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Refractory Osteosarcoma

MedGen UID:
1648182
•Concept ID:
C4684870
•
Neoplastic Process

Definition

Osteosarcoma that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Osteosarcoma

Professional guidelines

PubMed

The early evolutionary landscape of osteosarcoma provides clues for targeted treatment strategies.
Kovac M, Ameline B, Ribi S, Kovacova M, Cross W, Barenboim M, Witt O, Bielack S, Krieg A, Hartmann W, Nathrath M, Baumhoer D
J Pathol 2021 Aug;254(5):556-566. Epub 2021 May 25 doi: 10.1002/path.5699. PMID: 33963544Free PMC Article
Gemcitabine for the treatment of patients with osteosarcoma.
Wei MY, Zhuang YF, Wang WM
Asian Pac J Cancer Prev 2014;15(17):7159-62. doi: 10.7314/apjcp.2014.15.17.7159. PMID: 25227807
Treatment of refractory osteosarcoma with fractionated cyclophosphamide and etoposide.
Rodríguez-Galindo C, Daw NC, Kaste SC, Meyer WH, Dome JS, Pappo AS, Rao BN, Pratt CB
J Pediatr Hematol Oncol 2002 May;24(4):250-5. doi: 10.1097/00043426-200205000-00006. PMID: 11972091

Recent clinical studies

Etiology

Exploratory study of an anti-PD-L1/TGF-β antibody, TQB2858, in patients with refractory or recurrent osteosarcoma and alveolar soft part sarcoma: a report from Chinese sarcoma study group (TQB2858-Ib-02).
Xie L, Liang X, Xu J, Sun X, Liu K, Sun K, Li Y, Tang X, Li X, Zhan X, Niu X, Guo W
BMC Cancer 2023 Sep 15;23(1):868. doi: 10.1186/s12885-023-11390-4. PMID: 37715133Free PMC Article
Safety and efficacy of multiple tyrosine kinase inhibitors in pediatric/adolescent and young adult patients with relapsed or refractory osteosarcomas: A single-institution retrospective analysis.
Sugiyama M, Arakawa A, Shirakawa N, Tao K, Tanimura K, Nakajima M, Watanabe Y, Kumamoto T, Maniwa J, Yoneda A, Iwata S, Kobayashi E, Kawai A, Ogawa C
Pediatr Blood Cancer 2023 Jul;70(7):e30360. Epub 2023 Apr 19 doi: 10.1002/pbc.30360. PMID: 37073613
Circular RNA circFIRRE drives osteosarcoma progression and metastasis through tumorigenic-angiogenic coupling.
Yu L, Zhu H, Wang Z, Huang J, Zhu Y, Fan G, Wang Y, Chen X, Zhou G
Mol Cancer 2022 Aug 19;21(1):167. doi: 10.1186/s12943-022-01624-7. PMID: 35986280Free PMC Article
Lenvatinib with etoposide plus ifosfamide in patients with refractory or relapsed osteosarcoma (ITCC-050): a multicentre, open-label, multicohort, phase 1/2 study.
Gaspar N, Venkatramani R, Hecker-Nolting S, Melcon SG, Locatelli F, Bautista F, Longhi A, Lervat C, Entz-Werle N, Casanova M, Aerts I, Strauss SJ, Thebaud E, Morland B, Nieto AC, Marec-Berard P, Gambart M, Rossig C, Okpara CE, He C, Dutta L, Campbell-Hewson Q
Lancet Oncol 2021 Sep;22(9):1312-1321. Epub 2021 Aug 17 doi: 10.1016/S1470-2045(21)00387-9. PMID: 34416158
Treatment of refractory osteosarcoma with fractionated cyclophosphamide and etoposide.
Rodríguez-Galindo C, Daw NC, Kaste SC, Meyer WH, Dome JS, Pappo AS, Rao BN, Pratt CB
J Pediatr Hematol Oncol 2002 May;24(4):250-5. doi: 10.1097/00043426-200205000-00006. PMID: 11972091

Diagnosis

The efficacy of gemcitabine and docetaxel chemotherapy for the treatment of relapsed and refractory osteosarcoma: A systematic review and pre-clinical study.
Low K, Foulkes P, Hills F, Roberts HC, Stordal B
Cancer Med 2024 Sep;13(18):e70248. doi: 10.1002/cam4.70248. PMID: 39315544Free PMC Article
Subclonal Somatic Copy-Number Alterations Emerge and Dominate in Recurrent Osteosarcoma.
Kinnaman MD, Zaccaria S, Makohon-Moore A, Arnold B, Levine MF, Gundem G, Arango Ossa JE, Glodzik D, Rodríguez-Sánchez MI, Bouvier N, Li S, Stockfisch E, Dunigan M, Cobbs C, Bhanot UK, You D, Mullen K, Melchor JP, Ortiz MV, O'Donohue TJ, Slotkin EK, Wexler LH, Dela Cruz FS, Hameed MR, Glade Bender JL, Tap WD, Meyers PA, Papaemmanuil E, Kung AL, Iacobuzio-Donahue CA
Cancer Res 2023 Nov 15;83(22):3796-3812. doi: 10.1158/0008-5472.CAN-23-0385. PMID: 37812025Free PMC Article
What is the best clinical approach to recurrent/refractory osteosarcoma?
Meazza C, Bastoni S, Scanagatta P
Expert Rev Anticancer Ther 2020 May;20(5):415-428. Epub 2020 May 7 doi: 10.1080/14737140.2020.1760848. PMID: 32379504
Anlotinib, a novel small molecular tyrosine kinase inhibitor, suppresses growth and metastasis via dual blockade of VEGFR2 and MET in osteosarcoma.
Wang G, Sun M, Jiang Y, Zhang T, Sun W, Wang H, Yin F, Wang Z, Sang W, Xu J, Mao M, Zuo D, Zhou Z, Wang C, Fu Z, Wang Z, Duan Z, Hua Y, Cai Z
Int J Cancer 2019 Aug 15;145(4):979-993. Epub 2019 Feb 15 doi: 10.1002/ijc.32180. PMID: 30719715
Sorafenib in patients with progressed and refractory bone tumors.
Raciborska A, Bilska K
Med Oncol 2018 Aug 16;35(10):126. doi: 10.1007/s12032-018-1180-x. PMID: 30116912Free PMC Article

Therapy

Exploratory study of an anti-PD-L1/TGF-β antibody, TQB2858, in patients with refractory or recurrent osteosarcoma and alveolar soft part sarcoma: a report from Chinese sarcoma study group (TQB2858-Ib-02).
Xie L, Liang X, Xu J, Sun X, Liu K, Sun K, Li Y, Tang X, Li X, Zhan X, Niu X, Guo W
BMC Cancer 2023 Sep 15;23(1):868. doi: 10.1186/s12885-023-11390-4. PMID: 37715133Free PMC Article
Safety and efficacy of multiple tyrosine kinase inhibitors in pediatric/adolescent and young adult patients with relapsed or refractory osteosarcomas: A single-institution retrospective analysis.
Sugiyama M, Arakawa A, Shirakawa N, Tao K, Tanimura K, Nakajima M, Watanabe Y, Kumamoto T, Maniwa J, Yoneda A, Iwata S, Kobayashi E, Kawai A, Ogawa C
Pediatr Blood Cancer 2023 Jul;70(7):e30360. Epub 2023 Apr 19 doi: 10.1002/pbc.30360. PMID: 37073613
What is the best clinical approach to recurrent/refractory osteosarcoma?
Meazza C, Bastoni S, Scanagatta P
Expert Rev Anticancer Ther 2020 May;20(5):415-428. Epub 2020 May 7 doi: 10.1080/14737140.2020.1760848. PMID: 32379504
The role of chemotherapy for metastatic, relapsed and refractory osteosarcoma.
Xiao X, Wang W, Wang Z
Paediatr Drugs 2014 Dec;16(6):503-12. doi: 10.1007/s40272-014-0095-z. PMID: 25392156
Gemcitabine for the treatment of patients with osteosarcoma.
Wei MY, Zhuang YF, Wang WM
Asian Pac J Cancer Prev 2014;15(17):7159-62. doi: 10.7314/apjcp.2014.15.17.7159. PMID: 25227807

Prognosis

Exploratory study of an anti-PD-L1/TGF-β antibody, TQB2858, in patients with refractory or recurrent osteosarcoma and alveolar soft part sarcoma: a report from Chinese sarcoma study group (TQB2858-Ib-02).
Xie L, Liang X, Xu J, Sun X, Liu K, Sun K, Li Y, Tang X, Li X, Zhan X, Niu X, Guo W
BMC Cancer 2023 Sep 15;23(1):868. doi: 10.1186/s12885-023-11390-4. PMID: 37715133Free PMC Article
Safety and efficacy of multiple tyrosine kinase inhibitors in pediatric/adolescent and young adult patients with relapsed or refractory osteosarcomas: A single-institution retrospective analysis.
Sugiyama M, Arakawa A, Shirakawa N, Tao K, Tanimura K, Nakajima M, Watanabe Y, Kumamoto T, Maniwa J, Yoneda A, Iwata S, Kobayashi E, Kawai A, Ogawa C
Pediatr Blood Cancer 2023 Jul;70(7):e30360. Epub 2023 Apr 19 doi: 10.1002/pbc.30360. PMID: 37073613
Circular RNA circFIRRE drives osteosarcoma progression and metastasis through tumorigenic-angiogenic coupling.
Yu L, Zhu H, Wang Z, Huang J, Zhu Y, Fan G, Wang Y, Chen X, Zhou G
Mol Cancer 2022 Aug 19;21(1):167. doi: 10.1186/s12943-022-01624-7. PMID: 35986280Free PMC Article
What is the best clinical approach to recurrent/refractory osteosarcoma?
Meazza C, Bastoni S, Scanagatta P
Expert Rev Anticancer Ther 2020 May;20(5):415-428. Epub 2020 May 7 doi: 10.1080/14737140.2020.1760848. PMID: 32379504
Gemcitabine for the treatment of patients with osteosarcoma.
Wei MY, Zhuang YF, Wang WM
Asian Pac J Cancer Prev 2014;15(17):7159-62. doi: 10.7314/apjcp.2014.15.17.7159. PMID: 25227807

Clinical prediction guides

Subclonal Somatic Copy-Number Alterations Emerge and Dominate in Recurrent Osteosarcoma.
Kinnaman MD, Zaccaria S, Makohon-Moore A, Arnold B, Levine MF, Gundem G, Arango Ossa JE, Glodzik D, Rodríguez-Sánchez MI, Bouvier N, Li S, Stockfisch E, Dunigan M, Cobbs C, Bhanot UK, You D, Mullen K, Melchor JP, Ortiz MV, O'Donohue TJ, Slotkin EK, Wexler LH, Dela Cruz FS, Hameed MR, Glade Bender JL, Tap WD, Meyers PA, Papaemmanuil E, Kung AL, Iacobuzio-Donahue CA
Cancer Res 2023 Nov 15;83(22):3796-3812. doi: 10.1158/0008-5472.CAN-23-0385. PMID: 37812025Free PMC Article
Exploratory study of an anti-PD-L1/TGF-β antibody, TQB2858, in patients with refractory or recurrent osteosarcoma and alveolar soft part sarcoma: a report from Chinese sarcoma study group (TQB2858-Ib-02).
Xie L, Liang X, Xu J, Sun X, Liu K, Sun K, Li Y, Tang X, Li X, Zhan X, Niu X, Guo W
BMC Cancer 2023 Sep 15;23(1):868. doi: 10.1186/s12885-023-11390-4. PMID: 37715133Free PMC Article
Safety and efficacy of multiple tyrosine kinase inhibitors in pediatric/adolescent and young adult patients with relapsed or refractory osteosarcomas: A single-institution retrospective analysis.
Sugiyama M, Arakawa A, Shirakawa N, Tao K, Tanimura K, Nakajima M, Watanabe Y, Kumamoto T, Maniwa J, Yoneda A, Iwata S, Kobayashi E, Kawai A, Ogawa C
Pediatr Blood Cancer 2023 Jul;70(7):e30360. Epub 2023 Apr 19 doi: 10.1002/pbc.30360. PMID: 37073613
MicroRNA-519d-3p antagonizes osteosarcoma resistance against cisplatin by targeting PD-L1.
Wang J, Zhang Z, Qiu C, Wang J
Mol Carcinog 2022 Mar;61(3):322-333. Epub 2021 Nov 15 doi: 10.1002/mc.23370. PMID: 34780678
What is the best clinical approach to recurrent/refractory osteosarcoma?
Meazza C, Bastoni S, Scanagatta P
Expert Rev Anticancer Ther 2020 May;20(5):415-428. Epub 2020 May 7 doi: 10.1080/14737140.2020.1760848. PMID: 32379504

Recent systematic reviews

The efficacy of gemcitabine and docetaxel chemotherapy for the treatment of relapsed and refractory osteosarcoma: A systematic review and pre-clinical study.
Low K, Foulkes P, Hills F, Roberts HC, Stordal B
Cancer Med 2024 Sep;13(18):e70248. doi: 10.1002/cam4.70248. PMID: 39315544Free PMC Article

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