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Sinonasal undifferentiated carcinoma(SNUC)

MedGen UID:
313704
•Concept ID:
C1710096
•
Neoplastic Process
Synonyms: Highly aggressive undifferentiated carcinoma of the nasal cavity and paranasal sinuses; SNUC
SNOMED CT: SNUC - sinonasal undifferentiated carcinoma (697993003); Undifferentiated carcinoma of nasal sinus (697993003); Sinonasal undifferentiated carcinoma (697993003)
 
Monarch Initiative: MONDO:0006411

Definition

A rare, highly aggressive carcinoma that arises from the sinonasal tract. It is characterized by the presence of small to medium size malignant cells. The prognosis is poor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSinonasal undifferentiated carcinoma

Professional guidelines

PubMed

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
The contemporary management of cancers of the sinonasal tract in adults.
Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666Free PMC Article
Induction Chemotherapy Response as a Guide for Treatment Optimization in Sinonasal Undifferentiated Carcinoma.
Amit M, Abdelmeguid AS, Watcherporn T, Takahashi H, Tam S, Bell D, Ferrarotto R, Glisson B, Kupferman ME, Roberts DB, Su SY, Raza SM, DeMonte F, Hanna EY
J Clin Oncol 2019 Feb 20;37(6):504-512. Epub 2019 Jan 7 doi: 10.1200/JCO.18.00353. PMID: 30615549Free PMC Article

Recent clinical studies

Etiology

Oncology for the rhinologist.
Tam K, Dunn LA, Cohen MA
Curr Opin Otolaryngol Head Neck Surg 2024 Feb 1;32(1):14-19. Epub 2023 Dec 6 doi: 10.1097/MOO.0000000000000951. PMID: 38116847
International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.
Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Modern treatment of sinonasal undifferentiated carcinoma.
Neo WL, Hanna EY, Kiong KL
Curr Opin Otolaryngol Head Neck Surg 2023 Apr 1;31(2):89-93. Epub 2023 Feb 7 doi: 10.1097/MOO.0000000000000877. PMID: 36912221
Induction Chemotherapy Response as a Guide for Treatment Optimization in Sinonasal Undifferentiated Carcinoma.
Amit M, Abdelmeguid AS, Watcherporn T, Takahashi H, Tam S, Bell D, Ferrarotto R, Glisson B, Kupferman ME, Roberts DB, Su SY, Raza SM, DeMonte F, Hanna EY
J Clin Oncol 2019 Feb 20;37(6):504-512. Epub 2019 Jan 7 doi: 10.1200/JCO.18.00353. PMID: 30615549Free PMC Article
Sinonasal undifferentiated carcinoma.
Mendenhall WM, Mendenhall CM, Riggs CE Jr, Villaret DB, Mendenhall NP
Am J Clin Oncol 2006 Feb;29(1):27-31. doi: 10.1097/01.coc.0000189691.04140.02. PMID: 16462499

Diagnosis

SWI/SNF-deficient Sinonasal Carcinomas.
Agaimy A
Adv Anat Pathol 2023 Mar 1;30(2):95-103. Epub 2022 Oct 20 doi: 10.1097/PAP.0000000000000372. PMID: 36580412
The contemporary management of cancers of the sinonasal tract in adults.
Thawani R, Kim MS, Arastu A, Feng Z, West MT, Taflin NF, Thein KZ, Li R, Geltzeiler M, Lee N, Fuller CD, Grandis JR, Floudas CS, Heinrich MC, Hanna E, Chandra RA
CA Cancer J Clin 2023 Jan;73(1):72-112. Epub 2022 Aug 2 doi: 10.3322/caac.21752. PMID: 35916666Free PMC Article
SMARCA4/BRG1-Deficient Sinonasal Carcinoma.
Kakkar A, Ashraf SF, Rathor A, Adhya AK, Mani S, Sikka K, Jain D
Arch Pathol Lab Med 2022 Sep 1;146(9):1122-1130. doi: 10.5858/arpa.2021-0001-OA. PMID: 34871352
Sinonasal Undifferentiated Carcinoma.
Abdelmeguid AS, Bell D, Hanna EY
Curr Oncol Rep 2019 Feb 26;21(3):26. doi: 10.1007/s11912-019-0776-4. PMID: 30806835
Induction Chemotherapy Response as a Guide for Treatment Optimization in Sinonasal Undifferentiated Carcinoma.
Amit M, Abdelmeguid AS, Watcherporn T, Takahashi H, Tam S, Bell D, Ferrarotto R, Glisson B, Kupferman ME, Roberts DB, Su SY, Raza SM, DeMonte F, Hanna EY
J Clin Oncol 2019 Feb 20;37(6):504-512. Epub 2019 Jan 7 doi: 10.1200/JCO.18.00353. PMID: 30615549Free PMC Article

Therapy

Oncology for the rhinologist.
Tam K, Dunn LA, Cohen MA
Curr Opin Otolaryngol Head Neck Surg 2024 Feb 1;32(1):14-19. Epub 2023 Dec 6 doi: 10.1097/MOO.0000000000000951. PMID: 38116847
Modern treatment of sinonasal undifferentiated carcinoma.
Neo WL, Hanna EY, Kiong KL
Curr Opin Otolaryngol Head Neck Surg 2023 Apr 1;31(2):89-93. Epub 2023 Feb 7 doi: 10.1097/MOO.0000000000000877. PMID: 36912221
Induction Chemotherapy Response as a Guide for Treatment Optimization in Sinonasal Undifferentiated Carcinoma.
Amit M, Abdelmeguid AS, Watcherporn T, Takahashi H, Tam S, Bell D, Ferrarotto R, Glisson B, Kupferman ME, Roberts DB, Su SY, Raza SM, DeMonte F, Hanna EY
J Clin Oncol 2019 Feb 20;37(6):504-512. Epub 2019 Jan 7 doi: 10.1200/JCO.18.00353. PMID: 30615549Free PMC Article
Outcome by treatment modality in sinonasal undifferentiated carcinoma (SNUC): A case-series, systematic review and meta-analysis.
Morand GB, Anderegg N, Vital D, Ikenberg K, Huber GF, Soyka MB, Egger M, Holzmann D
Oral Oncol 2017 Dec;75:28-34. Epub 2017 Oct 22 doi: 10.1016/j.oraloncology.2017.10.008. PMID: 29224819
Gaze-induced strabismus.
Newman SA
Surv Ophthalmol 1993 Nov-Dec;38(3):303-9. doi: 10.1016/0039-6257(93)90079-m. PMID: 8310398

Prognosis

Oncology for the rhinologist.
Tam K, Dunn LA, Cohen MA
Curr Opin Otolaryngol Head Neck Surg 2024 Feb 1;32(1):14-19. Epub 2023 Dec 6 doi: 10.1097/MOO.0000000000000951. PMID: 38116847
DNA methylation-based classification of sinonasal tumors.
Jurmeister P, Glöß S, Roller R, Leitheiser M, Schmid S, Mochmann LH, Payá Capilla E, Fritz R, Dittmayer C, Friedrich C, Thieme A, Keyl P, Jarosch A, Schallenberg S, Bläker H, Hoffmann I, Vollbrecht C, Lehmann A, Hummel M, Heim D, Haji M, Harter P, Englert B, Frank S, Hench J, Paulus W, Hasselblatt M, Hartmann W, Dohmen H, Keber U, Jank P, Denkert C, Stadelmann C, Bremmer F, Richter A, Wefers A, Ribbat-Idel J, Perner S, Idel C, Chiariotti L, Della Monica R, Marinelli A, Schüller U, Bockmayr M, Liu J, Lund VJ, Forster M, Lechner M, Lorenzo-Guerra SL, Hermsen M, Johann PD, Agaimy A, Seegerer P, Koch A, Heppner F, Pfister SM, Jones DTW, Sill M, von Deimling A, Snuderl M, Müller KR, Forgó E, Howitt BE, Mertins P, Klauschen F, Capper D
Nat Commun 2022 Nov 28;13(1):7148. doi: 10.1038/s41467-022-34815-3. PMID: 36443295Free PMC Article
Neuroendocrine Carcinoma and Sinonasal Undifferentiated Carcinoma.
Abdelmeguid AS, Bell D, Hanna EY
Adv Otorhinolaryngol 2020;84:168-184. Epub 2020 Jul 30 doi: 10.1159/000457936. PMID: 32731236
Sinonasal Undifferentiated Carcinoma.
Abdelmeguid AS, Bell D, Hanna EY
Curr Oncol Rep 2019 Feb 26;21(3):26. doi: 10.1007/s11912-019-0776-4. PMID: 30806835
Sinonasal undifferentiated carcinoma.
Mendenhall WM, Mendenhall CM, Riggs CE Jr, Villaret DB, Mendenhall NP
Am J Clin Oncol 2006 Feb;29(1):27-31. doi: 10.1097/01.coc.0000189691.04140.02. PMID: 16462499

Clinical prediction guides

Novel Biomarkers in Sinonasal Cancers: from Bench to Bedside.
Lechner M, Liu J, Lund VJ
Curr Oncol Rep 2020 Jul 29;22(10):106. doi: 10.1007/s11912-020-00947-2. PMID: 32725435Free PMC Article
Elective neck treatment in sinonasal undifferentiated carcinoma: Systematic review and meta-analysis.
Faisal M, Seemann R, Lill C, Hamzavi S, Wutzl A, Erovic BM, Janik S
Head Neck 2020 May;42(5):1057-1066. Epub 2020 Jan 10 doi: 10.1002/hed.26077. PMID: 31922316Free PMC Article
DNA methylation-based classification of sinonasal undifferentiated carcinoma.
Dogan S, Vasudevaraja V, Xu B, Serrano J, Ptashkin RN, Jung HJ, Chiang S, Jungbluth AA, Cohen MA, Ganly I, Berger MF, Momeni Boroujeni A, Ghossein RA, Ladanyi M, Chute DJ, Snuderl M
Mod Pathol 2019 Oct;32(10):1447-1459. Epub 2019 Jun 11 doi: 10.1038/s41379-019-0285-x. PMID: 31186531Free PMC Article
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Sinonasal undifferentiated carcinoma.
Mendenhall WM, Mendenhall CM, Riggs CE Jr, Villaret DB, Mendenhall NP
Am J Clin Oncol 2006 Feb;29(1):27-31. doi: 10.1097/01.coc.0000189691.04140.02. PMID: 16462499

Recent systematic reviews

Contemporary treatment and outcome of sinonasal undifferentiated carcinoma: A meta-analysis.
Burggraf M, Schiele S, Thölken R, López FJF, Elawany N, Zenk J, Doescher J
Head Neck 2024 Nov;46(11):2890-2900. Epub 2024 Aug 20 doi: 10.1002/hed.27910. PMID: 39162231
Meta-analysis of multi-modality therapies in sinonasal undifferentiated carcinoma-A timely update.
See ASY, Chu C, Lim ICZY, Tan BKJ, Ang SXQ, Xu S, Teo NWY, Charn TC
Clin Otolaryngol 2024 Jan;49(1):29-40. Epub 2023 Oct 20 doi: 10.1111/coa.14100. PMID: 37859617
Elective neck treatment in sinonasal undifferentiated carcinoma: Systematic review and meta-analysis.
Faisal M, Seemann R, Lill C, Hamzavi S, Wutzl A, Erovic BM, Janik S
Head Neck 2020 May;42(5):1057-1066. Epub 2020 Jan 10 doi: 10.1002/hed.26077. PMID: 31922316Free PMC Article
Outcome by treatment modality in sinonasal undifferentiated carcinoma (SNUC): A case-series, systematic review and meta-analysis.
Morand GB, Anderegg N, Vital D, Ikenberg K, Huber GF, Soyka MB, Egger M, Holzmann D
Oral Oncol 2017 Dec;75:28-34. Epub 2017 Oct 22 doi: 10.1016/j.oraloncology.2017.10.008. PMID: 29224819
Endoscopic Resection of Sinonasal Malignancy: A Systematic Review and Meta-analysis.
Rawal RB, Farzal Z, Federspiel JJ, Sreenath SB, Thorp BD, Zanation AM
Otolaryngol Head Neck Surg 2016 Sep;155(3):376-86. Epub 2016 May 10 doi: 10.1177/0194599816646968. PMID: 27165676

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