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Triple-Class Refractory Plasma Cell Myeloma

MedGen UID:
1791432
Concept ID:
C5554991
Neoplastic Process
Synonym: Triple-Class Refractory Multiple Myeloma

Definition

Plasma cell myeloma that is resistant to three classes of therapeutic agents, including proteasome inhibitors, immunomodulatory agents, and monoclonal antibodies. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTriple-Class Refractory Plasma Cell Myeloma

Professional guidelines

PubMed

Nooka AK, Rodriguez C, Mateos MV, Manier S, Chastain K, Banerjee A, Kobos R, Qi K, Verona R, Doyle M, Martin TG, van de Donk NWCJ
Cancer 2024 Mar 15;130(6):886-900. Epub 2023 Nov 14 doi: 10.1002/cncr.35107. PMID: 37960969
Kikuchi T, Tsukada N, Nomura M, Kasuya Y, Oda Y, Sato K, Takei T, Ogura M, Abe Y, Suzuki K, Ishida T
Ann Hematol 2023 Jun;102(6):1477-1483. Epub 2023 Apr 28 doi: 10.1007/s00277-023-05218-1. PMID: 37115297
Pennipede D, Mohyuddin GR, Hawkins R, Ganguly S, Shune L, Ahmed N, Mohan M, Cui W, Mahmoudjafari Z, McGuirk J, Atrash S, Abdallah AO
Eur J Haematol 2021 Dec;107(6):602-608. Epub 2021 Aug 31 doi: 10.1111/ejh.13697. PMID: 34378251

Recent clinical studies

Etiology

Holstein SA, Grant SJ, Wildes TM
J Clin Oncol 2023 Sep 20;41(27):4416-4429. Epub 2023 Jul 20 doi: 10.1200/JCO.23.00512. PMID: 37471687Free PMC Article
Rodriguez-Otero P, Ailawadhi S, Arnulf B, Patel K, Cavo M, Nooka AK, Manier S, Callander N, Costa LJ, Vij R, Bahlis NJ, Moreau P, Solomon SR, Delforge M, Berdeja J, Truppel-Hartmann A, Yang Z, Favre-Kontula L, Wu F, Piasecki J, Cook M, Giralt S
N Engl J Med 2023 Mar 16;388(11):1002-1014. Epub 2023 Feb 10 doi: 10.1056/NEJMoa2213614. PMID: 36762851
Mateos MV, Weisel K, De Stefano V, Goldschmidt H, Delforge M, Mohty M, Cavo M, Vij R, Lindsey-Hill J, Dytfeld D, Angelucci E, Perrot A, Benjamin R, van de Donk NWCJ, Ocio EM, Scheid C, Gay F, Roeloffzen W, Rodriguez-Otero P, Broijl A, Potamianou A, Sakabedoyan C, Semerjian M, Keim S, Strulev V, Schecter JM, Vogel M, Wapenaar R, Nesheiwat T, San-Miguel J, Sonneveld P, Einsele H, Moreau P
Leukemia 2022 May;36(5):1371-1376. Epub 2022 Mar 24 doi: 10.1038/s41375-022-01531-2. PMID: 35332278Free PMC Article
Pennipede D, Mohyuddin GR, Hawkins R, Ganguly S, Shune L, Ahmed N, Mohan M, Cui W, Mahmoudjafari Z, McGuirk J, Atrash S, Abdallah AO
Eur J Haematol 2021 Dec;107(6):602-608. Epub 2021 Aug 31 doi: 10.1111/ejh.13697. PMID: 34378251
Chari A, Vogl DT, Gavriatopoulou M, Nooka AK, Yee AJ, Huff CA, Moreau P, Dingli D, Cole C, Lonial S, Dimopoulos M, Stewart AK, Richter J, Vij R, Tuchman S, Raab MS, Weisel KC, Delforge M, Cornell RF, Kaminetzky D, Hoffman JE, Costa LJ, Parker TL, Levy M, Schreder M, Meuleman N, Frenzel L, Mohty M, Choquet S, Schiller G, Comenzo RL, Engelhardt M, Illmer T, Vlummens P, Doyen C, Facon T, Karlin L, Perrot A, Podar K, Kauffman MG, Shacham S, Li L, Tang S, Picklesimer C, Saint-Martin JR, Crochiere M, Chang H, Parekh S, Landesman Y, Shah J, Richardson PG, Jagannath S
N Engl J Med 2019 Aug 22;381(8):727-738. doi: 10.1056/NEJMoa1903455. PMID: 31433920

Diagnosis

Mohan M, Monge J, Shah N, Luan D, Forsberg M, Bhatlapenumarthi V, Balev M, Patwari A, Cheruvalath H, Bhutani D, Thanendrarajan S, Dhakal B, Zangari M, Al-Hadidi S, Cooper D, Lentzsch S, van Rhee F, D'Souza A, Szabo A, Schinke C, Chakraborty R
Blood Cancer J 2024 Mar 5;14(1):35. doi: 10.1038/s41408-024-01003-z. PMID: 38443345Free PMC Article
Trudel S, McCurdy A, Louzada ML, Parkin S, White D, Chu MP, Kotb R, Mian H, Othman I, Su J, Khan A, Gul E, Reece D
Nat Med 2024 Feb;30(2):543-551. Epub 2024 Jan 4 doi: 10.1038/s41591-023-02703-y. PMID: 38177852Free PMC Article
Abdallah AO, Mahmoudjafari Z, Ahmed N, Cui W, Shune L, McGuirk J, Mohan M, Mohyuddin GR, Afrough A, Alkharabsheh O, Atrash S
Eur J Haematol 2023 Jun;110(6):626-632. Epub 2023 Feb 21 doi: 10.1111/ejh.13942. PMID: 36752328
Qiu L, Xia Z, Fu C, Chen W, Chang C, Fang B, An G, Wei Y, Cai Z, Gao S, Weng J, Chen L, Jing H, Li F, Liu Z, Chen X, Liu J, Wang A, Yu Y, Xiang W, Lynch K, Yu Z, Fu W
BMC Med 2022 Apr 5;20(1):108. doi: 10.1186/s12916-022-02305-4. PMID: 35379237Free PMC Article
Madduri D, Hagiwara M, Parikh K, Pelletier C, Delea TE, Kee A, Chari A
Future Oncol 2021 Feb;17(5):503-515. Epub 2020 Dec 2 doi: 10.2217/fon-2020-1003. PMID: 33522834

Therapy

Holstein SA, Grant SJ, Wildes TM
J Clin Oncol 2023 Sep 20;41(27):4416-4429. Epub 2023 Jul 20 doi: 10.1200/JCO.23.00512. PMID: 37471687Free PMC Article
Rodriguez-Otero P, Ailawadhi S, Arnulf B, Patel K, Cavo M, Nooka AK, Manier S, Callander N, Costa LJ, Vij R, Bahlis NJ, Moreau P, Solomon SR, Delforge M, Berdeja J, Truppel-Hartmann A, Yang Z, Favre-Kontula L, Wu F, Piasecki J, Cook M, Giralt S
N Engl J Med 2023 Mar 16;388(11):1002-1014. Epub 2023 Feb 10 doi: 10.1056/NEJMoa2213614. PMID: 36762851
Parikh RH, Lonial S
CA Cancer J Clin 2023 May-Jun;73(3):275-285. Epub 2023 Jan 10 doi: 10.3322/caac.21771. PMID: 36627265
Moreau P, Garfall AL, van de Donk NWCJ, Nahi H, San-Miguel JF, Oriol A, Nooka AK, Martin T, Rosinol L, Chari A, Karlin L, Benboubker L, Mateos MV, Bahlis N, Popat R, Besemer B, Martínez-López J, Sidana S, Delforge M, Pei L, Trancucci D, Verona R, Girgis S, Lin SXW, Olyslager Y, Jaffe M, Uhlar C, Stephenson T, Van Rampelbergh R, Banerjee A, Goldberg JD, Kobos R, Krishnan A, Usmani SZ
N Engl J Med 2022 Aug 11;387(6):495-505. Epub 2022 Jun 5 doi: 10.1056/NEJMoa2203478. PMID: 35661166Free PMC Article
Chari A, Vogl DT, Gavriatopoulou M, Nooka AK, Yee AJ, Huff CA, Moreau P, Dingli D, Cole C, Lonial S, Dimopoulos M, Stewart AK, Richter J, Vij R, Tuchman S, Raab MS, Weisel KC, Delforge M, Cornell RF, Kaminetzky D, Hoffman JE, Costa LJ, Parker TL, Levy M, Schreder M, Meuleman N, Frenzel L, Mohty M, Choquet S, Schiller G, Comenzo RL, Engelhardt M, Illmer T, Vlummens P, Doyen C, Facon T, Karlin L, Perrot A, Podar K, Kauffman MG, Shacham S, Li L, Tang S, Picklesimer C, Saint-Martin JR, Crochiere M, Chang H, Parekh S, Landesman Y, Shah J, Richardson PG, Jagannath S
N Engl J Med 2019 Aug 22;381(8):727-738. doi: 10.1056/NEJMoa1903455. PMID: 31433920

Prognosis

Moreau P, van de Donk NWCJ, Delforge M, Einsele H, De Stefano V, Perrot A, Besemer B, Pawlyn C, Karlin L, Manier S, Leleu X, Weisel K, Ghilotti F, Diels J, Elsada A, Morano R, Strulev V, Pei L, Kobos R, Smit J, Slavcev M, Mateos MV
Adv Ther 2023 May;40(5):2412-2425. Epub 2023 Mar 24 doi: 10.1007/s12325-023-02480-7. PMID: 36961654Free PMC Article
Costa LJ, Hungria V, Mohty M, Mateos MV
Br J Haematol 2022 Jul;198(2):244-256. Epub 2022 Apr 3 doi: 10.1111/bjh.18185. PMID: 35373352
Pennipede D, Mohyuddin GR, Hawkins R, Ganguly S, Shune L, Ahmed N, Mohan M, Cui W, Mahmoudjafari Z, McGuirk J, Atrash S, Abdallah AO
Eur J Haematol 2021 Dec;107(6):602-608. Epub 2021 Aug 31 doi: 10.1111/ejh.13697. PMID: 34378251
Martin T, Usmani SZ, Schecter JM, Vogel M, Jackson CC, Deraedt W, Tian H, Yeh TM, Banerjee A, Pacaud L, Garrett A, Haltner A, Cameron C, Van Sanden S, Diels J, Valluri S, Samjoo IA
Curr Med Res Opin 2021 Oct;37(10):1779-1788. Epub 2021 Jul 23 doi: 10.1080/03007995.2021.1953456. PMID: 34256668
Jagannath S, Lin Y, Goldschmidt H, Reece D, Nooka A, Senin A, Rodriguez-Otero P, Powles R, Matsue K, Shah N, Anderson LD Jr, Streetly M, Wilson K, Le HV, Swern AS, Agarwal A, Siegel DS
Blood Cancer J 2021 Jun 18;11(6):116. doi: 10.1038/s41408-021-00507-2. PMID: 34145225Free PMC Article

Clinical prediction guides

Bahlis NJ, Costello CL, Raje NS, Levy MY, Dholaria B, Solh M, Tomasson MH, Damore MA, Jiang S, Basu C, Skoura A, Chan EM, Trudel S, Jakubowiak A, Gasparetto C, Chu MP, Dalovisio A, Sebag M, Lesokhin AM
Nat Med 2023 Oct;29(10):2570-2576. Epub 2023 Oct 2 doi: 10.1038/s41591-023-02589-w. PMID: 37783970Free PMC Article
Krishnan A, Nooka AK, Chari A, Garfall AL, Martin TG, Nair S, Lin X, Qi K, Londhe A, Pei L, Ammann E, Kobos R, Smit J, Parekh T, Marshall A, Slavcev M, Usmani SZ
J Comp Eff Res 2023 Jun;12(6):e220186. Epub 2023 Apr 28 doi: 10.57264/cer-2022-0186. PMID: 37114426Free PMC Article
Lonial S, Popat R, Hulin C, Jagannath S, Oriol A, Richardson PG, Facon T, Weisel K, Larsen JT, Minnema MC, Abdallah AO, Badros AZ, Knop S, Stadtmauer EA, Cheng Y, Amatangelo M, Chen M, Nguyen TV, Amin A, Peluso T, van de Donk NWCJ
Lancet Haematol 2022 Nov;9(11):e822-e832. Epub 2022 Oct 6 doi: 10.1016/S2352-3026(22)00290-3. PMID: 36209764
Costa LJ, Hungria V, Mohty M, Mateos MV
Br J Haematol 2022 Jul;198(2):244-256. Epub 2022 Apr 3 doi: 10.1111/bjh.18185. PMID: 35373352
Chari A, Vogl DT, Gavriatopoulou M, Nooka AK, Yee AJ, Huff CA, Moreau P, Dingli D, Cole C, Lonial S, Dimopoulos M, Stewart AK, Richter J, Vij R, Tuchman S, Raab MS, Weisel KC, Delforge M, Cornell RF, Kaminetzky D, Hoffman JE, Costa LJ, Parker TL, Levy M, Schreder M, Meuleman N, Frenzel L, Mohty M, Choquet S, Schiller G, Comenzo RL, Engelhardt M, Illmer T, Vlummens P, Doyen C, Facon T, Karlin L, Perrot A, Podar K, Kauffman MG, Shacham S, Li L, Tang S, Picklesimer C, Saint-Martin JR, Crochiere M, Chang H, Parekh S, Landesman Y, Shah J, Richardson PG, Jagannath S
N Engl J Med 2019 Aug 22;381(8):727-738. doi: 10.1056/NEJMoa1903455. PMID: 31433920

Recent systematic reviews

Masood A, Iqbal Q, Ehsan H, Davis JA, Hansen DK, Hashmi H
Ann Hematol 2022 Dec;101(12):2601-2610. Epub 2022 Oct 10 doi: 10.1007/s00277-022-04999-1. PMID: 36214853
Shah N, Sussman M, Crivera C, Valluri S, Benner J, Jagannath S
Clin Drug Investig 2021 Mar;41(3):201-210. Epub 2021 Feb 18 doi: 10.1007/s40261-021-01012-x. PMID: 33598857

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