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Familial Waldenstrom Macroglobulinemia

MedGen UID:
422439
•Concept ID:
C2936755
•
Neoplastic Process
Synonyms: Familial Waldenstrom Macroglobulinaemia; Familial Waldenstrom's Macroglobulinaemia; Familial Waldenstroms Macroglobulinaemia; Macroglobulinaemia, Familial Waldenstrom's; Waldenstrom's Macroglobulinaemia, Familial

Definition

Waldenstrom macroglobulinemia in a patient who has at least one first degree relative with either Waldenstrom macroglobulinemia or another B-cell lymphoproliferative disorder. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFamilial Waldenstrom Macroglobulinemia

Professional guidelines

PubMed

Waldenstrom Macroglobulinemia: Familial Predisposition and the Role of Genomics in Prognosis and Treatment Selection.
Kapoor P, Paludo J, Ansell SM
Curr Treat Options Oncol 2016 Mar;17(3):16. doi: 10.1007/s11864-016-0391-7. PMID: 26942591

Recent clinical studies

Etiology

Genetic predisposition to leukemia and other hematologic malignancies.
Feurstein S, Drazer MW, Godley LA
Semin Oncol 2016 Oct;43(5):598-608. Epub 2016 Oct 25 doi: 10.1053/j.seminoncol.2016.10.003. PMID: 27899193
Protein electrophoresis, immunoelectrophoresis and immunofixation electrophoresis as predictors for high-risk phenotype in familial Waldenström macroglobulinemia.
McMaster ML, Csako G
Int J Cancer 2008 Mar 1;122(5):1183-8. doi: 10.1002/ijc.23229. PMID: 17990319
Long-term evaluation of three multiple-case Waldenstrom macroglobulinemia families.
McMaster ML, Csako G, Giambarresi TR, Vasquez L, Berg M, Saddlemire S, Hulley B, Tucker MA
Clin Cancer Res 2007 Sep 1;13(17):5063-9. doi: 10.1158/1078-0432.CCR-07-0299. PMID: 17785558

Diagnosis

Screening and identification of a novel FHL2 mutation by whole exome sequencing in twins with familial Waldenström macroglobulinemia.
Wan Y, Cheng Y, Liu Y, Shen L, Hou J
Cancer 2021 Jun 15;127(12):2039-2048. Epub 2021 Mar 25 doi: 10.1002/cncr.33454. PMID: 33764527
Protein electrophoresis, immunoelectrophoresis and immunofixation electrophoresis as predictors for high-risk phenotype in familial Waldenström macroglobulinemia.
McMaster ML, Csako G
Int J Cancer 2008 Mar 1;122(5):1183-8. doi: 10.1002/ijc.23229. PMID: 17990319

Therapy

Exome sequencing reveals recurrent germ line variants in patients with familial Waldenström macroglobulinemia.
Roccaro AM, Sacco A, Shi J, Chiarini M, Perilla-Glen A, Manier S, Glavey S, Aljawai Y, Mishima Y, Kawano Y, Moschetta M, Correll M, Improgo MR, Brown JR, Imberti L, Rossi G, Castillo JJ, Treon SP, Freedman ML, Van Allen EM, Hide W, Hiller E, Rainville I, Ghobrial IM
Blood 2016 May 26;127(21):2598-606. Epub 2016 Feb 22 doi: 10.1182/blood-2015-11-680199. PMID: 26903547

Prognosis

Protein electrophoresis, immunoelectrophoresis and immunofixation electrophoresis as predictors for high-risk phenotype in familial Waldenström macroglobulinemia.
McMaster ML, Csako G
Int J Cancer 2008 Mar 1;122(5):1183-8. doi: 10.1002/ijc.23229. PMID: 17990319

Clinical prediction guides

Screening and identification of a novel FHL2 mutation by whole exome sequencing in twins with familial Waldenström macroglobulinemia.
Wan Y, Cheng Y, Liu Y, Shen L, Hou J
Cancer 2021 Jun 15;127(12):2039-2048. Epub 2021 Mar 25 doi: 10.1002/cncr.33454. PMID: 33764527
Familial Waldenström Macroglobulinemia: Families Informing Populations.
McMaster ML
Hematol Oncol Clin North Am 2018 Oct;32(5):787-809. Epub 2018 Jul 26 doi: 10.1016/j.hoc.2018.05.006. PMID: 30190018
Rare Circulating Cells in Familial Waldenström Macroglobulinemia Displaying the MYD88 L265P Mutation Are Enriched by Epstein-Barr Virus Immortalization.
Pertesi M, Galia P, Nazaret N, Vallée M, Garderet L, Leleu X, Avet-Loiseau H, Foll M, Byrnes G, Lachuer J, McKay JD, Dumontet C
PLoS One 2015;10(9):e0136505. Epub 2015 Sep 9 doi: 10.1371/journal.pone.0136505. PMID: 26352266Free PMC Article
Protein electrophoresis, immunoelectrophoresis and immunofixation electrophoresis as predictors for high-risk phenotype in familial Waldenström macroglobulinemia.
McMaster ML, Csako G
Int J Cancer 2008 Mar 1;122(5):1183-8. doi: 10.1002/ijc.23229. PMID: 17990319
Long-term evaluation of three multiple-case Waldenstrom macroglobulinemia families.
McMaster ML, Csako G, Giambarresi TR, Vasquez L, Berg M, Saddlemire S, Hulley B, Tucker MA
Clin Cancer Res 2007 Sep 1;13(17):5063-9. doi: 10.1158/1078-0432.CCR-07-0299. PMID: 17785558

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