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Myocardium cancer

MedGen UID:
138067
•Concept ID:
C0346611
•
Neoplastic Process
Synonyms: cancer of myocardium; Malignant Myocardial Neoplasm; malignant myocardial neoplasm; Malignant Myocardial Tumor; malignant myocardial tumor; malignant myocardial tumour; malignant myocardium neoplasm; Malignant Neoplasm of Myocardium; malignant neoplasm of myocardium; Malignant Neoplasm of the Myocardium; malignant neoplasm of the myocardium; Malignant tumor of myocardium; Malignant Tumor of Myocardium; malignant tumor of myocardium; Malignant Tumor of the Myocardium; malignant tumor of the myocardium; malignant tumour of myocardium; malignant tumour of the myocardium; myocardium cancer
SNOMED CT: Malignant tumor of myocardium (363437005)
 
Monarch Initiative: MONDO:0004749

Definition

A primary or metastatic malignant neoplasm that affects the myocardium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyocardium cancer

Professional guidelines

PubMed

MicroRNA in the Diagnosis and Treatment of Doxorubicin-Induced Cardiotoxicity.
Kuang Z, Wu J, Tan Y, Zhu G, Li J, Wu M
Biomolecules 2023 Mar 20;13(3) doi: 10.3390/biom13030568. PMID: 36979503Free PMC Article
Immune Checkpoint Inhibitor Myocarditis: Pathophysiological Characteristics, Diagnosis, and Treatment.
Palaskas N, Lopez-Mattei J, Durand JB, Iliescu C, Deswal A
J Am Heart Assoc 2020 Jan 21;9(2):e013757. doi: 10.1161/JAHA.119.013757. PMID: 31960755Free PMC Article
Cardiac Amyloidosis: Diagnosis and Treatment Strategies.
Tuzovic M, Yang EH, Baas AS, Depasquale EC, Deng MC, Cruz D, Vorobiof G
Curr Oncol Rep 2017 Jul;19(7):46. doi: 10.1007/s11912-017-0607-4. PMID: 28528458

Recent clinical studies

Etiology

Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure.
Yuan Y, Mei Z, Qu Z, Li G, Yu S, Liu Y, Liu K, Shen Z, Pu J, Wang Y, Wang C, Sun Z, Liu Q, Pang X, Wang A, Ren Z, Wang T, Liu Y, Hong J, Xie J, Li X, Wang Z, Du W, Yang B
Signal Transduct Target Ther 2023 Mar 27;8(1):121. doi: 10.1038/s41392-023-01336-4. PMID: 36967385Free PMC Article
The Role of Biomarkers in Cardio-Oncology.
Ananthan K, Lyon AR
J Cardiovasc Transl Res 2020 Jun;13(3):431-450. Epub 2020 Jul 8 doi: 10.1007/s12265-020-10042-3. PMID: 32642841Free PMC Article
Multiparametric Echocardiography Scores for the Diagnosis of Cardiac Amyloidosis.
Boldrini M, Cappelli F, Chacko L, Restrepo-Cordoba MA, Lopez-Sainz A, Giannoni A, Aimo A, Baggiano A, Martinez-Naharro A, Whelan C, Quarta C, Passino C, Castiglione V, Chubuchnyi V, Spini V, Taddei C, Vergaro G, Petrie A, Ruiz-Guerrero L, Moñivas V, Mingo-Santos S, Mirelis JG, Dominguez F, Gonzalez-Lopez E, Perlini S, Pontone G, Gillmore J, Hawkins PN, Garcia-Pavia P, Emdin M, Fontana M
JACC Cardiovasc Imaging 2020 Apr;13(4):909-920. Epub 2019 Dec 18 doi: 10.1016/j.jcmg.2019.10.011. PMID: 31864973
Cardioprotective strategies to prevent breast cancer therapy-induced cardiotoxicity.
Padegimas A, Clasen S, Ky B
Trends Cardiovasc Med 2020 Jan;30(1):22-28. Epub 2019 Jan 29 doi: 10.1016/j.tcm.2019.01.006. PMID: 30745071Free PMC Article
Cardiovascular Metabolomics.
McGarrah RW, Crown SB, Zhang GF, Shah SH, Newgard CB
Circ Res 2018 Apr 27;122(9):1238-1258. doi: 10.1161/CIRCRESAHA.117.311002. PMID: 29700070Free PMC Article

Diagnosis

Hypertensive Heartbreak.
Lau ES, Scirica B, Schaefer IM, Miller AL, Loscalzo J
N Engl J Med 2021 Jun 3;384(22):2145-2152. doi: 10.1056/NEJMcps2018493. PMID: 34077647
Cardiac Neoplasms: Radiologic-Pathologic Correlation.
Lichtenberger JP 3rd, Carter BW, Pavio MA, Biko DM
Radiol Clin North Am 2021 Mar;59(2):231-242. Epub 2020 Dec 29 doi: 10.1016/j.rcl.2020.10.002. PMID: 33551084
Immune Checkpoint Inhibitor Myocarditis: Pathophysiological Characteristics, Diagnosis, and Treatment.
Palaskas N, Lopez-Mattei J, Durand JB, Iliescu C, Deswal A
J Am Heart Assoc 2020 Jan 21;9(2):e013757. doi: 10.1161/JAHA.119.013757. PMID: 31960755Free PMC Article
Cardioprotective strategies to prevent breast cancer therapy-induced cardiotoxicity.
Padegimas A, Clasen S, Ky B
Trends Cardiovasc Med 2020 Jan;30(1):22-28. Epub 2019 Jan 29 doi: 10.1016/j.tcm.2019.01.006. PMID: 30745071Free PMC Article
MRI of Cardiotoxicity.
Jordan JH, Hundley WG
Cardiol Clin 2019 Nov;37(4):429-439. Epub 2019 Aug 31 doi: 10.1016/j.ccl.2019.07.007. PMID: 31587784Free PMC Article

Therapy

Malonate Promotes Adult Cardiomyocyte Proliferation and Heart Regeneration.
Bae J, Salamon RJ, Brandt EB, Paltzer WG, Zhang Z, Britt EC, Hacker TA, Fan J, Mahmoud AI
Circulation 2021 May 18;143(20):1973-1986. Epub 2021 Mar 5 doi: 10.1161/CIRCULATIONAHA.120.049952. PMID: 33666092Free PMC Article
The Role of Biomarkers in Cardio-Oncology.
Ananthan K, Lyon AR
J Cardiovasc Transl Res 2020 Jun;13(3):431-450. Epub 2020 Jul 8 doi: 10.1007/s12265-020-10042-3. PMID: 32642841Free PMC Article
Cardioprotective strategies to prevent breast cancer therapy-induced cardiotoxicity.
Padegimas A, Clasen S, Ky B
Trends Cardiovasc Med 2020 Jan;30(1):22-28. Epub 2019 Jan 29 doi: 10.1016/j.tcm.2019.01.006. PMID: 30745071Free PMC Article
MRI of Cardiotoxicity.
Jordan JH, Hundley WG
Cardiol Clin 2019 Nov;37(4):429-439. Epub 2019 Aug 31 doi: 10.1016/j.ccl.2019.07.007. PMID: 31587784Free PMC Article
Fulminant Myocarditis with Combination Immune Checkpoint Blockade.
Johnson DB, Balko JM, Compton ML, Chalkias S, Gorham J, Xu Y, Hicks M, Puzanov I, Alexander MR, Bloomer TL, Becker JR, Slosky DA, Phillips EJ, Pilkinton MA, Craig-Owens L, Kola N, Plautz G, Reshef DS, Deutsch JS, Deering RP, Olenchock BA, Lichtman AH, Roden DM, Seidman CE, Koralnik IJ, Seidman JG, Hoffman RD, Taube JM, Diaz LA Jr, Anders RA, Sosman JA, Moslehi JJ
N Engl J Med 2016 Nov 3;375(18):1749-1755. doi: 10.1056/NEJMoa1609214. PMID: 27806233Free PMC Article

Prognosis

Single-Cell RNA Sequencing Analysis Reveals a Crucial Role for CTHRC1 (Collagen Triple Helix Repeat Containing 1) Cardiac Fibroblasts After Myocardial Infarction.
Ruiz-Villalba A, Romero JP, Hernández SC, Vilas-Zornoza A, Fortelny N, Castro-Labrador L, San Martin-Uriz P, Lorenzo-Vivas E, García-Olloqui P, Palacio M, Gavira JJ, Bastarrika G, Janssens S, Wu M, Iglesias E, Abizanda G, de Morentin XM, Lasaga M, Planell N, Bock C, Alignani D, Medal G, Prudovsky I, Jin YR, Ryzhov S, Yin H, Pelacho B, Gomez-Cabrero D, Lindner V, Lara-Astiaso D, Prósper F
Circulation 2020 Nov 10;142(19):1831-1847. Epub 2020 Sep 25 doi: 10.1161/CIRCULATIONAHA.119.044557. PMID: 32972203Free PMC Article
The Role of Biomarkers in Cardio-Oncology.
Ananthan K, Lyon AR
J Cardiovasc Transl Res 2020 Jun;13(3):431-450. Epub 2020 Jul 8 doi: 10.1007/s12265-020-10042-3. PMID: 32642841Free PMC Article
Immune Checkpoint Inhibitor Myocarditis: Pathophysiological Characteristics, Diagnosis, and Treatment.
Palaskas N, Lopez-Mattei J, Durand JB, Iliescu C, Deswal A
J Am Heart Assoc 2020 Jan 21;9(2):e013757. doi: 10.1161/JAHA.119.013757. PMID: 31960755Free PMC Article
Cardioprotective strategies to prevent breast cancer therapy-induced cardiotoxicity.
Padegimas A, Clasen S, Ky B
Trends Cardiovasc Med 2020 Jan;30(1):22-28. Epub 2019 Jan 29 doi: 10.1016/j.tcm.2019.01.006. PMID: 30745071Free PMC Article
Fulminant Myocarditis with Combination Immune Checkpoint Blockade.
Johnson DB, Balko JM, Compton ML, Chalkias S, Gorham J, Xu Y, Hicks M, Puzanov I, Alexander MR, Bloomer TL, Becker JR, Slosky DA, Phillips EJ, Pilkinton MA, Craig-Owens L, Kola N, Plautz G, Reshef DS, Deutsch JS, Deering RP, Olenchock BA, Lichtman AH, Roden DM, Seidman CE, Koralnik IJ, Seidman JG, Hoffman RD, Taube JM, Diaz LA Jr, Anders RA, Sosman JA, Moslehi JJ
N Engl J Med 2016 Nov 3;375(18):1749-1755. doi: 10.1056/NEJMoa1609214. PMID: 27806233Free PMC Article

Clinical prediction guides

The Role of Biomarkers in Cardio-Oncology.
Ananthan K, Lyon AR
J Cardiovasc Transl Res 2020 Jun;13(3):431-450. Epub 2020 Jul 8 doi: 10.1007/s12265-020-10042-3. PMID: 32642841Free PMC Article
Multiparametric Echocardiography Scores for the Diagnosis of Cardiac Amyloidosis.
Boldrini M, Cappelli F, Chacko L, Restrepo-Cordoba MA, Lopez-Sainz A, Giannoni A, Aimo A, Baggiano A, Martinez-Naharro A, Whelan C, Quarta C, Passino C, Castiglione V, Chubuchnyi V, Spini V, Taddei C, Vergaro G, Petrie A, Ruiz-Guerrero L, Moñivas V, Mingo-Santos S, Mirelis JG, Dominguez F, Gonzalez-Lopez E, Perlini S, Pontone G, Gillmore J, Hawkins PN, Garcia-Pavia P, Emdin M, Fontana M
JACC Cardiovasc Imaging 2020 Apr;13(4):909-920. Epub 2019 Dec 18 doi: 10.1016/j.jcmg.2019.10.011. PMID: 31864973
Metabolic Imaging in Cardio-oncology.
Tong D, Zaha VG
J Cardiovasc Transl Res 2020 Jun;13(3):357-366. Epub 2019 Nov 6 doi: 10.1007/s12265-019-09927-9. PMID: 31696405
Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair.
Tiburcy M, Hudson JE, Balfanz P, Schlick S, Meyer T, Chang Liao ML, Levent E, Raad F, Zeidler S, Wingender E, Riegler J, Wang M, Gold JD, Kehat I, Wettwer E, Ravens U, Dierickx P, van Laake LW, Goumans MJ, Khadjeh S, Toischer K, Hasenfuss G, Couture LA, Unger A, Linke WA, Araki T, Neel B, Keller G, Gepstein L, Wu JC, Zimmermann WH
Circulation 2017 May 9;135(19):1832-1847. Epub 2017 Feb 6 doi: 10.1161/CIRCULATIONAHA.116.024145. PMID: 28167635Free PMC Article
Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma.
Linette GP, Stadtmauer EA, Maus MV, Rapoport AP, Levine BL, Emery L, Litzky L, Bagg A, Carreno BM, Cimino PJ, Binder-Scholl GK, Smethurst DP, Gerry AB, Pumphrey NJ, Bennett AD, Brewer JE, Dukes J, Harper J, Tayton-Martin HK, Jakobsen BK, Hassan NJ, Kalos M, June CH
Blood 2013 Aug 8;122(6):863-71. Epub 2013 Jun 14 doi: 10.1182/blood-2013-03-490565. PMID: 23770775Free PMC Article

Recent systematic reviews

Pharmacological management of transthyretin amyloid cardiomyopathy: a scoping review.
Rehman S, Masthan SS, Ibrahim R, Pham HN, Hassan D, Ahmad F, Asif MS, Safdar A, Anwar Z, Raza S, William P
Eur Heart J Cardiovasc Pharmacother 2024 Oct 4;10(6):547-556. doi: 10.1093/ehjcvp/pvae044. PMID: 38830793
MRI-derived extracellular volume as a biomarker of cancer therapy cardiotoxicity: systematic review and meta-analysis.
Folco G, Monti CB, Zanardo M, Silletta F, Capra D, Secchi F, Sardanelli F
Eur Radiol 2024 Apr;34(4):2699-2710. Epub 2023 Oct 12 doi: 10.1007/s00330-023-10260-8. PMID: 37823922Free PMC Article
Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion-dependent beta thalassaemia.
Padhani ZA, Gangwani MK, Sadaf A, Hasan B, Colan S, Alvi N, Das JK
Cochrane Database Syst Rev 2023 Nov 17;11(11):CD011626. doi: 10.1002/14651858.CD011626.pub3. PMID: 37975597Free PMC Article
Hamartoma of mature cardiac myocytes: systematic review.
Techasatian W, Gozun M, Morihara C, Pham A, Benavente K, Nagamine T, Nishimura Y
Cardiovasc Pathol 2023 Jul-Aug;65:107538. Epub 2023 Apr 7 doi: 10.1016/j.carpath.2023.107538. PMID: 37031829
A systematic review of left ventricular cardio-endoscopic surgery.
Soylu E, Kidher E, Ashrafian H, Stavridis G, Harling L, Athanasiou T
J Cardiothorac Surg 2017 May 25;12(1):41. doi: 10.1186/s13019-017-0599-z. PMID: 28545585Free PMC Article

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