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Digestive system mixed adenoneuroendocrine carcinoma

MedGen UID:
459355
•Concept ID:
C2987129
•
Neoplastic Process
Synonyms: digestive system Mixed Adenoneuroendocrine cancer; Digestive System Mixed Adenoneuroendocrine Carcinoma; digestive system mixed adenoneuroendocrine carcinoma; Gastrointestinal MANEC; gastrointestinal MANEC; Gastrointestinal Mixed Adenoneuroendocrine Carcinoma; gastrointestinal mixed Adenoneuroendocrine carcinoma; MANEC; Mixed Adenoneuroendocrine Carcinoma; mixed Adenoneuroendocrine carcinoma
 
Monarch Initiative: MONDO:0006182

Definition

A carcinoma that arises from the digestive system and is characterized by the presence of a malignant glandular epithelial component and a malignant neuroendocrine component. At least 30% of either component should be present for the diagnosis to be made. [from NCI]

Professional guidelines

PubMed

Ampullary Mixed Adenoneuroendocrine Carcinoma: Surprise Histology, Familiar Management.
Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015

Recent clinical studies

Etiology

Rectal mixed adenoneuroendocrine carcinoma: Case report.
Silva DJ, Dos Santos J, Vaz AP, Mesquita A
Medicine (Baltimore) 2021 Oct 8;100(40):e27348. doi: 10.1097/MD.0000000000027348. PMID: 34622834Free PMC Article
Goblet cell tumors of the appendix: A review.
Sinno SAJ, Jurdi NMH
Ann Diagn Pathol 2019 Dec;43:151401. Epub 2019 Aug 21 doi: 10.1016/j.anndiagpath.2019.151401. PMID: 31675676
Ampullary Mixed Adenoneuroendocrine Carcinoma: Surprise Histology, Familiar Management.
Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015
Mixed Neuroendocrine-Nonneuroendocrine Neoplasms (MiNENs): Unifying the Concept of a Heterogeneous Group of Neoplasms.
La Rosa S, Sessa F, Uccella S
Endocr Pathol 2016 Dec;27(4):284-311. doi: 10.1007/s12022-016-9432-9. PMID: 27169712
Gastric neuroendocrine neoplasms and related precursor lesions.
La Rosa S, Vanoli A
J Clin Pathol 2014 Nov;67(11):938-48. Epub 2014 Jul 22 doi: 10.1136/jclinpath-2014-202515. PMID: 25053544

Diagnosis

Management and outcomes of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A systematic review and pooled analysis of 56 patients.
Ziogas IA, Rallis KS, Tasoudis PT, Moris D, Schulick RD, Del Chiaro M
Eur J Surg Oncol 2023 Apr;49(4):682-687. Epub 2023 Jan 9 doi: 10.1016/j.ejso.2023.01.005. PMID: 36646615
Rectal mixed adenoneuroendocrine carcinoma: Case report.
Silva DJ, Dos Santos J, Vaz AP, Mesquita A
Medicine (Baltimore) 2021 Oct 8;100(40):e27348. doi: 10.1097/MD.0000000000027348. PMID: 34622834Free PMC Article
Mixed adenoneuroendocrine carcinoma of the hepatic bile duct: a case report and review of the literature.
Liu S, Zhong Z, Xiao M, Song Y, Zhu Y, Hu B, Sun Z, Yi W, Peng C
BMC Gastroenterol 2020 Nov 25;20(1):399. doi: 10.1186/s12876-020-01550-2. PMID: 33238879Free PMC Article
Mixed adenoneuroendocrine carcinoma of the ampulla of Vater: a case report and literature review.
Yoshimachi S, Ohtsuka H, Aoki T, Miura T, Ariake K, Masuda K, Ishida M, Mizuma M, Hayashi H, Nakagawa K, Morikawa T, Motoi F, Kanno A, Masamune A, Fujishima F, Sasano H, Kamei T, Naitoh T, Unno M
Clin J Gastroenterol 2020 Feb;13(1):37-45. Epub 2019 Jul 24 doi: 10.1007/s12328-019-01009-2. PMID: 31342462
Goblet cell tumors of the appendix: A review.
Sinno SAJ, Jurdi NMH
Ann Diagn Pathol 2019 Dec;43:151401. Epub 2019 Aug 21 doi: 10.1016/j.anndiagpath.2019.151401. PMID: 31675676

Therapy

Rectal mixed adenoneuroendocrine carcinoma: Case report.
Silva DJ, Dos Santos J, Vaz AP, Mesquita A
Medicine (Baltimore) 2021 Oct 8;100(40):e27348. doi: 10.1097/MD.0000000000027348. PMID: 34622834Free PMC Article
A Rare Case of Mixed Adenoneuroendocrine Carcinoma (MANEC) of the Gastroesophageal Junction with HER2/neu Overexpression and Distinct Orbital and Optic Nerve Toxicity after Intravenous Administration of Cisplatin.
Golombek T, Henker R, Rehak M, Quäschling U, Lordick F, Knödler M
Oncol Res Treat 2019;42(3):123-127. Epub 2019 Feb 23 doi: 10.1159/000495218. PMID: 30799422
Clinicopathological and Prognostic Evaluations of Mixed Adenoneuroendocrine Carcinoma of the Colon and Rectum: A Case-Matched Study.
Watanabe J, Suwa Y, Ota M, Ishibe A, Masui H, Nagahori K, Tsuura Y, Endo I
Dis Colon Rectum 2016 Dec;59(12):1160-1167. doi: 10.1097/DCR.0000000000000702. PMID: 27824701
Digestive Neuroendocrine Tumor Distribution and Characteristics According to the 2010 WHO Classification: a Single Institution Experience in Lebanon.
Kourie HR, Ghorra C, Rassy M, Kesserouani C, Kattan J
Asian Pac J Cancer Prev 2016;17(5):2679-81. PMID: 27268650
Two cases of neuroendocrine carcinoma of the gallbladder.
Chen H, Shen YY, Ni XZ
World J Gastroenterol 2014 Sep 7;20(33):11916-20. doi: 10.3748/wjg.v20.i33.11916. PMID: 25206300Free PMC Article

Prognosis

Mixed adenoneuroendocrine carcinoma of the hepatic bile duct: a case report and review of the literature.
Liu S, Zhong Z, Xiao M, Song Y, Zhu Y, Hu B, Sun Z, Yi W, Peng C
BMC Gastroenterol 2020 Nov 25;20(1):399. doi: 10.1186/s12876-020-01550-2. PMID: 33238879Free PMC Article
Mixed adenoneuroendocrine carcinoma of the ampulla of Vater: a case report and literature review.
Yoshimachi S, Ohtsuka H, Aoki T, Miura T, Ariake K, Masuda K, Ishida M, Mizuma M, Hayashi H, Nakagawa K, Morikawa T, Motoi F, Kanno A, Masamune A, Fujishima F, Sasano H, Kamei T, Naitoh T, Unno M
Clin J Gastroenterol 2020 Feb;13(1):37-45. Epub 2019 Jul 24 doi: 10.1007/s12328-019-01009-2. PMID: 31342462
Goblet cell tumors of the appendix: A review.
Sinno SAJ, Jurdi NMH
Ann Diagn Pathol 2019 Dec;43:151401. Epub 2019 Aug 21 doi: 10.1016/j.anndiagpath.2019.151401. PMID: 31675676
Ampullary Mixed Adenoneuroendocrine Carcinoma: Surprise Histology, Familiar Management.
Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015
Gastric neuroendocrine neoplasms and related precursor lesions.
La Rosa S, Vanoli A
J Clin Pathol 2014 Nov;67(11):938-48. Epub 2014 Jul 22 doi: 10.1136/jclinpath-2014-202515. PMID: 25053544

Clinical prediction guides

Mixed adenoneuroendocrine carcinoma originating from the appendix and colorectum: a comparative analysis of a large population-based database.
Zhao B, Wang J, Ye H, Cheng X, Meng K, Yang T
Tech Coloproctol 2023 Nov;27(11):1017-1024. Epub 2023 Mar 30 doi: 10.1007/s10151-023-02786-2. PMID: 36995458
Mixed adenoneuroendocrine carcinomas of stomach and ampulla of vater after curative-intent resection: a single center cases series.
Yang S, Lu J, Cai Y, Li B, Xiong X
BMC Gastroenterol 2021 Aug 25;21(1):329. doi: 10.1186/s12876-021-01909-z. PMID: 34433421Free PMC Article
Clinicopathological features and lymph node and distant metastasis patterns in patients with gastroenteropancreatic mixed neuroendocrine-non-neuroendocrine neoplasm.
Zhang P, Li Z, Li J, Li J, Zhang X, Lu Z, Sun Y, Li Y, Zhou J, Wang X, Peng Z, Shen L, Lu M
Cancer Med 2021 Jul;10(14):4855-4863. Epub 2021 Jun 10 doi: 10.1002/cam4.4031. PMID: 34109756Free PMC Article
Neuroendocrine, goblet cell and mixed adeno-neuroendocrine tumours of the appendix: updates, clinical applications and the future.
Clift AK, Frilling A
Expert Rev Gastroenterol Hepatol 2017 Mar;11(3):237-247. Epub 2017 Jan 20 doi: 10.1080/17474124.2017.1282314. PMID: 28081662
Mixed Neuroendocrine-Nonneuroendocrine Neoplasms (MiNENs): Unifying the Concept of a Heterogeneous Group of Neoplasms.
La Rosa S, Sessa F, Uccella S
Endocr Pathol 2016 Dec;27(4):284-311. doi: 10.1007/s12022-016-9432-9. PMID: 27169712

Recent systematic reviews

Management and outcomes of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A systematic review and pooled analysis of 56 patients.
Ziogas IA, Rallis KS, Tasoudis PT, Moris D, Schulick RD, Del Chiaro M
Eur J Surg Oncol 2023 Apr;49(4):682-687. Epub 2023 Jan 9 doi: 10.1016/j.ejso.2023.01.005. PMID: 36646615
Mixed adenoneuroendocrine carcinoma (MANEC) of the lower gastrointestinal tract: A systematic review with Bayesian hierarchical survival analysis.
Grossi U, Bonis A, Carrington EV, Mazzobel E, Santoro GA, Cattaneo L, Centonze G, Gallo G, Kazemi Nava A, Romano M, Di Tanna GL, Zanus G
Eur J Surg Oncol 2021 Nov;47(11):2893-2899. Epub 2021 May 14 doi: 10.1016/j.ejso.2021.05.021. PMID: 34052038

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