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Vulva verrucous carcinoma

MedGen UID:
234482
Concept ID:
C1336983
Neoplastic Process
Synonyms: mammalian vulva verrucous carcinoma; Verrucous Carcinoma of the Vulva; verrucous carcinoma of the vulva; Verrucous Carcinoma of Vulva; verrucous carcinoma of vulva; vulva verrucous carcinoma; Vulvar Verrucous Carcinoma; vulvar verrucous carcinoma
 
Monarch Initiative: MONDO:0002758

Definition

A highly differentiated squamous cell carcinoma that arises from the vulva. It is characterized by the presence of a warty and hyperkeratinized surface, malignant cells with abundant eosinophilic cytoplasm, minimal cytologic atypia, and absence or rarity of mitotic figures. The tumor infiltrates the underlying stroma with a pushing border. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulva verrucous carcinoma

Professional guidelines

PubMed

Abu-Rustum NR, Yashar CM, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Gaillard S, Giuntoli R II, Glaser S, Holmes J, Howitt BE, Kendra K, Lea J, Lee N, Mantia-Smaldone G, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Rodabaugh K, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian N, Espinosa S
J Natl Compr Canc Netw 2024 Mar;22(2):117-135. doi: 10.6004/jnccn.2024.0013. PMID: 38503056
Namuduri RP, Lee LY, Aan Koh MJ
Dermatol Ther 2020 Nov;33(6):e14253. Epub 2020 Sep 11 doi: 10.1111/dth.14253. PMID: 32862466
Int J Gynaecol Obstet 1994 Jan;44(1):79-85. PMID: 7907068

Recent clinical studies

Etiology

Abu-Rustum NR, Yashar CM, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Gaillard S, Giuntoli R II, Glaser S, Holmes J, Howitt BE, Kendra K, Lea J, Lee N, Mantia-Smaldone G, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Rodabaugh K, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian N, Espinosa S
J Natl Compr Canc Netw 2024 Mar;22(2):117-135. doi: 10.6004/jnccn.2024.0013. PMID: 38503056
Shimizu A, Yamaguchi R, Kuriyama Y
J Dermatol 2023 Mar;50(3):290-298. Epub 2023 Jan 5 doi: 10.1111/1346-8138.16697. PMID: 36601717
Parra-Herran C, Nucci MR, Singh N, Rakislova N, Howitt BE, Hoang L, Gilks CB, Bosse T, Watkins JC
Mod Pathol 2022 Oct;35(10):1317-1326. Epub 2022 Apr 18 doi: 10.1038/s41379-022-01079-7. PMID: 35437330
Tessier-Cloutier B, Kortekaas KE, Thompson E, Pors J, Chen J, Ho J, Prentice LM, McConechy MK, Chow C, Proctor L, McAlpine JN, Huntsman DG, Gilks CB, Bosse T, Hoang LN
Mod Pathol 2020 Aug;33(8):1595-1605. Epub 2020 Mar 20 doi: 10.1038/s41379-020-0524-1. PMID: 32203095
Watkins JC
Surg Pathol Clin 2019 Jun;12(2):249-261. Epub 2019 Apr 5 doi: 10.1016/j.path.2019.01.001. PMID: 31097103

Diagnosis

Abu-Rustum NR, Yashar CM, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Gaillard S, Giuntoli R II, Glaser S, Holmes J, Howitt BE, Kendra K, Lea J, Lee N, Mantia-Smaldone G, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Rodabaugh K, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian N, Espinosa S
J Natl Compr Canc Netw 2024 Mar;22(2):117-135. doi: 10.6004/jnccn.2024.0013. PMID: 38503056
Parra-Herran C, Nucci MR, Singh N, Rakislova N, Howitt BE, Hoang L, Gilks CB, Bosse T, Watkins JC
Mod Pathol 2022 Oct;35(10):1317-1326. Epub 2022 Apr 18 doi: 10.1038/s41379-022-01079-7. PMID: 35437330
Dryden SM, Reshko LB, Gaskins JT, Silva SR
Cancer Rep (Hoboken) 2022 Oct;5(10):e21591. Epub 2022 Jan 24 doi: 10.1002/cnr2.1591. PMID: 35075817Free PMC Article
Wohlmuth C, Wohlmuth-Wieser I
J Dtsch Dermatol Ges 2019 Dec;17(12):1257-1276. Epub 2019 Dec 12 doi: 10.1111/ddg.13995. PMID: 31829526Free PMC Article
Watkins JC
Surg Pathol Clin 2019 Jun;12(2):249-261. Epub 2019 Apr 5 doi: 10.1016/j.path.2019.01.001. PMID: 31097103

Therapy

Luu YT, Kimmis BD, Bodine JS, Gloyeske NC, Dai H
J Cutan Pathol 2022 May;49(5):426-433. Epub 2021 Dec 21 doi: 10.1111/cup.14181. PMID: 34877687
Ward RA, Udechukwu NS, Selim MA, Jaleel T
Dermatol Online J 2020 Jun 15;26(7) PMID: 32898403
Chen X, Zhou Y, Tan Y, Duan G, Li Z, Zou P, Xiao R, Zhan Y
Photodiagnosis Photodyn Ther 2020 Sep;31:101847. Epub 2020 May 30 doi: 10.1016/j.pdpdt.2020.101847. PMID: 32479901
Baseskioğlu B, Yenilmez A, Acıkalın M, Can C, Dönmez T
Urol Int 2012;88(1):115-7. Epub 2011 Sep 28 doi: 10.1159/000330906. PMID: 21968520
Mehta RK, Rytina E, Sterling JC
Br J Dermatol 2000 Jun;142(6):1195-8. doi: 10.1046/j.1365-2133.2000.03548.x. PMID: 10848746

Prognosis

Jenkins TM, Mills AM
Semin Diagn Pathol 2021 Jan;38(1):27-36. Epub 2020 Sep 6 doi: 10.1053/j.semdp.2020.09.006. PMID: 32948383
Tessier-Cloutier B, Kortekaas KE, Thompson E, Pors J, Chen J, Ho J, Prentice LM, McConechy MK, Chow C, Proctor L, McAlpine JN, Huntsman DG, Gilks CB, Bosse T, Hoang LN
Mod Pathol 2020 Aug;33(8):1595-1605. Epub 2020 Mar 20 doi: 10.1038/s41379-020-0524-1. PMID: 32203095
Wohlmuth C, Wohlmuth-Wieser I
J Dtsch Dermatol Ges 2019 Dec;17(12):1257-1276. Epub 2019 Dec 12 doi: 10.1111/ddg.13995. PMID: 31829526Free PMC Article
Watkins JC
Surg Pathol Clin 2019 Jun;12(2):249-261. Epub 2019 Apr 5 doi: 10.1016/j.path.2019.01.001. PMID: 31097103
Zhang W, Wang Y, Chen W, Du J, Xiang L, Ye S, Yang H
Am J Case Rep 2019 Apr 19;20:551-556. doi: 10.12659/AJCR.914367. PMID: 31002657Free PMC Article

Clinical prediction guides

Wanka G, Jueckstock J, Wild CM, Vattai A, Fürst S, Heidegger HH, Kuhn C, Schmoeckel E, Jeschke U, Dannecker C
J Cancer Res Clin Oncol 2023 Aug;149(9):6191-6201. Epub 2023 Jan 23 doi: 10.1007/s00432-023-04579-4. PMID: 36689059Free PMC Article
Dryden SM, Reshko LB, Gaskins JT, Silva SR
Cancer Rep (Hoboken) 2022 Oct;5(10):e21591. Epub 2022 Jan 24 doi: 10.1002/cnr2.1591. PMID: 35075817Free PMC Article
Ward RA, Udechukwu NS, Selim MA, Jaleel T
Dermatol Online J 2020 Jun 15;26(7) PMID: 32898403
Tessier-Cloutier B, Kortekaas KE, Thompson E, Pors J, Chen J, Ho J, Prentice LM, McConechy MK, Chow C, Proctor L, McAlpine JN, Huntsman DG, Gilks CB, Bosse T, Hoang LN
Mod Pathol 2020 Aug;33(8):1595-1605. Epub 2020 Mar 20 doi: 10.1038/s41379-020-0524-1. PMID: 32203095
Dvoretsky PM, Bonfiglio TA
Pathol Annu 1986;21 Pt 2:23-45. PMID: 3748617

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