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Metastatic Malignant Neoplasm in the Orbit

MedGen UID:
91116
•Concept ID:
C0347020
•
Neoplastic Process
Synonyms: Metastasis to orbit; Metastasis to the Orbit; Metastatic malignant neoplasm of orbit; Metastatic malignant neoplasm to orbit; Metastatic Malignant Neoplasm to the Orbit; Metastatic Neoplasm to the Orbit; Metastatic Tumor to the Orbit; Secondary malignant neoplasm of orbit; Secondary malignant neoplasm of orbit proper; Secondary tumor of orbit
SNOMED CT: Secondary tumor of orbit (94453007); Metastasis to orbit (94453007); Secondary malignant neoplasm of orbit (94453007); Metastatic malignant neoplasm to orbit (94453007); Secondary malignant neoplasm of orbit proper (94453007); Metastatic malignant neoplasm of orbit (94453007)

Definition

A malignant neoplasm that has spread to the orbit from another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Orbit

Professional guidelines

PubMed

Current opinions on diagnosis and treatment of adenoid cystic carcinoma.
Fang Y, Peng Z, Wang Y, Gao K, Liu Y, Fan R, Zhang H, Xie Z, Jiang W
Oral Oncol 2022 Jul;130:105945. Epub 2022 Jun 2 doi: 10.1016/j.oraloncology.2022.105945. PMID: 35662026
Clinical Management of Uveal and Conjunctival Melanoma.
Blum ES, Yang J, Komatsubara KM, Carvajal RD
Oncology (Williston Park) 2016 Jan;30(1):29-32, 34-43, 48. PMID: 26791842
Current treatment of retinoblastoma.
De Potter P
Curr Opin Ophthalmol 2002 Oct;13(5):331-6. doi: 10.1097/00055735-200210000-00007. PMID: 12218465

Recent clinical studies

Etiology

Ophthalmic Presentation and Outcome for Sinonasal Mucoceles.
Malik M, Vahdani K, Rose GE
Ophthalmic Plast Reconstr Surg 2023 Jan-Feb 01;39(1):44-48. Epub 2022 Jun 14 doi: 10.1097/IOP.0000000000002234. PMID: 35699210
Patients presenting with stage IV uveal melanoma: Lessons learned.
Garg G, Kivelä TT, Finger PT
Indian J Ophthalmol 2022 Jan;70(1):271-274. doi: 10.4103/ijo.IJO_1478_21. PMID: 34937253Free PMC Article
Leksell Radiosurgery for Orbital, Uveal, and Choroidal Tumors.
Ares WJ, Flickinger JC, Lunsford LD
Prog Neurol Surg 2019;34:298-305. Epub 2019 May 16 doi: 10.1159/000493077. PMID: 31096229
Secondary orbital tumors.
Günalp I, Gündüz K
Ophthalmic Plast Reconstr Surg 1997 Mar;13(1):31-5. doi: 10.1097/00002341-199703000-00006. PMID: 9076781
Intraocular and extraocular retinoblastoma.
Grabowski EF, Abramson DH
Hematol Oncol Clin North Am 1987 Dec;1(4):721-35. PMID: 3323180

Diagnosis

Ophthalmic Presentation and Outcome for Sinonasal Mucoceles.
Malik M, Vahdani K, Rose GE
Ophthalmic Plast Reconstr Surg 2023 Jan-Feb 01;39(1):44-48. Epub 2022 Jun 14 doi: 10.1097/IOP.0000000000002234. PMID: 35699210
Orbital Ependymoma.
Tsimchi IM, Malik AI, Takashima M, Lee AG
Ophthalmic Plast Reconstr Surg 2022 Mar-Apr 01;38(2):e51-e54. doi: 10.1097/IOP.0000000000002095. PMID: 35030150
Orbital metastatic osteosarcoma.
Lin PY, Chen WM, Hsieh YL, Chen WY, Chen TH
J Chin Med Assoc 2005 Jun;68(6):286-9. doi: 10.1016/S1726-4901(09)70153-4. PMID: 15984825
Orbital tumors.
Weisman RA, Kikkawa D, Moe KS, Osguthorpe JD
Otolaryngol Clin North Am 2001 Dec;34(6):1157-74, ix-x. doi: 10.1016/s0030-6665(05)70372-8. PMID: 11728939
Secondary orbital tumors.
Günalp I, Gündüz K
Ophthalmic Plast Reconstr Surg 1997 Mar;13(1):31-5. doi: 10.1097/00002341-199703000-00006. PMID: 9076781

Therapy

Lymphoma of the Lacrimal Gland - An International Multicenter Retrospective Study.
Vest SD, Mikkelsen LH, Holm F, Rasmussen PK, Hindso TG, Knudsen MKH, Coupland SE, Esmaeli B, Finger PT, Graue GF, Grossniklaus HE, Honavar SG, Mulay K, Sjö LD, Sniegowski MC, Vemuganti GK, Thuro BA, Heegaard S
Am J Ophthalmol 2020 Nov;219:107-120. Epub 2020 Jun 20 doi: 10.1016/j.ajo.2020.06.015. PMID: 32574779
Lymphoproliferative tumors involving the lacrimal drainage system: a major review.
Singh S, Ali MJ
Orbit 2020 Aug;39(4):276-284. Epub 2019 Jul 3 doi: 10.1080/01676830.2019.1634104. PMID: 31267826
Review of periorbital nerve enlargement and biopsy techniques.
Chen VH, Hayek BR, Grossniklaus HE, Wojno TH, Kim HJ
Orbit 2017 Oct;36(5):293-297. Epub 2017 Aug 18 doi: 10.1080/01676830.2017.1337177. PMID: 28820280
Current treatments for radiation retinopathy.
Giuliari GP, Sadaka A, Hinkle DM, Simpson ER
Acta Oncol 2011 Jan;50(1):6-13. Epub 2010 Aug 20 doi: 10.3109/0284186X.2010.500299. PMID: 20722590
Orbital metastatic angiosarcoma.
Hassane S, Fouad E, Said I, Karim R, Asmae N, Houcine C, Abdelbar O
Korean J Ophthalmol 2010 Dec;24(6):364-6. Epub 2010 Nov 23 doi: 10.3341/kjo.2010.24.6.364. PMID: 21165236Free PMC Article

Prognosis

Characteristics and Survival Outcomes of Second Primary Cancers in Long-term Retinoblastoma Survivors.
Zhao NO, Daewoo P, El-Hadad C, Debnam JM, Ning J, Esmaeli B
Asia Pac J Ophthalmol (Phila) 2021 Jan 19;10(4):366-372. doi: 10.1097/APO.0000000000000361. PMID: 33481394
Orbital metastases from neuroendocrine neoplasms: clinical implications and outcomes.
Kamieniarz L, Armeni E, O'Mahony LF, Leigh C, Miah L, Narayan A, Bhatt A, Cox N, Mandair D, Navalkissoor S, Caplin M, Toumpanakis C
Endocrine 2020 Feb;67(2):485-493. Epub 2019 Nov 15 doi: 10.1007/s12020-019-02130-5. PMID: 31732922
Orbital metastatic angiosarcoma.
Hassane S, Fouad E, Said I, Karim R, Asmae N, Houcine C, Abdelbar O
Korean J Ophthalmol 2010 Dec;24(6):364-6. Epub 2010 Nov 23 doi: 10.3341/kjo.2010.24.6.364. PMID: 21165236Free PMC Article
Secondary orbital tumors.
Günalp I, Gündüz K
Ophthalmic Plast Reconstr Surg 1997 Mar;13(1):31-5. doi: 10.1097/00002341-199703000-00006. PMID: 9076781
Orbital lymphangiomas.
Iliff WJ, Green WR
Ophthalmology 1979 May;86(5):914-29. doi: 10.1016/s0161-6420(79)35441-0. PMID: 545219

Clinical prediction guides

Lymph node metastasis in cancer progression: molecular mechanisms, clinical significance and therapeutic interventions.
Ji H, Hu C, Yang X, Liu Y, Ji G, Ge S, Wang X, Wang M
Signal Transduct Target Ther 2023 Sep 27;8(1):367. doi: 10.1038/s41392-023-01576-4. PMID: 37752146Free PMC Article
Conjunctival Melanoma in 430 Cases: Comparative Analysis of the Impact of Orbital Invasion on Tumor Recurrence, Metastasis, and Death.
Bas Z, Dockery PW, Lally SE, Shields JA, Shields CL
Ophthalmic Plast Reconstr Surg 2023 Jan-Feb 01;39(1):49-57. Epub 2023 Jan 2 doi: 10.1097/IOP.0000000000002238. PMID: 36598390
Cancers of the eye.
Maheshwari A, Finger PT
Cancer Metastasis Rev 2018 Dec;37(4):677-690. doi: 10.1007/s10555-018-9762-9. PMID: 30203109
Extranodal Diffuse Large B Cell Lymphoma: Molecular Features, Prognosis, and Risk of Central Nervous System Recurrence.
Ollila TA, Olszewski AJ
Curr Treat Options Oncol 2018 Jun 21;19(8):38. doi: 10.1007/s11864-018-0555-8. PMID: 29931605Free PMC Article
Metastatic patterns of retinoblastoma.
MacKay CJ, Abramson DH, Ellsworth RM
Arch Ophthalmol 1984 Mar;102(3):391-6. doi: 10.1001/archopht.1984.01040030309025. PMID: 6703986

Recent systematic reviews

Endoscopic Transorbital Approach for the Management of Spheno-Orbital Meningiomas: Literature Review and Preliminary Experience.
Di Somma A, De Rosa A, Ferrés A, Mosteiro A, Guizzardi G, Fassi JM, Topczewski TE, Reyes L, Roldán P, Torné R, Alobid I, Enseñat J
World Neurosurg 2023 Aug;176:43-59. Epub 2023 Apr 5 doi: 10.1016/j.wneu.2023.03.126. PMID: 37024084
Metastatic Meningioma of the Neck: A Case Report and Systematic Review.
Nguyen HCB, Mady LJ, Panara K, Andrianus S, Cooper K, Chen IH, Chalian AA, Brody RM
ORL J Otorhinolaryngol Relat Spec 2022;84(5):361-369. Epub 2022 Feb 3 doi: 10.1159/000521076. PMID: 35114675
Ophthalmic involvement of chronic lymphocytic leukemia: A systematic review of 123 cases.
Delestre F, Blanche P, Bouayed E, Bouscary D, Mouthon L, Brezin A, Le Jeunne C, Chaigne B
Surv Ophthalmol 2021 Jan-Feb;66(1):124-131. Epub 2020 May 11 doi: 10.1016/j.survophthal.2020.05.001. PMID: 32407752
High frequency of lobular breast cancer in distant metastases to the orbit.
Raap M, Antonopoulos W, Dämmrich M, Christgen H, Steinmann D, Länger F, Lehmann U, Kreipe H, Christgen M
Cancer Med 2015 Jan;4(1):104-11. Epub 2014 Oct 30 doi: 10.1002/cam4.331. PMID: 25355547Free PMC Article
Cutaneous malignant melanoma metastatic to the eye, lids, and orbit.
Rosenberg C, Finger PT
Surv Ophthalmol 2008 May-Jun;53(3):187-202. doi: 10.1016/j.survophthal.2008.02.003. PMID: 18501266

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