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Scrotal carcinoma

MedGen UID:
235088
•Concept ID:
C1370468
•
Neoplastic Process
Synonyms: Cancer of Scrotum; Cancer of the Scrotum; Carcinoma of Scrotum; carcinoma of scrotum; Carcinoma of the Scrotum; carcinoma of the scrotum; Scrotal Cancer; Scrotal Carcinoma; scrotal carcinoma; scrotum carcinoma
 
Monarch Initiative: MONDO:0002650

Definition

A carcinoma occurring in the scrotum. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVScrotal carcinoma

Professional guidelines

PubMed

Extramammary Paget's Disease: Diagnosis, Pathogenesis, and Treatment with Focus on Recent Developments.
Ishizuki S, Nakamura Y
Curr Oncol 2021 Aug 5;28(4):2969-2986. doi: 10.3390/curroncol28040260. PMID: 34436026Free PMC Article
Surgical Management of Primary Scrotal Cancer.
Huang JH, Broggi M, Osunkoya AO, Master VA
Urol Clin North Am 2016 Nov;43(4):531-544. Epub 2016 Sep 3 doi: 10.1016/j.ucl.2016.06.014. PMID: 27717439
Preneoplastic and Primary Scrotal Cancer: Updates on Pathogenesis and Diagnostic Evaluation.
Zhu Y, Ye DW
Urol Clin North Am 2016 Nov;43(4):523-530. doi: 10.1016/j.ucl.2016.06.013. PMID: 27717438

Recent clinical studies

Etiology

Primary Neuroendocrine Tumor of the Scrotum: An Uncommon Site for a Rare Tumor.
Akhtar K, Vyas V, Ashok Kumar P, Corines J, de la Roza G, Basnet A
J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211008717. doi: 10.1177/23247096211008717. PMID: 33834875Free PMC Article
Scrotal neoplasia: would truck drivers be at greater risk?
Seabra D, Fava G, Faria E, Sacheto T, Hidalgo G
Int Braz J Urol 2007 Jul-Aug;33(4):515-9; discussion 520. doi: 10.1590/s1677-55382007000400009. PMID: 17767756
Verrucous scrotal carcinoma in a patient with hypospadias: is there a possible association?
Pomara G, Pomara S, Travaglini F, Maras L, Selli C
Urology 2003 Jan;61(1):224. doi: 10.1016/s0090-4295(02)02095-2. PMID: 12559309
Squamous cell carcinoma of the scrotum associated with human papillomaviruses.
Burmer GC, True LD, Krieger JN
J Urol 1993 Feb;149(2):374-7. doi: 10.1016/s0022-5347(17)36089-5. PMID: 8381191
Scrotal carcinoma in Connecticut metalworkers: sequel to a study of sinonasal cancer.
Roush GC, Kelly JA, Meigs JW, Flannery JT
Am J Epidemiol 1982 Jul;116(1):76-85. doi: 10.1093/oxfordjournals.aje.a113404. PMID: 7102658

Diagnosis

Poorly Differentiated Scrotal Carcinoma With Apocrine Immunophenotype.
Kamanda S, Epstein JI, Osunkoya AO, Cimino-Mathews A, Argani P, Sangüeza M, Plaza JA, Matoso A
Am J Dermatopathol 2022 Apr 1;44(4):260-266. doi: 10.1097/DAD.0000000000002100. PMID: 34726185Free PMC Article
Human papillomavirus 16 is an aetiological factor of scrotal cancer.
Guimerà N, Alemany L, Halec G, Pawlita M, Wain GV, Vailén JSS, Azike JE, Jenkins D, de Sanjosé S, Quint W, Bosch FX
Br J Cancer 2017 Apr 25;116(9):1218-1222. Epub 2017 Apr 4 doi: 10.1038/bjc.2017.74. PMID: 28376081Free PMC Article
Scrotal carcinoma.
Casasola Chamorro J, Gutiérrez García S, de Blas Gómez V
Arch Esp Urol 2011 Jul;64(6):541-3. PMID: 21791720
Carcinoma of scrotum.
McDonald MW
Urology 1982 Mar;19(3):269-74. doi: 10.1016/0090-4295(82)90497-6. PMID: 7064253
Experience with carcinoma of the scrotum.
Ray B, Whitmore WF Jr
J Urol 1977 Jun;117(6):741-5. doi: 10.1016/s0022-5347(17)58608-5. PMID: 559784

Therapy

Primary Neuroendocrine Tumor of the Scrotum: An Uncommon Site for a Rare Tumor.
Akhtar K, Vyas V, Ashok Kumar P, Corines J, de la Roza G, Basnet A
J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211008717. doi: 10.1177/23247096211008717. PMID: 33834875Free PMC Article
Scrotal neoplasia: would truck drivers be at greater risk?
Seabra D, Fava G, Faria E, Sacheto T, Hidalgo G
Int Braz J Urol 2007 Jul-Aug;33(4):515-9; discussion 520. doi: 10.1590/s1677-55382007000400009. PMID: 17767756
Development of human papillomavirus type 16 associated squamous cell carcinoma of the scrotum in a patient with Darier's disease treated with systemic isotretinoin.
Orihuela E, Tyring SK, Pow-Sang M, Dozier S, Cirelli R, Arany I, Rady P, Sanchez R
J Urol 1995 Jun;153(6):1940-3. PMID: 7752363
Scrotal carcinoma following prolonged use of crude coal tar ointment.
McGarry GW, Robertson JR
Br J Urol 1989 Feb;63(2):211. doi: 10.1111/j.1464-410x.1989.tb05168.x. PMID: 2702411
Scrotal carcinoma in Connecticut metalworkers: sequel to a study of sinonasal cancer.
Roush GC, Kelly JA, Meigs JW, Flannery JT
Am J Epidemiol 1982 Jul;116(1):76-85. doi: 10.1093/oxfordjournals.aje.a113404. PMID: 7102658

Prognosis

Scrotal carcinoma.
Casasola Chamorro J, Gutiérrez García S, de Blas Gómez V
Arch Esp Urol 2011 Jul;64(6):541-3. PMID: 21791720
Cumulation of TP53 mutations and p16INK4A/p15INK4B homozygous deletions in human papilloma virus type 16 positive scrotal cancer.
Güran S, Pak I
Cancer Genet Cytogenet 1999 Mar;109(2):108-13. doi: 10.1016/s0165-4608(98)00155-1. PMID: 10087941
A population-based study of survival after scrotal carcinoma.
Roush GC, Fischer DB, Flannery JT
Cancer 1985 Feb 1;55(3):666-71. doi: 10.1002/1097-0142(19850201)55:3<666::aid-cncr2820550332>3.0.co;2-r. PMID: 3965115
A young gastric carcinoma patient with umbilical and scrotal metastasis.
Miwa M, Matsumura H, Miwa T, Sato S
Tokai J Exp Clin Med 1981 Jul;6(3):305-8. PMID: 6272450
Experience with carcinoma of the scrotum.
Ray B, Whitmore WF Jr
J Urol 1977 Jun;117(6):741-5. doi: 10.1016/s0022-5347(17)58608-5. PMID: 559784

Clinical prediction guides

Verrucous scrotal carcinoma in a patient with hypospadias: is there a possible association?
Pomara G, Pomara S, Travaglini F, Maras L, Selli C
Urology 2003 Jan;61(1):224. doi: 10.1016/s0090-4295(02)02095-2. PMID: 12559309
Cumulation of TP53 mutations and p16INK4A/p15INK4B homozygous deletions in human papilloma virus type 16 positive scrotal cancer.
Güran S, Pak I
Cancer Genet Cytogenet 1999 Mar;109(2):108-13. doi: 10.1016/s0165-4608(98)00155-1. PMID: 10087941
A population-based study of survival after scrotal carcinoma.
Roush GC, Fischer DB, Flannery JT
Cancer 1985 Feb 1;55(3):666-71. doi: 10.1002/1097-0142(19850201)55:3<666::aid-cncr2820550332>3.0.co;2-r. PMID: 3965115

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