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Acute biphenotypic leukemia

MedGen UID:
7318
•Concept ID:
C0023464
•
Neoplastic Process
Synonyms: Acute Biphenotypic Leukemia; Acute Biphenotypic Leukemias; Acute Leukemia, Biphenotypic; Acute Leukemia, Hybrid; Acute Leukemia, Mixed-Lineage; Acute Leukemias, Biphenotypic; Acute Leukemias, Hybrid; Acute Leukemias, Mixed-Lineage; B and T Cell Acute Lymphoblastic Leukemia; B and T Cell Leukemia, Acute; B- and T-Cell Acute Lymphoblastic Leukemia; B- and T-Cell Leukemia, Acute; Biphenotypic Acute Leukemia; Biphenotypic Acute Leukemias; Biphenotypic Leukemia, Acute; Biphenotypic Leukemias, Acute; Hybrid Acute Leukemia; Hybrid Acute Leukemias; Leukemia, Acute Biphenotypic; Leukemia, Biphenotypic Acute; Leukemia, Biphenotypic, Acute; Leukemia, Hybrid Acute; Leukemia, Lymphocytic, Acute, Mixed Cell; Leukemia, Lymphocytic, Acute, Mixed-Cell; Leukemia, Mixed Cell; Leukemia, Mixed, B and T Cell; Leukemia, Mixed, B- and T-Cell; Leukemia, Mixed-Cell; Leukemia, Mixed-Lineage Acute; Leukemias, Acute Biphenotypic; Leukemias, Biphenotypic Acute; Leukemias, Hybrid Acute; Leukemias, Mixed-Cell; Leukemias, Mixed-Lineage Acute; Lymphocytic Leukemia, Acute, B and T Cell; Lymphocytic Leukemia, Acute, B- and T-Cell; Mixed Lineage Acute Leukemias; Mixed-Cell Leukemia; Mixed-Cell Leukemias; Mixed-Lineage Acute Leukemia; Mixed-Lineage Acute Leukemias
SNOMED CT: Acute biphenotypic leukemia (128818009); Acute biphenotypic leukemia (278453007)
 
HPO: HP:0005531
Monarch Initiative: MONDO:0020322

Definition

A type of actue leukemia with features characteristic of both the myeloid and lymphoid lineages. These leukemias are for this reason are designated mixed-lineage, hybrid or biphenotypic acute leukemias. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute biphenotypic leukemia
Follow this link to review classifications for Acute biphenotypic leukemia in Orphanet.

Professional guidelines

PubMed

Mixed phenotype acute leukemia: A study of 61 cases using World Health Organization and European Group for the Immunological Classification of Leukaemias criteria.
Weinberg OK, Seetharam M, Ren L, Alizadeh A, Arber DA
Am J Clin Pathol 2014 Dec;142(6):803-8. doi: 10.1309/AJCPPVUPOTUVOIB5. PMID: 25389334
What is the optimal treatment for biphenotypic acute leukemia?
Zheng C, Wu J, Liu X, Ding K, Cai X, Zhu W
Haematologica 2009 Dec;94(12):1778-80; author reply 1780. doi: 10.3324/haematol.2009.014829. PMID: 19996120Free PMC Article
Stem cell transplant in the treatment of childhood biphenotypic acute leukemia.
Park JA, Ghim TT, Bae Kw, Im HJ, Jang SS, Park CJ, Chi HS, Seo JJ
Pediatr Blood Cancer 2009 Sep;53(3):444-52. doi: 10.1002/pbc.22105. PMID: 19489056

Recent clinical studies

Etiology

The genetic basis and cell of origin of mixed phenotype acute leukaemia.
Alexander TB, Gu Z, Iacobucci I, Dickerson K, Choi JK, Xu B, Payne-Turner D, Yoshihara H, Loh ML, Horan J, Buldini B, Basso G, Elitzur S, de Haas V, Zwaan CM, Yeoh A, Reinhardt D, Tomizawa D, Kiyokawa N, Lammens T, De Moerloose B, Catchpoole D, Hori H, Moorman A, Moore AS, Hrusak O, Meshinchi S, Orgel E, Devidas M, Borowitz M, Wood B, Heerema NA, Carrol A, Yang YL, Smith MA, Davidsen TM, Hermida LC, Gesuwan P, Marra MA, Ma Y, Mungall AJ, Moore RA, Jones SJM, Valentine M, Janke LJ, Rubnitz JE, Pui CH, Ding L, Liu Y, Zhang J, Nichols KE, Downing JR, Cao X, Shi L, Pounds S, Newman S, Pei D, Guidry Auvil JM, Gerhard DS, Hunger SP, Inaba H, Mullighan CG
Nature 2018 Oct;562(7727):373-379. Epub 2018 Sep 12 doi: 10.1038/s41586-018-0436-0. PMID: 30209392Free PMC Article
Mixed-phenotype acute leukemia: state-of-the-art of the diagnosis, classification and treatment.
Cernan M, Szotkowski T, Pikalova Z
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2017 Sep;161(3):234-241. Epub 2017 Apr 18 doi: 10.5507/bp.2017.013. PMID: 28422191
Mixed-phenotype acute leukemia: current challenges in diagnosis and therapy.
Wolach O, Stone RM
Curr Opin Hematol 2017 Mar;24(2):139-145. doi: 10.1097/MOH.0000000000000322. PMID: 28099272
Mixed phenotype acute leukemia.
Ye Z, Wang S
Chin Med J (Engl) 2014;127(16):2999-3003. PMID: 25131241
Definition of acute biphenotypic leukemia.
Matutes E, Morilla R, Farahat N, Carbonell F, Swansbury J, Dyer M, Catovsky D
Haematologica 1997 Jan-Feb;82(1):64-6. PMID: 9107085

Diagnosis

How I Diagnose Acute Leukemia of Ambiguous Lineage.
Weinberg OK, Arber DA
Am J Clin Pathol 2022 Jul 1;158(1):27-34. doi: 10.1093/ajcp/aqac070. PMID: 35775438
Genetic Testing in the Diagnosis and Biology of Acute Leukemia.
Harris MH, Czuchlewski DR, Arber DA, Czader M
Am J Clin Pathol 2019 Aug 1;152(3):322-346. doi: 10.1093/ajcp/aqz093. PMID: 31367767
Mixed-Phenotype Acute Leukemia: Diagnostic Criteria and Pitfalls.
Charles NJ, Boyer DF
Arch Pathol Lab Med 2017 Nov;141(11):1462-1468. doi: 10.5858/arpa.2017-0218-RA. PMID: 29072953
Mixed-phenotype acute leukemia: current challenges in diagnosis and therapy.
Wolach O, Stone RM
Curr Opin Hematol 2017 Mar;24(2):139-145. doi: 10.1097/MOH.0000000000000322. PMID: 28099272
Mixed phenotype acute leukemia.
Ye Z, Wang S
Chin Med J (Engl) 2014;127(16):2999-3003. PMID: 25131241

Therapy

An update on classification, genetics, and clinical approach to mixed phenotype acute leukemia (MPAL).
Khan M, Siddiqi R, Naqvi K
Ann Hematol 2018 Jun;97(6):945-953. Epub 2018 Mar 15 doi: 10.1007/s00277-018-3297-6. PMID: 29546454
A systematic description of MLL fusion gene formation.
Wright RL, Vaughan AT
Crit Rev Oncol Hematol 2014 Sep;91(3):283-91. Epub 2014 Apr 8 doi: 10.1016/j.critrevonc.2014.03.004. PMID: 24787275
Clinical and laboratory features of adult biphenotypic acute leukemia.
Tong H, Liu Z, Lu C, Wang Q
Asia Pac J Clin Oncol 2013 Jun;9(2):146-54. Epub 2012 Jul 9 doi: 10.1111/j.1743-7563.2012.01571.x. PMID: 22898323
Diagnosis and management of neonatal leukaemia.
van der Linden MH, Creemers S, Pieters R
Semin Fetal Neonatal Med 2012 Aug;17(4):192-195. Epub 2012 Apr 15 doi: 10.1016/j.siny.2012.03.003. PMID: 22510298
Acute leukemias of ambiguous lineage.
Béné MC, Porwit A
Semin Diagn Pathol 2012 Feb;29(1):12-8. doi: 10.1053/j.semdp.2011.08.004. PMID: 22372202

Prognosis

Genetic Testing in the Diagnosis and Biology of Acute Leukemia.
Harris MH, Czuchlewski DR, Arber DA, Czader M
Am J Clin Pathol 2019 Aug 1;152(3):322-346. doi: 10.1093/ajcp/aqz093. PMID: 31367767
Mixed-Phenotype Acute Leukemia: Diagnostic Criteria and Pitfalls.
Charles NJ, Boyer DF
Arch Pathol Lab Med 2017 Nov;141(11):1462-1468. doi: 10.5858/arpa.2017-0218-RA. PMID: 29072953
Mixed-phenotype acute leukemia: state-of-the-art of the diagnosis, classification and treatment.
Cernan M, Szotkowski T, Pikalova Z
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2017 Sep;161(3):234-241. Epub 2017 Apr 18 doi: 10.5507/bp.2017.013. PMID: 28422191
Mixed phenotype acute leukemia.
Ye Z, Wang S
Chin Med J (Engl) 2014;127(16):2999-3003. PMID: 25131241
Definition of acute biphenotypic leukemia.
Matutes E, Morilla R, Farahat N, Carbonell F, Swansbury J, Dyer M, Catovsky D
Haematologica 1997 Jan-Feb;82(1):64-6. PMID: 9107085

Clinical prediction guides

Multiomic single cell sequencing identifies stemlike nature of mixed phenotype acute leukemia.
Peretz CAC, Kennedy VE, Walia A, Delley CL, Koh A, Tran E, Clark IC, Hayford CE, D'Amato C, Xue Y, Fontanez KM, May-Zhang AA, Smithers T, Agam Y, Wang Q, Dai HP, Roy R, Logan AC, Perl AE, Abate A, Olshen A, Smith CC
Nat Commun 2024 Sep 18;15(1):8191. doi: 10.1038/s41467-024-52317-2. PMID: 39294124Free PMC Article
Mixed Phenotype Acute Leukemia, B/Myeloid (Bilineal and Biphenotypic), With t(2;22)(q35;q12);EWSR1-FEV.
Montgomery-Goecker C, Koduru P, Botten G, Xu J, Ghisoli M, Goldman SC, Krueger J, Bhushan V, Fuda F, Chen W
J Pediatr Hematol Oncol 2021 Apr 1;43(3):e388-e394. doi: 10.1097/MPH.0000000000001934. PMID: 32925408
Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia.
Granja JM, Klemm S, McGinnis LM, Kathiria AS, Mezger A, Corces MR, Parks B, Gars E, Liedtke M, Zheng GXY, Chang HY, Majeti R, Greenleaf WJ
Nat Biotechnol 2019 Dec;37(12):1458-1465. Epub 2019 Dec 2 doi: 10.1038/s41587-019-0332-7. PMID: 31792411Free PMC Article
Cytogenetic abnormalities in acute leukaemia of ambiguous lineage: an overview.
Manola KN
Br J Haematol 2013 Oct;163(1):24-39. Epub 2013 Jul 25 doi: 10.1111/bjh.12484. PMID: 23888868
Definition of acute biphenotypic leukemia.
Matutes E, Morilla R, Farahat N, Carbonell F, Swansbury J, Dyer M, Catovsky D
Haematologica 1997 Jan-Feb;82(1):64-6. PMID: 9107085

Recent systematic reviews

Therapy for children and adults with mixed phenotype acute leukemia: a systematic review and meta-analysis.
Maruffi M, Sposto R, Oberley MJ, Kysh L, Orgel E
Leukemia 2018 Jul;32(7):1515-1528. Epub 2018 Feb 27 doi: 10.1038/s41375-018-0058-4. PMID: 29550836Free PMC Article

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