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Large cell carcinoma

MedGen UID:
61665
Concept ID:
C0206704
Neoplastic Process
Synonyms: Carcinoma, Large Cell; Carcinomas, Large Cell; Cell Carcinoma, Large; Cell Carcinomas, Large; Large Cell Carcinoma; Large Cell Carcinomas
SNOMED CT: Large cell carcinoma (22687000)
 
Monarch Initiative: MONDO:0005232

Definition

A malignant epithelial neoplasm composed of large, atypical cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLarge cell carcinoma

Professional guidelines

PubMed

Brinkmeyer JK, Moore DC
J Oncol Pharm Pract 2018 Jan;24(1):37-41. Epub 2016 Dec 2 doi: 10.1177/1078155216682365. PMID: 27913776
Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA
Mayo Clin Proc 2008 May;83(5):584-94. doi: 10.4065/83.5.584. PMID: 18452692Free PMC Article
Collins LG, Haines C, Perkel R, Enck RE
Am Fam Physician 2007 Jan 1;75(1):56-63. PMID: 17225705

Recent clinical studies

Etiology

Zhang Y, Vaccarella S, Morgan E, Li M, Etxeberria J, Chokunonga E, Manraj SS, Kamate B, Omonisi A, Bray F
Lancet Oncol 2023 Nov;24(11):1206-1218. Epub 2023 Oct 11 doi: 10.1016/S1470-2045(23)00444-8. PMID: 37837979
Latimer KM
FP Essent 2018 Jan;464:23-26. PMID: 29313654
Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, Chirieac LR, Dacic S, Duhig E, Flieder DB, Geisinger K, Hirsch FR, Ishikawa Y, Kerr KM, Noguchi M, Pelosi G, Powell CA, Tsao MS, Wistuba I; WHO Panel
J Thorac Oncol 2015 Sep;10(9):1243-1260. doi: 10.1097/JTO.0000000000000630. PMID: 26291008
Sorbye H, Strosberg J, Baudin E, Klimstra DS, Yao JC
Cancer 2014 Sep 15;120(18):2814-23. Epub 2014 Apr 25 doi: 10.1002/cncr.28721. PMID: 24771552
Collins LG, Haines C, Perkel R, Enck RE
Am Fam Physician 2007 Jan 1;75(1):56-63. PMID: 17225705

Diagnosis

Raiker R, Chauhan A, Hasanein H, Burkeen G, Horn M, Veedu J, Vela C, Arnold S, Kolesar J, Anthony L, Evers BM, Cavnar M
Orphanet J Rare Dis 2019 Nov 21;14(1):266. doi: 10.1186/s13023-019-1230-2. PMID: 31752927Free PMC Article
Skřičková J, Kadlec B, Venclíček O, Merta Z
Cas Lek Cesk 2018 Fall;157(5):226-236. PMID: 30441934
Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, Chirieac LR, Dacic S, Duhig E, Flieder DB, Geisinger K, Hirsch FR, Ishikawa Y, Kerr KM, Noguchi M, Pelosi G, Powell CA, Tsao MS, Wistuba I; WHO Panel
J Thorac Oncol 2015 Sep;10(9):1243-1260. doi: 10.1097/JTO.0000000000000630. PMID: 26291008
Gollard R, Jhatakia S, Elliott M, Kosty M
Lung Cancer 2010 Jul;69(1):13-8. Epub 2010 Feb 4 doi: 10.1016/j.lungcan.2009.12.011. PMID: 20133008
Collins LG, Haines C, Perkel R, Enck RE
Am Fam Physician 2007 Jan 1;75(1):56-63. PMID: 17225705

Therapy

Li M, Yang L, Lu H
Pathol Oncol Res 2022;28:1610747. Epub 2022 Nov 23 doi: 10.3389/pore.2022.1610747. PMID: 36507119Free PMC Article
National Lung Screening Trial Research Team
J Thorac Oncol 2019 Oct;14(10):1732-1742. Epub 2019 Jun 28 doi: 10.1016/j.jtho.2019.05.044. PMID: 31260833Free PMC Article
Skřičková J, Kadlec B, Venclíček O, Merta Z
Cas Lek Cesk 2018 Fall;157(5):226-236. PMID: 30441934
Gollard R, Jhatakia S, Elliott M, Kosty M
Lung Cancer 2010 Jul;69(1):13-8. Epub 2010 Feb 4 doi: 10.1016/j.lungcan.2009.12.011. PMID: 20133008
Scagliotti GV, Parikh P, von Pawel J, Biesma B, Vansteenkiste J, Manegold C, Serwatowski P, Gatzemeier U, Digumarti R, Zukin M, Lee JS, Mellemgaard A, Park K, Patil S, Rolski J, Goksel T, de Marinis F, Simms L, Sugarman KP, Gandara D
J Clin Oncol 2008 Jul 20;26(21):3543-51. Epub 2008 May 27 doi: 10.1200/JCO.2007.15.0375. PMID: 18506025

Prognosis

Zhang Y, Vaccarella S, Morgan E, Li M, Etxeberria J, Chokunonga E, Manraj SS, Kamate B, Omonisi A, Bray F
Lancet Oncol 2023 Nov;24(11):1206-1218. Epub 2023 Oct 11 doi: 10.1016/S1470-2045(23)00444-8. PMID: 37837979
di Mauro P, Ferrari V
N Engl J Med 2020 Dec 17;383(25):e137. doi: 10.1056/NEJMicm2018535. PMID: 33326718
National Lung Screening Trial Research Team
J Thorac Oncol 2019 Oct;14(10):1732-1742. Epub 2019 Jun 28 doi: 10.1016/j.jtho.2019.05.044. PMID: 31260833Free PMC Article
Rudin CM, Pietanza MC, Bauer TM, Ready N, Morgensztern D, Glisson BS, Byers LA, Johnson ML, Burris HA 3rd, Robert F, Han TH, Bheddah S, Theiss N, Watson S, Mathur D, Vennapusa B, Zayed H, Lally S, Strickland DK, Govindan R, Dylla SJ, Peng SL, Spigel DR; SCRX16-001 investigators
Lancet Oncol 2017 Jan;18(1):42-51. Epub 2016 Dec 5 doi: 10.1016/S1470-2045(16)30565-4. PMID: 27932068Free PMC Article
Bradley JD, Paulus R, Komaki R, Masters G, Blumenschein G, Schild S, Bogart J, Hu C, Forster K, Magliocco A, Kavadi V, Garces YI, Narayan S, Iyengar P, Robinson C, Wynn RB, Koprowski C, Meng J, Beitler J, Gaur R, Curran W Jr, Choy H
Lancet Oncol 2015 Feb;16(2):187-99. Epub 2015 Jan 16 doi: 10.1016/S1470-2045(14)71207-0. PMID: 25601342Free PMC Article

Clinical prediction guides

Williams JF, Vivero M
Histopathology 2022 Nov;81(5):556-568. Epub 2022 Aug 2 doi: 10.1111/his.14714. PMID: 35758205
Latimer KM
FP Essent 2018 Jan;464:23-26. PMID: 29313654
Sholl LM
Curr Opin Pulm Med 2014 Jul;20(4):324-31. doi: 10.1097/MCP.0000000000000068. PMID: 24811836
Sorbye H, Strosberg J, Baudin E, Klimstra DS, Yao JC
Cancer 2014 Sep 15;120(18):2814-23. Epub 2014 Apr 25 doi: 10.1002/cncr.28721. PMID: 24771552
Hage R, Seldenrijk K, de Bruin P, van Swieten H, van den Bosch J
Eur J Cardiothorac Surg 2003 Apr;23(4):457-60. doi: 10.1016/s1010-7940(02)00837-0. PMID: 12694759

Recent systematic reviews

Jelli B, Brandão M, Mekinda Z, Durieux V, Berghmans T
Lung Cancer 2023 Jul;181:107232. Epub 2023 May 10 doi: 10.1016/j.lungcan.2023.107232. PMID: 37216840
Prodromidou A, Phelps DL, Pergialiotis V, Cunnea P, Thomakos N, Rodolakis A, Fotopoulou C, Haidopoulos D
Eur J Obstet Gynecol Reprod Biol 2022 Mar;270:212-220. Epub 2022 Jan 17 doi: 10.1016/j.ejogrb.2022.01.014. PMID: 35093830
Schuch LF, Schmidt TR, de Oliveira Zigmundo G, Kirschnick LB, Silveira FM, Martins MAT, Carlos R, Dos Santos JN, Fonseca FP, Vargas PA, Wagner VP, Martins MD
Head Neck Pathol 2022 Jun;16(2):525-537. Epub 2021 Dec 6 doi: 10.1007/s12105-021-01398-2. PMID: 34870796Free PMC Article
Strojan P, Hernandez-Prera JC, Beitler JJ, Eisbruch A, Saba NF, Mendenhall WM, Nieto CS, Smee R, Rinaldo A, Ferlito A
Cancer Treat Rev 2019 Aug;78:42-51. Epub 2019 Aug 8 doi: 10.1016/j.ctrv.2019.08.002. PMID: 31437725
Tu X, Chang T, Nie L, Qiu S, Xu H, Huang Y, Bao Y, Liu Z, Yang L, Wei Q
Urol Int 2019;103(4):383-390. Epub 2019 Apr 9 doi: 10.1159/000499883. PMID: 30965328

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