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Squamous cell lung carcinoma

MedGen UID:
56202
•Concept ID:
C0149782
•
Neoplastic Process
Synonyms: Lung cancer, squamous cell, somatic; Squamous cell carcinoma of lung
SNOMED CT: Squamous cell carcinoma of lung (254634000); Epidermoid carcinoma of lung (254634000); SCC - Squamous cell carcinoma of lung (254634000)
 
HPO: HP:0030359
Monarch Initiative: MONDO:0005097

Definition

A type of non-small cell lung carcinoma that is derived from stratified squamous epithelial cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Squamous cell lung carcinoma

Professional guidelines

PubMed

Assessment of causal effects of visceral adipose tissue on risk of cancers: a Mendelian randomization study.
Lu Y, Tang H, Huang P, Wang J, Deng P, Li Y, Zheng J, Weng L
Int J Epidemiol 2022 Aug 10;51(4):1204-1218. doi: 10.1093/ije/dyac025. PMID: 35218345Free PMC Article
Best practice in the treatment of advanced squamous cell lung cancer.
Ang YL, Tan HL, Soo RA
Ther Adv Respir Dis 2015 Oct;9(5):224-35. Epub 2015 Apr 22 doi: 10.1177/1753465815581147. PMID: 25902866
New developments in the treatment of squamous cell lung cancer.
Filipits M
Curr Opin Oncol 2014 Mar;26(2):152-8. doi: 10.1097/CCO.0000000000000049. PMID: 24441504

Curated

UK NICE guideline NG122, Lung cancer: diagnosis and management, 2023

Recent clinical studies

Etiology

Bidirectional Mendelian randomization analysis of the genetic association between primary lung cancer and colorectal cancer.
Xiao Z, Wang Z, Zhang T, Liu Y, Si M
J Transl Med 2023 Oct 15;21(1):722. doi: 10.1186/s12967-023-04612-7. PMID: 37840123Free PMC Article
Type 2 Diabetes and Cancer: An Umbrella Review of Observational and Mendelian Randomization Studies.
Pearson-Stuttard J, Papadimitriou N, Markozannes G, Cividini S, Kakourou A, Gill D, Rizos EC, Monori G, Ward HA, Kyrgiou M, Gunter MJ, Tsilidis KK
Cancer Epidemiol Biomarkers Prev 2021 Jun;30(6):1218-1228. Epub 2021 Mar 18 doi: 10.1158/1055-9965.EPI-20-1245. PMID: 33737302Free PMC Article
Genetic alterations in squamous cell lung cancer associated with idiopathic pulmonary fibrosis.
Hata A, Nakajima T, Matsusaka K, Fukuyo M, Nakayama M, Morimoto J, Ito Y, Yamamoto T, Sakairi Y, Rahmutulla B, Ota S, Wada H, Suzuki H, Iwata T, Matsubara H, Ohara O, Yoshino I, Kaneda A
Int J Cancer 2021 Jun 15;148(12):3008-3018. Epub 2021 Feb 19 doi: 10.1002/ijc.33499. PMID: 33533494
EGFR mutation exists in squamous cell lung carcinoma.
Cheung AH, Tong JH, Chung LY, Chau SL, Ng CS, Wan IYP, To KF
Pathology 2020 Apr;52(3):323-328. Epub 2020 Feb 27 doi: 10.1016/j.pathol.2019.12.003. PMID: 32113673
Premalignant lesions of squamous cell carcinoma of the lung: The molecular make-up and factors affecting their progression.
Denisov EV, Schegoleva AA, Gervas PA, Ponomaryova AA, Tashireva LA, Boyarko VV, Bukreeva EB, Pankova OV, Perelmuter VM
Lung Cancer 2019 Sep;135:21-28. Epub 2019 Jul 5 doi: 10.1016/j.lungcan.2019.07.001. PMID: 31446997

Diagnosis

Bidirectional Mendelian randomization analysis of the genetic association between primary lung cancer and colorectal cancer.
Xiao Z, Wang Z, Zhang T, Liu Y, Si M
J Transl Med 2023 Oct 15;21(1):722. doi: 10.1186/s12967-023-04612-7. PMID: 37840123Free PMC Article
The causal relationship between thyroid function, autoimune thyroid dysfunction and lung cancer: a mendelian randomization study.
Wang X, Liu X, Li Y, Tang M, Meng X, Chai Y, Zhang L, Zhang H
BMC Pulm Med 2023 Sep 11;23(1):338. doi: 10.1186/s12890-023-02588-0. PMID: 37697335Free PMC Article
Genetic alteration and PD-L1 expression profiles of Chinese patients with lung squamous cell carcinoma.
Chen Y, Kong W, Yu Z, Zhao Z
Pathol Res Pract 2022 Mar;231:153761. Epub 2022 Jan 8 doi: 10.1016/j.prp.2022.153761. PMID: 35151031
EGFR mutation exists in squamous cell lung carcinoma.
Cheung AH, Tong JH, Chung LY, Chau SL, Ng CS, Wan IYP, To KF
Pathology 2020 Apr;52(3):323-328. Epub 2020 Feb 27 doi: 10.1016/j.pathol.2019.12.003. PMID: 32113673
Premalignant lesions of squamous cell carcinoma of the lung: The molecular make-up and factors affecting their progression.
Denisov EV, Schegoleva AA, Gervas PA, Ponomaryova AA, Tashireva LA, Boyarko VV, Bukreeva EB, Pankova OV, Perelmuter VM
Lung Cancer 2019 Sep;135:21-28. Epub 2019 Jul 5 doi: 10.1016/j.lungcan.2019.07.001. PMID: 31446997

Therapy

Bidirectional Mendelian randomization analysis of the genetic association between primary lung cancer and colorectal cancer.
Xiao Z, Wang Z, Zhang T, Liu Y, Si M
J Transl Med 2023 Oct 15;21(1):722. doi: 10.1186/s12967-023-04612-7. PMID: 37840123Free PMC Article
The causal relationship between thyroid function, autoimune thyroid dysfunction and lung cancer: a mendelian randomization study.
Wang X, Liu X, Li Y, Tang M, Meng X, Chai Y, Zhang L, Zhang H
BMC Pulm Med 2023 Sep 11;23(1):338. doi: 10.1186/s12890-023-02588-0. PMID: 37697335Free PMC Article
Type 2 Diabetes and Cancer: An Umbrella Review of Observational and Mendelian Randomization Studies.
Pearson-Stuttard J, Papadimitriou N, Markozannes G, Cividini S, Kakourou A, Gill D, Rizos EC, Monori G, Ward HA, Kyrgiou M, Gunter MJ, Tsilidis KK
Cancer Epidemiol Biomarkers Prev 2021 Jun;30(6):1218-1228. Epub 2021 Mar 18 doi: 10.1158/1055-9965.EPI-20-1245. PMID: 33737302Free PMC Article
Association between systemic sclerosis and risk of lung cancer: results from a pool of cohort studies and Mendelian randomization analysis.
Peng H, Wu X, Wen Y, Li C, Lin J, Li J, Xiong S, Zhong R, Liang H, Cheng B, Liu J, He J, Liang W
Autoimmun Rev 2020 Oct;19(10):102633. Epub 2020 Aug 13 doi: 10.1016/j.autrev.2020.102633. PMID: 32801043
Best practice in the treatment of advanced squamous cell lung cancer.
Ang YL, Tan HL, Soo RA
Ther Adv Respir Dis 2015 Oct;9(5):224-35. Epub 2015 Apr 22 doi: 10.1177/1753465815581147. PMID: 25902866

Prognosis

Bidirectional Mendelian randomization analysis of the genetic association between primary lung cancer and colorectal cancer.
Xiao Z, Wang Z, Zhang T, Liu Y, Si M
J Transl Med 2023 Oct 15;21(1):722. doi: 10.1186/s12967-023-04612-7. PMID: 37840123Free PMC Article
An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers.
Mezheyeuski A, Backman M, Mattsson J, Martín-Bernabé A, Larsson C, Hrynchyk I, Hammarström K, Ström S, Ekström J, Mauchanski S, Khelashvili S, Lindberg A, Agnarsdóttir M, Edqvist PH, Huvila J, Segersten U, Malmström PU, Botling J, Nodin B, Hedner C, Borg D, Brändstedt J, Sartor H, Leandersson K, Glimelius B, Portyanko A, Ponten F, Jirström K, Micke P, Sjöblom T
EBioMedicine 2023 Feb;88:104452. Epub 2023 Jan 30 doi: 10.1016/j.ebiom.2023.104452. PMID: 36724681Free PMC Article
Type 2 Diabetes and Cancer: An Umbrella Review of Observational and Mendelian Randomization Studies.
Pearson-Stuttard J, Papadimitriou N, Markozannes G, Cividini S, Kakourou A, Gill D, Rizos EC, Monori G, Ward HA, Kyrgiou M, Gunter MJ, Tsilidis KK
Cancer Epidemiol Biomarkers Prev 2021 Jun;30(6):1218-1228. Epub 2021 Mar 18 doi: 10.1158/1055-9965.EPI-20-1245. PMID: 33737302Free PMC Article
Genetic alterations in squamous cell lung cancer associated with idiopathic pulmonary fibrosis.
Hata A, Nakajima T, Matsusaka K, Fukuyo M, Nakayama M, Morimoto J, Ito Y, Yamamoto T, Sakairi Y, Rahmutulla B, Ota S, Wada H, Suzuki H, Iwata T, Matsubara H, Ohara O, Yoshino I, Kaneda A
Int J Cancer 2021 Jun 15;148(12):3008-3018. Epub 2021 Feb 19 doi: 10.1002/ijc.33499. PMID: 33533494
Premalignant lesions of squamous cell carcinoma of the lung: The molecular make-up and factors affecting their progression.
Denisov EV, Schegoleva AA, Gervas PA, Ponomaryova AA, Tashireva LA, Boyarko VV, Bukreeva EB, Pankova OV, Perelmuter VM
Lung Cancer 2019 Sep;135:21-28. Epub 2019 Jul 5 doi: 10.1016/j.lungcan.2019.07.001. PMID: 31446997

Clinical prediction guides

Bidirectional Mendelian randomization analysis of the genetic association between primary lung cancer and colorectal cancer.
Xiao Z, Wang Z, Zhang T, Liu Y, Si M
J Transl Med 2023 Oct 15;21(1):722. doi: 10.1186/s12967-023-04612-7. PMID: 37840123Free PMC Article
An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers.
Mezheyeuski A, Backman M, Mattsson J, Martín-Bernabé A, Larsson C, Hrynchyk I, Hammarström K, Ström S, Ekström J, Mauchanski S, Khelashvili S, Lindberg A, Agnarsdóttir M, Edqvist PH, Huvila J, Segersten U, Malmström PU, Botling J, Nodin B, Hedner C, Borg D, Brändstedt J, Sartor H, Leandersson K, Glimelius B, Portyanko A, Ponten F, Jirström K, Micke P, Sjöblom T
EBioMedicine 2023 Feb;88:104452. Epub 2023 Jan 30 doi: 10.1016/j.ebiom.2023.104452. PMID: 36724681Free PMC Article
Lactate Dehydrogenase and its clinical significance in pancreatic and thoracic cancers.
Comandatore A, Franczak M, Smolenski RT, Morelli L, Peters GJ, Giovannetti E
Semin Cancer Biol 2022 Nov;86(Pt 2):93-100. Epub 2022 Sep 9 doi: 10.1016/j.semcancer.2022.09.001. PMID: 36096316
Type 2 Diabetes and Cancer: An Umbrella Review of Observational and Mendelian Randomization Studies.
Pearson-Stuttard J, Papadimitriou N, Markozannes G, Cividini S, Kakourou A, Gill D, Rizos EC, Monori G, Ward HA, Kyrgiou M, Gunter MJ, Tsilidis KK
Cancer Epidemiol Biomarkers Prev 2021 Jun;30(6):1218-1228. Epub 2021 Mar 18 doi: 10.1158/1055-9965.EPI-20-1245. PMID: 33737302Free PMC Article
EGFR mutation exists in squamous cell lung carcinoma.
Cheung AH, Tong JH, Chung LY, Chau SL, Ng CS, Wan IYP, To KF
Pathology 2020 Apr;52(3):323-328. Epub 2020 Feb 27 doi: 10.1016/j.pathol.2019.12.003. PMID: 32113673

Supplemental Content

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    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE guideline NG122, Lung cancer: diagnosis and management, 2023

    Consumer resources

    Reviews

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