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Clear cell sarcoma

MedGen UID:
104909
Concept ID:
C0206651
Neoplastic Process
Synonyms: Clear Cell Sarcoma; Clear Cell Sarcoma of Soft Tissue; Clear Cell Sarcomas; Malignant Melanoma of Soft Parts; Melanoma of Soft Parts; Melanoma, Malignant, of Soft Parts; Sarcoma, Clear Cell; Sarcomas, Clear Cell
SNOMED CT: Malignant melanoma of soft tissues (402561003); Clear cell sarcoma (402561003); Malignant melanoma of soft tissue (271944004); Clear cell sarcoma (271944004)
 
Monarch Initiative: MONDO:0002926

Definition

A rare malignant neoplasm with melanocytic differentiation characterized by the presence of polygonal or spindle shaped clear cells. This sarcoma usually affects the tendons and aponeuroses and is associated with a poor prognosis due to recurrences and metastases. [from NCI]

Professional guidelines

PubMed

Ikuta K, Nishida Y, Imagama S, Tanaka K, Ozaki T
Jpn J Clin Oncol 2023 Oct 4;53(10):899-904. doi: 10.1093/jjco/hyad083. PMID: 37451697
Datta NK, Das KP, Aish PK, Datta M, Banik SK, Sen SK, Chowdhury RM
Mymensingh Med J 2023 Jan;32(1):135-143. PMID: 36594313
Wu HY, Snyder HM 3rd, D'Angio GJ
Curr Opin Urol 2005 Jul;15(4):273-6. doi: 10.1097/01.mou.0000172403.69890.eb. PMID: 15928519

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

Recent clinical studies

Etiology

Cassalia F, Danese A, Tudurachi I, Federico S, Zambello A, Guidotti A, Franceschin L, Bolzon A, Naldi L, Belloni Fortina A
Int J Mol Sci 2024 Jan 27;25(3) doi: 10.3390/ijms25031582. PMID: 38338862Free PMC Article
Kunisada T, Nakata E, Fujiwara T, Hosono A, Takihira S, Kondo H, Ozaki T
Int J Clin Oncol 2023 Jan;28(1):1-11. Epub 2022 Jan 27 doi: 10.1007/s10147-022-02119-7. PMID: 35084598
Hanna J, Ko JS, Billings SD, Boivin F, Beaudoux O, Pissaloux D, Tirode F, Laga A, Fletcher CDM, de la Fouchardiere A
Am J Surg Pathol 2022 Nov 1;46(11):1457-1466. Epub 2022 Aug 23 doi: 10.1097/PAS.0000000000001952. PMID: 35993578
Aldera AP, Pillay K
Arch Pathol Lab Med 2020 Jan;144(1):119-123. Epub 2019 Mar 27 doi: 10.5858/arpa.2018-0353-RS. PMID: 30917048
Astolfi A, Fiore M, Melchionda F, Indio V, Bertuccio SN, Pession A
Epigenomics 2019 May;11(7):835-855. Epub 2019 May 31 doi: 10.2217/epi-2018-0195. PMID: 31150281Free PMC Article

Diagnosis

Ikuta K, Nishida Y, Imagama S, Tanaka K, Ozaki T
Jpn J Clin Oncol 2023 Oct 4;53(10):899-904. doi: 10.1093/jjco/hyad083. PMID: 37451697
Sze SK
Clin Perinatol 2021 Mar;48(1):71-81. Epub 2021 Jan 11 doi: 10.1016/j.clp.2020.11.004. PMID: 33583508
Aldera AP, Pillay K
Arch Pathol Lab Med 2020 Jan;144(1):119-123. Epub 2019 Mar 27 doi: 10.5858/arpa.2018-0353-RS. PMID: 30917048
Aw SJ, Chang KTE
Arch Pathol Lab Med 2019 Aug;143(8):1022-1026. Epub 2019 Jan 10 doi: 10.5858/arpa.2018-0045-RS. PMID: 30628851
Ray-Coquard I, Serre D, Reichardt P, Martín-Broto J, Bauer S
Future Oncol 2018 May;14(10s):25-49. doi: 10.2217/fon-2018-0076. PMID: 29768052

Therapy

Benedetti DJ, Renfro LA, Tfirn I, Daw NC, Kalapurakal JA, Ehrlich PF, Khanna G, Perlman E, Warwick A, Gow KW, Paulino AC, Seibel NL, Grundy P, Fernandez CV, Geller JI, Mullen EA, Dome JS
Cancer 2024 Jul 1;130(13):2361-2371. Epub 2024 Feb 23 doi: 10.1002/cncr.35266. PMID: 38396300Free PMC Article
Ray-Coquard I, Serre D, Reichardt P, Martín-Broto J, Bauer S
Future Oncol 2018 May;14(10s):25-49. doi: 10.2217/fon-2018-0076. PMID: 29768052
Cornillie J, van Cann T, Wozniak A, Hompes D, Schöffski P
Expert Rev Anticancer Ther 2016 Aug;16(8):839-45. Epub 2016 Jun 20 doi: 10.1080/14737140.2016.1197122. PMID: 27253849
Hyman DM, Puzanov I, Subbiah V, Faris JE, Chau I, Blay JY, Wolf J, Raje NS, Diamond EL, Hollebecque A, Gervais R, Elez-Fernandez ME, Italiano A, Hofheinz RD, Hidalgo M, Chan E, Schuler M, Lasserre SF, Makrutzki M, Sirzen F, Veronese ML, Tabernero J, Baselga J
N Engl J Med 2015 Aug 20;373(8):726-36. doi: 10.1056/NEJMoa1502309. PMID: 26287849Free PMC Article
Wu HY, Snyder HM 3rd, D'Angio GJ
Curr Opin Urol 2005 Jul;15(4):273-6. doi: 10.1097/01.mou.0000172403.69890.eb. PMID: 15928519

Prognosis

Cassalia F, Danese A, Tudurachi I, Federico S, Zambello A, Guidotti A, Franceschin L, Bolzon A, Naldi L, Belloni Fortina A
Int J Mol Sci 2024 Jan 27;25(3) doi: 10.3390/ijms25031582. PMID: 38338862Free PMC Article
Wetterwald L, Riggi N, Kyriazoglou A, Dei Tos G, Dei Tos A, Digklia A
Expert Rev Anticancer Ther 2023 Mar;23(3):235-242. Epub 2023 Feb 27 doi: 10.1080/14737140.2023.2183846. PMID: 36811446
Kunisada T, Nakata E, Fujiwara T, Hosono A, Takihira S, Kondo H, Ozaki T
Int J Clin Oncol 2023 Jan;28(1):1-11. Epub 2022 Jan 27 doi: 10.1007/s10147-022-02119-7. PMID: 35084598
Hanna J, Ko JS, Billings SD, Boivin F, Beaudoux O, Pissaloux D, Tirode F, Laga A, Fletcher CDM, de la Fouchardiere A
Am J Surg Pathol 2022 Nov 1;46(11):1457-1466. Epub 2022 Aug 23 doi: 10.1097/PAS.0000000000001952. PMID: 35993578
Ray-Coquard I, Serre D, Reichardt P, Martín-Broto J, Bauer S
Future Oncol 2018 May;14(10s):25-49. doi: 10.2217/fon-2018-0076. PMID: 29768052

Clinical prediction guides

Rotaru V, Chitoran E, Mitroiu MN, Ionescu SO, Neicu A, Cirimbei C, Alecu M, Gelal A, Prie AD, Simion L
Medicina (Kaunas) 2024 May 22;60(6) doi: 10.3390/medicina60060847. PMID: 38929464Free PMC Article
A E, Prakash A, Ashta A, Garg A, Verma A, Padaliya P
Acta Radiol 2023 Dec;64(12):3056-3073. Epub 2023 Sep 27 doi: 10.1177/02841851231202688. PMID: 37753549
Ulici V, Hornick JL, Davis JL, Mehrotra S, Meis JM, Halling KC, Fletcher CDM, Kao E, Folpe AL
Mod Pathol 2023 Jul;36(7):100160. Epub 2023 Mar 17 doi: 10.1016/j.modpat.2023.100160. PMID: 36934861
Panza E, Ozenberger BB, Straessler KM, Barrott JJ, Li L, Wang Y, Xie M, Boulet A, Titen SW, Mason CC, Lazar AJ, Ding L, Capecchi MR, Jones KB
J Clin Invest 2021 Aug 2;131(15) doi: 10.1172/JCI146301. PMID: 34156976Free PMC Article
Hyman DM, Puzanov I, Subbiah V, Faris JE, Chau I, Blay JY, Wolf J, Raje NS, Diamond EL, Hollebecque A, Gervais R, Elez-Fernandez ME, Italiano A, Hofheinz RD, Hidalgo M, Chan E, Schuler M, Lasserre SF, Makrutzki M, Sirzen F, Veronese ML, Tabernero J, Baselga J
N Engl J Med 2015 Aug 20;373(8):726-36. doi: 10.1056/NEJMoa1502309. PMID: 26287849Free PMC Article

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Soft Tissue Sarcoma, 2024

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