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Gastroesophageal junction adenocarcinoma

MedGen UID:
231030
Concept ID:
C1332166
Neoplastic Process
Synonyms: adenocarcinoma - GEJ; Adenocarcinoma of Cardioesophageal Junction; adenocarcinoma of cardioesophageal junction; Adenocarcinoma of Gastroesophageal Junction; adenocarcinoma of gastroesophageal junction; Adenocarcinoma of the Cardioesophageal Junction; adenocarcinoma of the cardioesophageal junction; Adenocarcinoma of the EG Junction; adenocarcinoma of the EG junction; Adenocarcinoma of the Esophagogastric Junction; adenocarcinoma of the esophagogastric junction; Adenocarcinoma of the Gastroesophageal Junction; adenocarcinoma of the gastroesophageal junction; Adenocarcinoma of the GE Junction; adenocarcinoma of the GE junction; esophagogastric adenocarcinoma; esophagogastric junction adenocarcinoma; Gastroesophageal Junction Adenocarcinoma; gastroesophageal junction adenocarcinoma
 
Monarch Initiative: MONDO:0003219

Definition

An adenocarcinoma that arises from and straddles the junction of the stomach and esophagus. The category of adenocarcinomas of the gastroesophageal junction also includes the majority of adenocarcinomas previously called gastric cardia adenocarcinomas. Squamous cell carcinomas that affect or cross the junction of the stomach and esophagus are classified as carcinomas of the distal esophagus. Adenocarcinoma of the gastroesophageal junction occurs more often in Caucasian middle aged and elderly males. Clinical signs and symptoms include dysphagia, abdominal pain, and weight loss. The prognosis depends on the completeness of the surgical resection, the number of lymph nodes involved by cancer, and the presence or absence of postoperative complications. The presence of TP53 mutations indicates worse prognosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastroesophageal junction adenocarcinoma

Professional guidelines

PubMed

Taieb J, Bennouna J, Penault-Llorca F, Basile D, Samalin E, Zaanan A
Eur J Cancer 2023 Dec;195:113370. Epub 2023 Oct 17 doi: 10.1016/j.ejca.2023.113370. PMID: 37948843
Li JJ, Rogers JE, Yamashita K, Waters RE, Blum Murphy M, Ajani JA
Biomolecules 2023 May 6;13(5) doi: 10.3390/biom13050796. PMID: 37238666Free PMC Article
Lin D, Khan U, Goetze TO, Reizine N, Goodman KA, Shah MA, Catenacci DV, Al-Batran SE, Posey JA
Am Soc Clin Oncol Educ Book 2019 Jan;39:e88-e95. Epub 2019 May 17 doi: 10.1200/EDBK_236827. PMID: 31099690

Recent clinical studies

Etiology

Leong T, Smithers BM, Michael M, Haustermans K, Wong R, Gebski V, O'Connell RL, Zalcberg J, Boussioutas A, Findlay M, Willis D, Moore A, Murray WK, Lordick F, O'Callaghan C, Swallow C, Darling G, Miller D, Strickland A, Liberman M, Mineur L, Simes J; Australasian Gastro-Intestinal Trials Group, National Health and Medical Research Council Clinical Trials Centre, Trans-Tasman Radiation Oncology Group, European Organisation for Research and Treatment of Cancer, and Canadian Cancer Trials Group
N Engl J Med 2024 Nov 14;391(19):1810-1821. Epub 2024 Sep 14 doi: 10.1056/NEJMoa2405195. PMID: 39282905
Xu RH, Zhang Y, Pan H, Feng J, Zhang T, Liu T, Qin Y, Qin S, Yin X, Liu B, Ba Y, Yang N, Voon PJ, Tanasanvimon S, Zhou C, Zhang WL, Shen L
Lancet Gastroenterol Hepatol 2021 Dec;6(12):1015-1024. Epub 2021 Oct 7 doi: 10.1016/S2468-1253(21)00313-7. PMID: 34626550
Kang YK, Yook JH, Park YK, Lee JS, Kim YW, Kim JY, Ryu MH, Rha SY, Chung IJ, Kim IH, Oh SC, Park YS, Son T, Jung MR, Heo MH, Kim HK, Park C, Yoo CH, Choi JH, Zang DY, Jang YJ, Sul JY, Kim JG, Kim BS, Beom SH, Cho SH, Ryu SW, Kook MC, Ryoo BY, Kim HK, Yoo MW, Lee NS, Lee SH, Kim G, Lee Y, Lee JH, Noh SH
J Clin Oncol 2021 Sep 10;39(26):2903-2913. Epub 2021 Jun 16 doi: 10.1200/JCO.20.02914. PMID: 34133211Free PMC Article
Shitara K, Bang YJ, Iwasa S, Sugimoto N, Ryu MH, Sakai D, Chung HC, Kawakami H, Yabusaki H, Lee J, Saito K, Kawaguchi Y, Kamio T, Kojima A, Sugihara M, Yamaguchi K; DESTINY-Gastric01 Investigators
N Engl J Med 2020 Jun 18;382(25):2419-2430. Epub 2020 May 29 doi: 10.1056/NEJMoa2004413. PMID: 32469182
Al-Batran SE, Homann N, Pauligk C, Illerhaus G, Martens UM, Stoehlmacher J, Schmalenberg H, Luley KB, Prasnikar N, Egger M, Probst S, Messmann H, Moehler M, Fischbach W, Hartmann JT, Mayer F, Höffkes HG, Koenigsmann M, Arnold D, Kraus TW, Grimm K, Berkhoff S, Post S, Jäger E, Bechstein W, Ronellenfitsch U, Mönig S, Hofheinz RD
JAMA Oncol 2017 Sep 1;3(9):1237-1244. doi: 10.1001/jamaoncol.2017.0515. PMID: 28448662Free PMC Article

Diagnosis

Xu J, Jiang H, Pan Y, Gu K, Cang S, Han L, Shu Y, Li J, Zhao J, Pan H, Luo S, Qin Y, Guo Q, Bai Y, Ling Y, Yang J, Yan Z, Yang L, Tang Y, He Y, Zhang L, Liang X, Niu Z, Zhang J, Mao Y, Guo Y, Peng B, Li Z, Liu Y, Wang Y, Zhou H; ORIENT-16 Investigators
JAMA 2023 Dec 5;330(21):2064-2074. doi: 10.1001/jama.2023.19918. PMID: 38051328Free PMC Article
Xu RH, Zhang Y, Pan H, Feng J, Zhang T, Liu T, Qin Y, Qin S, Yin X, Liu B, Ba Y, Yang N, Voon PJ, Tanasanvimon S, Zhou C, Zhang WL, Shen L
Lancet Gastroenterol Hepatol 2021 Dec;6(12):1015-1024. Epub 2021 Oct 7 doi: 10.1016/S2468-1253(21)00313-7. PMID: 34626550
Kang YK, Yook JH, Park YK, Lee JS, Kim YW, Kim JY, Ryu MH, Rha SY, Chung IJ, Kim IH, Oh SC, Park YS, Son T, Jung MR, Heo MH, Kim HK, Park C, Yoo CH, Choi JH, Zang DY, Jang YJ, Sul JY, Kim JG, Kim BS, Beom SH, Cho SH, Ryu SW, Kook MC, Ryoo BY, Kim HK, Yoo MW, Lee NS, Lee SH, Kim G, Lee Y, Lee JH, Noh SH
J Clin Oncol 2021 Sep 10;39(26):2903-2913. Epub 2021 Jun 16 doi: 10.1200/JCO.20.02914. PMID: 34133211Free PMC Article
Tabernero J, Bang YJ, Van Cutsem E, Fuchs CS, Janjigian YY, Bhagia P, Li K, Adelberg D, Qin SK
Future Oncol 2021 Aug;17(22):2847-2855. Epub 2021 May 12 doi: 10.2217/fon-2021-0176. PMID: 33975465Free PMC Article
Chung HC, Bang YJ, S Fuchs C, Qin SK, Satoh T, Shitara K, Tabernero J, Van Cutsem E, Alsina M, Cao ZA, Lu J, Bhagia P, Shih CS, Janjigian YY
Future Oncol 2021 Feb;17(5):491-501. Epub 2020 Nov 10 doi: 10.2217/fon-2020-0737. PMID: 33167735Free PMC Article

Therapy

Xu J, Jiang H, Pan Y, Gu K, Cang S, Han L, Shu Y, Li J, Zhao J, Pan H, Luo S, Qin Y, Guo Q, Bai Y, Ling Y, Yang J, Yan Z, Yang L, Tang Y, He Y, Zhang L, Liang X, Niu Z, Zhang J, Mao Y, Guo Y, Peng B, Li Z, Liu Y, Wang Y, Zhou H; ORIENT-16 Investigators
JAMA 2023 Dec 5;330(21):2064-2074. doi: 10.1001/jama.2023.19918. PMID: 38051328Free PMC Article
Shah MA, Shitara K, Ajani JA, Bang YJ, Enzinger P, Ilson D, Lordick F, Van Cutsem E, Gallego Plazas J, Huang J, Shen L, Oh SC, Sunpaweravong P, Soo Hoo HF, Turk HM, Oh M, Park JW, Moran D, Bhattacharya P, Arozullah A, Xu RH
Nat Med 2023 Aug;29(8):2133-2141. Epub 2023 Jul 31 doi: 10.1038/s41591-023-02465-7. PMID: 37524953Free PMC Article
Deeks ED
Drugs 2021 Nov;81(16):1929-1935. doi: 10.1007/s40265-021-01614-x. PMID: 34661865
Tabernero J, Bang YJ, Van Cutsem E, Fuchs CS, Janjigian YY, Bhagia P, Li K, Adelberg D, Qin SK
Future Oncol 2021 Aug;17(22):2847-2855. Epub 2021 May 12 doi: 10.2217/fon-2021-0176. PMID: 33975465Free PMC Article
Shitara K, Bang YJ, Iwasa S, Sugimoto N, Ryu MH, Sakai D, Chung HC, Kawakami H, Yabusaki H, Lee J, Saito K, Kawaguchi Y, Kamio T, Kojima A, Sugihara M, Yamaguchi K; DESTINY-Gastric01 Investigators
N Engl J Med 2020 Jun 18;382(25):2419-2430. Epub 2020 May 29 doi: 10.1056/NEJMoa2004413. PMID: 32469182

Prognosis

Verschoor YL, van de Haar J, van den Berg JG, van Sandick JW, Kodach LL, van Dieren JM, Balduzzi S, Grootscholten C, IJsselsteijn ME, Veenhof AAFA, Hartemink KJ, Vollebergh MA, Jurdi A, Sharma S, Spickard E, Owers EC, Bartels-Rutten A, den Hartog P, de Miranda NFCC, van Leerdam ME, Haanen JBAG, Schumacher TN, Voest EE, Chalabi M
Nat Med 2024 Feb;30(2):519-530. Epub 2024 Jan 8 doi: 10.1038/s41591-023-02758-x. PMID: 38191613Free PMC Article
Li JJ, Rogers JE, Yamashita K, Waters RE, Blum Murphy M, Ajani JA
Biomolecules 2023 May 6;13(5) doi: 10.3390/biom13050796. PMID: 37238666Free PMC Article
Jiang H, Yu X, Li N, Kong M, Ma Z, Zhou D, Wang W, Wang H, Wang H, He K, Li Z, Lu Y, Zhang J, Zhao K, Zhang Y, Xu N, Li Z, Liu Y, Wang Y, Wang Y, Teng L
J Immunother Cancer 2022 Mar;10(3) doi: 10.1136/jitc-2021-003635. PMID: 35296556Free PMC Article
Chung HC, Bang YJ, S Fuchs C, Qin SK, Satoh T, Shitara K, Tabernero J, Van Cutsem E, Alsina M, Cao ZA, Lu J, Bhagia P, Shih CS, Janjigian YY
Future Oncol 2021 Feb;17(5):491-501. Epub 2020 Nov 10 doi: 10.2217/fon-2020-0737. PMID: 33167735Free PMC Article
Al-Batran SE, Homann N, Pauligk C, Illerhaus G, Martens UM, Stoehlmacher J, Schmalenberg H, Luley KB, Prasnikar N, Egger M, Probst S, Messmann H, Moehler M, Fischbach W, Hartmann JT, Mayer F, Höffkes HG, Koenigsmann M, Arnold D, Kraus TW, Grimm K, Berkhoff S, Post S, Jäger E, Bechstein W, Ronellenfitsch U, Mönig S, Hofheinz RD
JAMA Oncol 2017 Sep 1;3(9):1237-1244. doi: 10.1001/jamaoncol.2017.0515. PMID: 28448662Free PMC Article

Clinical prediction guides

Verschoor YL, van de Haar J, van den Berg JG, van Sandick JW, Kodach LL, van Dieren JM, Balduzzi S, Grootscholten C, IJsselsteijn ME, Veenhof AAFA, Hartemink KJ, Vollebergh MA, Jurdi A, Sharma S, Spickard E, Owers EC, Bartels-Rutten A, den Hartog P, de Miranda NFCC, van Leerdam ME, Haanen JBAG, Schumacher TN, Voest EE, Chalabi M
Nat Med 2024 Feb;30(2):519-530. Epub 2024 Jan 8 doi: 10.1038/s41591-023-02758-x. PMID: 38191613Free PMC Article
Xu J, Jiang H, Pan Y, Gu K, Cang S, Han L, Shu Y, Li J, Zhao J, Pan H, Luo S, Qin Y, Guo Q, Bai Y, Ling Y, Yang J, Yan Z, Yang L, Tang Y, He Y, Zhang L, Liang X, Niu Z, Zhang J, Mao Y, Guo Y, Peng B, Li Z, Liu Y, Wang Y, Zhou H; ORIENT-16 Investigators
JAMA 2023 Dec 5;330(21):2064-2074. doi: 10.1001/jama.2023.19918. PMID: 38051328Free PMC Article
Jiang H, Yu X, Li N, Kong M, Ma Z, Zhou D, Wang W, Wang H, Wang H, He K, Li Z, Lu Y, Zhang J, Zhao K, Zhang Y, Xu N, Li Z, Liu Y, Wang Y, Wang Y, Teng L
J Immunother Cancer 2022 Mar;10(3) doi: 10.1136/jitc-2021-003635. PMID: 35296556Free PMC Article
Tabernero J, Bang YJ, Van Cutsem E, Fuchs CS, Janjigian YY, Bhagia P, Li K, Adelberg D, Qin SK
Future Oncol 2021 Aug;17(22):2847-2855. Epub 2021 May 12 doi: 10.2217/fon-2021-0176. PMID: 33975465Free PMC Article
Sahin U, Türeci Ö, Manikhas G, Lordick F, Rusyn A, Vynnychenko I, Dudov A, Bazin I, Bondarenko I, Melichar B, Dhaene K, Wiechen K, Huber C, Maurus D, Arozullah A, Park JW, Schuler M, Al-Batran SE
Ann Oncol 2021 May;32(5):609-619. Epub 2021 Feb 19 doi: 10.1016/j.annonc.2021.02.005. PMID: 33610734

Recent systematic reviews

Huang D, Sun F, Ke L, Li S
Int Immunopharmacol 2024 Sep 10;138:112576. Epub 2024 Jun 27 doi: 10.1016/j.intimp.2024.112576. PMID: 38941672
Zhang X, Zhou L, Zhou C, Shen L
Adv Ther 2024 Jun;41(6):2112-2132. Epub 2024 Apr 15 doi: 10.1007/s12325-024-02838-5. PMID: 38619719Free PMC Article
Fei S, Lu Y, Chen J, Qi J, Wu W, Wang B, Han Y, Wang K, Han X, Zhou H, Wang J, Chen J
Chemotherapy 2023;68(4):197-209. Epub 2023 Jun 16 doi: 10.1159/000531457. PMID: 37331333
Grizzi G, Petrelli F, Di Bartolomeo M, Viti M, Texeira Moraes M, Luciani A, Passalacqua R, Ghidini M, Tomasello G, Baiocchi GL, Celotti A
Gastric Cancer 2022 Sep;25(5):982-987. Epub 2022 Jun 15 doi: 10.1007/s10120-022-01314-9. PMID: 35704113
Petrelli F, Ghidini M, Barni S, Sgroi G, Passalacqua R, Tomasello G
Gastric Cancer 2019 Mar;22(2):245-254. Epub 2018 Nov 27 doi: 10.1007/s10120-018-0901-3. PMID: 30483986

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