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Pulmonary Adenomatosis, Ovine

MedGen UID:
19576
•Concept ID:
C0034049
•
Disease or Syndrome
Synonyms: Adenomatoses, Ovine Pulmonary; Adenomatoses, Pulmonary Ovine; Adenomatosis, Ovine Pulmonary; Adenomatosis, Pulmonary Ovine; Adenomatosis, Pulmonary, Ovine; Carcinoma, Ovine Pulmonary; Carcinomas, Ovine Pulmonary; Jaagsiekte; Ovine Adenomatoses, Pulmonary; Ovine Adenomatosis, Pulmonary; Ovine Pulmonary Adenomatoses; Ovine Pulmonary Adenomatosis; Ovine Pulmonary Carcinoma; Ovine Pulmonary Carcinomas; Pulmonary Adenomatoses, Ovine; Pulmonary Carcinoma, Ovine; Pulmonary Carcinomas, Ovine; Pulmonary Ovine Adenomatoses; Pulmonary Ovine Adenomatosis

Definition

A contagious, neoplastic, pulmonary disease of sheep characterized by hyperplasia and hypertrophy of pneumocytes and epithelial cells of the lung. It is caused by JAAGSIEKTE SHEEP RETROVIRUS. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPulmonary Adenomatosis, Ovine

Professional guidelines

PubMed

Sequence comparison of JSRV with endogenous proviruses: envelope genotypes and a novel ORF with similarity to a G-protein-coupled receptor.
Bai J, Bishop JV, Carlson JO, DeMartini JC
Virology 1999 Jun 5;258(2):333-43. doi: 10.1006/viro.1999.9728. PMID: 10366570

Recent clinical studies

Etiology

Lung cancer in never smokers--a different disease.
Sun S, Schiller JH, Gazdar AF
Nat Rev Cancer 2007 Oct;7(10):778-90. doi: 10.1038/nrc2190. PMID: 17882278
Pathology of human bronchioloalveolar carcinoma and its relationship to the ovine disease.
Mornex JF, Thivolet F, De las Heras M, Leroux C
Curr Top Microbiol Immunol 2003;275:225-48. doi: 10.1007/978-3-642-55638-8_9. PMID: 12596901
Molecular cloning and functional analysis of three type D endogenous retroviruses of sheep reveal a different cell tropism from that of the highly related exogenous jaagsiekte sheep retrovirus.
Palmarini M, Hallwirth C, York D, Murgia C, de Oliveira T, Spencer T, Fan H
J Virol 2000 Sep;74(17):8065-76. doi: 10.1128/jvi.74.17.8065-8076.2000. PMID: 10933716Free PMC Article

Diagnosis

OPA study may benefit human lung cancer research.
Vet Rec 2011 Apr 16;168(15):393. doi: 10.1136/vr.d2396. PMID: 21498444
Pathology and pathogenesis of ovine pulmonary adenocarcinoma.
Griffiths DJ, Martineau HM, Cousens C
J Comp Pathol 2010 May;142(4):260-83. Epub 2010 Feb 16 doi: 10.1016/j.jcpa.2009.12.013. PMID: 20163805
Telomerase activation in a model of lung adenocarcinoma.
Suau F, Cottin V, Archer F, Croze S, Chastang J, Cordier G, Thivolet-Béjui F, Mornex JF, Leroux C
Eur Respir J 2006 Jun;27(6):1175-82. Epub 2006 Feb 2 doi: 10.1183/09031936.06.00125105. PMID: 16455826
In vitro infection of ovine cell lines by Jaagsiekte sheep retrovirus.
Palmarini M, Sharp JM, Lee C, Fan H
J Virol 1999 Dec;73(12):10070-8. doi: 10.1128/JVI.73.12.10070-10078.1999. PMID: 10559321Free PMC Article
Sheep lung carcinoma: an endemic analogue of a sporadic human neoplasm.
Perk K, Hod I
J Natl Cancer Inst 1982 Oct;69(4):747-9. PMID: 6288989

Prognosis

Lung cancer in never smokers--a different disease.
Sun S, Schiller JH, Gazdar AF
Nat Rev Cancer 2007 Oct;7(10):778-90. doi: 10.1038/nrc2190. PMID: 17882278
Pathology of human bronchioloalveolar carcinoma and its relationship to the ovine disease.
Mornex JF, Thivolet F, De las Heras M, Leroux C
Curr Top Microbiol Immunol 2003;275:225-48. doi: 10.1007/978-3-642-55638-8_9. PMID: 12596901

Clinical prediction guides

The U3 and Env Proteins of Jaagsiekte Sheep Retrovirus and Enzootic Nasal Tumor Virus Both Contribute to Tissue Tropism.
Rosales Gerpe MC, van Lieshout LP, Domm JM, Ingrao JC, Datu J, Walsh SR, Yu DL, Jong J, Krell PJ, Wootton SK
Viruses 2019 Nov 14;11(11) doi: 10.3390/v11111061. PMID: 31739606Free PMC Article
Early Steps of Jaagsiekte Sheep Retrovirus-Mediated Cell Transformation Involve the Interaction between Env and the RALBP1 Cellular Protein.
Monot M, Erny A, Gineys B, Desloire S, Dolmazon C, Aublin-Gex A, Lotteau V, Archer F, Leroux C
J Virol 2015 Aug;89(16):8462-73. Epub 2015 Jun 3 doi: 10.1128/JVI.00590-15. PMID: 26041289Free PMC Article
IFITM proteins restrict viral membrane hemifusion.
Li K, Markosyan RM, Zheng YM, Golfetto O, Bungart B, Li M, Ding S, He Y, Liang C, Lee JC, Gratton E, Cohen FS, Liu SL
PLoS Pathog 2013 Jan;9(1):e1003124. Epub 2013 Jan 24 doi: 10.1371/journal.ppat.1003124. PMID: 23358889Free PMC Article
Pathology of human bronchioloalveolar carcinoma and its relationship to the ovine disease.
Mornex JF, Thivolet F, De las Heras M, Leroux C
Curr Top Microbiol Immunol 2003;275:225-48. doi: 10.1007/978-3-642-55638-8_9. PMID: 12596901
In vitro infection of ovine cell lines by Jaagsiekte sheep retrovirus.
Palmarini M, Sharp JM, Lee C, Fan H
J Virol 1999 Dec;73(12):10070-8. doi: 10.1128/JVI.73.12.10070-10078.1999. PMID: 10559321Free PMC Article

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