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Malignant non-dysgerminomatous germ cell tumor of ovary

MedGen UID:
1826164
Concept ID:
C5679783
Neoplastic Process
Synonyms: malignant non-dysgerminomatous germ cell tumor of ovary; Non-dysgerminomatous germ cell cancer of ovary; non-dysgerminomatous germ cell cancer of ovary; ovarian non-dysgerminomatous germ cell tumor; ovarian non-dysgerminomatous germ cell tumour; ovarian Nondysgerminomatous germ cell tumor; ovarian Nondysgerminomatous germ cell tumour
SNOMED CT: Malignant non-dysgerminomatous germ cell tumor of ovary (1263450003); Non-dysgerminomatous germ cell cancer of ovary (1263450003)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
Concept ID:
CN307042
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
 
Monarch Initiative: MONDO:0016096
Orphanet: ORPHA206538

Definition

A rare malignant germ cell tumour of ovary arising from germ cells in the ovary, frequently unilateral at diagnosis, usually presenting during adolescence with pelvic mass, fever, vaginal bleeding and acute abdomen, with certain subtypes being occasionally associated with isosexual precocity, virilisation, hyperthyroidism or carcinoid syndrome. Histologically they comprise the following: embryonal carcinoma, yolk sac tumour, polyembryoma and mixed germ cell tumour. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant non-dysgerminomatous germ cell tumor of ovary

Recent clinical studies

Etiology

Bakri YN, Ezzat A, Akhtar, Dohami, Zahrani
Eur J Obstet Gynecol Reprod Biol 2000 May;90(1):87-91. doi: 10.1016/s0301-2115(99)00213-4. PMID: 10767517
Parkash V, Carcangiu ML
Mod Pathol 1995 Oct;8(8):881-7. PMID: 8552580

Diagnosis

Schwartz PE
Forum (Genova) 2000 Oct-Dec;10(4):355-65. PMID: 11535985
Pippitt CH Jr, Cain JM, Hakes TB, Pierce VK, Lewis JL Jr
Gynecol Oncol 1988 Oct;31(2):268-75. doi: 10.1016/s0090-8258(88)80004-0. PMID: 2458993

Therapy

Schwartz PE
Forum (Genova) 2000 Oct-Dec;10(4):355-65. PMID: 11535985
Culine S, Lhomme C, Kattan J, Duvillard P, Michel G, Droz JP
Eur J Cancer 1994;30A(9):1239-44. doi: 10.1016/0959-8049(94)90165-1. PMID: 7528029
Pippitt CH Jr, Cain JM, Hakes TB, Pierce VK, Lewis JL Jr
Gynecol Oncol 1988 Oct;31(2):268-75. doi: 10.1016/s0090-8258(88)80004-0. PMID: 2458993

Prognosis

Schwartz PE
Forum (Genova) 2000 Oct-Dec;10(4):355-65. PMID: 11535985
Bakri YN, Ezzat A, Akhtar, Dohami, Zahrani
Eur J Obstet Gynecol Reprod Biol 2000 May;90(1):87-91. doi: 10.1016/s0301-2115(99)00213-4. PMID: 10767517
Pippitt CH Jr, Cain JM, Hakes TB, Pierce VK, Lewis JL Jr
Gynecol Oncol 1988 Oct;31(2):268-75. doi: 10.1016/s0090-8258(88)80004-0. PMID: 2458993

Clinical prediction guides

Culine S, Lhomme C, Kattan J, Duvillard P, Michel G, Droz JP
Eur J Cancer 1994;30A(9):1239-44. doi: 10.1016/0959-8049(94)90165-1. PMID: 7528029
Pippitt CH Jr, Cain JM, Hakes TB, Pierce VK, Lewis JL Jr
Gynecol Oncol 1988 Oct;31(2):268-75. doi: 10.1016/s0090-8258(88)80004-0. PMID: 2458993

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