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Methotrexate-Associated Peripheral T-Cell Lymphoma

MedGen UID:
277368
•Concept ID:
C1334750
•
Neoplastic Process

Definition

A peripheral T-cell lymphoma that develops in patients who are immunosuppressed with methotrexate. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMethotrexate-Associated Peripheral T-Cell Lymphoma

Recent clinical studies

Etiology

Outcomes of methotrexate-associated lymphoproliferative disorders in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs.
Harada T, Iwasaki H, Muta T, Urata S, Sakamoto A, Kohno K, Takase K, Miyamura T, Sawabe T, Asaoku H, Oryoji K, Fujisaki T, Mori Y, Yoshimoto G, Ayano M, Mitoma H, Miyamoto T, Niiro H, Yamamoto H, Oshiro Y, Miyoshi H, Ohshima K, Takeshita M, Akashi K, Kato K
Br J Haematol 2021 Jul;194(1):101-110. Epub 2021 Apr 6 doi: 10.1111/bjh.17456. PMID: 33822354
Methotrexate-associated lymphoproliferative disorders of T-cell phenotype: clinicopathological analysis of 28 cases.
Satou A, Tabata T, Miyoshi H, Kohno K, Suzuki Y, Yamashita D, Shimada K, Kawasaki T, Sato Y, Yoshino T, Ohshima K, Takahara T, Tsuzuki T, Nakamura S
Mod Pathol 2019 Jul;32(8):1135-1146. Epub 2019 Apr 5 doi: 10.1038/s41379-019-0264-2. PMID: 30952973

Diagnosis

Concurrent Presentation of Mycosis Fungoides and Primary Cutaneous Marginal Zone LPD: Clinicopathological Study of 4 Cases and Literature Review.
Prieto-Torres L, Machan S, Haro R, Cerroni L, Requena L, Rodríguez-Pinilla SM
Am J Dermatopathol 2023 Mar 1;45(3):163-169. Epub 2023 Jan 10 doi: 10.1097/DAD.0000000000002378. PMID: 36728288
Angioimmunoblastic T-cell Lymphoma Presenting as a Methotrexate-associated Lymphoproliferative Disorder with Extreme Peripheral Blood Plasmacytosis.
Murakami H, Makita M, Ishikawa T, Yoshioka T, Nagakita K, Shinno Y, Yoshino T, Maeda Y, Sunami K
Intern Med 2022 Sep 1;61(17):2655-2660. Epub 2022 Feb 8 doi: 10.2169/internalmedicine.8422-21. PMID: 35135913Free PMC Article
Rheumatoid Arthritis Complicated with Nasal Septum Perforation Due to Methotrexate-associated Lymphoproliferative Disorder.
Sakaguchi R, Fujikawa K, Okamoto M, Matsuo E, Matsumoto K, Uchida T, Shin-Ya K, Nakashima M, Mizokami A, Kawakami A
Intern Med 2019 Nov 1;58(21):3167-3171. Epub 2019 Jul 10 doi: 10.2169/internalmedicine.2995-19. PMID: 31292392Free PMC Article
Methotrexate-associated lymphoproliferative disorders of T-cell phenotype: clinicopathological analysis of 28 cases.
Satou A, Tabata T, Miyoshi H, Kohno K, Suzuki Y, Yamashita D, Shimada K, Kawasaki T, Sato Y, Yoshino T, Ohshima K, Takahara T, Tsuzuki T, Nakamura S
Mod Pathol 2019 Jul;32(8):1135-1146. Epub 2019 Apr 5 doi: 10.1038/s41379-019-0264-2. PMID: 30952973

Therapy

Angioimmunoblastic T-cell Lymphoma Presenting as a Methotrexate-associated Lymphoproliferative Disorder with Extreme Peripheral Blood Plasmacytosis.
Murakami H, Makita M, Ishikawa T, Yoshioka T, Nagakita K, Shinno Y, Yoshino T, Maeda Y, Sunami K
Intern Med 2022 Sep 1;61(17):2655-2660. Epub 2022 Feb 8 doi: 10.2169/internalmedicine.8422-21. PMID: 35135913Free PMC Article
Outcomes of methotrexate-associated lymphoproliferative disorders in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs.
Harada T, Iwasaki H, Muta T, Urata S, Sakamoto A, Kohno K, Takase K, Miyamura T, Sawabe T, Asaoku H, Oryoji K, Fujisaki T, Mori Y, Yoshimoto G, Ayano M, Mitoma H, Miyamoto T, Niiro H, Yamamoto H, Oshiro Y, Miyoshi H, Ohshima K, Takeshita M, Akashi K, Kato K
Br J Haematol 2021 Jul;194(1):101-110. Epub 2021 Apr 6 doi: 10.1111/bjh.17456. PMID: 33822354
Rheumatoid Arthritis Complicated with Nasal Septum Perforation Due to Methotrexate-associated Lymphoproliferative Disorder.
Sakaguchi R, Fujikawa K, Okamoto M, Matsuo E, Matsumoto K, Uchida T, Shin-Ya K, Nakashima M, Mizokami A, Kawakami A
Intern Med 2019 Nov 1;58(21):3167-3171. Epub 2019 Jul 10 doi: 10.2169/internalmedicine.2995-19. PMID: 31292392Free PMC Article
Methotrexate-associated lymphoproliferative disorders of T-cell phenotype: clinicopathological analysis of 28 cases.
Satou A, Tabata T, Miyoshi H, Kohno K, Suzuki Y, Yamashita D, Shimada K, Kawasaki T, Sato Y, Yoshino T, Ohshima K, Takahara T, Tsuzuki T, Nakamura S
Mod Pathol 2019 Jul;32(8):1135-1146. Epub 2019 Apr 5 doi: 10.1038/s41379-019-0264-2. PMID: 30952973

Prognosis

Angioimmunoblastic T-cell Lymphoma Presenting as a Methotrexate-associated Lymphoproliferative Disorder with Extreme Peripheral Blood Plasmacytosis.
Murakami H, Makita M, Ishikawa T, Yoshioka T, Nagakita K, Shinno Y, Yoshino T, Maeda Y, Sunami K
Intern Med 2022 Sep 1;61(17):2655-2660. Epub 2022 Feb 8 doi: 10.2169/internalmedicine.8422-21. PMID: 35135913Free PMC Article
Outcomes of methotrexate-associated lymphoproliferative disorders in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs.
Harada T, Iwasaki H, Muta T, Urata S, Sakamoto A, Kohno K, Takase K, Miyamura T, Sawabe T, Asaoku H, Oryoji K, Fujisaki T, Mori Y, Yoshimoto G, Ayano M, Mitoma H, Miyamoto T, Niiro H, Yamamoto H, Oshiro Y, Miyoshi H, Ohshima K, Takeshita M, Akashi K, Kato K
Br J Haematol 2021 Jul;194(1):101-110. Epub 2021 Apr 6 doi: 10.1111/bjh.17456. PMID: 33822354
Methotrexate-associated lymphoproliferative disorders of T-cell phenotype: clinicopathological analysis of 28 cases.
Satou A, Tabata T, Miyoshi H, Kohno K, Suzuki Y, Yamashita D, Shimada K, Kawasaki T, Sato Y, Yoshino T, Ohshima K, Takahara T, Tsuzuki T, Nakamura S
Mod Pathol 2019 Jul;32(8):1135-1146. Epub 2019 Apr 5 doi: 10.1038/s41379-019-0264-2. PMID: 30952973

Clinical prediction guides

Outcomes of methotrexate-associated lymphoproliferative disorders in rheumatoid arthritis patients treated with disease-modifying anti-rheumatic drugs.
Harada T, Iwasaki H, Muta T, Urata S, Sakamoto A, Kohno K, Takase K, Miyamura T, Sawabe T, Asaoku H, Oryoji K, Fujisaki T, Mori Y, Yoshimoto G, Ayano M, Mitoma H, Miyamoto T, Niiro H, Yamamoto H, Oshiro Y, Miyoshi H, Ohshima K, Takeshita M, Akashi K, Kato K
Br J Haematol 2021 Jul;194(1):101-110. Epub 2021 Apr 6 doi: 10.1111/bjh.17456. PMID: 33822354

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