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Refractory Chronic Leukemia

MedGen UID:
1653223
Concept ID:
C4725602
Neoplastic Process

Definition

Chronic leukemia that is resistant to treatment. [from NCI]

Professional guidelines

PubMed

Greinix HT, Ayuk F, Zeiser R
Leukemia 2022 Nov;36(11):2558-2566. Epub 2022 Sep 24 doi: 10.1038/s41375-022-01701-2. PMID: 36153436Free PMC Article
Shomali W, Gotlib J
Am J Hematol 2022 Jan 1;97(1):129-148. Epub 2021 Oct 8 doi: 10.1002/ajh.26352. PMID: 34533850
Hallek M
Am J Hematol 2019 Nov;94(11):1266-1287. Epub 2019 Oct 4 doi: 10.1002/ajh.25595. PMID: 31364186

Recent clinical studies

Etiology

Hallek M, Al-Sawaf O
Am J Hematol 2021 Dec 1;96(12):1679-1705. doi: 10.1002/ajh.26367. PMID: 34625994
Mihalyova J, Jelinek T, Growkova K, Hrdinka M, Simicek M, Hajek R
Exp Hematol 2018 May;61:10-25. Epub 2018 Mar 2 doi: 10.1016/j.exphem.2018.02.002. PMID: 29477371
Routledge DJ, Bloor AJ
Br J Haematol 2016 Aug;174(3):351-67. Epub 2016 Jun 13 doi: 10.1111/bjh.14184. PMID: 27291144
Delgado J, Baumann T, Ghita G, Montserrat E
Curr Pharm Des 2012;18(23):3356-62. doi: 10.2174/138161212801227014. PMID: 22591384
Dreger P
Hematology Am Soc Hematol Educ Program 2009:602-9. doi: 10.1182/asheducation-2009.1.602. PMID: 20008245

Diagnosis

Wierda WG, Brown J, Abramson JS, Awan F, Bilgrami SF, Bociek G, Brander D, Cortese M, Cripe L, Davis RS, Eradat H, Fakhri B, Fletcher CD, Gaballa S, Hamid MS, Hill B, Kaesberg P, Kahl B, Kamdar M, Kipps TJ, Ma S, Mosse C, Nakhoda S, Parikh S, Schorr A, Schuster S, Seshadri M, Siddiqi T, Stephens DM, Thompson M, Ujjani C, Valdez R, Wagner-Johnston N, Woyach JA, Sundar H, Dwyer M
J Natl Compr Canc Netw 2024 Apr;22(3):175-204. doi: 10.6004/jnccn.2024.0018. PMID: 38626800
Wierda WG, Brown J, Abramson JS, Awan F, Bilgrami SF, Bociek G, Brander D, Chanan-Khan AA, Coutre SE, Davis RS, Eradat H, Fletcher CD, Gaballa S, Ghobadi A, Hamid MS, Hernandez-Ilizaliturri F, Hill B, Kaesberg P, Kamdar M, Kaplan LD, Khan N, Kipps TJ, Ma S, Mato A, Mosse C, Schuster S, Siddiqi T, Stephens DM, Ujjani C, Wagner-Johnston N, Woyach JA, Ye JC, Dwyer MA, Sundar H
J Natl Compr Canc Netw 2022 Jun;20(6):622-634. doi: 10.6004/jnccn.2022.0031. PMID: 35714675
Hallek M, Al-Sawaf O
Am J Hematol 2021 Dec 1;96(12):1679-1705. doi: 10.1002/ajh.26367. PMID: 34625994
Shallis RM, Wang R, Davidoff A, Ma X, Zeidan AM
Blood Rev 2019 Jul;36:70-87. Epub 2019 Apr 29 doi: 10.1016/j.blre.2019.04.005. PMID: 31101526
Frankel AE, Kreitman RJ
Leuk Res 2005 Sep;29(9):985-6. Epub 2005 Mar 17 doi: 10.1016/j.leukres.2005.02.008. PMID: 16038723

Therapy

Jabbour E, Short NJ, Jain N, Huang X, Montalban-Bravo G, Banerjee P, Rezvani K, Jiang X, Kim KH, Kanagal-Shamanna R, Khoury JD, Patel K, Kadia TM, Daver N, Chien K, Alvarado Y, Garcia-Manero G, Issa GC, Haddad FG, Kwari M, Thankachan J, Delumpa R, Macaron W, Garris R, Konopleva M, Ravandi F, Kantarjian H
Lancet Haematol 2023 Jan;10(1):e24-e34. Epub 2022 Nov 16 doi: 10.1016/S2352-3026(22)00319-2. PMID: 36402146
Hallek M, Al-Sawaf O
Am J Hematol 2021 Dec 1;96(12):1679-1705. doi: 10.1002/ajh.26367. PMID: 34625994
Blair HA
Drugs 2018 Nov;78(17):1847-1853. doi: 10.1007/s40265-018-1013-4. PMID: 30430368
Frampton JE, Wagstaff AJ
Drugs 2003;63(12):1229-43; discussion 1245-6. doi: 10.2165/00003495-200363120-00003. PMID: 12790693
Goodman M, Cabral L, Cassileth P
Leukemia 1998 Nov;12(11):1671-5. doi: 10.1038/sj.leu.2401199. PMID: 9823939

Prognosis

Wierda WG, Brown J, Abramson JS, Awan F, Bilgrami SF, Bociek G, Brander D, Cortese M, Cripe L, Davis RS, Eradat H, Fakhri B, Fletcher CD, Gaballa S, Hamid MS, Hill B, Kaesberg P, Kahl B, Kamdar M, Kipps TJ, Ma S, Mosse C, Nakhoda S, Parikh S, Schorr A, Schuster S, Seshadri M, Siddiqi T, Stephens DM, Thompson M, Ujjani C, Valdez R, Wagner-Johnston N, Woyach JA, Sundar H, Dwyer M
J Natl Compr Canc Netw 2024 Apr;22(3):175-204. doi: 10.6004/jnccn.2024.0018. PMID: 38626800
Hallek M, Al-Sawaf O
Am J Hematol 2021 Dec 1;96(12):1679-1705. doi: 10.1002/ajh.26367. PMID: 34625994
Hallek M
Am J Hematol 2019 Nov;94(11):1266-1287. Epub 2019 Oct 4 doi: 10.1002/ajh.25595. PMID: 31364186
Castagna L, Devillier R, Vey N, Blaise D
Exp Hematol 2018 Feb;58:5-16. Epub 2017 Nov 17 doi: 10.1016/j.exphem.2017.11.001. PMID: 29155271
Frampton JE, Wagstaff AJ
Drugs 2003;63(12):1229-43; discussion 1245-6. doi: 10.2165/00003495-200363120-00003. PMID: 12790693

Clinical prediction guides

Jabbour E, Short NJ, Jain N, Huang X, Montalban-Bravo G, Banerjee P, Rezvani K, Jiang X, Kim KH, Kanagal-Shamanna R, Khoury JD, Patel K, Kadia TM, Daver N, Chien K, Alvarado Y, Garcia-Manero G, Issa GC, Haddad FG, Kwari M, Thankachan J, Delumpa R, Macaron W, Garris R, Konopleva M, Ravandi F, Kantarjian H
Lancet Haematol 2023 Jan;10(1):e24-e34. Epub 2022 Nov 16 doi: 10.1016/S2352-3026(22)00319-2. PMID: 36402146
Wierda WG, Brown J, Abramson JS, Awan F, Bilgrami SF, Bociek G, Brander D, Chanan-Khan AA, Coutre SE, Davis RS, Eradat H, Fletcher CD, Gaballa S, Ghobadi A, Hamid MS, Hernandez-Ilizaliturri F, Hill B, Kaesberg P, Kamdar M, Kaplan LD, Khan N, Kipps TJ, Ma S, Mato A, Mosse C, Schuster S, Siddiqi T, Stephens DM, Ujjani C, Wagner-Johnston N, Woyach JA, Ye JC, Dwyer MA, Sundar H
J Natl Compr Canc Netw 2022 Jun;20(6):622-634. doi: 10.6004/jnccn.2022.0031. PMID: 35714675
Hallek M, Al-Sawaf O
Am J Hematol 2021 Dec 1;96(12):1679-1705. doi: 10.1002/ajh.26367. PMID: 34625994
Hallek M
Am J Hematol 2019 Nov;94(11):1266-1287. Epub 2019 Oct 4 doi: 10.1002/ajh.25595. PMID: 31364186
Frampton JE, Wagstaff AJ
Drugs 2003;63(12):1229-43; discussion 1245-6. doi: 10.2165/00003495-200363120-00003. PMID: 12790693

Recent systematic reviews

Zinzi A, Gaio M, Liguori V, Cagnotta C, Paolino D, Paolisso G, Castaldo G, Nicoletti GF, Rossi F, Capuano A, Rafaniello C
Pharmacol Res 2023 Apr;190:106742. Epub 2023 Mar 22 doi: 10.1016/j.phrs.2023.106742. PMID: 36963592
Pan T, Han S, Zhou M, Qi J, Wang H, Xu X, Li X, Yao Y, Han Y
Expert Rev Hematol 2022 May;15(5):457-464. Epub 2022 May 10 doi: 10.1080/17474086.2022.2073214. PMID: 35535679
Grant SJ, Grimshaw AA, Silberstein J, Murdaugh D, Wildes TM, Rosko AE, Giri S
Transplant Cell Ther 2022 Jun;28(6):294-302. Epub 2022 Mar 11 doi: 10.1016/j.jtct.2022.03.006. PMID: 35288347Free PMC Article
Hill QA, Hill A, Berentsen S
Blood Adv 2019 Jun 25;3(12):1897-1906. doi: 10.1182/bloodadvances.2019000036. PMID: 31235526Free PMC Article
Police RL, Trask PC, Wang J, Olivares R, Khan S, Abbe A, Colosia A, Njue A, Sherrill B, Ruiz-Soto R, Kaye JA, Hamadani M
Clin Lymphoma Myeloma Leuk 2015 Apr;15(4):199-207. Epub 2014 Oct 2 doi: 10.1016/j.clml.2014.09.008. PMID: 25445467

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