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Gallbladder Goblet Cell Adenocarcinoma

MedGen UID:
474756
•Concept ID:
C3273123
•
Neoplastic Process
Synonym: Gallbladder Goblet Cell Carcinoid

Definition

An invasive mixed adenoneuroendocrine carcinoma of the gallbladder characterized by the presence of neoplastic signet-ring cells resembling goblet cells of the intestine. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGallbladder Goblet Cell Adenocarcinoma

Recent clinical studies

Etiology

Cystadenomas of the liver and extrahepatic bile ducts: Morphologic and immunohistochemical characterization of the biliary and intestinal variants.
Albores-Saavedra J, Córdova-Ramón JC, Chablé-Montero F, Dorantes-Heredia R, Henson DE
Ann Diagn Pathol 2015 Jun;19(3):124-9. Epub 2015 Mar 6 doi: 10.1016/j.anndiagpath.2015.03.001. PMID: 25792461
From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II.
Young RH
Adv Anat Pathol 2007 May;14(3):149-77. doi: 10.1097/PAP.0b013e3180504abf. PMID: 17452813
MUC1 and MUC2 expression in human gallbladder carcinoma: a clinicopathological study and relationship with prognosis.
Kashiwagi H, Kijima H, Dowaki S, Ohtani Y, Tobita K, Yamazaki H, Nakamura M, Ueyama Y, Tanaka M, Inokuchi S, Makuuchi H
Oncol Rep 2001 May-Jun;8(3):485-9. doi: 10.3892/or.8.3.485. PMID: 11295067
Adeno-endocrine cell carcinoma of the gallbladder.
Eriguchi N, Aoyagi S, Noritomi T, Imamura M, Sato S, Fujiki K, Furukawa S, Shirozu K, Hayashi I
J Hepatobiliary Pancreat Surg 2000;7(1):97-101. doi: 10.1007/s005340050161. PMID: 10982599
Histogenesis of epithelial neoplasms of human gallbladder II. Classification of carcinoma on the basis of morphological features.
Laitio M
Pathol Res Pract 1983 Aug;178(1):57-66. doi: 10.1016/S0344-0338(83)80086-7. PMID: 6316306

Diagnosis

Rokitansky-Aschoff sinuses mimicking adenocarcinoma of the gallbladder: a study of 8 cases.
Dorantes-Heredia R, Chablé-Montero F, Henson DE, Albores-Saavedra J
Am J Surg Pathol 2013 Aug;37(8):1269-74. doi: 10.1097/PAS.0b013e318286bd39. PMID: 23715158
Nonneoplastic signet-ring cells in the gallbladder and uterine cervix. A potential source of overdiagnosis.
Ragazzi M, Carbonara C, Rosai J
Hum Pathol 2009 Mar;40(3):326-31. Epub 2008 Oct 29 doi: 10.1016/j.humpath.2008.07.016. PMID: 18973921
From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II.
Young RH
Adv Anat Pathol 2007 May;14(3):149-77. doi: 10.1097/PAP.0b013e3180504abf. PMID: 17452813
Cell lineage specificity of newly raised monoclonal antibodies against gastric mucins in normal, metaplastic, and neoplastic human tissues and their application to pathology diagnosis.
Ota H, Hayama M, Nakayama J, Hidaka H, Honda T, Ishii K, Fukushima M, Uehara T, Kurihara M, Ishihara K, Hotta K, Katsuyama T
Am J Clin Pathol 2001 Jan;115(1):69-79. doi: 10.1309/AMUR-K5L3-M2DN-2DK5. PMID: 11190809
Adeno-endocrine cell carcinoma of the gallbladder.
Eriguchi N, Aoyagi S, Noritomi T, Imamura M, Sato S, Fujiki K, Furukawa S, Shirozu K, Hayashi I
J Hepatobiliary Pancreat Surg 2000;7(1):97-101. doi: 10.1007/s005340050161. PMID: 10982599

Therapy

Gallbladder adenocarcinoma: prognostic significance of tumor acid mucopolysaccharide content.
Johnson LA, Lavin PT, Dayal YY, Geller SA, Doos WG, Cooper HS, Gerber JE, Masse ST, Weiland LH, Moertel CG
J Surg Oncol 1986 Dec;33(4):243-5. doi: 10.1002/jso.2930330408. PMID: 2946897

Prognosis

Cystadenomas of the liver and extrahepatic bile ducts: Morphologic and immunohistochemical characterization of the biliary and intestinal variants.
Albores-Saavedra J, Córdova-Ramón JC, Chablé-Montero F, Dorantes-Heredia R, Henson DE
Ann Diagn Pathol 2015 Jun;19(3):124-9. Epub 2015 Mar 6 doi: 10.1016/j.anndiagpath.2015.03.001. PMID: 25792461
Rokitansky-Aschoff sinuses mimicking adenocarcinoma of the gallbladder: a study of 8 cases.
Dorantes-Heredia R, Chablé-Montero F, Henson DE, Albores-Saavedra J
Am J Surg Pathol 2013 Aug;37(8):1269-74. doi: 10.1097/PAS.0b013e318286bd39. PMID: 23715158
MUC1 and MUC2 expression in human gallbladder carcinoma: a clinicopathological study and relationship with prognosis.
Kashiwagi H, Kijima H, Dowaki S, Ohtani Y, Tobita K, Yamazaki H, Nakamura M, Ueyama Y, Tanaka M, Inokuchi S, Makuuchi H
Oncol Rep 2001 May-Jun;8(3):485-9. doi: 10.3892/or.8.3.485. PMID: 11295067
Adeno-endocrine cell carcinoma of the gallbladder.
Eriguchi N, Aoyagi S, Noritomi T, Imamura M, Sato S, Fujiki K, Furukawa S, Shirozu K, Hayashi I
J Hepatobiliary Pancreat Surg 2000;7(1):97-101. doi: 10.1007/s005340050161. PMID: 10982599
Gallbladder adenocarcinoma: prognostic significance of tumor acid mucopolysaccharide content.
Johnson LA, Lavin PT, Dayal YY, Geller SA, Doos WG, Cooper HS, Gerber JE, Masse ST, Weiland LH, Moertel CG
J Surg Oncol 1986 Dec;33(4):243-5. doi: 10.1002/jso.2930330408. PMID: 2946897

Clinical prediction guides

Rokitansky-Aschoff sinuses mimicking adenocarcinoma of the gallbladder: a study of 8 cases.
Dorantes-Heredia R, Chablé-Montero F, Henson DE, Albores-Saavedra J
Am J Surg Pathol 2013 Aug;37(8):1269-74. doi: 10.1097/PAS.0b013e318286bd39. PMID: 23715158
Expression of a colorectal antigen defined by a new monoclonal antibody, CO-TL1.
ten Dam GB, Poels LG, Pullens R, Jap PH, van de Molengraft FJ
Lab Invest 2004 Sep;84(9):1160-73. doi: 10.1038/labinvest.3700130. PMID: 15195115
MUC1 and MUC2 expression in human gallbladder carcinoma: a clinicopathological study and relationship with prognosis.
Kashiwagi H, Kijima H, Dowaki S, Ohtani Y, Tobita K, Yamazaki H, Nakamura M, Ueyama Y, Tanaka M, Inokuchi S, Makuuchi H
Oncol Rep 2001 May-Jun;8(3):485-9. doi: 10.3892/or.8.3.485. PMID: 11295067
Adeno-endocrine cell carcinoma of the gallbladder.
Eriguchi N, Aoyagi S, Noritomi T, Imamura M, Sato S, Fujiki K, Furukawa S, Shirozu K, Hayashi I
J Hepatobiliary Pancreat Surg 2000;7(1):97-101. doi: 10.1007/s005340050161. PMID: 10982599
Heterogeneity of mucin gene expression in normal and neoplastic tissues.
Ho SB, Niehans GA, Lyftogt C, Yan PS, Cherwitz DL, Gum ET, Dahiya R, Kim YS
Cancer Res 1993 Feb 1;53(3):641-51. PMID: 7678777

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