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Adenosquamous lung carcinoma

MedGen UID:
79006
•Concept ID:
C0279557
•
Neoplastic Process
Synonyms: Adenosquamous carcinoma of lung; Adenosquamous Cell Lung Carcinoma; adenosquamous cell lung carcinoma; adenosquamous lung cancer; Adenosquamous Lung Carcinoma; adenosquamous lung carcinoma; Lung Adenosquamous Carcinoma; lung adenosquamous carcinoma
SNOMED CT: Adenosquamous carcinoma of lung (1260042002)
 
Monarch Initiative: MONDO:0004973

Definition

An aggressive carcinoma with a poor prognosis characterized by a presence of both malignant squamous cells and glandular cells. [from NCI]

Professional guidelines

PubMed

Ensartinib in the treatment of anaplastic lymphoma kinase-positive locally advanced or metastatic patients with lung squamous or adenosquamous carcinoma: A real-world, retrospective study.
Ding L, Yuan X, Wang Y, Yang M, Wu P, Chen H, Yun Y, Shen Z, Ji D, Ma Y
Asia Pac J Clin Oncol 2024 Dec;20(6):700-706. Epub 2024 Jun 19 doi: 10.1111/ajco.14091. PMID: 38898784
Adenosquamous lung carcinoma: clinical characteristics, treatment, and prognosis.
Naunheim KS, Taylor JR, Skosey C, Hoffman PC, Ferguson MK, Golomb HM, Little AG
Ann Thorac Surg 1987 Nov;44(5):462-6. doi: 10.1016/s0003-4975(10)62102-9. PMID: 3675050

Recent clinical studies

Etiology

Adenocarcinomatous-predominant subtype associated with a better prognosis in adenosquamous lung carcinoma.
Liu Y, Zhu Y, Bai L, Chen F, Wang J, Guo Y
BMC Cancer 2020 Jun 5;20(1):520. doi: 10.1186/s12885-020-06972-5. PMID: 32503451Free PMC Article
Predictive and prognostic value of preoperative serum tumor markers in resectable adenosqamous lung carcinoma.
Zhi Q, Wang Y, Wang X, Yue D, Li K, Jiang R
Oncotarget 2016 Oct 4;7(40):64798-64809. doi: 10.18632/oncotarget.11703. PMID: 27623437Free PMC Article
Clinicopathological characteristics and prognosis of patients with adenosquamous lung carcinoma.
Guo Y, Jia L, Shao GG, Sun HW, Wang XX, Wang GJ, Ma KW
J Huazhong Univ Sci Technolog Med Sci 2015 Jun;35(3):350-355. Epub 2015 Jun 14 doi: 10.1007/s11596-015-1436-z. PMID: 26072072
EGFR gene mutations in patients with adenosquamous lung carcinoma.
Powrózek T, Krawczyk P, Ramlau R, Sura S, Wojas-Krawczyk K, Kucharczyk T, Walczyna B, Szumiło J, Szyszka-Barth K, Milecki P, Barinow-Wojewódzki A, Milanowski J
Asia Pac J Clin Oncol 2014 Dec;10(4):340-5. Epub 2014 Feb 27 doi: 10.1111/ajco.12177. PMID: 24575772
Adenosquamous lung carcinoma: clinical characteristics, surgical treament and prognosis.
Ben Y, Yu H, Wang Z, Miao Q, Ren H, Zhang Z, Li Z
Chin Med Sci J 2000 Dec;15(4):238-40. PMID: 12906147

Diagnosis

Adenosquamous carcinoma lung radiologically mimicking pneumonia: A potentially disastrous diagnostic challenge in an unusual malignancy.
Bakshi N, Nayar S, Kalra S, Duggal R
J Cancer Res Ther 2023 Apr-Jun;19(3):839-841. doi: 10.4103/jcrt.jcrt_2174_21. PMID: 37470624
Hypercalcemia-Leukocytosis syndrome and adenosquamous lung carcinoma: An overlooked conjugation.
Oliveira Pereira J, Gama J, Ferreira D, Santos A
Oncol Res 2021;29(2):81-85. Epub 2022 Jul 13 doi: 10.32604/or.2022.023450. PMID: 37305400Free PMC Article
Adenocarcinomatous-predominant subtype associated with a better prognosis in adenosquamous lung carcinoma.
Liu Y, Zhu Y, Bai L, Chen F, Wang J, Guo Y
BMC Cancer 2020 Jun 5;20(1):520. doi: 10.1186/s12885-020-06972-5. PMID: 32503451Free PMC Article
Predictive and prognostic value of preoperative serum tumor markers in resectable adenosqamous lung carcinoma.
Zhi Q, Wang Y, Wang X, Yue D, Li K, Jiang R
Oncotarget 2016 Oct 4;7(40):64798-64809. doi: 10.18632/oncotarget.11703. PMID: 27623437Free PMC Article
Clinicopathological characteristics and prognosis of patients with adenosquamous lung carcinoma.
Guo Y, Jia L, Shao GG, Sun HW, Wang XX, Wang GJ, Ma KW
J Huazhong Univ Sci Technolog Med Sci 2015 Jun;35(3):350-355. Epub 2015 Jun 14 doi: 10.1007/s11596-015-1436-z. PMID: 26072072

Therapy

Epithelial-to-mesenchymal transition (EMT) to sarcoma in recurrent lung adenosquamous carcinoma following adjuvant chemotherapy.
Poh ME, Liam CK, Mun KS, Chai CS, Wong CK, Tan JL, Loh TC, Chin KK
Thorac Cancer 2019 Sep;10(9):1841-1845. Epub 2019 Jul 27 doi: 10.1111/1759-7714.13156. PMID: 31350945Free PMC Article
Comprehensive investigation of oncogenic driver mutations in Chinese non-small cell lung cancer patients.
Wang R, Zhang Y, Pan Y, Li Y, Hu H, Cai D, Li H, Ye T, Luo X, Zhang Y, Li B, Shen L, Sun Y, Chen H
Oncotarget 2015 Oct 27;6(33):34300-8. doi: 10.18632/oncotarget.5549. PMID: 26486077Free PMC Article
EGFR gene mutations in patients with adenosquamous lung carcinoma.
Powrózek T, Krawczyk P, Ramlau R, Sura S, Wojas-Krawczyk K, Kucharczyk T, Walczyna B, Szumiło J, Szyszka-Barth K, Milecki P, Barinow-Wojewódzki A, Milanowski J
Asia Pac J Clin Oncol 2014 Dec;10(4):340-5. Epub 2014 Feb 27 doi: 10.1111/ajco.12177. PMID: 24575772
The long-term survival of a patient with adenosquamous lung carcinoma harboring EGFR-activating mutations who was treated with gefitinib.
Iwanaga K, Sueoka-Aragane N, Nakamura T, Mori D, Kimura S
Intern Med 2012;51(19):2771-4. Epub 2012 Oct 1 doi: 10.2169/internalmedicine.51.7428. PMID: 23037472

Prognosis

Hypercalcemia-Leukocytosis syndrome and adenosquamous lung carcinoma: An overlooked conjugation.
Oliveira Pereira J, Gama J, Ferreira D, Santos A
Oncol Res 2021;29(2):81-85. Epub 2022 Jul 13 doi: 10.32604/or.2022.023450. PMID: 37305400Free PMC Article
Adenocarcinomatous-predominant subtype associated with a better prognosis in adenosquamous lung carcinoma.
Liu Y, Zhu Y, Bai L, Chen F, Wang J, Guo Y
BMC Cancer 2020 Jun 5;20(1):520. doi: 10.1186/s12885-020-06972-5. PMID: 32503451Free PMC Article
Clinicopathological characteristics and prognosis of patients with adenosquamous lung carcinoma.
Guo Y, Jia L, Shao GG, Sun HW, Wang XX, Wang GJ, Ma KW
J Huazhong Univ Sci Technolog Med Sci 2015 Jun;35(3):350-355. Epub 2015 Jun 14 doi: 10.1007/s11596-015-1436-z. PMID: 26072072
Clinical significance of PIK3CA and survivin in primary adenosquamous lung carcinoma.
Yu S, Zhang Z, Zhang B, Shu Y, Wu H, Huang X, Yu Q, Guo R
Med Oncol 2014 Jun;31(6):983. Epub 2014 May 17 doi: 10.1007/s12032-014-0983-7. PMID: 24838432
Adenosquamous lung carcinoma: clinical characteristics, surgical treament and prognosis.
Ben Y, Yu H, Wang Z, Miao Q, Ren H, Zhang Z, Li Z
Chin Med Sci J 2000 Dec;15(4):238-40. PMID: 12906147

Clinical prediction guides

Predictive and prognostic value of preoperative serum tumor markers in resectable adenosqamous lung carcinoma.
Zhi Q, Wang Y, Wang X, Yue D, Li K, Jiang R
Oncotarget 2016 Oct 4;7(40):64798-64809. doi: 10.18632/oncotarget.11703. PMID: 27623437Free PMC Article
Genetic polymorphism rs3760396 of the chemokine (C-C motif) ligand 2 gene (CCL2) associated with the susceptibility of lung cancer in a pathological subtype-specific manner in Han-ancestry Chinese: a case control study.
Li X, Lin F, Zhou H
BMC Cancer 2016 May 4;16:298. doi: 10.1186/s12885-016-2328-8. PMID: 27145753Free PMC Article
Comprehensive investigation of oncogenic driver mutations in Chinese non-small cell lung cancer patients.
Wang R, Zhang Y, Pan Y, Li Y, Hu H, Cai D, Li H, Ye T, Luo X, Zhang Y, Li B, Shen L, Sun Y, Chen H
Oncotarget 2015 Oct 27;6(33):34300-8. doi: 10.18632/oncotarget.5549. PMID: 26486077Free PMC Article
Clinical significance of PIK3CA and survivin in primary adenosquamous lung carcinoma.
Yu S, Zhang Z, Zhang B, Shu Y, Wu H, Huang X, Yu Q, Guo R
Med Oncol 2014 Jun;31(6):983. Epub 2014 May 17 doi: 10.1007/s12032-014-0983-7. PMID: 24838432
EGFR gene mutations in patients with adenosquamous lung carcinoma.
Powrózek T, Krawczyk P, Ramlau R, Sura S, Wojas-Krawczyk K, Kucharczyk T, Walczyna B, Szumiło J, Szyszka-Barth K, Milecki P, Barinow-Wojewódzki A, Milanowski J
Asia Pac J Clin Oncol 2014 Dec;10(4):340-5. Epub 2014 Feb 27 doi: 10.1111/ajco.12177. PMID: 24575772

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