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Polyembryoma of the ovary

MedGen UID:
271323
•Concept ID:
C1514199
•
Neoplastic Process
Synonyms: Ovarian Polyembryoma; ovarian polyembryoma; polyembryoma; Polyembryoma of the Ovary; polyembryoma of the ovary
 
Monarch Initiative: MONDO:0003989

Definition

A rare, malignant germ cell tumor arising from the ovary. It is characterized by the presence of embryoid bodies which resemble early embryos. [from NCI]

Professional guidelines

PubMed

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467
Current management of malignant germ cell tumor of the ovary.
Aziz MF
Gan To Kagaku Ryoho 1995 Aug;22 Suppl 3:262-76. PMID: 7661594

Recent clinical studies

Etiology

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467
Prognostic factors in yolk sac tumors of the ovary. A clinicopathologic analysis of 29 cases.
Kawai M, Kano T, Furuhashi Y, Mizuno K, Nakashima N, Hattori SE, Kazeto S, Iida S, Ohta M, Arii Y
Cancer 1991 Jan 1;67(1):184-92. doi: 10.1002/1097-0142(19910101)67:1<184::aid-cncr2820670131>3.0.co;2-c. PMID: 1845936
Alpha-fetoprotein in malignant germ cell tumors of the ovary.
Kawai M, Furuhashi Y, Kano T, Misawa T, Nakashima N, Hattori S, Okamoto Y, Kobayashi I, Ohta M, Arii Y
Gynecol Oncol 1990 Nov;39(2):160-6. doi: 10.1016/0090-8258(90)90425-k. PMID: 1699854

Diagnosis

Malignant mixed ovarian germ cell tumor with embryonal component.
Moniaga NC, Randall LM
J Pediatr Adolesc Gynecol 2011 Feb;24(1):e1-3. Epub 2010 Sep 24 doi: 10.1016/j.jpag.2010.05.001. PMID: 20869284Free PMC Article
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467
Pure nongestational choriocarcinoma of ovary.
Corakçi A, Ozeren S, Ozkan S, Gürbüz Y, Ustün H, Yücesoy I
Arch Gynecol Obstet 2005 Feb;271(2):176-7. Epub 2004 Feb 28 doi: 10.1007/s00404-004-0604-3. PMID: 14991382
Current management of malignant germ cell tumor of the ovary.
Aziz MF
Gan To Kagaku Ryoho 1995 Aug;22 Suppl 3:262-76. PMID: 7661594
Mixed germ cell tumor of the ovary with a prominent polyembryoma component.
King ME, Hubbell MJ, Talerman A
Int J Gynecol Pathol 1991;10(1):88-95. doi: 10.1097/00004347-199101000-00010. PMID: 1848837

Therapy

Ovarian mixed germ cell tumor comprising polyembryoma and choriocarcinoma.
Nishida T, Oda T, Sugiyama T, Kataoka A, Honda S, Yakushiji M
Eur J Obstet Gynecol Reprod Biol 1998 May;78(1):95-7. doi: 10.1016/s0301-2115(98)00013-x. PMID: 9605457
Current management of malignant germ cell tumor of the ovary.
Aziz MF
Gan To Kagaku Ryoho 1995 Aug;22 Suppl 3:262-76. PMID: 7661594

Prognosis

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467
Current management of malignant germ cell tumor of the ovary.
Aziz MF
Gan To Kagaku Ryoho 1995 Aug;22 Suppl 3:262-76. PMID: 7661594
Prognostic factors in yolk sac tumors of the ovary. A clinicopathologic analysis of 29 cases.
Kawai M, Kano T, Furuhashi Y, Mizuno K, Nakashima N, Hattori SE, Kazeto S, Iida S, Ohta M, Arii Y
Cancer 1991 Jan 1;67(1):184-92. doi: 10.1002/1097-0142(19910101)67:1<184::aid-cncr2820670131>3.0.co;2-c. PMID: 1845936
Alpha-fetoprotein in malignant germ cell tumors of the ovary.
Kawai M, Furuhashi Y, Kano T, Misawa T, Nakashima N, Hattori S, Okamoto Y, Kobayashi I, Ohta M, Arii Y
Gynecol Oncol 1990 Nov;39(2):160-6. doi: 10.1016/0090-8258(90)90425-k. PMID: 1699854

Clinical prediction guides

Alpha-fetoprotein in malignant germ cell tumors of the ovary.
Kawai M, Furuhashi Y, Kano T, Misawa T, Nakashima N, Hattori S, Okamoto Y, Kobayashi I, Ohta M, Arii Y
Gynecol Oncol 1990 Nov;39(2):160-6. doi: 10.1016/0090-8258(90)90425-k. PMID: 1699854
The frequency and histology of hepatic tissue in germ cell tumors.
Nakashima N, Fukatsu T, Nagasaka T, Sobue M, Takeuchi J
Am J Surg Pathol 1987 Sep;11(9):682-92. doi: 10.1097/00000478-198709000-00004. PMID: 2443027

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