lymphoma.
Tsuji K, Suzuki D, Naito Y, Sato Y, Yoshino T, Iwatsuki K
Eur J Dermatol 2005 Nov-Dec;15(6):480-3. PMID: 16280304
Primary cutaneous B-cell lymphoma.
Bogle MA, Riddle CC, Triana EM, Jones D, Duvic M
J Am Acad Dermatol 2005 Sep;53(3):479-84. doi: 10.1016/j.jaad.2005.04.043. PMID: 16112357

Therapy

Pediatric Primary Cutaneous Marginal Zone Lymphoma Treated With Doxycycline.
Chan GC, Kamath S
Cutis 2023 Nov;112(5):E1-E4. doi: 10.12788/cutis.0881. PMID: 38091439
Diagnosis and Management of Cutaneous B-Cell Lymphomas.
Malachowski SJ, Sun J, Chen PL, Seminario-Vidal L
Dermatol Clin 2019 Oct;37(4):443-454. Epub 2019 Jul 30 doi: 10.1016/j.det.2019.05.004. PMID: 31466585
The role of infectious agents, antibiotics, and antiviral therapy in the treatment of extranodal marginal zone lymphoma and other low-grade lymphomas.
Foster LH, Portell CA
Curr Treat Options Oncol 2015 Jun;16(6):28. doi: 10.1007/s11864-015-0344-6. PMID: 25975444
Primary cutaneous marginal zone lymphoma as a complication of radiation therapy: Case report and review.
Breton AL, Poulalhon N, Balme B, Thomas L, Dalle S
Dermatol Online J 2010 Dec 15;16(12):6. PMID: 21199632
Primary cutaneous B-cell lymphoma.
Bogle MA, Riddle CC, Triana EM, Jones D, Duvic M
J Am Acad Dermatol 2005 Sep;53(3):479-84. doi: 10.1016/j.jaad.2005.04.043. PMID: 16112357

Prognosis

Primary cutaneous marginal zone lymphoma in children: a report of 3 cases and review of the literature.
Kempf W, Kazakov DV, Buechner SA, Graf M, Zettl A, Zimmermann DR, Tinguely M
Am J Dermatopathol 2014 Aug;36(8):661-6. doi: 10.1097/DAD.0000000000000062. PMID: 24698939
Primary cutaneous marginal zone lymphoma.
Dalle S, Thomas L, Balme B, Dumontet C, Thieblemont C
Crit Rev Oncol Hematol 2010 Jun;74(3):156-62. Epub 2009 Oct 12 doi: 10.1016/j.critrevonc.2009.09.003. PMID: 19819717
Primary cutaneous marginal zone B-cell lymphoma.
Cho-Vega JH, Vega F, Rassidakis G, Medeiros LJ
Am J Clin Pathol 2006 Jun;125 Suppl:S38-49. doi: 10.1309/CVFYBQNMX1PKNAA7. PMID: 16830956
FISH analysis of MALT lymphoma-specific translocations and aneuploidy in primary cutaneous marginal zone lymphoma.
Schreuder MI, Hoefnagel JJ, Jansen PM, van Krieken JH, Willemze R, Hebeda KM
J Pathol 2005 Feb;205(3):302-10. doi: 10.1002/path.1711. PMID: 15682432

Clinical prediction guides

Clinicopathological features of primary cutaneous B-cell lymphomas from an academic regional hospital in central Italy: no evidence of Borrelia burgdorferi association.
Goteri G, Ranaldi R, Simonetti O, Capretti R, Menzo S, Stramazzotti D, Morichetti D, Offidani AM, Rupoli S, Leoni P
Leuk Lymphoma 2007 Nov;48(11):2184-8. doi: 10.1080/10428190701618250. PMID: 17926178
Differential diagnosis of cutaneous infiltrates of B lymphocytes with follicular growth pattern.
Leinweber B, Colli C, Chott A, Kerl H, Cerroni L
Am J Dermatopathol 2004 Feb;26(1):4-13. doi: 10.1097/00000372-200402000-00002. PMID: 14726817
Primary cutaneous marginal zone B-cell lymphoma: a molecular and clinicopathologic study of 24 asian cases.
Li C, Inagaki H, Kuo TT, Hu S, Okabe M, Eimoto T
Am J Surg Pathol 2003 Aug;27(8):1061-9. doi: 10.1097/00000478-200308000-00003. PMID: 12883238
Eradication of Borrelia burgdorferi infection in primary marginal zone B-cell lymphoma of the skin.
Roggero E, Zucca E, Mainetti C, Bertoni F, Valsangiacomo C, Pedrinis E, Borisch B, Piffaretti JC, Cavalli F, Isaacson PG
Hum Pathol 2000 Feb;31(2):263-8. doi: 10.1016/s0046-8177(00)80233-6. PMID: 10685647

Recent systematic reviews

Borrelia burgdorferi in primary cutaneous lymphomas: a systematic review and meta-analysis.
Travaglino A, Varricchio S, Pace M, Russo D, Picardi M, Baldo A, Staibano S, Mascolo M
J Dtsch Dermatol Ges 2020 Dec;18(12):1379-1384. Epub 2020 Oct 8 doi: 10.1111/ddg.14289. PMID: 33029842

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