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Sarcomatoid squamous cell skin carcinoma

MedGen UID:
87611
•Concept ID:
C0349656
•
Neoplastic Process
Synonyms: Epidermoid carcinoma - spindle cell; Epidermoid carcinoma, spindle cell; Epidermoid Spindle Cell Carcinoma; Pseudosarcoma of the skin; Sarcomatoid Squamous Cell Carcinoma; sarcomatoid squamous cell skin carcinoma; Spindle Cell (Sarcomatoid) Squamous Cell Carcinoma; spindle cell (sarcomatoid) squamous cell carcinoma; spindle cell (sarcomatoid) squamous cell skin carcinoma; spindle cell squamous carcinoma of skin; spindle cell squamous carcinoma of the skin; Spindle Cell Squamous Cell Carcinoma; Spindle cell squamous cell carcinoma; spindle cell squamous cell carcinoma; Squamous cell carcinoma - spindle cell; Squamous cell carcinoma, sarcomatoid; Squamous Cell Carcinoma, Sarcomatoid; Squamous cell carcinoma, spindle cell; Squamous Cell Carcinoma, Spindle Cell; Squamous Cell Carcinoma, Spindle Cell Variant; Squamous Cell Spindle Cell Carcinoma
SNOMED CT: Epidermoid carcinoma - spindle cell (10288008); Squamous cell carcinoma - spindle cell (10288008); Spindle cell squamous cell carcinoma (403900000); Pseudosarcoma of the skin (403900000); Squamous cell carcinoma, spindle cell (10288008); Epidermoid carcinoma, spindle cell (10288008); Squamous cell carcinoma, sarcomatoid (10288008)
 
Monarch Initiative: MONDO:0003499

Definition

A poorly differentiated squamous cell carcinoma characterized by the presence of malignant cells with spindle cell features. [from NCI]

Professional guidelines

PubMed

CD10, p63 and CD99 expression in the differential diagnosis of atypical fibroxanthoma, spindle cell squamous cell carcinoma and desmoplastic melanoma.
Kanner WA, Brill LB 2nd, Patterson JW, Wick MR
J Cutan Pathol 2010 Jul;37(7):744-50. Epub 2010 Feb 24 doi: 10.1111/j.1600-0560.2010.01534.x. PMID: 20184665

Recent clinical studies

Etiology

Expression of SATB2 in primary cutaneous sarcomatoid neoplasms: a potential diagnostic pitfall.
Szczepanski JM, Siddiqui J, Patel RM, Harms PW, Hrycaj SM, Chan MP
Pathology 2023 Apr;55(3):350-354. Epub 2023 Jan 10 doi: 10.1016/j.pathol.2022.10.011. PMID: 36732203
The predictive role of neutrophil-to-lymphocyte ratio in the outcomes of patients with sarcomatoid carcinoma of oral cavity.
Patil R, Pandit P, Palwe V, Patil R, Gandhe S, Kate S, Yasam VR, Nagarkar R
Eur Arch Otorhinolaryngol 2022 Jan;279(1):433-441. Epub 2021 Apr 13 doi: 10.1007/s00405-021-06800-x. PMID: 33847789
Sarcoma-like tumor of head and neck skin.
Nonaka D, Bishop PW
Am J Surg Pathol 2014 Jul;38(7):956-65. doi: 10.1097/PAS.0000000000000210. PMID: 24705313
Concurrent basal cell and squamous cell carcinomas associated with hydroxyurea therapy.
Radić J, Batinac T, Hadžisejdić I, Načinović-Duletić A, Valković T, Jonjić N
Acta Dermatovenerol Croat 2011;19(3):183-6. PMID: 21933645
Spindle-cell and pleomorphic neoplasms of the skin. A clinicopathologic and immunohistochemical study of 30 cases, with emphasis on "atypical fibroxanthomas".
Silvis NG, Swanson PE, Manivel JC, Kaye VN, Wick MR
Am J Dermatopathol 1988 Feb;10(1):9-19. doi: 10.1097/00000372-198802000-00002. PMID: 3177827

Diagnosis

Expression of SATB2 in primary cutaneous sarcomatoid neoplasms: a potential diagnostic pitfall.
Szczepanski JM, Siddiqui J, Patel RM, Harms PW, Hrycaj SM, Chan MP
Pathology 2023 Apr;55(3):350-354. Epub 2023 Jan 10 doi: 10.1016/j.pathol.2022.10.011. PMID: 36732203
PRAME expression in spindle cell melanoma, malignant peripheral nerve sheath tumour, and other cutaneous sarcomatoid neoplasms: a comparative analysis.
Hrycaj SM, Szczepanski JM, Zhao L, Siddiqui J, Thomas DG, Lucas DR, Patel RM, Harms PW, Bresler SC, Chan MP
Histopathology 2022 Dec;81(6):818-825. Epub 2022 Sep 28 doi: 10.1111/his.14797. PMID: 36102613Free PMC Article
Metastatic sarcomatoid renal cell carcinoma manifesting as a subcutaneous soft tissue mass.
Logunova V, Sokumbi O, Iczkowski KA
J Cutan Pathol 2017 Oct;44(10):874-877. Epub 2017 Jul 24 doi: 10.1111/cup.12998. PMID: 28675457
CARCINOSARCOMA OF SKIN (SARCOMATOID CARCINOMA) - A RARE NON-MELANOMA SKIN CANCER (CASE REVIEW).
Wollina U, Koch A, Schönlebe J, Tchernev G
Georgian Med News 2017 Feb;(263):7-10. PMID: 28452720
High-grade trichoblastic carcinosarcoma.
Kazakov DV, Vittay G, Michal M, Calonje E
Am J Dermatopathol 2008 Feb;30(1):62-4. doi: 10.1097/DAD.0b013e31815c6c7f. PMID: 18212548

Therapy

Tertiary lymphoid structures with overlapping histopathologic features of cutaneous marginal zone lymphoma during neoadjuvant cemiplimab therapy are associated with antitumor response.
Sweeney KJ, Tetzlaff MT, Vega F, Gillenwater A, Zuo Z, Gross N, Nagarajan P, Wargo J, Nelson K, Prieto VG, Torres-Cabala CA, Curry JL
J Cutan Pathol 2021 May;48(5):674-679. Epub 2021 Jan 13 doi: 10.1111/cup.13953. PMID: 33399228
A genomic survey of sarcomas on sun-exposed skin reveals distinctive candidate drivers and potentially targetable mutations.
Miller TI, Zoumberos NA, Johnson B, Rhodes DR, Tomlins SA, Chan MP, Andea AA, Lucas DR, McHugh JB, Smith N, Harms KL, Brewer C, Saleh J, Patel RM, Harms PW
Hum Pathol 2020 Aug;102:60-69. Epub 2020 Jun 12 doi: 10.1016/j.humpath.2020.06.003. PMID: 32540221
Dramatic response to nivolumab in xeroderma pigmentosum skin tumor.
Chambon F, Osdoit S, Bagny K, Moro A, Nguyen J, Réguerre Y
Pediatr Blood Cancer 2018 Feb;65(2) Epub 2017 Oct 8 doi: 10.1002/pbc.26837. PMID: 28988442
Sarcomatoid carcinoma arising in the congenital pigmented nevus after treatment with carbon dioxide snow freezing method.
Nakajima R, Komine M, Miyamoto Y, Fusumae T, Fujita Y, Maekawa T, Murata S, Fukushima N, Ohtsuki M
J Dermatol 2015 Nov;42(11):1083-6. Epub 2015 Jun 13 doi: 10.1111/1346-8138.12962. PMID: 26074124
Concurrent basal cell and squamous cell carcinomas associated with hydroxyurea therapy.
Radić J, Batinac T, Hadžisejdić I, Načinović-Duletić A, Valković T, Jonjić N
Acta Dermatovenerol Croat 2011;19(3):183-6. PMID: 21933645

Prognosis

The predictive role of neutrophil-to-lymphocyte ratio in the outcomes of patients with sarcomatoid carcinoma of oral cavity.
Patil R, Pandit P, Palwe V, Patil R, Gandhe S, Kate S, Yasam VR, Nagarkar R
Eur Arch Otorhinolaryngol 2022 Jan;279(1):433-441. Epub 2021 Apr 13 doi: 10.1007/s00405-021-06800-x. PMID: 33847789
Sarcoma-like tumor of head and neck skin.
Nonaka D, Bishop PW
Am J Surg Pathol 2014 Jul;38(7):956-65. doi: 10.1097/PAS.0000000000000210. PMID: 24705313
Sarcomatoid squamous cell carcinoma of the penis: a clinical and pathological study of 5 cases.
Lont AP, Gallee MP, Snijders P, Horenblas S
J Urol 2004 Sep;172(3):932-5. doi: 10.1097/01.ju.0000136363.90911.e5. PMID: 15311001
Limitations in the interpretation of biopsies in patients with penile squamous cell carcinoma.
Velazquez EF, Barreto JE, Rodriguez I, Piris A, Cubilla AL
Int J Surg Pathol 2004 Apr;12(2):139-46. doi: 10.1177/106689690401200207. PMID: 15173919
Basal cell carcinoma with sarcomatoid features (sarcomatoid carcinoma): report of a case and review of the literature.
Gómez-Espejo C, Herrera-Sabal A, Ríos-Martín JJ, Camacho-Martínez F
J Dermatol 2003 Jul;30(7):543-9. doi: 10.1111/j.1346-8138.2003.tb00430.x. PMID: 12928545

Clinical prediction guides

Expression of SATB2 in primary cutaneous sarcomatoid neoplasms: a potential diagnostic pitfall.
Szczepanski JM, Siddiqui J, Patel RM, Harms PW, Hrycaj SM, Chan MP
Pathology 2023 Apr;55(3):350-354. Epub 2023 Jan 10 doi: 10.1016/j.pathol.2022.10.011. PMID: 36732203
PRAME expression in spindle cell melanoma, malignant peripheral nerve sheath tumour, and other cutaneous sarcomatoid neoplasms: a comparative analysis.
Hrycaj SM, Szczepanski JM, Zhao L, Siddiqui J, Thomas DG, Lucas DR, Patel RM, Harms PW, Bresler SC, Chan MP
Histopathology 2022 Dec;81(6):818-825. Epub 2022 Sep 28 doi: 10.1111/his.14797. PMID: 36102613Free PMC Article
Manifestation of osteoblastic phenotypes in the sarcomatous component of epithelial carcinoma and sarcomatoid carcinoma.
Takashima Y, Murakami T, Inoue T, Hagiyama M, Yoneshige A, Nishimura S, Akagi M, Ito A
Tumour Biol 2017 Jun;39(6):1010428317704365. doi: 10.1177/1010428317704365. PMID: 28651491
A cellular model reflecting the phenotypic heterogeneity of mutant HRAS driven squamous cell carcinoma.
Cantariño N, Fernández-Figueras MT, Valero V, Musulén E, Malinverni R, Granada I, Goldie SJ, Martín-Caballero J, Douet J, Forcales SV, Buschbeck M
Int J Cancer 2016 Sep 1;139(5):1106-16. Epub 2016 May 5 doi: 10.1002/ijc.30139. PMID: 27074337
Sarcoma-like tumor of head and neck skin.
Nonaka D, Bishop PW
Am J Surg Pathol 2014 Jul;38(7):956-65. doi: 10.1097/PAS.0000000000000210. PMID: 24705313

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