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Metastatic Malignant Neoplasm in the Small Intestine

MedGen UID:
99212
•Concept ID:
C0494164
•
Neoplastic Process
Synonyms: Cancer metastatic to small intestine; Metastases to Small Intestine; Metastasis to small intestine; Metastasis to the Small Bowel; Metastasis to the Small Intestine; Metastatic malignant neoplasm of small intestine; Metastatic malignant neoplasm to small intestine; Metastatic Malignant Neoplasm to the Small Intestine; Metastatic Neoplasm to the Small Intestine; Secondary malignant neoplasm of small intestine; Secondary Malignant Neoplasm to the Small Bowel; Secondary Malignant Neoplasm to the Small Intestine; Secondary Malignant Tumor to the Small Bowel; Secondary Malignant Tumor to the Small Intestine
SNOMED CT: Metastasis to small intestine (94580002); Secondary malignant neoplasm of small intestine (94580002); Metastatic malignant neoplasm to small intestine (94580002); Cancer metastatic to small intestine (94580002); Metastatic malignant neoplasm of small intestine (94580002)

Definition

A malignant neoplasm that has spread to the small intestine from another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Small Intestine

Professional guidelines

PubMed

The Diagnosis and Treatment of Ampullary Carcinoma.
Walter D, Schnitzbauer AA, Schulze F, Trojan J
Dtsch Arztebl Int 2023 Oct 27;120(43):729-735. doi: 10.3238/arztebl.m2023.0195. PMID: 37656482Free PMC Article
Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Chiorean EG, Chiaro MD, Tempero MA, Malafa MP, Benson AB, Cardin DB, Christensen JA, Chung V, Czito B, Dillhoff M, Donahue TR, Dotan E, Fountzilas C, Glazer ES, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Masood A, Moravek C, Nakakura EK, Narang AK, Nardo L, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Truty MJ, Vollmer C, Wolff RA, Wolpin BM, Rn BM, Lubin S, Darlow SD
J Natl Compr Canc Netw 2023 Jul;21(7):753-782. doi: 10.6004/jnccn.2023.0034. PMID: 37433437
Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis.
Miettinen M, Lasota J
Arch Pathol Lab Med 2006 Oct;130(10):1466-78. doi: 10.5858/2006-130-1466-GSTROM. PMID: 17090188

Recent clinical studies

Etiology

The impact of surgery and survival prediction in patients with gastroenteropancreatic neuroendocrine tumors: a population-based cohort study.
Wu Z, Wang W, Zhang K, Fan M, Lin R
Int J Surg 2023 Jun 1;109(6):1629-1638. doi: 10.1097/JS9.0000000000000336. PMID: 37133986Free PMC Article
Dietary fat, bile acid metabolism and colorectal cancer.
Ocvirk S, O'Keefe SJD
Semin Cancer Biol 2021 Aug;73:347-355. Epub 2020 Oct 16 doi: 10.1016/j.semcancer.2020.10.003. PMID: 33069873
Small Bowel Adenocarcinoma, Version 1.2020, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, Venook AP, Al-Hawary MM, Arain MA, Chen YJ, Ciombor KK, Cohen SA, Cooper HS, Deming DA, Garrido-Laguna I, Grem JL, Hoffe SE, Hubbard J, Hunt S, Kamel A, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen KS, Saltz LB, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Johnson-Chilla A, Gregory KM, Gurski LA
J Natl Compr Canc Netw 2019 Sep 1;17(9):1109-1133. doi: 10.6004/jnccn.2019.0043. PMID: 31487687Free PMC Article
Small Bowel Adenocarcinoma.
Aparicio T, Zaanan A, Mary F, Afchain P, Manfredi S, Evans TR
Gastroenterol Clin North Am 2016 Sep;45(3):447-57. doi: 10.1016/j.gtc.2016.04.004. PMID: 27546842
Ampullary cancer: an overview.
Ahn DH, Bekaii-Saab T
Am Soc Clin Oncol Educ Book 2014:112-5. doi: 10.14694/EdBook_AM.2014.34.112. PMID: 24857067Free PMC Article

Diagnosis

Small Bowel Adenocarcinoma, Version 1.2020, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, Venook AP, Al-Hawary MM, Arain MA, Chen YJ, Ciombor KK, Cohen SA, Cooper HS, Deming DA, Garrido-Laguna I, Grem JL, Hoffe SE, Hubbard J, Hunt S, Kamel A, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen KS, Saltz LB, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Johnson-Chilla A, Gregory KM, Gurski LA
J Natl Compr Canc Netw 2019 Sep 1;17(9):1109-1133. doi: 10.6004/jnccn.2019.0043. PMID: 31487687Free PMC Article
Demystifying the mesenteric root lesions.
Kumar P, Malla S, Singh A, Razik A, Madhusudhan KS
Abdom Radiol (NY) 2019 Aug;44(8):2708-2720. Epub 2019 May 11 doi: 10.1007/s00261-019-02053-9. PMID: 31079195
Small Bowel Adenocarcinoma.
Aparicio T, Zaanan A, Mary F, Afchain P, Manfredi S, Evans TR
Gastroenterol Clin North Am 2016 Sep;45(3):447-57. doi: 10.1016/j.gtc.2016.04.004. PMID: 27546842
Small bowel adenocarcinoma.
Zouhairi ME, Venner A, Charabaty A, Pishvaian MJ
Curr Treat Options Oncol 2008 Dec;9(4-6):388-99. Epub 2009 Apr 14 doi: 10.1007/s11864-009-0098-0. PMID: 19365735
Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis.
Miettinen M, Lasota J
Arch Pathol Lab Med 2006 Oct;130(10):1466-78. doi: 10.5858/2006-130-1466-GSTROM. PMID: 17090188

Therapy

FDA Approval Summary: Selpercatinib for the Treatment of Advanced RET Fusion-Positive Solid Tumors.
Duke ES, Bradford D, Marcovitz M, Amatya AK, Mishra-Kalyani PS, Nguyen E, Price LSL, Fourie Zirkelbach J, Li Y, Bi Y, Kraft J, Dorff SE, Scepura B, Stephenson M, Ojofeitimi I, Nair A, Han Y, Tezak Z, Lemery SJ, Pazdur R, Larkins E, Singh H
Clin Cancer Res 2023 Sep 15;29(18):3573-3578. doi: 10.1158/1078-0432.CCR-23-0459. PMID: 37265412Free PMC Article
Dietary fat, bile acid metabolism and colorectal cancer.
Ocvirk S, O'Keefe SJD
Semin Cancer Biol 2021 Aug;73:347-355. Epub 2020 Oct 16 doi: 10.1016/j.semcancer.2020.10.003. PMID: 33069873
Understanding short bowel syndrome: Current status and future perspectives.
Massironi S, Cavalcoli F, Rausa E, Invernizzi P, Braga M, Vecchi M
Dig Liver Dis 2020 Mar;52(3):253-261. Epub 2019 Dec 28 doi: 10.1016/j.dld.2019.11.013. PMID: 31892505
Ampullary cancer: an overview.
Ahn DH, Bekaii-Saab T
Am Soc Clin Oncol Educ Book 2014:112-5. doi: 10.14694/EdBook_AM.2014.34.112. PMID: 24857067Free PMC Article
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.
Neoptolemos JP, Moore MJ, Cox TF, Valle JW, Palmer DH, McDonald AC, Carter R, Tebbutt NC, Dervenis C, Smith D, Glimelius B, Charnley RM, Lacaine F, Scarfe AG, Middleton MR, Anthoney A, Ghaneh P, Halloran CM, Lerch MM, Oláh A, Rawcliffe CL, Verbeke CS, Campbell F, Büchler MW; European Study Group for Pancreatic Cancer
JAMA 2012 Jul 11;308(2):147-56. doi: 10.1001/jama.2012.7352. PMID: 22782416

Prognosis

Epidemiology of liver metastases.
Horn SR, Stoltzfus KC, Lehrer EJ, Dawson LA, Tchelebi L, Gusani NJ, Sharma NK, Chen H, Trifiletti DM, Zaorsky NG
Cancer Epidemiol 2020 Aug;67:101760. Epub 2020 Jun 17 doi: 10.1016/j.canep.2020.101760. PMID: 32562887
Management of Small Bowel Neuroendocrine Tumors.
Scott AT, Howe JR
J Oncol Pract 2018 Aug;14(8):471-482. doi: 10.1200/JOP.18.00135. PMID: 30096273Free PMC Article
Small Bowel Adenocarcinoma.
Aparicio T, Zaanan A, Mary F, Afchain P, Manfredi S, Evans TR
Gastroenterol Clin North Am 2016 Sep;45(3):447-57. doi: 10.1016/j.gtc.2016.04.004. PMID: 27546842
Small bowel adenocarcinoma.
Zouhairi ME, Venner A, Charabaty A, Pishvaian MJ
Curr Treat Options Oncol 2008 Dec;9(4-6):388-99. Epub 2009 Apr 14 doi: 10.1007/s11864-009-0098-0. PMID: 19365735
Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis.
Miettinen M, Lasota J
Arch Pathol Lab Med 2006 Oct;130(10):1466-78. doi: 10.5858/2006-130-1466-GSTROM. PMID: 17090188

Clinical prediction guides

First-Line Genomic Profiling in Previously Untreated Advanced Solid Tumors for Identification of Targeted Therapy Opportunities.
Matsubara J, Mukai K, Kondo T, Yoshioka M, Kage H, Oda K, Kudo R, Ikeda S, Ebi H, Muro K, Hayashi R, Tokudome N, Yamamoto N, Muto M
JAMA Netw Open 2023 Jul 3;6(7):e2323336. doi: 10.1001/jamanetworkopen.2023.23336. PMID: 37459099Free PMC Article
The impact of surgery and survival prediction in patients with gastroenteropancreatic neuroendocrine tumors: a population-based cohort study.
Wu Z, Wang W, Zhang K, Fan M, Lin R
Int J Surg 2023 Jun 1;109(6):1629-1638. doi: 10.1097/JS9.0000000000000336. PMID: 37133986Free PMC Article
More advantages in detecting bone and soft tissue metastases from prostate cancer using (18)F-PSMA PET/CT.
Pianou NK, Stavrou PZ, Vlontzou E, Rondogianni P, Exarhos DN, Datseris IE
Hell J Nucl Med 2019 Jan-Apr;22(1):6-9. Epub 2019 Mar 7 doi: 10.1967/s002449910952. PMID: 30843003
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.
Neoptolemos JP, Moore MJ, Cox TF, Valle JW, Palmer DH, McDonald AC, Carter R, Tebbutt NC, Dervenis C, Smith D, Glimelius B, Charnley RM, Lacaine F, Scarfe AG, Middleton MR, Anthoney A, Ghaneh P, Halloran CM, Lerch MM, Oláh A, Rawcliffe CL, Verbeke CS, Campbell F, Büchler MW; European Study Group for Pancreatic Cancer
JAMA 2012 Jul 11;308(2):147-56. doi: 10.1001/jama.2012.7352. PMID: 22782416
Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis.
Miettinen M, Lasota J
Arch Pathol Lab Med 2006 Oct;130(10):1466-78. doi: 10.5858/2006-130-1466-GSTROM. PMID: 17090188

Recent systematic reviews

Positive margins and plexitis increase the risk of recurrence after ileocecal resection: A systematic review and meta-analysis.
Yzet C, Riault C, Brazier F, Grados L, Nguyen-Khac E, Chatelain D, Sabbagh C, Buisson A, Diouf M, Fumery M
Dig Liver Dis 2023 Dec;55(12):1611-1620. Epub 2023 Jan 17 doi: 10.1016/j.dld.2022.12.021. PMID: 36658042
Ileorectal anastomosis in patients with Crohn's disease. Postoperative complications and functional outcome-a systematic review.
Baelum JK, Qvist N, Ellebaek MB
Colorectal Dis 2021 Oct;23(10):2501-2514. Epub 2021 Aug 10 doi: 10.1111/codi.15839. PMID: 34309170
Management of primary and metastatic malignant small bowel obstruction, operate or palliate. A systematic review.
Banting SP, Waters PS, Peacock O, Narasimhan V, Lynch AC, McCormick JJ, Warrier SK, Heriot AG
ANZ J Surg 2021 Mar;91(3):282-290. Epub 2020 Aug 31 doi: 10.1111/ans.16188. PMID: 32869479
Imaging spectrum of nonneoplastic duodenal diseases.
Srisajjakul S, Prapaisilp P, Bangchokdee S
Clin Imaging 2016 Nov-Dec;40(6):1173-1181. Epub 2016 Aug 6 doi: 10.1016/j.clinimag.2016.08.007. PMID: 27572283
Extranodal extension in N1-adenocarcinoma of the pancreas and papilla of Vater: a systematic review and meta-analysis of its prognostic significance.
Luchini C, Veronese N, Pea A, Sergi G, Manzato E, Nottegar A, Solmi M, Capelli P, Scarpa A
Eur J Gastroenterol Hepatol 2016 Feb;28(2):205-9. doi: 10.1097/MEG.0000000000000520. PMID: 26566063

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