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Refractory Merkel Cell Carcinoma

MedGen UID:
1720265
Concept ID:
C5237418
Neoplastic Process

Definition

Merkel cell carcinoma that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Merkel Cell Carcinoma

Professional guidelines

PubMed

Nakano E, Ogata D, Namikawa K, Yamazaki N
Jpn J Clin Oncol 2023 Jul 31;53(8):673-679. doi: 10.1093/jjco/hyad059. PMID: 37288476
Cordes LM, Gulley JL
Drugs Today (Barc) 2017 Jul;53(7):377-383. doi: 10.1358/dot.2017.53.7.2654888. PMID: 28837181Free PMC Article

Recent clinical studies

Etiology

Strong J, Hallaert P, Brownell I
Hematol Oncol Clin North Am 2024 Oct;38(5):1133-1147. Epub 2024 Jul 26 doi: 10.1016/j.hoc.2024.05.013. PMID: 39060119Free PMC Article
Singh N, McClure EM, Akaike T, Park SY, Huynh ET, Goff PH, Nghiem P
Curr Treat Options Oncol 2023 Sep;24(9):1231-1258. Epub 2023 Jul 5 doi: 10.1007/s11864-023-01118-8. PMID: 37403007Free PMC Article
Nakano E, Ogata D, Namikawa K, Yamazaki N
Jpn J Clin Oncol 2023 Jul 31;53(8):673-679. doi: 10.1093/jjco/hyad059. PMID: 37288476
Askari E, Moghadam SZ, Wild D, Delpassand E, Baldari S, Nilica B, Hartrampf PE, Kong G, Grana CM, Alexander Walter M, Capoccetti F, Kasi PM, Strosberg J
J Nucl Med Technol 2023 Mar;51(1):22-25. Epub 2022 Oct 4 doi: 10.2967/jnmt.122.264904. PMID: 36195446
Shirley M
Target Oncol 2018 Jun;13(3):409-416. doi: 10.1007/s11523-018-0571-4. PMID: 29799096

Diagnosis

Strong J, Hallaert P, Brownell I
Hematol Oncol Clin North Am 2024 Oct;38(5):1133-1147. Epub 2024 Jul 26 doi: 10.1016/j.hoc.2024.05.013. PMID: 39060119Free PMC Article
Singh N, McClure EM, Akaike T, Park SY, Huynh ET, Goff PH, Nghiem P
Curr Treat Options Oncol 2023 Sep;24(9):1231-1258. Epub 2023 Jul 5 doi: 10.1007/s11864-023-01118-8. PMID: 37403007Free PMC Article
Krug J, Rodrian G, Petter K, Yang H, Khoziainova S, Guo W, Bénard A, Merkel S, Gellert S, Maschauer S, Spermann M, Waldner M, Bailey P, Pilarsky C, Liebl A, Tripal P, Christoph J, Naschberger E, Croner R, Schellerer VS, Becker C, Hartmann A, Tüting T, Prante O, Grützmann R, Grivennikov SI, Stürzl M, Britzen-Laurent N
Gastroenterology 2023 Mar;164(3):392-406.e5. Epub 2022 Nov 17 doi: 10.1053/j.gastro.2022.11.018. PMID: 36402190Free PMC Article
Steven N, Lawton P, Poulsen M
Clin Oncol (R Coll Radiol) 2019 Nov;31(11):789-796. doi: 10.1016/j.clon.2019.08.012. PMID: 31594644
Becker JC, Stang A, DeCaprio JA, Cerroni L, Lebbé C, Veness M, Nghiem P
Nat Rev Dis Primers 2017 Oct 26;3:17077. doi: 10.1038/nrdp.2017.77. PMID: 29072302Free PMC Article

Therapy

Strong J, Hallaert P, Brownell I
Hematol Oncol Clin North Am 2024 Oct;38(5):1133-1147. Epub 2024 Jul 26 doi: 10.1016/j.hoc.2024.05.013. PMID: 39060119Free PMC Article
Zadeh S, Price H, Drews R, Bouffard MA, Young LH, Narayanaswami P
Muscle Nerve 2024 Mar;69(3):368-372. Epub 2024 Jan 11 doi: 10.1002/mus.28037. PMID: 38205840
Prokoph N, Matthews JD, Trigg RM, Montes-Mojarro IA, Burke GAA, Fend F, Merkel O, Kenner L, Geoerger B, Johnston R, Murray MJ, Riguad C, Brugières L, Turner SD
Br J Haematol 2023 Sep;202(5):985-994. Epub 2023 Jun 25 doi: 10.1111/bjh.18953. PMID: 37357529Free PMC Article
Davies A, Salisbury J, Mehra V, Papa S, Basu T
Clin Exp Dermatol 2022 Nov;47(11):2059-2064. Epub 2022 Aug 25 doi: 10.1111/ced.15305. PMID: 36004622
Shalhout SZ, Emerick KS, Kaufman HL, Miller DM
Curr Oncol Rep 2021 Aug 27;23(11):125. doi: 10.1007/s11912-021-01120-z. PMID: 34448958Free PMC Article

Prognosis

Krug J, Rodrian G, Petter K, Yang H, Khoziainova S, Guo W, Bénard A, Merkel S, Gellert S, Maschauer S, Spermann M, Waldner M, Bailey P, Pilarsky C, Liebl A, Tripal P, Christoph J, Naschberger E, Croner R, Schellerer VS, Becker C, Hartmann A, Tüting T, Prante O, Grützmann R, Grivennikov SI, Stürzl M, Britzen-Laurent N
Gastroenterology 2023 Mar;164(3):392-406.e5. Epub 2022 Nov 17 doi: 10.1053/j.gastro.2022.11.018. PMID: 36402190Free PMC Article
Steven N, Lawton P, Poulsen M
Clin Oncol (R Coll Radiol) 2019 Nov;31(11):789-796. doi: 10.1016/j.clon.2019.08.012. PMID: 31594644
Femia D, Prinzi N, Anichini A, Mortarini R, Nichetti F, Corti F, Torchio M, Peverelli G, Pagani F, Maurichi A, Mattavelli I, Milione M, Bedini N, Corti A, Di Bartolomeo M, de Braud F, Pusceddu S
Target Oncol 2018 Oct;13(5):567-582. doi: 10.1007/s11523-018-0585-y. PMID: 30073632
Becker JC, Stang A, DeCaprio JA, Cerroni L, Lebbé C, Veness M, Nghiem P
Nat Rev Dis Primers 2017 Oct 26;3:17077. doi: 10.1038/nrdp.2017.77. PMID: 29072302Free PMC Article
Bommareddy PK, Kaufman HL
Future Oncol 2017 Dec;13(30):2771-2783. Epub 2017 Oct 4 doi: 10.2217/fon-2017-0305. PMID: 28976209

Clinical prediction guides

Krug J, Rodrian G, Petter K, Yang H, Khoziainova S, Guo W, Bénard A, Merkel S, Gellert S, Maschauer S, Spermann M, Waldner M, Bailey P, Pilarsky C, Liebl A, Tripal P, Christoph J, Naschberger E, Croner R, Schellerer VS, Becker C, Hartmann A, Tüting T, Prante O, Grützmann R, Grivennikov SI, Stürzl M, Britzen-Laurent N
Gastroenterology 2023 Mar;164(3):392-406.e5. Epub 2022 Nov 17 doi: 10.1053/j.gastro.2022.11.018. PMID: 36402190Free PMC Article
Barrios DM, Do MH, Phillips GS, Postow MA, Akaike T, Nghiem P, Lacouture ME
J Am Acad Dermatol 2020 Nov;83(5):1239-1253. Epub 2020 May 24 doi: 10.1016/j.jaad.2020.03.131. PMID: 32461079Free PMC Article
Steven N, Lawton P, Poulsen M
Clin Oncol (R Coll Radiol) 2019 Nov;31(11):789-796. doi: 10.1016/j.clon.2019.08.012. PMID: 31594644
Femia D, Prinzi N, Anichini A, Mortarini R, Nichetti F, Corti F, Torchio M, Peverelli G, Pagani F, Maurichi A, Mattavelli I, Milione M, Bedini N, Corti A, Di Bartolomeo M, de Braud F, Pusceddu S
Target Oncol 2018 Oct;13(5):567-582. doi: 10.1007/s11523-018-0585-y. PMID: 30073632
Shirley M
Target Oncol 2018 Jun;13(3):409-416. doi: 10.1007/s11523-018-0571-4. PMID: 29799096

Recent systematic reviews

Zago E, Galluzzo A, Pradella S, Antonuzzo L, Maggi M, Petrone L, Sparano C
Endocrine 2024 Jan;83(1):26-40. Epub 2023 Oct 18 doi: 10.1007/s12020-023-03526-0. PMID: 37851242Free PMC Article

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