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Vaginal adenocarcinoma

MedGen UID:
124643
•Concept ID:
C0279668
•
Neoplastic Process
Synonyms: Adenocarcinoma of the Vagina; adenocarcinoma of the vagina; Adenocarcinoma of Vagina; adenocarcinoma of vagina; Vagina Adenocarcinoma; vagina adenocarcinoma; Vaginal Adenocarcinoma; vaginal adenocarcinoma
 
Monarch Initiative: MONDO:0020653

Definition

An adenocarcinoma arising from the vagina. Morphologic variants include the clear cell, endometrioid, mesonephric, and mucinous adenocarcinoma. [from NCI]

Professional guidelines

PubMed

Neoadjuvant chemotherapy combined with surgery for the treatment of a rare primary vaginal adenocarcinoma.
Liu S, Li M, Zhang H
Asian J Surg 2024 Apr;47(4):2039-2040. Epub 2024 Jan 13 doi: 10.1016/j.asjsur.2024.01.030. PMID: 38220528
Primary Vaginal Gastric-type Adenocarcinoma and Vaginal Adenosis Exhibiting Gastric Differentiation: Report of a Series With Detailed Immunohistochemical Analysis.
Wong RW, Moore M, Talia KL, Ganesan R, McCluggage WG
Am J Surg Pathol 2018 Jul;42(7):958-970. doi: 10.1097/PAS.0000000000001068. PMID: 29664741
Vaginal cytologic evaluation as a practical link between hormone blood levels and tumor hormone dependency in exclusive medroxyprogesterone treatment of recurrent or metastatic endometrial adenocarcinoma.
Bonte J, Decoster JM, Ide P
Acta Cytol 1977 Mar-Apr;21(2):218-24. PMID: 266331

Recent clinical studies

Etiology

Primary vaginal malignancies: a single oncology centre experience.
Lima M, Rio G, Horta M, Cunha TM
J Obstet Gynaecol 2019 Aug;39(6):827-832. Epub 2019 Apr 25 doi: 10.1080/01443615.2019.1579786. PMID: 31020870
Non-diethylstilbestrol exposed vaginal adenocarcinoma in young patients associated with unilateral renal agenesis: two case reports and literature review.
Plesinac-Karapandzic V, Stojanovic Rundic S, Jankovic R, Nadrljanski M, Milovanovic Z, Tomasevic A, Perisie Jeremic N
Eur J Gynaecol Oncol 2017;38(1):157-161. PMID: 29767889
Outcomes of Definitive Radiation Therapy for Primary Vaginal Carcinoma.
Greenwalt JC, Amdur RJ, Morris CG, Morgan LS, Castagno J, Markham MJ, Rich S, Yeung AR
Am J Clin Oncol 2015 Dec;38(6):583-7. doi: 10.1097/COC.0000000000000002. PMID: 24136141
Hormones, medications, and cancer.
Lipsett MB
Cancer 1983 Jun 15;51(12 Suppl):2426-9. doi: 10.1002/1097-0142(19830615)51:12+<2426::aid-cncr2820511307>3.0.co;2-c. PMID: 6850519
Stilbestrol and vaginal cancer in young women.
Herbst AL
CA Cancer J Clin 1972 Sep-Oct;22(5):292-5. doi: 10.3322/canjclin.22.5.292. PMID: 4627406

Diagnosis

Diagnostic and Therapeutic Approach in a Metastatic Vaginal Adenocarcinoma: A Case Report.
Egger EK, Ralser DJ, Lindner K, Recker F, Marinova M, Savchenko O, Lau JF, Mustea A
Front Immunol 2021;12:686879. Epub 2021 Jul 23 doi: 10.3389/fimmu.2021.686879. PMID: 34367146Free PMC Article
Primary vaginal malignancies: a single oncology centre experience.
Lima M, Rio G, Horta M, Cunha TM
J Obstet Gynaecol 2019 Aug;39(6):827-832. Epub 2019 Apr 25 doi: 10.1080/01443615.2019.1579786. PMID: 31020870
Primary Vaginal Gastric-type Adenocarcinoma and Vaginal Adenosis Exhibiting Gastric Differentiation: Report of a Series With Detailed Immunohistochemical Analysis.
Wong RW, Moore M, Talia KL, Ganesan R, McCluggage WG
Am J Surg Pathol 2018 Jul;42(7):958-970. doi: 10.1097/PAS.0000000000001068. PMID: 29664741
Non-diethylstilbestrol exposed vaginal adenocarcinoma in young patients associated with unilateral renal agenesis: two case reports and literature review.
Plesinac-Karapandzic V, Stojanovic Rundic S, Jankovic R, Nadrljanski M, Milovanovic Z, Tomasevic A, Perisie Jeremic N
Eur J Gynaecol Oncol 2017;38(1):157-161. PMID: 29767889
Stilbestrol and vaginal cancer in young women.
Herbst AL
CA Cancer J Clin 1972 Sep-Oct;22(5):292-5. doi: 10.3322/canjclin.22.5.292. PMID: 4627406

Therapy

Diagnostic and Therapeutic Approach in a Metastatic Vaginal Adenocarcinoma: A Case Report.
Egger EK, Ralser DJ, Lindner K, Recker F, Marinova M, Savchenko O, Lau JF, Mustea A
Front Immunol 2021;12:686879. Epub 2021 Jul 23 doi: 10.3389/fimmu.2021.686879. PMID: 34367146Free PMC Article
The history of Distilbène® (Diethylstilbestrol) told to grandchildren--the transgenerational effect.
Fénichel P, Brucker-Davis F, Chevalier N
Ann Endocrinol (Paris) 2015 Jul;76(3):253-9. Epub 2015 Apr 28 doi: 10.1016/j.ando.2015.03.008. PMID: 25934356
Primary vaginal adenocarcinoma arising in vaginal adenosis after CO2 laser vaporization and 5-fluorouracil therapy.
Paczos TA, Ackers S, Odunsi K, Lele S, Mhawech-Fauceglia P
Int J Gynecol Pathol 2010 Mar;29(2):193-6. doi: 10.1097/PGP.0b013e3181b6a7d7. PMID: 20173507Free PMC Article
Epidemiology of vaginal adenocarcinoma and adenosis: current status.
Weiss K
J Am Med Womens Assoc (1972) 1975 Feb;30(2):59-63. PMID: 163267
Transplacental carcinogenesis by stilbestrol.
Folkman J
N Engl J Med 1971 Aug 12;285(7):404-5. doi: 10.1056/NEJM197108122850711. PMID: 5556579

Prognosis

Diagnostic and Therapeutic Approach in a Metastatic Vaginal Adenocarcinoma: A Case Report.
Egger EK, Ralser DJ, Lindner K, Recker F, Marinova M, Savchenko O, Lau JF, Mustea A
Front Immunol 2021;12:686879. Epub 2021 Jul 23 doi: 10.3389/fimmu.2021.686879. PMID: 34367146Free PMC Article
Primary Vaginal Gastric-type Adenocarcinoma and Vaginal Adenosis Exhibiting Gastric Differentiation: Report of a Series With Detailed Immunohistochemical Analysis.
Wong RW, Moore M, Talia KL, Ganesan R, McCluggage WG
Am J Surg Pathol 2018 Jul;42(7):958-970. doi: 10.1097/PAS.0000000000001068. PMID: 29664741
Outcomes of Definitive Radiation Therapy for Primary Vaginal Carcinoma.
Greenwalt JC, Amdur RJ, Morris CG, Morgan LS, Castagno J, Markham MJ, Rich S, Yeung AR
Am J Clin Oncol 2015 Dec;38(6):583-7. doi: 10.1097/COC.0000000000000002. PMID: 24136141
Primary vaginal adenocarcinoma arising in vaginal adenosis after CO2 laser vaporization and 5-fluorouracil therapy.
Paczos TA, Ackers S, Odunsi K, Lele S, Mhawech-Fauceglia P
Int J Gynecol Pathol 2010 Mar;29(2):193-6. doi: 10.1097/PGP.0b013e3181b6a7d7. PMID: 20173507Free PMC Article
Diethylstilbestrol exposure and the risk of clear cell cervical and vaginal adenocarcinoma.
Edelman DA
Int J Fertil 1989 Jul-Aug;34(4):251-5. PMID: 2570761

Clinical prediction guides

Diagnostic and Therapeutic Approach in a Metastatic Vaginal Adenocarcinoma: A Case Report.
Egger EK, Ralser DJ, Lindner K, Recker F, Marinova M, Savchenko O, Lau JF, Mustea A
Front Immunol 2021;12:686879. Epub 2021 Jul 23 doi: 10.3389/fimmu.2021.686879. PMID: 34367146Free PMC Article
Immunohistochemical Loss of DPC4 in Tumors With Mucinous Differentiation Arising in or Involving the Gynecologic Tract.
Kwon DH, Malpica A, Zaleski M, Euscher ED, Ramalingam P
Int J Gynecol Pathol 2021 Nov 1;40(6):523-532. doi: 10.1097/PGP.0000000000000754. PMID: 33405429
Primary Vaginal Gastric-type Adenocarcinoma and Vaginal Adenosis Exhibiting Gastric Differentiation: Report of a Series With Detailed Immunohistochemical Analysis.
Wong RW, Moore M, Talia KL, Ganesan R, McCluggage WG
Am J Surg Pathol 2018 Jul;42(7):958-970. doi: 10.1097/PAS.0000000000001068. PMID: 29664741
Incidental vaginal müllerianosis.
Val-Bernal JF, Mayorga M
Pathol Res Pract 2016 Jun;212(6):568-72. Epub 2016 Feb 26 doi: 10.1016/j.prp.2016.02.023. PMID: 26970930
Immunoprofile of adenocarcinomas of the endometrium, endocervix, and ovary with mucinous differentiation.
Park KJ, Bramlage MP, Ellenson LH, Pirog EC
Appl Immunohistochem Mol Morphol 2009 Jan;17(1):8-11. doi: 10.1097/PAI.0b013e318174f012. PMID: 18776815

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