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Metastatic Chondrosarcoma

MedGen UID:
208940
•Concept ID:
C0855012
•
Neoplastic Process
Synonym: Chondrosarcoma, Metastatic

Definition

A chondrosarcoma that has spread to a secondary anatomical site. [from NCI]

Professional guidelines

PubMed

Molecular oncogenesis of chondrosarcoma: impact for targeted treatment.
Speetjens FM, de Jong Y, Gelderblom H, Bovée JV
Curr Opin Oncol 2016 Jul;28(4):314-22. doi: 10.1097/CCO.0000000000000300. PMID: 27166664
NYESO-1/LAGE-1s and PRAME are targets for antigen specific T cells in chondrosarcoma following treatment with 5-Aza-2-deoxycitabine.
Pollack SM, Li Y, Blaisdell MJ, Farrar EA, Chou J, Hoch BL, Loggers ET, Rodler E, Eary JF, Conrad EU 3rd, Jones RL, Yee C
PLoS One 2012;7(2):e32165. Epub 2012 Feb 27 doi: 10.1371/journal.pone.0032165. PMID: 22384167Free PMC Article
Total femur replacement procedures in tumor treatment.
Mankin HJ, Hornicek FJ, Harris M
Clin Orthop Relat Res 2005 Sep;438:60-4. doi: 10.1097/00003086-200509000-00012. PMID: 16131870

Recent clinical studies

Etiology

IMP3, CDK4, MDM2 and β-catenin expression in Enchondroma and Central Chondrosarcoma: Diagnostic and prognostic utility.
Losada DM, Etchebehere M, Cintra FF, Amstalden EMI
Clinics (Sao Paulo) 2024;79:100483. Epub 2024 Oct 4 doi: 10.1016/j.clinsp.2024.100483. PMID: 39368400Free PMC Article
Prognostic Factors and Surgical Impact of Non-metastatic Conventional Chondrosarcoma of the Extremities.
Wang W, Zhen J
Orthop Surg 2023 Dec;15(12):3288-3299. Epub 2023 Oct 24 doi: 10.1111/os.13916. PMID: 37875420Free PMC Article
Does primary tumor resection improve survival for patients with sarcomas of pelvic bones, sacrum, and coccyx who have metastasis at diagnosis ?
Hu X, Fujiwara T, Sun Y, Huang W, Yan W
Eur Spine J 2023 Dec;32(12):4362-4376. Epub 2023 Oct 23 doi: 10.1007/s00586-023-07985-x. PMID: 37870700
Efficacy and safety of regorafenib in patients with metastatic or locally advanced chondrosarcoma: Results of a non-comparative, randomised, double-blind, placebo controlled, multicentre phase II study.
Duffaud F, Italiano A, Bompas E, Rios M, Penel N, Mir O, Piperno-Neumann S, Chevreau C, Delcambre C, Bertucci F, Boudou-Rouquette P, Cancel M, Perrin C, Saada-Bouzid E, Monard L, Schiffler C, Chaigneau L, Hervieu A, Collard O, Bouvier C, Vidal V, Chabaud S, Blay JY; French Sarcoma Group
Eur J Cancer 2021 Jun;150:108-118. Epub 2021 Apr 22 doi: 10.1016/j.ejca.2021.03.039. PMID: 33895682
Multicentric chondrosarcomas.
Damron TA, Sim FH, Unni KK
Clin Orthop Relat Res 1996 Jul;(328):211-9. doi: 10.1097/00003086-199607000-00033. PMID: 8653959

Diagnosis

IMP3, CDK4, MDM2 and β-catenin expression in Enchondroma and Central Chondrosarcoma: Diagnostic and prognostic utility.
Losada DM, Etchebehere M, Cintra FF, Amstalden EMI
Clinics (Sao Paulo) 2024;79:100483. Epub 2024 Oct 4 doi: 10.1016/j.clinsp.2024.100483. PMID: 39368400Free PMC Article
Does primary tumor resection improve survival for patients with sarcomas of pelvic bones, sacrum, and coccyx who have metastasis at diagnosis ?
Hu X, Fujiwara T, Sun Y, Huang W, Yan W
Eur Spine J 2023 Dec;32(12):4362-4376. Epub 2023 Oct 23 doi: 10.1007/s00586-023-07985-x. PMID: 37870700
Electropermeabilization of metastatic chondrosarcoma cells from primary cell culture.
Michel O, Błasiak P, Saczko J, Kulbacka J, Drąg-Zalesińska M, Rzechonek A
Biotechnol Appl Biochem 2019 Nov;66(6):945-954. Epub 2019 Sep 18 doi: 10.1002/bab.1809. PMID: 31476023
Does Resection of the Primary Tumor Improve Survival in Patients With Metastatic Chondrosarcoma?
Song K, Song J, Chen F, Lin K, Ma X, Jiang J
Clin Orthop Relat Res 2019 Mar;477(3):573-583. doi: 10.1097/CORR.0000000000000632. PMID: 30762691Free PMC Article
Multicentric chondrosarcomas.
Damron TA, Sim FH, Unni KK
Clin Orthop Relat Res 1996 Jul;(328):211-9. doi: 10.1097/00003086-199607000-00033. PMID: 8653959

Therapy

Preclinical Characterization and Phase I Trial Results of INBRX-109, A Third-Generation, Recombinant, Humanized, Death Receptor 5 Agonist Antibody, in Chondrosarcoma.
Subbiah V, Chawla SP, Conley AP, Wilky BA, Tolcher A, Lakhani NJ, Berz D, Andrianov V, Crago W, Holcomb M, Hussain A, Veldstra C, Kalabus J, O'Neill B, Senne L, Rowell E, Heidt AB, Willis KM, Eckelman BP
Clin Cancer Res 2023 Aug 15;29(16):2988-3003. doi: 10.1158/1078-0432.CCR-23-0974. PMID: 37265425Free PMC Article
Efficacy and safety of regorafenib in patients with metastatic or locally advanced chondrosarcoma: Results of a non-comparative, randomised, double-blind, placebo controlled, multicentre phase II study.
Duffaud F, Italiano A, Bompas E, Rios M, Penel N, Mir O, Piperno-Neumann S, Chevreau C, Delcambre C, Bertucci F, Boudou-Rouquette P, Cancel M, Perrin C, Saada-Bouzid E, Monard L, Schiffler C, Chaigneau L, Hervieu A, Collard O, Bouvier C, Vidal V, Chabaud S, Blay JY; French Sarcoma Group
Eur J Cancer 2021 Jun;150:108-118. Epub 2021 Apr 22 doi: 10.1016/j.ejca.2021.03.039. PMID: 33895682
Clinical benefit of antiangiogenic therapy in advanced and metastatic chondrosarcoma.
Jones RL, Katz D, Loggers ET, Davidson D, Rodler ET, Pollack SM
Med Oncol 2017 Aug 29;34(10):167. doi: 10.1007/s12032-017-1030-2. PMID: 28852958Free PMC Article
Molecular oncogenesis of chondrosarcoma: impact for targeted treatment.
Speetjens FM, de Jong Y, Gelderblom H, Bovée JV
Curr Opin Oncol 2016 Jul;28(4):314-22. doi: 10.1097/CCO.0000000000000300. PMID: 27166664
Src kinases in chondrosarcoma chemoresistance and migration: dasatinib sensitises to doxorubicin in TP53 mutant cells.
van Oosterwijk JG, van Ruler MA, Briaire-de Bruijn IH, Herpers B, Gelderblom H, van de Water B, Bovée JV
Br J Cancer 2013 Sep 3;109(5):1214-22. Epub 2013 Aug 6 doi: 10.1038/bjc.2013.451. PMID: 23922104Free PMC Article

Prognosis

IMP3, CDK4, MDM2 and β-catenin expression in Enchondroma and Central Chondrosarcoma: Diagnostic and prognostic utility.
Losada DM, Etchebehere M, Cintra FF, Amstalden EMI
Clinics (Sao Paulo) 2024;79:100483. Epub 2024 Oct 4 doi: 10.1016/j.clinsp.2024.100483. PMID: 39368400Free PMC Article
Prognostic Factors and Surgical Impact of Non-metastatic Conventional Chondrosarcoma of the Extremities.
Wang W, Zhen J
Orthop Surg 2023 Dec;15(12):3288-3299. Epub 2023 Oct 24 doi: 10.1111/os.13916. PMID: 37875420Free PMC Article
Preclinical Characterization and Phase I Trial Results of INBRX-109, A Third-Generation, Recombinant, Humanized, Death Receptor 5 Agonist Antibody, in Chondrosarcoma.
Subbiah V, Chawla SP, Conley AP, Wilky BA, Tolcher A, Lakhani NJ, Berz D, Andrianov V, Crago W, Holcomb M, Hussain A, Veldstra C, Kalabus J, O'Neill B, Senne L, Rowell E, Heidt AB, Willis KM, Eckelman BP
Clin Cancer Res 2023 Aug 15;29(16):2988-3003. doi: 10.1158/1078-0432.CCR-23-0974. PMID: 37265425Free PMC Article
Molecular oncogenesis of chondrosarcoma: impact for targeted treatment.
Speetjens FM, de Jong Y, Gelderblom H, Bovée JV
Curr Opin Oncol 2016 Jul;28(4):314-22. doi: 10.1097/CCO.0000000000000300. PMID: 27166664
Multicentric chondrosarcomas.
Damron TA, Sim FH, Unni KK
Clin Orthop Relat Res 1996 Jul;(328):211-9. doi: 10.1097/00003086-199607000-00033. PMID: 8653959

Clinical prediction guides

IMP3, CDK4, MDM2 and β-catenin expression in Enchondroma and Central Chondrosarcoma: Diagnostic and prognostic utility.
Losada DM, Etchebehere M, Cintra FF, Amstalden EMI
Clinics (Sao Paulo) 2024;79:100483. Epub 2024 Oct 4 doi: 10.1016/j.clinsp.2024.100483. PMID: 39368400Free PMC Article
Prognostic Factors and Surgical Impact of Non-metastatic Conventional Chondrosarcoma of the Extremities.
Wang W, Zhen J
Orthop Surg 2023 Dec;15(12):3288-3299. Epub 2023 Oct 24 doi: 10.1111/os.13916. PMID: 37875420Free PMC Article
Identifying the Prognosis Factors and Predicting the Survival Probability in Patients with Non-Metastatic Chondrosarcoma from the SEER Database.
Huang R, Sun Z, Zheng H, Yan P, Hu P, Yin H, Zhang J, Meng T, Huang Z
Orthop Surg 2019 Oct;11(5):801-810. doi: 10.1111/os.12521. PMID: 31663279Free PMC Article
Epigenetic regulation of embryonic stem cell marker miR302C in human chondrosarcoma as determinant of antiproliferative activity of proline-rich polypeptide 1.
Galoian K, Qureshi A, D'Ippolito G, Schiller PC, Molinari M, Johnstone AL, Brothers SP, Paz AC, Temple HT
Int J Oncol 2015 Aug;47(2):465-72. Epub 2015 Jun 18 doi: 10.3892/ijo.2015.3054. PMID: 26094604Free PMC Article
Multicentric chondrosarcomas.
Damron TA, Sim FH, Unni KK
Clin Orthop Relat Res 1996 Jul;(328):211-9. doi: 10.1097/00003086-199607000-00033. PMID: 8653959

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