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Breast lobular carcinoma

MedGen UID:
64634
•Concept ID:
C0206692
•
Neoplastic Process
Synonyms: Breast cancer, lobular; BREAST CANCER, LOBULAR, SOMATIC
SNOMED CT: Lobular carcinoma (89740008); Lobular adenocarcinoma (89740008); Infiltrating lobular carcinoma (89740008); Infiltrating lobular carcinoma of breast (278054005); Lobular carcinoma of breast (278054005)
 
Monarch Initiative: MONDO:0000552

Definition

An adenocarcinoma of the breast arising from the lobules. This is a relatively uncommon carcinoma, represents approximately 10% of the breast adenocarcinomas and is often bilateral or multifocal. [from NCI]

Professional guidelines

PubMed

Gastric Metastasis of Invasive Lobular Breast Carcinoma, a Current Diagnostic and Treatment Challenge - A Review.
Birla R, Dinu D, Iosif C, Constantinoiu S
Chirurgia (Bucur) 2019 Sept-Oct;114(5):571-578. doi: 10.21614/chirurgia.114.5.571. PMID: 31670632
Distant metastases from invasive lobular breast carcinoma classic type - treatment and prognosis.
Skotnicki P, Sas-Korczynska B, Wohadlo L, Jakubowicz J, Blecharz P, Reinfuss M, Walasek T
Eur J Gynaecol Oncol 2016;37(5):666-670. PMID: 29787007
Differences in Response and Surgical Management with Neoadjuvant Chemotherapy in Invasive Lobular Versus Ductal Breast Cancer.
Truin W, Vugts G, Roumen RM, Maaskant-Braat AJ, Nieuwenhuijzen GA, van der Heiden-van der Loo M, Tjan-Heijnen VC, Voogd AC
Ann Surg Oncol 2016 Jan;23(1):51-7. Epub 2015 May 16 doi: 10.1245/s10434-015-4603-3. PMID: 25980321Free PMC Article

Recent clinical studies

Etiology

Triple-negative breast lobular carcinoma: a luminal androgen receptor carcinoma with specific ESRRA mutations.
Bergeron A, MacGrogan G, Bertaut A, Ladoire S, Arveux P, Desmoulins I, Bonnefoi H, Loustalot C, Auriol S, Beltjens F, Degrolard-Courcet E, Charon-Barra C, Richard C, Boidot R, Arnould L
Mod Pathol 2021 Jul;34(7):1282-1296. Epub 2021 Mar 22 doi: 10.1038/s41379-021-00742-9. PMID: 33753865Free PMC Article
Cervical Squamous Carcinomas With Prominent Acantholysis and Areas Resembling Breast Lobular Carcinoma: An Aggressive Form of Dedifferentation.
Scott K, Bryson G, Jamison J, Coutts M, McCluggage WG
Int J Gynecol Pathol 2018 Jan;37(1):74-81. doi: 10.1097/PGP.0000000000000387. PMID: 28700422
Management of breast lobular carcinoma in situ: radio-pathological correlation, clinical implications, and follow-up.
Capobianco G, Simbula L, Soro D, Meloni F, Cossu-Rocca P, Dessole S, Ambrosini G, Cherchi PL, Meloni GB
Eur J Gynaecol Oncol 2014;35(2):157-62. PMID: 24772919
Cervical adenocarcinoma resembling breast lobular carcinoma: a hitherto Undescribed Variant of Primary Cervical Adenocarcinoma.
Mansor S, McCluggage WG
Int J Gynecol Pathol 2010 Nov;29(6):594-9. doi: 10.1097/PGP.0b013e3181e36337. PMID: 20881849
Identification of an aptamer targeting hnRNP A1 by tissue slide-based SELEX.
Li S, Xu H, Ding H, Huang Y, Cao X, Yang G, Li J, Xie Z, Meng Y, Li X, Zhao Q, Shen B, Shao N
J Pathol 2009 Jul;218(3):327-36. doi: 10.1002/path.2543. PMID: 19291713

Diagnosis

Triple-negative breast lobular carcinoma: a luminal androgen receptor carcinoma with specific ESRRA mutations.
Bergeron A, MacGrogan G, Bertaut A, Ladoire S, Arveux P, Desmoulins I, Bonnefoi H, Loustalot C, Auriol S, Beltjens F, Degrolard-Courcet E, Charon-Barra C, Richard C, Boidot R, Arnould L
Mod Pathol 2021 Jul;34(7):1282-1296. Epub 2021 Mar 22 doi: 10.1038/s41379-021-00742-9. PMID: 33753865Free PMC Article
UK national survey of management of breast lobular carcinoma in situ.
Chester R, Bokinni O, Ahmed I, Kasem A
Ann R Coll Surg Engl 2015 Nov;97(8):574-7. doi: 10.1308/rcsann.2015.0037. PMID: 26492902Free PMC Article
Management of breast lobular carcinoma in situ: radio-pathological correlation, clinical implications, and follow-up.
Capobianco G, Simbula L, Soro D, Meloni F, Cossu-Rocca P, Dessole S, Ambrosini G, Cherchi PL, Meloni GB
Eur J Gynaecol Oncol 2014;35(2):157-62. PMID: 24772919
Survivin expression in breast lobular carcinoma: correlations with normal breast tissue and clinicomorphological parameters.
Adamkov M, Výbohová D, Horáček J, Kovalská M, Furjelová M
Acta Histochem 2013 Jun;115(5):412-7. Epub 2012 Dec 6 doi: 10.1016/j.acthis.2012.10.001. PMID: 23219440
Gastric metastasis 14 years after mastectomy for breast lobular carcinoma: case report and literature review.
Aurello P, D'Angelo F, Cosenza G, Petrocca S, Stoppacciaro A, Ramacciato G, Ziparo V
Am Surg 2006 May;72(5):456-60. PMID: 16719204

Therapy

PET Imaging of (18)F-(2 S,4 R)4-Fluoroglutamine Accumulation in Breast Cancer: From Xenografts to Patients.
Liu F, Xu X, Zhu H, Zhang Y, Yang J, Zhang L, Li N, Zhu L, Kung HF, Yang Z
Mol Pharm 2018 Aug 6;15(8):3448-3455. Epub 2018 Jul 20 doi: 10.1021/acs.molpharmaceut.8b00430. PMID: 29985631
A digestive allergic reaction with hypereosinophilia imputable to docetaxel in a breast cancer patient: a case report.
Hamdan D, Leboeuf C, Pereira C, Jourdan N, Verneuil L, Bousquet G, Janin A
BMC Cancer 2015 Dec 21;15:993. doi: 10.1186/s12885-015-2008-0. PMID: 26810399Free PMC Article
UK national survey of management of breast lobular carcinoma in situ.
Chester R, Bokinni O, Ahmed I, Kasem A
Ann R Coll Surg Engl 2015 Nov;97(8):574-7. doi: 10.1308/rcsann.2015.0037. PMID: 26492902Free PMC Article
Metastatic breast lobular carcinoma to tamoxifen-associated endometrial polyp: case report and literature review.
Al-Brahim N, Elavathil LJ
Ann Diagn Pathol 2005 Jun;9(3):166-8. doi: 10.1016/j.anndiagpath.2005.03.003. PMID: 15944961
Metastatic breast lobular carcinoma involving tamoxifen-associated endometrial polyps: report of two cases and review of tamoxifen-associated polypoid uterine lesions.
Houghton JP, Ioffe OB, Silverberg SG, McGrady B, McCluggage WG
Mod Pathol 2003 Apr;16(4):395-8. doi: 10.1097/01.MP.0000062655.62606.86. PMID: 12692205

Prognosis

Cervical Squamous Carcinomas With Prominent Acantholysis and Areas Resembling Breast Lobular Carcinoma: An Aggressive Form of Dedifferentation.
Scott K, Bryson G, Jamison J, Coutts M, McCluggage WG
Int J Gynecol Pathol 2018 Jan;37(1):74-81. doi: 10.1097/PGP.0000000000000387. PMID: 28700422
Survivin expression in breast lobular carcinoma: correlations with normal breast tissue and clinicomorphological parameters.
Adamkov M, Výbohová D, Horáček J, Kovalská M, Furjelová M
Acta Histochem 2013 Jun;115(5):412-7. Epub 2012 Dec 6 doi: 10.1016/j.acthis.2012.10.001. PMID: 23219440
Anal metastasis from recurrent breast lobular carcinoma: a case report.
Puglisi M, Varaldo E, Assalino M, Ansaldo G, Torre G, Borgonovo G
World J Gastroenterol 2009 Mar 21;15(11):1388-90. doi: 10.3748/wjg.15.1388. PMID: 19294770Free PMC Article
Gastric metastases originating from occult breast lobular carcinoma: diagnostic and therapeutic problems.
Ciulla A, Castronovo G, Tomasello G, Maiorana AM, Russo L, Daniele E, Genova G
World J Surg Oncol 2008 Jul 25;6:78. doi: 10.1186/1477-7819-6-78. PMID: 18652707Free PMC Article
Breast lobular carcinoma in a fibroadenoma.
Betta PG, Cosimi MF
Eur J Surg Oncol 1985 Sep;11(3):283-5. PMID: 4029410

Clinical prediction guides

A digestive allergic reaction with hypereosinophilia imputable to docetaxel in a breast cancer patient: a case report.
Hamdan D, Leboeuf C, Pereira C, Jourdan N, Verneuil L, Bousquet G, Janin A
BMC Cancer 2015 Dec 21;15:993. doi: 10.1186/s12885-015-2008-0. PMID: 26810399Free PMC Article
Distribution of thrombospondin and integrin alpha V in DCIS, invasive ductal and lobular human breast carcinomas. Analysis by electron microscopy.
Serre CM, Clezardin P, Frappart L, Boivin G, Delmas PD
Virchows Arch 1995;427(4):365-72. doi: 10.1007/BF00199384. PMID: 8548120

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