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Breast lobular carcinoma

MedGen UID:
64634
Concept ID:
C0206692
Neoplastic Process
Synonyms: Breast cancer, lobular; BREAST CANCER, LOBULAR, SOMATIC
SNOMED CT: Lobular carcinoma (89740008); Lobular adenocarcinoma (89740008); Infiltrating lobular carcinoma (89740008); Infiltrating lobular carcinoma of breast (278054005); Lobular carcinoma of breast (278054005)
 
Monarch Initiative: MONDO:0000552

Definition

An adenocarcinoma of the breast arising from the lobules. This is a relatively uncommon carcinoma, represents approximately 10% of the breast adenocarcinomas and is often bilateral or multifocal. [from NCI]

Professional guidelines

PubMed

De Schepper M, Koorman T, Richard F, Christgen M, Vincent-Salomon A, Schnitt SJ, van Diest PJ, Zels G, Mertens F, Maetens M, Vanden Bempt I, Harbeck N, Nitz U, Gräser M, Kümmel S, Gluz O, Weynand B, Floris G, Derksen PWB, Desmedt C; Pathology Working Group of the European Lobular Breast Cancer Consortium
Mod Pathol 2024 Jul;37(7):100497. Epub 2024 Apr 17 doi: 10.1016/j.modpat.2024.100497. PMID: 38641322
Birla R, Dinu D, Iosif C, Constantinoiu S
Chirurgia (Bucur) 2019 Sept-Oct;114(5):571-578. doi: 10.21614/chirurgia.114.5.571. PMID: 31670632
Skotnicki P, Sas-Korczynska B, Wohadlo L, Jakubowicz J, Blecharz P, Reinfuss M, Walasek T
Eur J Gynaecol Oncol 2016;37(5):666-670. PMID: 29787007

Recent clinical studies

Etiology

Bergeron A, MacGrogan G, Bertaut A, Ladoire S, Arveux P, Desmoulins I, Bonnefoi H, Loustalot C, Auriol S, Beltjens F, Degrolard-Courcet E, Charon-Barra C, Richard C, Boidot R, Arnould L
Mod Pathol 2021 Jul;34(7):1282-1296. Epub 2021 Mar 22 doi: 10.1038/s41379-021-00742-9. PMID: 33753865Free PMC Article
Scott K, Bryson G, Jamison J, Coutts M, McCluggage WG
Int J Gynecol Pathol 2018 Jan;37(1):74-81. doi: 10.1097/PGP.0000000000000387. PMID: 28700422
Capobianco G, Simbula L, Soro D, Meloni F, Cossu-Rocca P, Dessole S, Ambrosini G, Cherchi PL, Meloni GB
Eur J Gynaecol Oncol 2014;35(2):157-62. PMID: 24772919
Mansor S, McCluggage WG
Int J Gynecol Pathol 2010 Nov;29(6):594-9. doi: 10.1097/PGP.0b013e3181e36337. PMID: 20881849
Li S, Xu H, Ding H, Huang Y, Cao X, Yang G, Li J, Xie Z, Meng Y, Li X, Zhao Q, Shen B, Shao N
J Pathol 2009 Jul;218(3):327-36. doi: 10.1002/path.2543. PMID: 19291713

Diagnosis

Bergeron A, MacGrogan G, Bertaut A, Ladoire S, Arveux P, Desmoulins I, Bonnefoi H, Loustalot C, Auriol S, Beltjens F, Degrolard-Courcet E, Charon-Barra C, Richard C, Boidot R, Arnould L
Mod Pathol 2021 Jul;34(7):1282-1296. Epub 2021 Mar 22 doi: 10.1038/s41379-021-00742-9. PMID: 33753865Free PMC Article
Chester R, Bokinni O, Ahmed I, Kasem A
Ann R Coll Surg Engl 2015 Nov;97(8):574-7. doi: 10.1308/rcsann.2015.0037. PMID: 26492902Free PMC Article
Capobianco G, Simbula L, Soro D, Meloni F, Cossu-Rocca P, Dessole S, Ambrosini G, Cherchi PL, Meloni GB
Eur J Gynaecol Oncol 2014;35(2):157-62. PMID: 24772919
Adamkov M, Výbohová D, Horáček J, Kovalská M, Furjelová M
Acta Histochem 2013 Jun;115(5):412-7. Epub 2012 Dec 6 doi: 10.1016/j.acthis.2012.10.001. PMID: 23219440
Aurello P, D'Angelo F, Cosenza G, Petrocca S, Stoppacciaro A, Ramacciato G, Ziparo V
Am Surg 2006 May;72(5):456-60. PMID: 16719204

Therapy

Liu F, Xu X, Zhu H, Zhang Y, Yang J, Zhang L, Li N, Zhu L, Kung HF, Yang Z
Mol Pharm 2018 Aug 6;15(8):3448-3455. Epub 2018 Jul 20 doi: 10.1021/acs.molpharmaceut.8b00430. PMID: 29985631
Hamdan D, Leboeuf C, Pereira C, Jourdan N, Verneuil L, Bousquet G, Janin A
BMC Cancer 2015 Dec 21;15:993. doi: 10.1186/s12885-015-2008-0. PMID: 26810399Free PMC Article
Chester R, Bokinni O, Ahmed I, Kasem A
Ann R Coll Surg Engl 2015 Nov;97(8):574-7. doi: 10.1308/rcsann.2015.0037. PMID: 26492902Free PMC Article
Al-Brahim N, Elavathil LJ
Ann Diagn Pathol 2005 Jun;9(3):166-8. doi: 10.1016/j.anndiagpath.2005.03.003. PMID: 15944961
Houghton JP, Ioffe OB, Silverberg SG, McGrady B, McCluggage WG
Mod Pathol 2003 Apr;16(4):395-8. doi: 10.1097/01.MP.0000062655.62606.86. PMID: 12692205

Prognosis

Scott K, Bryson G, Jamison J, Coutts M, McCluggage WG
Int J Gynecol Pathol 2018 Jan;37(1):74-81. doi: 10.1097/PGP.0000000000000387. PMID: 28700422
Adamkov M, Výbohová D, Horáček J, Kovalská M, Furjelová M
Acta Histochem 2013 Jun;115(5):412-7. Epub 2012 Dec 6 doi: 10.1016/j.acthis.2012.10.001. PMID: 23219440
Puglisi M, Varaldo E, Assalino M, Ansaldo G, Torre G, Borgonovo G
World J Gastroenterol 2009 Mar 21;15(11):1388-90. doi: 10.3748/wjg.15.1388. PMID: 19294770Free PMC Article
Ciulla A, Castronovo G, Tomasello G, Maiorana AM, Russo L, Daniele E, Genova G
World J Surg Oncol 2008 Jul 25;6:78. doi: 10.1186/1477-7819-6-78. PMID: 18652707Free PMC Article
Betta PG, Cosimi MF
Eur J Surg Oncol 1985 Sep;11(3):283-5. PMID: 4029410

Clinical prediction guides

Hamdan D, Leboeuf C, Pereira C, Jourdan N, Verneuil L, Bousquet G, Janin A
BMC Cancer 2015 Dec 21;15:993. doi: 10.1186/s12885-015-2008-0. PMID: 26810399Free PMC Article
Serre CM, Clezardin P, Frappart L, Boivin G, Delmas PD
Virchows Arch 1995;427(4):365-72. doi: 10.1007/BF00199384. PMID: 8548120

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