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Salivary gland adenosquamous carcinoma

MedGen UID:
277627
•Concept ID:
C1335894
•
Neoplastic Process
Synonyms: saliva-secreting gland adenosquamous carcinoma; Salivary Gland Adenosquamous Carcinoma; salivary gland adenosquamous carcinoma
 
Monarch Initiative: MONDO:0006401

Definition

A rare, aggressive carcinoma that arises from the salivary glands. It is characterized by the presence of a squamous and a glandular epithelial component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSalivary gland adenosquamous carcinoma

Professional guidelines

PubMed

Adenosquamous carcinoma of the head and neck: criteria for diagnosis in a study of 12 cases.
Alos L, Castillo M, Nadal A, Caballero M, Mallofre C, Palacin A, Cardesa A
Histopathology 2004 Jun;44(6):570-9. doi: 10.1111/j.1365-2559.2004.01881.x. PMID: 15186272
Induction of cyclin-dependent kinase inhibitor, p21WAF1, by treatment with 3,4-dihydro-6-[4-(3,4)-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinoline (vesnarinone) in a human salivary cancer cell line with mutant p53 gene.
Sato M, Kawamata H, Harada K, Nakashiro K, Ikeda Y, Gohda H, Yoshida H, Nishida T, Ono K, Kinoshita M, Adachi M
Cancer Lett 1997 Jan 30;112(2):181-9. doi: 10.1016/s0304-3835(96)04581-8. PMID: 9066726

Recent clinical studies

Etiology

Diagnostic Value of MAML2 Rearrangements in Mucoepidermoid Carcinoma.
Thierauf JC, Farahani AA, Indave BI, Bard AZ, White VA, Smith CR, Marble H, Hyrcza MD, Chan JKC, Bishop J, Shi Q, Ely K, Agaimy A, Martinez-Lage M, Nose V, Rivera M, Nardi V, Dias-Santagata D, Garg S, Sadow P, Le LP, Faquin W, Ritterhouse LL, Cree IA, Iafrate AJ, Lennerz JK
Int J Mol Sci 2022 Apr 13;23(8) doi: 10.3390/ijms23084322. PMID: 35457138Free PMC Article
Mucoepidermoid Carcinoma of the Uterine Cervix-Single-Center Study Over a 10-Year Period.
Yordanov A, Karamanliev M, Tantchev L, Konsoulova A, Strashilov S, Vasileva-Slaveva M
Medicina (Kaunas) 2020 Jan 18;56(1) doi: 10.3390/medicina56010037. PMID: 31963763Free PMC Article
"Pancreatic Mucoepidermoid Carcinoma" Is not a Pancreatic Counterpart of CRTC1/3-MAML2 Fusion Gene-related Mucoepidermoid Carcinoma of the Salivary Gland, and May More Appropriately be Termed Pancreatic Adenosquamous Carcinoma With Mucoepidermoid Carcinoma-like Features.
Saeki K, Ohishi Y, Matsuda R, Mochidome N, Miyasaka Y, Yamamoto H, Koga Y, Maehara Y, Nakamura M, Oda Y
Am J Surg Pathol 2018 Nov;42(11):1419-1428. doi: 10.1097/PAS.0000000000001135. PMID: 30138216
Ciliated Adenosquamous Carcinoma: Expanding the Phenotypic Diversity of Human Papillomavirus-Associated Tumors.
Radkay-Gonzalez L, Faquin W, McHugh JB, Lewis JS Jr, Tuluc M, Seethala RR
Head Neck Pathol 2016 Jun;10(2):167-75. Epub 2015 Sep 28 doi: 10.1007/s12105-015-0653-x. PMID: 26411881Free PMC Article
Salivary gland-like tumours of the breast: surgical and molecular pathology.
Pia-Foschini M, Reis-Filho JS, Eusebi V, Lakhani SR
J Clin Pathol 2003 Jul;56(7):497-506. doi: 10.1136/jcp.56.7.497. PMID: 12835294Free PMC Article

Diagnosis

Tumour 63 protein (p63) in breast pathology: biology, immunohistochemistry, diagnostic applications, and pitfalls.
Alkhayyat R, Abbas A, Quinn CM, Rakha EA
Histopathology 2024 Apr;84(5):723-741. Epub 2023 Nov 27 doi: 10.1111/his.15101. PMID: 38012539
Mucoepidermoid carcinoma (MEC) and adenosquamous carcinoma (ASC), the same or different entities?
White VA, Hyrcza MD, Lennerz JK, Thierauf J, Lokuhetty D, Cree IA, Indave BI
Mod Pathol 2022 Oct;35(10):1484-1493. Epub 2022 Jul 23 doi: 10.1038/s41379-022-01100-z. PMID: 35871081Free PMC Article
Diagnostic Value of MAML2 Rearrangements in Mucoepidermoid Carcinoma.
Thierauf JC, Farahani AA, Indave BI, Bard AZ, White VA, Smith CR, Marble H, Hyrcza MD, Chan JKC, Bishop J, Shi Q, Ely K, Agaimy A, Martinez-Lage M, Nose V, Rivera M, Nardi V, Dias-Santagata D, Garg S, Sadow P, Le LP, Faquin W, Ritterhouse LL, Cree IA, Iafrate AJ, Lennerz JK
Int J Mol Sci 2022 Apr 13;23(8) doi: 10.3390/ijms23084322. PMID: 35457138Free PMC Article
Metastatic mucoepidermoid carcinoma to the pleura: a case report.
Mashiana S, Duarte EM
J Med Case Rep 2022 Feb 16;16(1):69. doi: 10.1186/s13256-022-03285-y. PMID: 35168684Free PMC Article
What the EWSR1-ATF1 fusion has taught us about hyalinizing clear cell carcinoma.
Tanguay J, Weinreb I
Head Neck Pathol 2013 Mar;7(1):28-34. Epub 2013 Mar 5 doi: 10.1007/s12105-013-0427-2. PMID: 23459838Free PMC Article

Therapy

A prospective study of salivary function sparing in patients with head-and-neck cancers receiving intensity-modulated or three-dimensional radiation therapy: initial results.
Chao KS, Deasy JO, Markman J, Haynie J, Perez CA, Purdy JA, Low DA
Int J Radiat Oncol Biol Phys 2001 Mar 15;49(4):907-16. doi: 10.1016/s0360-3016(00)01441-3. PMID: 11240231

Prognosis

Don't SUMP it! Utility of PLAG1 immunocytochemistry in basaloid SUMP subcategory.
Sanchez-Avila M, Tjendra Y, Zuo Y, Ruiz-Cordero R, Garcia-Buitrago M, Jorda M, Gomez-Fernandez C, Velez Torres JM
Cancer Cytopathol 2024 Jan;132(1):60-68. Epub 2023 Sep 13 doi: 10.1002/cncy.22762. PMID: 37702124
Metastatic mucoepidermoid carcinoma to the pleura: a case report.
Mashiana S, Duarte EM
J Med Case Rep 2022 Feb 16;16(1):69. doi: 10.1186/s13256-022-03285-y. PMID: 35168684Free PMC Article
Mucoepidermoid Carcinoma of the Uterine Cervix-Single-Center Study Over a 10-Year Period.
Yordanov A, Karamanliev M, Tantchev L, Konsoulova A, Strashilov S, Vasileva-Slaveva M
Medicina (Kaunas) 2020 Jan 18;56(1) doi: 10.3390/medicina56010037. PMID: 31963763Free PMC Article
MAML2 rearrangement in primary pulmonary mucoepidermoid carcinoma and the correlation with FLT1 expression.
Zhu F, Wang W, Hou Y, Shi J, Liu Z, He D, Bai C, Li S, Jiang L
PLoS One 2014;9(4):e94399. Epub 2014 Apr 8 doi: 10.1371/journal.pone.0094399. PMID: 24714697Free PMC Article
Mucoepidermoid carcinoma of the skin: a distinct entity from adenosquamous carcinoma: a case study with a review of the literature.
Riedlinger WF, Hurley MY, Dehner LP, Lind AC
Am J Surg Pathol 2005 Jan;29(1):131-5. doi: 10.1097/01.pas.0000147397.08853.6f. PMID: 15613868

Clinical prediction guides

Don't SUMP it! Utility of PLAG1 immunocytochemistry in basaloid SUMP subcategory.
Sanchez-Avila M, Tjendra Y, Zuo Y, Ruiz-Cordero R, Garcia-Buitrago M, Jorda M, Gomez-Fernandez C, Velez Torres JM
Cancer Cytopathol 2024 Jan;132(1):60-68. Epub 2023 Sep 13 doi: 10.1002/cncy.22762. PMID: 37702124
Mucoepidermoid Carcinoma of the Uterine Cervix-Single-Center Study Over a 10-Year Period.
Yordanov A, Karamanliev M, Tantchev L, Konsoulova A, Strashilov S, Vasileva-Slaveva M
Medicina (Kaunas) 2020 Jan 18;56(1) doi: 10.3390/medicina56010037. PMID: 31963763Free PMC Article
Evaluation of real-time qualitative sonoelastography of focal lesions in the parotid and submandibular glands: applications and limitations.
Bhatia KS, Rasalkar DD, Lee YP, Wong KT, King AD, Yuen HY, Ahuja AT
Eur Radiol 2010 Aug;20(8):1958-64. Epub 2010 Apr 21 doi: 10.1007/s00330-010-1756-0. PMID: 20407904
Mammalian mastermind like 2 11q21 gene rearrangement in bronchopulmonary mucoepidermoid carcinoma.
Achcar Rde O, Nikiforova MN, Dacic S, Nicholson AG, Yousem SA
Hum Pathol 2009 Jun;40(6):854-60. Epub 2009 Mar 9 doi: 10.1016/j.humpath.2008.11.007. PMID: 19269006
Immunohistochemical localization of keratin, vimentin and myosin in salivary gland tumors.
Matsushima R, Nakayama I, Shimizu M
Acta Pathol Jpn 1988 Apr;38(4):445-54. doi: 10.1111/j.1440-1827.1988.tb02318.x. PMID: 2456668

Recent systematic reviews

Mucoepidermoid carcinoma (MEC) and adenosquamous carcinoma (ASC), the same or different entities?
White VA, Hyrcza MD, Lennerz JK, Thierauf J, Lokuhetty D, Cree IA, Indave BI
Mod Pathol 2022 Oct;35(10):1484-1493. Epub 2022 Jul 23 doi: 10.1038/s41379-022-01100-z. PMID: 35871081Free PMC Article

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