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Sweat gland carcinoma

MedGen UID:
234685
•Concept ID:
C1412016
•
Neoplastic Process
Synonyms: Carcinoma of Sweat Gland; carcinoma of sweat gland; Carcinoma of the Sweat Gland; carcinoma of the sweat gland; carcinoma, sweat gland, malignant; Sweat Gland Carcinoma; sweat gland carcinoma; sweat gland carcinoma/apocrine eccrine carcinoma
SNOMED CT: Sweat gland carcinoma (254707006); Sweat gland carcinoma (32272007)
 
Monarch Initiative: MONDO:0005524

Definition

A carcinoma arising from the sweat glands. Representative examples include tubular carcinoma, spiradenocarcinoma, eccrine carcinoma, hidradenocarcinoma, and apocrine carcinoma. [from NCI]

Professional guidelines

PubMed

Cutaneous Sweat Gland Carcinomas with Basaloid Differentiation: An Update with Emphasis on Differential Diagnoses.
Flux K, Brenn T
Clin Lab Med 2017 Sep;37(3):587-601. Epub 2017 Jun 9 doi: 10.1016/j.cll.2017.05.006. PMID: 28802502
Adamantinoma of the pretibial soft tissue. Clinicopathologic features, differential diagnosis, and possible relationship to intraosseous disease.
Mills SE, Rosai J
Am J Clin Pathol 1985 Jan;83(1):108-14. doi: 10.1093/ajcp/83.1.108. PMID: 3966430

Recent clinical studies

Etiology

Recurrent GATA3 P409Afs*99 Frameshift Extension Mutations in Sweat-gland Carcinoma With Neuroendocrine Differentiation.
Goto K, Kiniwa Y, Kukita Y, Ohe S, Hiraki T, Hishima T, Takai T, Honma K
Am J Surg Pathol 2024 May 1;48(5):528-537. Epub 2024 Feb 14 doi: 10.1097/PAS.0000000000002195. PMID: 38353459
Endocrine mucin-producing sweat gland carcinoma: a systematic review and meta-analysis.
Froehlich MH, Conti KR, Norris II, Allensworth JJ, Ufkes NA, Nguyen SA, Bruner ET, Cook J, Day TA
J Dermatolog Treat 2022 Jun;33(4):2182-2191. Epub 2022 Mar 25 doi: 10.1080/09546634.2021.1937479. PMID: 34057875
Do not break a sweat: avoiding pitfalls in the diagnosis of sweat gland tumors.
Brenn T
Mod Pathol 2020 Jan;33(Suppl 1):25-41. Epub 2019 Sep 26 doi: 10.1038/s41379-019-0377-7. PMID: 31558783
Polymorphous Sweat Gland Carcinoma: An Immunohistochemical and Molecular Study.
Ronen S, Aguilera-Barrantes I, Giorgadze T, Šteiner P, Grossmann P, Suster S
Am J Dermatopathol 2018 Aug;40(8):580-587. doi: 10.1097/DAD.0000000000001128. PMID: 29533280
Sweat gland carcinoma.
Hirsh LF, Enterline HT, Rosato EF, Rosato FE
Ann Surg 1971 Aug;174(2):283-6. doi: 10.1097/00000658-197108000-00015. PMID: 5560851Free PMC Article

Diagnosis

Endocrine mucin-producing sweat gland carcinoma: a systematic review and meta-analysis.
Froehlich MH, Conti KR, Norris II, Allensworth JJ, Ufkes NA, Nguyen SA, Bruner ET, Cook J, Day TA
J Dermatolog Treat 2022 Jun;33(4):2182-2191. Epub 2022 Mar 25 doi: 10.1080/09546634.2021.1937479. PMID: 34057875
Do not break a sweat: avoiding pitfalls in the diagnosis of sweat gland tumors.
Brenn T
Mod Pathol 2020 Jan;33(Suppl 1):25-41. Epub 2019 Sep 26 doi: 10.1038/s41379-019-0377-7. PMID: 31558783
Malignant Sweat Gland Tumors.
Ahn CS, Sangüeza OP
Hematol Oncol Clin North Am 2019 Feb;33(1):53-71. doi: 10.1016/j.hoc.2018.09.002. PMID: 30497677
Topics in histopathology of sweat gland and sebaceous neoplasms.
Ansai SI
J Dermatol 2017 Mar;44(3):315-326. doi: 10.1111/1346-8138.13555. PMID: 28256768
Sweat gland carcinoma.
Geisse JK, McCalmont TH
Dermatol Surg 1997 Apr;23(4):235. doi: 10.1111/j.1524-4725.1997.tb00032.x. PMID: 9149787

Therapy

FIGHT-102: A phase 1 study of pemigatinib in Japanese patients with advanced malignancies.
Fujiwara Y, Kuboki Y, Furukawa M, Mizuno N, Hara H, Ioka T, Ueno M, Takahashi Y, Takahashi S, Takeuchi S, Lihou C, Ji T, Tian C, Shimizu T
Cancer Med 2023 May;12(9):10597-10611. Epub 2023 Mar 31 doi: 10.1002/cam4.5798. PMID: 37000035Free PMC Article
Treatment of Sweat gland carcinoma with Topical Aminolevulinic Acid Photodynamic therapy: An effective treatment method to improve surgical outcomes.
He X, Yang Y, Yang Y, Wang Y, Wang W, Song Y, Zeng Y, Yang Y, Zhang X, Li G, Gao Y, Lu Y
Photodiagnosis Photodyn Ther 2017 Mar;17:233-235. Epub 2016 Dec 27 doi: 10.1016/j.pdpdt.2016.12.004. PMID: 28034762
Sweat gland carcinoma with lung metastases.
Bahl A, Sharma DN, Julka PK, Das A, Rath GK
J Cancer Res Ther 2006 Oct-Dec;2(4):209-11. doi: 10.4103/0973-1482.29836. PMID: 17998708
Eccrine sweat gland carcinoma: a case report and review of diagnosis and treatment.
Voutsadakis IA, Bruckner HW
Conn Med 2000 May;64(5):263-6. PMID: 10860232
Carcinoma of eccrine sweat gland: experience with chemotherapy, autopsy findings in a patient with metastatic eccrine carcinoma, and a review of the literature.
Morris DM, Sanusi ID, Lanehart WH
J Surg Oncol 1986 Jan;31(1):26-30. doi: 10.1002/jso.2930310105. PMID: 3511326

Prognosis

Reappraisal and literature review of primary cutaneous cribriform apocrine carcinoma.
Davis A, Khachemoune A
Arch Dermatol Res 2023 Jan;315(1):7-16. Epub 2022 Feb 6 doi: 10.1007/s00403-022-02323-5. PMID: 35124722
Do not break a sweat: avoiding pitfalls in the diagnosis of sweat gland tumors.
Brenn T
Mod Pathol 2020 Jan;33(Suppl 1):25-41. Epub 2019 Sep 26 doi: 10.1038/s41379-019-0377-7. PMID: 31558783
Topics in histopathology of sweat gland and sebaceous neoplasms.
Ansai SI
J Dermatol 2017 Mar;44(3):315-326. doi: 10.1111/1346-8138.13555. PMID: 28256768
Epidemiology and Prognosis of Primary Periocular Sweat Gland Carcinomas.
Baker MS, Yin VT, Ivan D, Allen RC, Carter KD, Esmaeli B, Shriver EM
Ophthalmic Plast Reconstr Surg 2017 Mar/Apr;33(2):101-105. doi: 10.1097/IOP.0000000000000658. PMID: 26974419
Rare emerging malignant skin tumours.
Rongioletti F, Ferreli C, Pinna AL, Atzori L
G Ital Dermatol Venereol 2015 Aug;150(4):407-17. PMID: 26086411

Clinical prediction guides

Ancillary immunohistochemical and molecular testing in the classification of cutaneous sweat gland/duct neoplasms: A validation study with emphasis on histomorphologic correlation and pathological diagnosis.
Nguyen AJ, Johnson E, Camilleri M, Wieland C, Lehman JS, Agrawal S, Comfere N, Fadra N, Knudson RA, Greipp P, Halling K, Ray Guo R
Hum Pathol 2024 Aug;150:1-8. Epub 2024 Jun 12 doi: 10.1016/j.humpath.2024.06.006. PMID: 38876201
NECTIN4 expression in sebaceous and sweat gland carcinoma.
Ito T, Hashimoto H, Tanaka Y, Tanegashima K, Murata M, Oda Y, Kaku-Ito Y
Eur J Dermatol 2022 Apr 1;32(2):181-186. doi: 10.1684/ejd.2022.4241. PMID: 35866909
Endocrine Mucin-Producing Sweat Gland Carcinoma: Emerging Evidence of Multicentric Cutaneous Origin and Occasional Concurrence With Analogous Breast Tumors.
Ravi PY, Walsh NM, Archibald C, Pasternak S
Am J Dermatopathol 2022 May 1;44(5):321-326. doi: 10.1097/DAD.0000000000002132. PMID: 35170475
Do not break a sweat: avoiding pitfalls in the diagnosis of sweat gland tumors.
Brenn T
Mod Pathol 2020 Jan;33(Suppl 1):25-41. Epub 2019 Sep 26 doi: 10.1038/s41379-019-0377-7. PMID: 31558783
Mucin-producing sweat gland carcinoma of the eyelid: diagnostic and prognostic considerations.
Hoguet A, Warrow D, Milite J, McCormick SA, Maher E, Della Rocca R, Della Rocca D, Goldbaum A, Milman T
Am J Ophthalmol 2013 Mar;155(3):585-592.e2. Epub 2012 Dec 4 doi: 10.1016/j.ajo.2012.09.030. PMID: 23218693

Recent systematic reviews

Endocrine mucin-producing sweat gland carcinoma: a systematic review and meta-analysis.
Froehlich MH, Conti KR, Norris II, Allensworth JJ, Ufkes NA, Nguyen SA, Bruner ET, Cook J, Day TA
J Dermatolog Treat 2022 Jun;33(4):2182-2191. Epub 2022 Mar 25 doi: 10.1080/09546634.2021.1937479. PMID: 34057875
Prognostic Value of the Staging System for Eyelid Tumors in the 7th Edition of the American Joint Committee on Cancer Staging Manual.
Ford J, Thakar S, Thuro B, Esmaeli B
Ophthalmic Plast Reconstr Surg 2017 Sep/Oct;33(5):317-324. doi: 10.1097/IOP.0000000000000901. PMID: 28350693
Primary cutaneous mucinous carcinoma: a systematic review and meta-analysis of outcomes after surgery.
Kamalpour L, Brindise RT, Nodzenski M, Bach DQ, Veledar E, Alam M
JAMA Dermatol 2014 Apr;150(4):380-4. doi: 10.1001/jamadermatol.2013.6006. PMID: 24452370

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