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Ear Carcinoma

MedGen UID:
167259
•Concept ID:
C0848859
•
Neoplastic Process

Definition

A carcinoma that arises from the ear. Representative examples include ceruminous adenocarcinoma and squamous cell carcinoma of the external ear and adenocarcinoma of the middle ear. [from NCI]

Professional guidelines

PubMed

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
2021 American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer.
Bible KC, Kebebew E, Brierley J, Brito JP, Cabanillas ME, Clark TJ Jr, Di Cristofano A, Foote R, Giordano T, Kasperbauer J, Newbold K, Nikiforov YE, Randolph G, Rosenthal MS, Sawka AM, Shah M, Shaha A, Smallridge R, Wong-Clark CK
Thyroid 2021 Mar;31(3):337-386. doi: 10.1089/thy.2020.0944. PMID: 33728999Free PMC Article
Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314

Recent clinical studies

Etiology

Temporal bone management in external and middle ear carcinoma.
Gowrishankar S, Borsetto D, Marinelli J, Panizza B
Curr Opin Otolaryngol Head Neck Surg 2024 Apr 1;32(2):138-142. Epub 2024 Jan 8 doi: 10.1097/MOO.0000000000000959. PMID: 38193562
Tumor Stage-Related Role of Radiotherapy in Patients with an External Auditory Canal and Middle Ear Carcinoma.
Choi J, Kim SH, Koh YW, Choi EC, Lee CG, Keum KC
Cancer Res Treat 2017 Jan;49(1):178-184. Epub 2016 Jul 4 doi: 10.4143/crt.2016.165. PMID: 27384159Free PMC Article
Temporal bone carcinoma: a first glance beyond the conventional clinical and pathological prognostic factors.
Marioni G, Martini A, Favaretto N, Franchella S, Cappellesso R, Marino F, Blandamura S, Mazzoni A, Zanoletti E
Eur Arch Otorhinolaryngol 2016 Oct;273(10):2903-10. Epub 2015 Oct 30 doi: 10.1007/s00405-015-3811-6. PMID: 26518208
Computed tomography and magnetic resonance imaging findings for primary middle-ear carcinoma.
Zhang F, Sha Y
J Laryngol Otol 2013 Jun;127(6):578-83. Epub 2013 May 2 doi: 10.1017/S0022215113000923. PMID: 23635547
Middle ear cancer: a population-based study.
Gurgel RK, Karnell LH, Hansen MR
Laryngoscope 2009 Oct;119(10):1913-7. doi: 10.1002/lary.20202. PMID: 19373882

Diagnosis

Tumor Stage-Related Role of Radiotherapy in Patients with an External Auditory Canal and Middle Ear Carcinoma.
Choi J, Kim SH, Koh YW, Choi EC, Lee CG, Keum KC
Cancer Res Treat 2017 Jan;49(1):178-184. Epub 2016 Jul 4 doi: 10.4143/crt.2016.165. PMID: 27384159Free PMC Article
En bloc temporal bone resections in squamous cell carcinoma of the ear. Technique, principles, and limits.
Mazzoni A, Zanoletti E, Marioni G, Martini A
Acta Otolaryngol 2016;136(5):425-32. Epub 2016 Jan 29 doi: 10.3109/00016489.2015.1126352. PMID: 26824405
Temporal bone carcinoma: a first glance beyond the conventional clinical and pathological prognostic factors.
Marioni G, Martini A, Favaretto N, Franchella S, Cappellesso R, Marino F, Blandamura S, Mazzoni A, Zanoletti E
Eur Arch Otorhinolaryngol 2016 Oct;273(10):2903-10. Epub 2015 Oct 30 doi: 10.1007/s00405-015-3811-6. PMID: 26518208
Computed tomography and magnetic resonance imaging findings for primary middle-ear carcinoma.
Zhang F, Sha Y
J Laryngol Otol 2013 Jun;127(6):578-83. Epub 2013 May 2 doi: 10.1017/S0022215113000923. PMID: 23635547
Middle ear cancer: a population-based study.
Gurgel RK, Karnell LH, Hansen MR
Laryngoscope 2009 Oct;119(10):1913-7. doi: 10.1002/lary.20202. PMID: 19373882

Therapy

Concurrent chemoradiation in locally advanced primary middle ear lymphoepithelial carcinoma: an effective treatment modality case report.
Fong PY, Tan TY, Kiong KL
J Otolaryngol Head Neck Surg 2021 Jan 6;50(1):1. doi: 10.1186/s40463-020-00489-4. PMID: 33407879Free PMC Article

Prognosis

Tumor Stage-Related Role of Radiotherapy in Patients with an External Auditory Canal and Middle Ear Carcinoma.
Choi J, Kim SH, Koh YW, Choi EC, Lee CG, Keum KC
Cancer Res Treat 2017 Jan;49(1):178-184. Epub 2016 Jul 4 doi: 10.4143/crt.2016.165. PMID: 27384159Free PMC Article
Temporal bone carcinoma: a first glance beyond the conventional clinical and pathological prognostic factors.
Marioni G, Martini A, Favaretto N, Franchella S, Cappellesso R, Marino F, Blandamura S, Mazzoni A, Zanoletti E
Eur Arch Otorhinolaryngol 2016 Oct;273(10):2903-10. Epub 2015 Oct 30 doi: 10.1007/s00405-015-3811-6. PMID: 26518208
Expression of reversion-inducing cysteine-rich protein with kazal motifs and matrix metalloproteinase 9 in middle ear squamous cell carcinoma.
Liu X, Wang W, Chen J, Chen C, Zhou J, Cao L
ORL J Otorhinolaryngol Relat Spec 2012;74(1):16-21. Epub 2011 Dec 16 doi: 10.1159/000334243. PMID: 22178867
Middle ear cancer: a population-based study.
Gurgel RK, Karnell LH, Hansen MR
Laryngoscope 2009 Oct;119(10):1913-7. doi: 10.1002/lary.20202. PMID: 19373882
Middle ear carcinoma.
Kulczyńskl B, Skonieczny J
Pol Tyg Lek 1976 Aug 2;31(31):1333-5. PMID: 967743

Clinical prediction guides

Middle ear cancer: a population-based study.
Gurgel RK, Karnell LH, Hansen MR
Laryngoscope 2009 Oct;119(10):1913-7. doi: 10.1002/lary.20202. PMID: 19373882

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