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Refractory Malignant Myoepithelioma

MedGen UID:
1705335
•Concept ID:
C5206781
•
Neoplastic Process

Definition

A malignant myoepithelioma that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Malignant Myoepithelioma

Recent clinical studies

Etiology

Excellent Response to MEK Inhibition in an AGK-BRAF Gene Fusion Driven Carcinoma: Case Report and Literature Review.
Domen A, Paesschen CV, Zwaenepoel K, Lambin S, Pauwels P, Rasschaert M, Segelov E, Peeters M, Prenen H
Anticancer Res 2022 Jan;42(1):373-379. doi: 10.21873/anticanres.15495. PMID: 34969747
Pediatric phase I and pharmacokinetic study of erlotinib followed by the combination of erlotinib and temozolomide: a Children's Oncology Group Phase I Consortium Study.
Jakacki RI, Hamilton M, Gilbertson RJ, Blaney SM, Tersak J, Krailo MD, Ingle AM, Voss SD, Dancey JE, Adamson PC
J Clin Oncol 2008 Oct 20;26(30):4921-7. Epub 2008 Sep 15 doi: 10.1200/JCO.2007.15.2306. PMID: 18794549Free PMC Article

Diagnosis

Pleomorphic carcinoma of the breast in a 17-year-old woman.
Yamaguchi R, Tanaka M, Yamaguchi M, Fukushima T, Kaneko Y, Otsuka H, Isobe S, Terasaki H, Nakashima O, Kage M, Yano H
Med Mol Morphol 2010 Mar;43(1):43-7. Epub 2010 Mar 26 doi: 10.1007/s00795-009-0468-5. PMID: 20340005

Therapy

Excellent Response to MEK Inhibition in an AGK-BRAF Gene Fusion Driven Carcinoma: Case Report and Literature Review.
Domen A, Paesschen CV, Zwaenepoel K, Lambin S, Pauwels P, Rasschaert M, Segelov E, Peeters M, Prenen H
Anticancer Res 2022 Jan;42(1):373-379. doi: 10.21873/anticanres.15495. PMID: 34969747
Pediatric phase I and pharmacokinetic study of erlotinib followed by the combination of erlotinib and temozolomide: a Children's Oncology Group Phase I Consortium Study.
Jakacki RI, Hamilton M, Gilbertson RJ, Blaney SM, Tersak J, Krailo MD, Ingle AM, Voss SD, Dancey JE, Adamson PC
J Clin Oncol 2008 Oct 20;26(30):4921-7. Epub 2008 Sep 15 doi: 10.1200/JCO.2007.15.2306. PMID: 18794549Free PMC Article

Prognosis

Pleomorphic carcinoma of the breast in a 17-year-old woman.
Yamaguchi R, Tanaka M, Yamaguchi M, Fukushima T, Kaneko Y, Otsuka H, Isobe S, Terasaki H, Nakashima O, Kage M, Yano H
Med Mol Morphol 2010 Mar;43(1):43-7. Epub 2010 Mar 26 doi: 10.1007/s00795-009-0468-5. PMID: 20340005
Pediatric phase I and pharmacokinetic study of erlotinib followed by the combination of erlotinib and temozolomide: a Children's Oncology Group Phase I Consortium Study.
Jakacki RI, Hamilton M, Gilbertson RJ, Blaney SM, Tersak J, Krailo MD, Ingle AM, Voss SD, Dancey JE, Adamson PC
J Clin Oncol 2008 Oct 20;26(30):4921-7. Epub 2008 Sep 15 doi: 10.1200/JCO.2007.15.2306. PMID: 18794549Free PMC Article

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