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Salivary duct carcinoma

MedGen UID:
220969
•Concept ID:
C1301194
•
Neoplastic Process
Synonyms: carcinoma of duct of salivary gland; Carcinoma of Salivary Duct; carcinoma of salivary duct; Carcinoma of the Salivary Duct; carcinoma of the salivary duct; duct of salivary gland carcinoma; High Grade Salivary Duct Carcinoma; high grade salivary duct carcinoma; Salivary Duct Carcinoma; salivary duct carcinoma
SNOMED CT: Salivary duct carcinoma (397082006)
 
Monarch Initiative: MONDO:0044915

Definition

An aggressive, high grade adenocarcinoma that arises from the salivary glands. It usually affects elderly males and presents as a rapidly enlarging mass. It metastasizes to regional lymph nodes and distant anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary duct carcinoma

Professional guidelines

PubMed

Oncocytoid Salivary Tumors: Differential Diagnosis and Utility of Newly Described Immunohistochemistry.
Katabi N
Head Neck Pathol 2024 Mar 19;18(1):20. doi: 10.1007/s12105-024-01622-9. PMID: 38502259Free PMC Article
Postoperative Management of Salivary Gland Tumors.
Joshi NP, Broughman JR
Curr Treat Options Oncol 2021 Feb 9;22(3):23. doi: 10.1007/s11864-021-00820-9. PMID: 33560478
Salivary duct carcinoma: Updates in histology, cytology, molecular biology, and treatment.
Nakaguro M, Tada Y, Faquin WC, Sadow PM, Wirth LJ, Nagao T
Cancer Cytopathol 2020 Oct;128(10):693-703. Epub 2020 May 18 doi: 10.1002/cncy.22288. PMID: 32421944Free PMC Article

Recent clinical studies

Etiology

Mucin-rich salivary gland tumors.
Bishop JA
Semin Diagn Pathol 2024 Jul;41(4):165-172. Epub 2024 Jun 8 doi: 10.1053/j.semdp.2024.06.001. PMID: 38853124
Salivary duct carcinoma: A report of 70 FNA cases and review of the literature.
Wakely PE
Cancer Cytopathol 2022 Aug;130(8):595-608. Epub 2022 Mar 7 doi: 10.1002/cncy.22568. PMID: 35255198
Salivary Gland Cancers.
Tchekmedyian V
Hematol Oncol Clin North Am 2021 Oct;35(5):973-990. doi: 10.1016/j.hoc.2021.05.011. PMID: 34503735
Salivary duct carcinoma.
D'heygere E, Meulemans J, Vander Poorten V
Curr Opin Otolaryngol Head Neck Surg 2018 Apr;26(2):142-151. doi: 10.1097/MOO.0000000000000436. PMID: 29373327
A prospective phase II study of combined androgen blockade in patients with androgen receptor-positive metastatic or locally advanced unresectable salivary gland carcinoma.
Fushimi C, Tada Y, Takahashi H, Nagao T, Ojiri H, Masubuchi T, Matsuki T, Miura K, Kawakita D, Hirai H, Hoshino E, Kamata S, Saotome T
Ann Oncol 2018 Apr 1;29(4):979-984. doi: 10.1093/annonc/mdx771. PMID: 29211833Free PMC Article

Diagnosis

Salivary duct carcinoma: Updates in histology, cytology, molecular biology, and treatment.
Nakaguro M, Tada Y, Faquin WC, Sadow PM, Wirth LJ, Nagao T
Cancer Cytopathol 2020 Oct;128(10):693-703. Epub 2020 May 18 doi: 10.1002/cncy.22288. PMID: 32421944Free PMC Article
Salivary duct carcinoma.
D'heygere E, Meulemans J, Vander Poorten V
Curr Opin Otolaryngol Head Neck Surg 2018 Apr;26(2):142-151. doi: 10.1097/MOO.0000000000000436. PMID: 29373327
A prospective phase II study of combined androgen blockade in patients with androgen receptor-positive metastatic or locally advanced unresectable salivary gland carcinoma.
Fushimi C, Tada Y, Takahashi H, Nagao T, Ojiri H, Masubuchi T, Matsuki T, Miura K, Kawakita D, Hirai H, Hoshino E, Kamata S, Saotome T
Ann Oncol 2018 Apr 1;29(4):979-984. doi: 10.1093/annonc/mdx771. PMID: 29211833Free PMC Article
Mammary Analogue Secretory Carcinoma.
Parekh V, Stevens TM
Arch Pathol Lab Med 2016 Sep;140(9):997-1001. doi: 10.5858/arpa.2015-0075-RS. PMID: 27575269
Salivary duct carcinoma.
Murrah VA, Batsakis JG
Ann Otol Rhinol Laryngol 1994 Mar;103(3):244-7. doi: 10.1177/000348949410300315. PMID: 8122843

Therapy

Role of HER2 in Prognosis of Salivary Duct Carcinoma: A Systematic Review and Meta-Analysis.
Williams CYK, Townson AT, Terry N, Schmitt NC, Sharma A
Laryngoscope 2023 Mar;133(3):476-484. Epub 2022 May 14 doi: 10.1002/lary.30214. PMID: 35567387
Systemic therapy for salivary gland malignancy: current status and future perspectives.
Imamura Y, Kiyota N, Tahara M, Hanai N, Asakage T, Matsuura K, Ota I, Saito Y, Sano D, Kodaira T, Motegi A, Yasuda K, Takahashi S, Yokota T, Okano S, Tanaka K, Onoe T, Ariizumi Y, Homma A
Jpn J Clin Oncol 2022 Apr 6;52(4):293-302. doi: 10.1093/jjco/hyac008. PMID: 35134985
Postoperative Management of Salivary Gland Tumors.
Joshi NP, Broughman JR
Curr Treat Options Oncol 2021 Feb 9;22(3):23. doi: 10.1007/s11864-021-00820-9. PMID: 33560478
Phase II Trial of Trastuzumab and Docetaxel in Patients With Human Epidermal Growth Factor Receptor 2-Positive Salivary Duct Carcinoma.
Takahashi H, Tada Y, Saotome T, Akazawa K, Ojiri H, Fushimi C, Masubuchi T, Matsuki T, Tani K, Osamura RY, Hirai H, Yamada S, Kawakita D, Miura K, Kamata SE, Nagao T
J Clin Oncol 2019 Jan 10;37(2):125-134. Epub 2018 Nov 19 doi: 10.1200/JCO.18.00545. PMID: 30452336
A prospective phase II study of combined androgen blockade in patients with androgen receptor-positive metastatic or locally advanced unresectable salivary gland carcinoma.
Fushimi C, Tada Y, Takahashi H, Nagao T, Ojiri H, Masubuchi T, Matsuki T, Miura K, Kawakita D, Hirai H, Hoshino E, Kamata S, Saotome T
Ann Oncol 2018 Apr 1;29(4):979-984. doi: 10.1093/annonc/mdx771. PMID: 29211833Free PMC Article

Prognosis

Prognostic value and clinicopathological roles of the tumor immune microenvironment in salivary duct carcinoma.
Hirai H, Nakaguro M, Tada Y, Saigusa N, Kawakita D, Honma Y, Kano S, Tsukahara K, Ozawa H, Okada T, Okami K, Yamazaki K, Sato Y, Urano M, Kajiwara M, Utsumi Y, Shimura T, Fushimi C, Shimizu A, Kondo T, Imanishi Y, Sakai A, Sato Y, Togashi T, Hanazawa T, Matsuki T, Yamazaki K, Nagao T
Virchows Arch 2023 Sep;483(3):367-379. Epub 2023 Jul 19 doi: 10.1007/s00428-023-03598-3. PMID: 37464232
Salivary duct carcinoma: Updates in histology, cytology, molecular biology, and treatment.
Nakaguro M, Tada Y, Faquin WC, Sadow PM, Wirth LJ, Nagao T
Cancer Cytopathol 2020 Oct;128(10):693-703. Epub 2020 May 18 doi: 10.1002/cncy.22288. PMID: 32421944Free PMC Article
Salivary duct carcinoma.
D'heygere E, Meulemans J, Vander Poorten V
Curr Opin Otolaryngol Head Neck Surg 2018 Apr;26(2):142-151. doi: 10.1097/MOO.0000000000000436. PMID: 29373327
Mammary Analogue Secretory Carcinoma.
Parekh V, Stevens TM
Arch Pathol Lab Med 2016 Sep;140(9):997-1001. doi: 10.5858/arpa.2015-0075-RS. PMID: 27575269
Salivary duct carcinoma.
Murrah VA, Batsakis JG
Ann Otol Rhinol Laryngol 1994 Mar;103(3):244-7. doi: 10.1177/000348949410300315. PMID: 8122843

Clinical prediction guides

Pitfalls in Salivary Gland Cytology.
Saoud C, Bailey GE, Graham A, Bonilla LM, Sanchez SI, Maleki Z
Acta Cytol 2024;68(3):194-205. Epub 2024 Feb 28 doi: 10.1159/000538069. PMID: 38417405
TRPS1 immunohistochemical expression in salivary gland tumors: A pilot study.
Tjendra Y, Kerr DA, Gomez-Fernandez C, Velez Torres JM
Am J Clin Pathol 2023 Dec 1;160(6):633-639. doi: 10.1093/ajcp/aqad100. PMID: 37565763
Phase II Trial of Trastuzumab and Docetaxel in Patients With Human Epidermal Growth Factor Receptor 2-Positive Salivary Duct Carcinoma.
Takahashi H, Tada Y, Saotome T, Akazawa K, Ojiri H, Fushimi C, Masubuchi T, Matsuki T, Tani K, Osamura RY, Hirai H, Yamada S, Kawakita D, Miura K, Kamata SE, Nagao T
J Clin Oncol 2019 Jan 10;37(2):125-134. Epub 2018 Nov 19 doi: 10.1200/JCO.18.00545. PMID: 30452336
Salivary duct carcinoma.
D'heygere E, Meulemans J, Vander Poorten V
Curr Opin Otolaryngol Head Neck Surg 2018 Apr;26(2):142-151. doi: 10.1097/MOO.0000000000000436. PMID: 29373327
Salivary Duct Carcinoma: An Update on Morphologic Mimics and Diagnostic Use of Androgen Receptor Immunohistochemistry.
Udager AM, Chiosea SI
Head Neck Pathol 2017 Sep;11(3):288-294. Epub 2017 Mar 20 doi: 10.1007/s12105-017-0798-x. PMID: 28321773Free PMC Article

Recent systematic reviews

Molecular Factors in Carcinoma Ex Pleomorphic Adenoma: Systematic Review and Meta-Analysis.
Key S, Chia C, Hasan Z, Sundaresan P, Riffat F, Dwivedi RC
Laryngoscope 2024 Mar;134(3):1042-1053. Epub 2023 Aug 23 doi: 10.1002/lary.30993. PMID: 37610148
Role of HER2 in Prognosis of Salivary Duct Carcinoma: A Systematic Review and Meta-Analysis.
Williams CYK, Townson AT, Terry N, Schmitt NC, Sharma A
Laryngoscope 2023 Mar;133(3):476-484. Epub 2022 May 14 doi: 10.1002/lary.30214. PMID: 35567387
Evaluation of HER2/neu expression in different types of salivary gland tumors: a systematic review and meta-analysis.
Javaheripour A, Saatloo MV, Vahed N, Gavgani LF, Kouhsoltani M
J Med Life 2022 May;15(5):595-600. doi: 10.25122/jml-2021-0394. PMID: 35815077Free PMC Article
Intraductal carcinomas of the salivary glands: systematic review and classification of 93 published cases.
Palicelli A
APMIS 2020 Mar;128(3):191-200. Epub 2020 Jan 3 doi: 10.1111/apm.13009. PMID: 31697865
Impact of tumour profiling on clinical trials in salivary gland cancer.
Rack S, Rahman R, Carter L, McKay C, Metcalf R
Clin Otolaryngol 2019 Jan;44(1):1-6. Epub 2018 Sep 3 doi: 10.1111/coa.13206. PMID: 30102009

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