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Pediatric leptomeningeal melanoma

MedGen UID:
232061
•Concept ID:
C1332976
•
Neoplastic Process
Synonyms: Childhood Leptomeningeal Melanoma; childhood leptomeningeal melanoma; Childhood Meningeal Melanoma; childhood meningeal melanoma; paediatric meningeal melanoma; Pediatric Leptomeningeal Melanoma; pediatric leptomeningeal melanoma; Pediatric Meningeal Melanoma; pediatric meningeal melanoma
 
Monarch Initiative: MONDO:0003764

Definition

A melanoma that arises from leptomeningeal melanocytes and occurs in childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPediatric leptomeningeal melanoma

Professional guidelines

PubMed

Leptomeningeal metastases from solid tumors: A Society for Neuro-Oncology and American Society of Clinical Oncology consensus review on clinical management and future directions.
Wilcox JA, Chukwueke UN, Ahn MJ, Aizer AA, Bale TA, Brandsma D, Brastianos PK, Chang S, Daras M, Forsyth P, Garzia L, Glantz M, Oliva ICG, Kumthekar P, Le Rhun E, Nagpal S, O'Brien B, Pentsova E, Lee EQ, Remsik J, Rudà R, Smalley I, Taylor MD, Weller M, Wefel J, Yang JT, Young RJ, Wen PY, Boire AA
Neuro Oncol 2024 Oct 3;26(10):1781-1804. doi: 10.1093/neuonc/noae103. PMID: 38902944Free PMC Article
Brain metastases in patients diagnosed with a solid primary cancer during childhood: experience from a single referral cancer center.
Suki D, Khoury Abdulla R, Ding M, Khatua S, Sawaya R
J Neurosurg Pediatr 2014 Oct;14(4):372-85. Epub 2014 Aug 15 doi: 10.3171/2014.7.PEDS13318. PMID: 25127097
Treatment of neoplastic meningeal xenografts by intraventricular administration of an antiganglioside monoclonal antibody, 3F8.
Bergman I, Barmada MA, Heller G, Griffin JA, Cheung NK
Int J Cancer 1999 Aug 12;82(4):538-48. doi: 10.1002/(sici)1097-0215(19990812)82:4<538::aid-ijc12>3.0.co;2-7. PMID: 10404068

Recent clinical studies

Etiology

Leptomeningeal metastases from solid tumors: A Society for Neuro-Oncology and American Society of Clinical Oncology consensus review on clinical management and future directions.
Wilcox JA, Chukwueke UN, Ahn MJ, Aizer AA, Bale TA, Brandsma D, Brastianos PK, Chang S, Daras M, Forsyth P, Garzia L, Glantz M, Oliva ICG, Kumthekar P, Le Rhun E, Nagpal S, O'Brien B, Pentsova E, Lee EQ, Remsik J, Rudà R, Smalley I, Taylor MD, Weller M, Wefel J, Yang JT, Young RJ, Wen PY, Boire AA
Neuro Oncol 2024 Oct 3;26(10):1781-1804. doi: 10.1093/neuonc/noae103. PMID: 38902944Free PMC Article
Neurocutaneous Melanocytosis and Leptomeningeal Melanoma.
Mitre V, Heym K, Clark GD, Venkatramani R
J Pediatr Hematol Oncol 2021 Mar 1;43(2):e195-e197. doi: 10.1097/MPH.0000000000001680. PMID: 31764519
Neurocutaneous melanocytosis (melanosis).
Ruggieri M, Polizzi A, Catanzaro S, Bianco ML, Praticò AD, Di Rocco C
Childs Nerv Syst 2020 Oct;36(10):2571-2596. Epub 2020 Oct 13 doi: 10.1007/s00381-020-04770-9. PMID: 33048248
Malignant transformation of neurocutaneous melanosis (NCM) following immunosuppression.
Schaff LR, Marghoob A, Rosenblum MK, Meyer R, Khakoo Y
Pediatr Dermatol 2019 Jul;36(4):497-500. Epub 2019 Mar 13 doi: 10.1111/pde.13804. PMID: 30868657Free PMC Article
Spectrum of central nervous system abnormalities in neurocutaneous melanocytosis.
Ramaswamy V, Delaney H, Haque S, Marghoob A, Khakoo Y
Dev Med Child Neurol 2012 Jun;54(6):563-8. Epub 2012 Apr 2 doi: 10.1111/j.1469-8749.2012.04275.x. PMID: 22469364

Diagnosis

Leptomeningeal metastases from solid tumors: A Society for Neuro-Oncology and American Society of Clinical Oncology consensus review on clinical management and future directions.
Wilcox JA, Chukwueke UN, Ahn MJ, Aizer AA, Bale TA, Brandsma D, Brastianos PK, Chang S, Daras M, Forsyth P, Garzia L, Glantz M, Oliva ICG, Kumthekar P, Le Rhun E, Nagpal S, O'Brien B, Pentsova E, Lee EQ, Remsik J, Rudà R, Smalley I, Taylor MD, Weller M, Wefel J, Yang JT, Young RJ, Wen PY, Boire AA
Neuro Oncol 2024 Oct 3;26(10):1781-1804. doi: 10.1093/neuonc/noae103. PMID: 38902944Free PMC Article
Neurocutaneous melanocytosis (melanosis).
Ruggieri M, Polizzi A, Catanzaro S, Bianco ML, Praticò AD, Di Rocco C
Childs Nerv Syst 2020 Oct;36(10):2571-2596. Epub 2020 Oct 13 doi: 10.1007/s00381-020-04770-9. PMID: 33048248
Pediatric primary diffuse leptomeningeal melanomatosis: Case report and review of the literature.
Xu X, Zheng Y, Li J, Wang F, Li F
Medicine (Baltimore) 2020 Feb;99(8):e19178. doi: 10.1097/MD.0000000000019178. PMID: 32080099Free PMC Article
Neurocutaneous melanosis presenting with hydrocephalus and malignant transformation: case-based update.
Sharouf F, Zaben M, Lammie A, Leach P, Bhatti MI
Childs Nerv Syst 2018 Aug;34(8):1471-1477. Epub 2018 Jun 12 doi: 10.1007/s00381-018-3851-5. PMID: 29948137Free PMC Article
Neurocutaneous melanosis.
Makkar HS, Frieden IJ
Semin Cutan Med Surg 2004 Jun;23(2):138-44. doi: 10.1016/j.sder.2004.01.007. PMID: 15295923

Therapy

Leptomeningeal metastases from solid tumors: A Society for Neuro-Oncology and American Society of Clinical Oncology consensus review on clinical management and future directions.
Wilcox JA, Chukwueke UN, Ahn MJ, Aizer AA, Bale TA, Brandsma D, Brastianos PK, Chang S, Daras M, Forsyth P, Garzia L, Glantz M, Oliva ICG, Kumthekar P, Le Rhun E, Nagpal S, O'Brien B, Pentsova E, Lee EQ, Remsik J, Rudà R, Smalley I, Taylor MD, Weller M, Wefel J, Yang JT, Young RJ, Wen PY, Boire AA
Neuro Oncol 2024 Oct 3;26(10):1781-1804. doi: 10.1093/neuonc/noae103. PMID: 38902944Free PMC Article
Combinatorial effects of azacitidine and trametinib on NRAS-mutated melanoma.
Hanft KM, Hamed E, Kaiser M, Würtemberger J, Schneider M, Pietsch T, Feige U, Meiss F, Krengel S, Niemeyer C, Hettmer S
Pediatr Blood Cancer 2022 Apr;69(4):e29468. Epub 2021 Dec 6 doi: 10.1002/pbc.29468. PMID: 34866327
Neurocutaneous Melanocytosis and Leptomeningeal Melanoma.
Mitre V, Heym K, Clark GD, Venkatramani R
J Pediatr Hematol Oncol 2021 Mar 1;43(2):e195-e197. doi: 10.1097/MPH.0000000000001680. PMID: 31764519
Malignant transformation of neurocutaneous melanosis (NCM) following immunosuppression.
Schaff LR, Marghoob A, Rosenblum MK, Meyer R, Khakoo Y
Pediatr Dermatol 2019 Jul;36(4):497-500. Epub 2019 Mar 13 doi: 10.1111/pde.13804. PMID: 30868657Free PMC Article
Treatment of neoplastic meningeal xenografts by intraventricular administration of an antiganglioside monoclonal antibody, 3F8.
Bergman I, Barmada MA, Heller G, Griffin JA, Cheung NK
Int J Cancer 1999 Aug 12;82(4):538-48. doi: 10.1002/(sici)1097-0215(19990812)82:4<538::aid-ijc12>3.0.co;2-7. PMID: 10404068

Prognosis

Neurocutaneous Melanocytosis and Leptomeningeal Melanoma.
Mitre V, Heym K, Clark GD, Venkatramani R
J Pediatr Hematol Oncol 2021 Mar 1;43(2):e195-e197. doi: 10.1097/MPH.0000000000001680. PMID: 31764519
Pediatric primary diffuse leptomeningeal melanomatosis: Case report and review of the literature.
Xu X, Zheng Y, Li J, Wang F, Li F
Medicine (Baltimore) 2020 Feb;99(8):e19178. doi: 10.1097/MD.0000000000019178. PMID: 32080099Free PMC Article
Neurocutaneous melanosis presenting with hydrocephalus and malignant transformation: case-based update.
Sharouf F, Zaben M, Lammie A, Leach P, Bhatti MI
Childs Nerv Syst 2018 Aug;34(8):1471-1477. Epub 2018 Jun 12 doi: 10.1007/s00381-018-3851-5. PMID: 29948137Free PMC Article
Neurocutaneous melanosis.
Makkar HS, Frieden IJ
Semin Cutan Med Surg 2004 Jun;23(2):138-44. doi: 10.1016/j.sder.2004.01.007. PMID: 15295923
Meningeal tumors of childhood and infancy. An update and literature review.
Perry A, Dehner LP
Brain Pathol 2003 Jul;13(3):386-408. doi: 10.1111/j.1750-3639.2003.tb00038.x. PMID: 12946028Free PMC Article

Clinical prediction guides

Combinatorial effects of azacitidine and trametinib on NRAS-mutated melanoma.
Hanft KM, Hamed E, Kaiser M, Würtemberger J, Schneider M, Pietsch T, Feige U, Meiss F, Krengel S, Niemeyer C, Hettmer S
Pediatr Blood Cancer 2022 Apr;69(4):e29468. Epub 2021 Dec 6 doi: 10.1002/pbc.29468. PMID: 34866327
Brain metastases in patients diagnosed with a solid primary cancer during childhood: experience from a single referral cancer center.
Suki D, Khoury Abdulla R, Ding M, Khatua S, Sawaya R
J Neurosurg Pediatr 2014 Oct;14(4):372-85. Epub 2014 Aug 15 doi: 10.3171/2014.7.PEDS13318. PMID: 25127097
Large congenital melanotic nevi in an extremity with neurocutaneous melanocytosis.
Becher OJ, Souweidane M, Lavi E, Kramer K, Lis E, Marghoob AA, Khakoo Y
Pediatr Dermatol 2009 Jan-Feb;26(1):79-82. doi: 10.1111/j.1525-1470.2008.00828.x. PMID: 19250413

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