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Basosquamous carcinoma

MedGen UID:
2841
•Concept ID:
C0007118
•
Neoplastic Process
Synonyms: Basosquamous Carcinoma; Basosquamous Carcinomas; Carcinoma, Basosquamous; Carcinomas, Basosquamous
SNOMED CT: Metatypical carcinoma (6641007); Mixed basal - squamous cell carcinoma (37304002); Basisquamous cell carcinoma (37304002); BCC - Metatypical basal cell carcinoma of skin (254702000); Metatypical basal cell carcinoma of skin (254702000); Basosquamous carcinoma of skin (254702000); Basosquamous carcinoma (37304002); Mixed basal-squamous cell carcinoma (37304002)
 
Monarch Initiative: MONDO:0003264

Definition

A basal cell carcinoma which displays squamous differentiation. The neoplastic cells have more abundant cytoplasm with more marked keratinization than typical basal cell carcinomas. It usually has a more aggressive clinical course compared to typical basal cell carcinoma, and it may produce regional or widespread metastases. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBasosquamous carcinoma

Professional guidelines

PubMed

Treatment of locally advanced and metastatic basosquamous carcinoma, navigating among sonic hedgehog pathway inhibitors, immune checkpoint inhibitors, chemotherapy, and radiotherapy: A case series and literature review.
Zelin E, Mazzoletti V, Cavallo F, Nardello C, Corio A, Toffoli L, Tagliaferri L, Conforti C, Di Meo N, Zalaudek I
Australas J Dermatol 2024 Mar;65(2):103-113. Epub 2023 Nov 5 doi: 10.1111/ajd.14182. PMID: 37927116
Reappraising basosquamous carcinoma: a summary of histologic features, diagnosis, and treatment.
Shukla S, Khachemoune A
Arch Dermatol Res 2020 Nov;312(9):605-609. Epub 2020 Mar 12 doi: 10.1007/s00403-020-02058-1. PMID: 32166375
Silymarin-loaded nanostructured lipid carrier gel for the treatment of skin cancer.
Iqbal B, Ali J, Ganguli M, Mishra S, Baboota S
Nanomedicine (Lond) 2019 May;14(9):1077-1093. Epub 2019 May 3 doi: 10.2217/nnm-2018-0235. PMID: 31050580

Recent clinical studies

Etiology

Basosquamous carcinoma: Dermoscopic clues to diagnosis.
Akay BN, Saral S, Heper AO, Erdem C, Rosendahl C
J Dermatol 2017 Feb;44(2):127-134. Epub 2016 Aug 29 doi: 10.1111/1346-8138.13563. PMID: 27570202
Basosquamous carcinoma: is it an aggressive tumor?
Kececi Y, Argon A, Kebat T, Sir E, Gungor M, Vardar E
J Plast Surg Hand Surg 2015 Apr;49(2):107-11. Epub 2014 Aug 20 doi: 10.3109/2000656X.2014.944188. PMID: 25139415
Dermoscopy of basosquamous carcinoma.
Giacomel J, Lallas A, Argenziano G, Reggiani C, Piana S, Apalla Z, Ferrara G, Moscarella E, Longo C, Zalaudek I
Br J Dermatol 2013 Aug;169(2):358-64. doi: 10.1111/bjd.12394. PMID: 23607676
Basosquamous carcinoma.
Garcia C, Poletti E, Crowson AN
J Am Acad Dermatol 2009 Jan;60(1):137-43. doi: 10.1016/j.jaad.2008.09.036. PMID: 19103364
Basosquamous carcinoma.
Bowman PH, Ratz JL, Knoepp TG, Barnes CJ, Finley EM
Dermatol Surg 2003 Aug;29(8):830-2; discussion 833. doi: 10.1046/j.1524-4725.2003.29217.x. PMID: 12859383

Diagnosis

Basosquamous Carcinoma: Comprehensive Clinical and Histopathological Aspects, Novel Imaging Tools, and Therapeutic Approaches.
Murgia G, Denaro N, Boggio F, Nazzaro G, Benzecry V, Bortoluzzi P, Passoni E, Garrone O, Marzano A
Cells 2023 Nov 30;12(23) doi: 10.3390/cells12232737. PMID: 38067165Free PMC Article
Reappraising basosquamous carcinoma: a summary of histologic features, diagnosis, and treatment.
Shukla S, Khachemoune A
Arch Dermatol Res 2020 Nov;312(9):605-609. Epub 2020 Mar 12 doi: 10.1007/s00403-020-02058-1. PMID: 32166375
Basosquamous carcinoma: Dermoscopic clues to diagnosis.
Akay BN, Saral S, Heper AO, Erdem C, Rosendahl C
J Dermatol 2017 Feb;44(2):127-134. Epub 2016 Aug 29 doi: 10.1111/1346-8138.13563. PMID: 27570202
Basosquamous carcinoma.
Garcia C, Poletti E, Crowson AN
J Am Acad Dermatol 2009 Jan;60(1):137-43. doi: 10.1016/j.jaad.2008.09.036. PMID: 19103364
What is basosquamous carcinoma?
Maloney ML
Dermatol Surg 2000 May;26(5):505-6. doi: 10.1046/j.1524-4725.2000.00057.x. PMID: 10816246

Therapy

Treatment of locally advanced and metastatic basosquamous carcinoma, navigating among sonic hedgehog pathway inhibitors, immune checkpoint inhibitors, chemotherapy, and radiotherapy: A case series and literature review.
Zelin E, Mazzoletti V, Cavallo F, Nardello C, Corio A, Toffoli L, Tagliaferri L, Conforti C, Di Meo N, Zalaudek I
Australas J Dermatol 2024 Mar;65(2):103-113. Epub 2023 Nov 5 doi: 10.1111/ajd.14182. PMID: 37927116
Complete response of a large basosquamous carcinoma following treatment with cemiplimab and vismodegib.
Pirruccello J, Afzal MZ, Voudouri M, Shirai K
BMJ Case Rep 2023 Jul 14;16(7) doi: 10.1136/bcr-2022-251273. PMID: 37451798Free PMC Article
How to spot a basosquamous carcinoma: a study on demographics, clinical-dermatoscopic features and histopathological correlations.
Sgouros D, Apalla Z, Theofili M, Damaskou V, Kokkalis G, Kitsiou E, Lallas A, Kanelleas A, Stratigos A, Nikolaidou C, Bobos M, Panayiotides I, Rigopoulos D, Katoulis A
Eur J Dermatol 2021 Dec 1;31(6):779-784. doi: 10.1684/ejd.2021.4178. PMID: 34933836
Silymarin-loaded nanostructured lipid carrier gel for the treatment of skin cancer.
Iqbal B, Ali J, Ganguli M, Mishra S, Baboota S
Nanomedicine (Lond) 2019 May;14(9):1077-1093. Epub 2019 May 3 doi: 10.2217/nnm-2018-0235. PMID: 31050580
Basosquamous Carcinoma: Controversy, Advances, and Future Directions.
Tan CZ, Rieger KE, Sarin KY
Dermatol Surg 2017 Jan;43(1):23-31. doi: 10.1097/DSS.0000000000000815. PMID: 27340741

Prognosis

Basosquamous Carcinoma: Comprehensive Clinical and Histopathological Aspects, Novel Imaging Tools, and Therapeutic Approaches.
Murgia G, Denaro N, Boggio F, Nazzaro G, Benzecry V, Bortoluzzi P, Passoni E, Garrone O, Marzano A
Cells 2023 Nov 30;12(23) doi: 10.3390/cells12232737. PMID: 38067165Free PMC Article
Basal cell carcinoma and basosquamous carcinoma, two faces of the same condition?
Urechescu HC, Balica NC, Sarău CA, Anghelina F, Horhat ID, Baderca F, Jifcu EM, Ştefănescu EH, Poenaru M, Pricop MO
Rom J Morphol Embryol 2018;59(3):989-996. PMID: 30534845
Basosquamous carcinoma and metatypical basal cell carcinoma: a review of treatment with Mohs micrographic surgery.
Allen KJ, Cappel MA, Killian JM, Brewer JD
Int J Dermatol 2014 Nov;53(11):1395-403. Epub 2014 Jun 25 doi: 10.1111/ijd.12587. PMID: 24961583
Basosquamous carcinoma.
Garcia C, Poletti E, Crowson AN
J Am Acad Dermatol 2009 Jan;60(1):137-43. doi: 10.1016/j.jaad.2008.09.036. PMID: 19103364
Basosquamous carcinoma-an under-recognized, high-risk cutaneous neoplasm: case study and review of the literature.
Costantino D, Lowe L, Brown DL
J Plast Reconstr Aesthet Surg 2006;59(4):424-8. doi: 10.1016/j.bjps.2005.06.007. PMID: 16756261

Clinical prediction guides

Basosquamous carcinoma: Comprehensive epidemiological, clinical, dermoscopic, and confocal features from a single center institution.
Venturi F, Erbacci V, Veronesi G, Scotti B, Baraldi C, Dika E
Skin Res Technol 2024 Aug;30(8):e70012. doi: 10.1111/srt.70012. PMID: 39137046Free PMC Article
How to spot a basosquamous carcinoma: a study on demographics, clinical-dermatoscopic features and histopathological correlations.
Sgouros D, Apalla Z, Theofili M, Damaskou V, Kokkalis G, Kitsiou E, Lallas A, Kanelleas A, Stratigos A, Nikolaidou C, Bobos M, Panayiotides I, Rigopoulos D, Katoulis A
Eur J Dermatol 2021 Dec 1;31(6):779-784. doi: 10.1684/ejd.2021.4178. PMID: 34933836
Xeroderma pigmentosum in Yemen.
Khatri ML
Int J Dermatol 2021 Mar;60(3):314-320. Epub 2021 Feb 4 doi: 10.1111/ijd.15395. PMID: 33538348
Basosquamous carcinoma: Dermoscopic clues to diagnosis.
Akay BN, Saral S, Heper AO, Erdem C, Rosendahl C
J Dermatol 2017 Feb;44(2):127-134. Epub 2016 Aug 29 doi: 10.1111/1346-8138.13563. PMID: 27570202
Basosquamous carcinoma.
Garcia C, Poletti E, Crowson AN
J Am Acad Dermatol 2009 Jan;60(1):137-43. doi: 10.1016/j.jaad.2008.09.036. PMID: 19103364

Recent systematic reviews

Secondary cutaneous malignancy after treatment of basal cell carcinoma with hedgehog pathway inhibitor: a systematic review.
Pierce CM, Wang RJ, Howe R, Burgess BA, Owen JL
Arch Dermatol Res 2024 Oct 26;316(10):716. doi: 10.1007/s00403-024-03471-6. PMID: 39460789
Basosquamous Carcinoma: Controversy, Advances, and Future Directions.
Tan CZ, Rieger KE, Sarin KY
Dermatol Surg 2017 Jan;43(1):23-31. doi: 10.1097/DSS.0000000000000815. PMID: 27340741

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