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Prostate Acinar Sarcomatoid Carcinoma

MedGen UID:
233357
•Concept ID:
C1335519
•
Neoplastic Process
Synonyms: Prostate Carcinosarcoma; Prostate Sarcomatoid Carcinoma; Sarcomatoid Carcinoma of Prostate; Sarcomatoid Carcinoma of the Prostate

Definition

A rare acinar adenocarcinoma of the prostate gland with unfavorable prognosis. It is composed of both malignant glandular and sarcomatous components. The sarcomatous component contains a malignant spindle cell proliferation or specific mesenchymal elements including osteosarcoma, chondrosarcoma, and leiomyosarcoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVProstate Acinar Sarcomatoid Carcinoma

Professional guidelines

PubMed

Current Understanding and Management of Intraductal Carcinoma of the Prostate.
Considine B, Adeniran A, Hurwitz ME
Curr Oncol Rep 2021 Jul 16;23(9):110. doi: 10.1007/s11912-021-01090-2. PMID: 34272624
Optimizing the diagnosis and management of ductal prostate cancer.
Ranasinghe W, Shapiro DD, Zhang M, Bathala T, Navone N, Thompson TC, Broom B, Aparicio A, Tu SM, Tang C, Davis JW, Pisters L, Chapin BF
Nat Rev Urol 2021 Jun;18(6):337-358. Epub 2021 Apr 6 doi: 10.1038/s41585-021-00447-3. PMID: 33824525
Pseudohyperplastic prostate carcinoma: histologic patterns and differential diagnosis.
Arista-Nasr J, Martínez-Benítez B, Aguilar-Ayala EL, Aleman-Sanchez CN, Bornstein-Quevedo L, Albores-Saavedra J
Ann Diagn Pathol 2015 Aug;19(4):253-60. Epub 2015 May 22 doi: 10.1016/j.anndiagpath.2015.04.009. PMID: 26101154

Recent clinical studies

Etiology

Genomic and Evolutionary Characterization of Concurrent Intraductal Carcinoma and Adenocarcinoma of the Prostate.
Zhao J, Xu N, Zhu S, Nie L, Zhang M, Zheng L, Cai D, Sun X, Chen J, Dai J, Ni Y, Wang Z, Zhang X, Liang J, Chen Y, Hu X, Pan X, Yin X, Liu H, Zhao F, Zhang B, Chen H, Miao J, Qin C, Zhao X, Yao J, Liu Z, Liao B, Wei Q, Li X, Liu J, Gao AC, Huang H, Shen P, Chen N, Zeng H, Sun G
Cancer Res 2024 Jan 2;84(1):154-167. doi: 10.1158/0008-5472.CAN-23-1176. PMID: 37847513
Updates on Grading and Staging of Prostate Cancer.
Braunhut BL, Punnen S, Kryvenko ON
Surg Pathol Clin 2018 Dec;11(4):759-774. doi: 10.1016/j.path.2018.07.003. PMID: 30447840
Spectrum of Cribriform Proliferations of the Prostate: From Benign to Malignant.
Lee TK, Ro JY
Arch Pathol Lab Med 2018 Aug;142(8):938-946. doi: 10.5858/arpa.2018-0005-RA. PMID: 30040459
The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part B: Prostate and Bladder Tumours.
Humphrey PA, Moch H, Cubilla AL, Ulbright TM, Reuter VE
Eur Urol 2016 Jul;70(1):106-119. Epub 2016 Mar 17 doi: 10.1016/j.eururo.2016.02.028. PMID: 26996659
Histologic classification of prostate cancer.
Mikuz G
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):39-47. PMID: 26072633

Diagnosis

Genomic Profiling Reveals Germline Predisposition and Homologous Recombination Deficiency in Pancreatic Acinar Cell Carcinoma.
Mandelker D, Marra A, Zheng-Lin B, Selenica P, Blanco-Heredia J, Zhu Y, Gazzo A, Wong D, Yelskaya Z, Rai V, Somar J, Ostafi S, Mehta N, Yang C, Li Y, Brown DN, da Silva EM, Pei X, Linkov I, Terraf P, Misyura M, Ceyhan-Birsoy O, Ladanyi M, Berger M, Pareja F, Stadler Z, Offit K, Riaz N, Park W, Chou J, Capanu M, Koehler M, Rosen E, O'Reilly EM, Reis-Filho JS
J Clin Oncol 2023 Nov 20;41(33):5151-5162. Epub 2023 Aug 22 doi: 10.1200/JCO.23.00561. PMID: 37607324Free PMC Article
Prostate Pathology: What is New in the 2022 WHO Classification of Urinary and Male Genital Tumors?
Surintrspanont J, Zhou M
Pathologica 2022 Feb;115(1):41-56. Epub 2023 Jan 16 doi: 10.32074/1591-951X-822. PMID: 36645399Free PMC Article
WHO Classification of Tumours fifth edition: evolving issues in the classification, diagnosis, and prognostication of prostate cancer.
Kench JG, Amin MB, Berney DM, Compérat EM, Cree IA, Gill AJ, Hartmann A, Menon S, Moch H, Netto GJ, Raspollini MR, Rubin MA, Tan PH, Tsuzuki T, Turjalic S, van der Kwast TH, Zhou M, Srigley JR
Histopathology 2022 Oct;81(4):447-458. Epub 2022 Aug 2 doi: 10.1111/his.14711. PMID: 35758185Free PMC Article
False-Negative Histopathologic Diagnosis of Prostatic Adenocarcinoma.
Yang C, Humphrey PA
Arch Pathol Lab Med 2020 Mar;144(3):326-334. Epub 2019 Nov 15 doi: 10.5858/arpa.2019-0456-RA. PMID: 31729886
Prostate Ductal Adenocarcinoma.
Amin A
Appl Immunohistochem Mol Morphol 2018 Aug;26(7):514-521. doi: 10.1097/PAI.0000000000000508. PMID: 28362706

Therapy

Feasibility study of ADCs targeting TROP-2, HER2, and CD46 in Ductal Adenocarcinoma and Intraductal Carcinoma of the prostate.
Wang X, Qi L, Chen M, Zhang Y, Gao X, Cai Y
World J Urol 2024 Jul 11;42(1):404. doi: 10.1007/s00345-024-05109-8. PMID: 38990246
Emerging Insights in Small-Cell Carcinoma of the Genitourinary Tract: From Diagnosis to Novel Therapeutic Horizons.
Liao RS, Ruan HT, Jang A, Huynh M, Nadal Rios R, Hoffman-Censits JH, Wei S, Mian OY, Barata PC
Am Soc Clin Oncol Educ Book 2024 Jan;44:e430336. doi: 10.1200/EDBK_430336. PMID: 38176691
Regional Histopathology and Prostate MRI Positivity: A Secondary Analysis of the PROMIS Trial.
Stavrinides V, Norris JM, Karapanagiotis S, Giganti F, Grey A, Trahearn N, Freeman A, Haider A, Carmona Echeverría LM, Bott SRJ, Brown LC, Burns-Cox N, Dudderidge TJ, El-Shater Bosaily A, Ghei M, Henderson A, Hindley RG, Kaplan RS, Oldroyd R, Parker C, Persad R, Rosario DJ, Shergill IS, Winkler M, Kirkham A, Punwani S, Whitaker HC, Ahmed HU, Emberton M; PROMIS Group
Radiology 2023 Apr;307(1):e220762. Epub 2022 Dec 13 doi: 10.1148/radiol.220762. PMID: 36511804Free PMC Article
Premalignancy in Prostate Cancer: Rethinking What we Know.
De Marzo AM, Haffner MC, Lotan TL, Yegnasubramanian S, Nelson WG
Cancer Prev Res (Phila) 2016 Aug;9(8):648-56. Epub 2016 Jan 26 doi: 10.1158/1940-6207.CAPR-15-0431. PMID: 26813971
Androgen-deprivation therapy-induced aggressive prostate cancer with neuroendocrine differentiation.
Lipianskaya J, Cohen A, Chen CJ, Hsia E, Squires J, Li Z, Zhang Y, Li W, Chen X, Xu H, Huang J
Asian J Androl 2014 Jul-Aug;16(4):541-4. doi: 10.4103/1008-682X.123669. PMID: 24589459Free PMC Article

Prognosis

Genomic and Evolutionary Characterization of Concurrent Intraductal Carcinoma and Adenocarcinoma of the Prostate.
Zhao J, Xu N, Zhu S, Nie L, Zhang M, Zheng L, Cai D, Sun X, Chen J, Dai J, Ni Y, Wang Z, Zhang X, Liang J, Chen Y, Hu X, Pan X, Yin X, Liu H, Zhao F, Zhang B, Chen H, Miao J, Qin C, Zhao X, Yao J, Liu Z, Liao B, Wei Q, Li X, Liu J, Gao AC, Huang H, Shen P, Chen N, Zeng H, Sun G
Cancer Res 2024 Jan 2;84(1):154-167. doi: 10.1158/0008-5472.CAN-23-1176. PMID: 37847513
Prostate Pathology: What is New in the 2022 WHO Classification of Urinary and Male Genital Tumors?
Surintrspanont J, Zhou M
Pathologica 2022 Feb;115(1):41-56. Epub 2023 Jan 16 doi: 10.32074/1591-951X-822. PMID: 36645399Free PMC Article
WHO Classification of Tumours fifth edition: evolving issues in the classification, diagnosis, and prognostication of prostate cancer.
Kench JG, Amin MB, Berney DM, Compérat EM, Cree IA, Gill AJ, Hartmann A, Menon S, Moch H, Netto GJ, Raspollini MR, Rubin MA, Tan PH, Tsuzuki T, Turjalic S, van der Kwast TH, Zhou M, Srigley JR
Histopathology 2022 Oct;81(4):447-458. Epub 2022 Aug 2 doi: 10.1111/his.14711. PMID: 35758185Free PMC Article
Prostate Ductal Adenocarcinoma.
Amin A
Appl Immunohistochem Mol Morphol 2018 Aug;26(7):514-521. doi: 10.1097/PAI.0000000000000508. PMID: 28362706
Histologic classification of prostate cancer.
Mikuz G
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):39-47. PMID: 26072633

Clinical prediction guides

The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part B: Prostate and Bladder Tumours.
Humphrey PA, Moch H, Cubilla AL, Ulbright TM, Reuter VE
Eur Urol 2016 Jul;70(1):106-119. Epub 2016 Mar 17 doi: 10.1016/j.eururo.2016.02.028. PMID: 26996659
Pseudohyperplastic prostate carcinoma: histologic patterns and differential diagnosis.
Arista-Nasr J, Martínez-Benítez B, Aguilar-Ayala EL, Aleman-Sanchez CN, Bornstein-Quevedo L, Albores-Saavedra J
Ann Diagn Pathol 2015 Aug;19(4):253-60. Epub 2015 May 22 doi: 10.1016/j.anndiagpath.2015.04.009. PMID: 26101154
Histologic classification of prostate cancer.
Mikuz G
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):39-47. PMID: 26072633
Models of neuroendocrine prostate cancer.
Berman-Booty LD, Knudsen KE
Endocr Relat Cancer 2015 Feb;22(1):R33-49. Epub 2014 Oct 27 doi: 10.1530/ERC-14-0393. PMID: 25349195Free PMC Article
Precursors of prostate cancer.
Bostwick DG, Cheng L
Histopathology 2012 Jan;60(1):4-27. doi: 10.1111/j.1365-2559.2011.04007.x. PMID: 22212075

Recent systematic reviews

What Do We Have to Know about PD-L1 Expression in Prostate Cancer? A Systematic Literature Review. Part 1: Focus on Immunohistochemical Results with Discussion of Pre-Analytical and Interpretation Variables.
Palicelli A, Bonacini M, Croci S, Magi-Galluzzi C, Cañete-Portillo S, Chaux A, Bisagni A, Zanetti E, De Biase D, Melli B, Sanguedolce F, Ragazzi M, Bonasoni MP, Soriano A, Ascani S, Zizzo M, Castro Ruiz C, De Leo A, Giordano G, Landriscina M, Carrieri G, Cormio L, Berney DM, Athanazio D, Gandhi J, Cavazza A, Santandrea G, Tafuni A, Zanelli M
Cells 2021 Nov 14;10(11) doi: 10.3390/cells10113166. PMID: 34831389Free PMC Article
The Association of Invasive Cribriform Lesions With Adverse Prostatic Adenocarcinoma Outcomes: An Institutional Experience, Systematic Review, and Meta-analysis.
Luo X, Khurana JS, Jhala N, Zhao H, Wang H
Arch Pathol Lab Med 2019 Aug;143(8):1012-1021. Epub 2019 Feb 1 doi: 10.5858/arpa.2017-0582-RA. PMID: 30702333
Diagnostic Difficulties With Atrophy, Atypical Adenomatous Hyperplasia, and Atypical Small Acinar Proliferation: A Systematic Review of Current Literature.
Kowalewski A, Szylberg Ł, Skórczewska A, Marszałek A
Clin Genitourin Cancer 2016 Oct;14(5):361-365. Epub 2016 Feb 23 doi: 10.1016/j.clgc.2016.02.003. PMID: 26992486
Prostate saturation biopsy following a first negative biopsy: state of the art.
Maccagnano C, Gallina A, Roscigno M, Raber M, Capitanio U, Saccà A, Pellucchi F, Suardi N, Abdollah F, Montorsi F, Rigatti P, Scattoni V
Urol Int 2012;89(2):126-35. Epub 2012 Jul 19 doi: 10.1159/000339521. PMID: 22814003

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