U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Signet ring cell carcinoma

MedGen UID:
61663
•Concept ID:
C0206696
•
Neoplastic Process
Synonym: Signet cell adenocarcinoma
SNOMED CT: Signet ring carcinoma (87737001); Signet ring cell carcinoma (87737001); Signet ring cell adenocarcinoma (87737001)
 
Monarch Initiative: MONDO:0005092

Definition

A usually aggressive, poorly differentiated invasive adenocarcinoma characterized by the presence of malignant glandular cells in which the nucleus is pressed to one side by the presence of intracytoplasmic mucus. It may arise from the stomach, small and large intestine, ampulla of Vater, appendix, gallbladder, pancreas, lung, bladder, breast, and prostate gland. [from NCI]

Professional guidelines

PubMed

Histopathologic and Molecular Biomarkers of PD-1/PD-L1 Inhibitor Treatment Response among Patients with Microsatellite Instability‒High Colon Cancer.
Hyung J, Cho EJ, Kim J, Kim JH, Kim JE, Hong YS, Kim TW, Sung CO, Kim SY
Cancer Res Treat 2022 Oct;54(4):1175-1190. Epub 2022 Jan 12 doi: 10.4143/crt.2021.1133. PMID: 35038827Free PMC Article
Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline CDH1 mutation carriers.
van der Post RS, Vogelaar IP, Carneiro F, Guilford P, Huntsman D, Hoogerbrugge N, Caldas C, Schreiber KE, Hardwick RH, Ausems MG, Bardram L, Benusiglio PR, Bisseling TM, Blair V, Bleiker E, Boussioutas A, Cats A, Coit D, DeGregorio L, Figueiredo J, Ford JM, Heijkoop E, Hermens R, Humar B, Kaurah P, Keller G, Lai J, Ligtenberg MJ, O'Donovan M, Oliveira C, Pinheiro H, Ragunath K, Rasenberg E, Richardson S, Roviello F, Schackert H, Seruca R, Taylor A, Ter Huurne A, Tischkowitz M, Joe ST, van Dijck B, van Grieken NC, van Hillegersberg R, van Sandick JW, Vehof R, van Krieken JH, Fitzgerald RC
J Med Genet 2015 Jun;52(6):361-74. Epub 2015 May 15 doi: 10.1136/jmedgenet-2015-103094. PMID: 25979631Free PMC Article
Clinical characteristics and outcomes of patients with primary signet-ring cell carcinoma of the urinary bladder.
Wang J, Wang FW
Urol Int 2011;86(4):453-60. Epub 2011 Apr 28 doi: 10.1159/000324263. PMID: 21525723

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Gastric Cancer, 2023

Recent clinical studies

Etiology

Prognosis prediction and comparison between pancreatic signet ring cell carcinoma and pancreatic duct adenocarcinoma: a retrospective observational study.
Zhou H, Li XX, Huang YP, Wang YX, Zou H, Xiong L, Liu ZT, Wen Y, Zhang ZJ
Front Endocrinol (Lausanne) 2023;14:1205594. Epub 2023 Jul 17 doi: 10.3389/fendo.2023.1205594. PMID: 37534212Free PMC Article
Survival analysis and individualized prediction of survival benefit for pancreatic signet ring cell carcinoma: a population study based on the SEER database.
Nie D, Yang J, Zheng H, Lai G, Wang F, Cao J, Gong C
BMC Gastroenterol 2023 Mar 9;23(1):62. doi: 10.1186/s12876-023-02650-5. PMID: 36894876Free PMC Article
A Prognostic Model for Patients With Gastric Signet Ring Cell Carcinoma.
Guo Q, Wang Y, An J, Wang S, Dong X, Zhao H
Technol Cancer Res Treat 2021 Jan-Dec;20:15330338211027912. doi: 10.1177/15330338211027912. PMID: 34190015Free PMC Article
Signet Ring Cell Gastric Carcinoma: Clinical Epidemiology and Outcomes in a Predominantly Latino County Hospital Population.
Fung BM, Patel M, Patel N, Brown AF, Ostrzega NL, Tabibian JH
Dig Dis Sci 2021 Apr;66(4):1240-1248. Epub 2020 May 24 doi: 10.1007/s10620-020-06341-z. PMID: 32448921Free PMC Article
Clinicopathological characteristics and survival in colorectal signet ring cell carcinoma: a population-based study.
Yang LL, Wang M, He P
Sci Rep 2020 Jun 26;10(1):10460. doi: 10.1038/s41598-020-67388-6. PMID: 32591589Free PMC Article

Diagnosis

Single-cell analysis of gastric signet ring cell carcinoma reveals cytological and immune microenvironment features.
Zhao W, Jia Y, Sun G, Yang H, Liu L, Qu X, Ding J, Yu H, Xu B, Zhao S, Xing L, Chai J
Nat Commun 2023 May 24;14(1):2985. doi: 10.1038/s41467-023-38426-4. PMID: 37225691Free PMC Article
Goblet cell adenocarcinoma of the appendix: an update and practical approach to diagnosis and grading.
Bell PD, Pai RK
Hum Pathol 2023 Feb;132:183-196. Epub 2022 Jun 9 doi: 10.1016/j.humpath.2022.06.002. PMID: 35691370
The updated WHO classification of digestive system tumours-gastric adenocarcinoma and dysplasia.
Kushima R
Pathologe 2022 Feb;43(1):8-15. Epub 2021 Nov 22 doi: 10.1007/s00292-021-01023-7. PMID: 34807275
Clinicopathological characteristics and survival in lung signet ring cell carcinoma: a population-based study.
Cai Y, Xie Y, Xiong Y, Guan W, Pu Y, Wang D, Xu M, Meng S
Bosn J Basic Med Sci 2021 Dec 1;21(6):752-759. doi: 10.17305/bjbms.2020.5454. PMID: 33596400Free PMC Article
Gastric adenocarcinoma of fundic gland type with signet-ring cell carcinoma component: A case report and review of the literature.
Kai K, Satake M, Tokunaga O
World J Gastroenterol 2018 Jul 14;24(26):2915-2920. doi: 10.3748/wjg.v24.i26.2915. PMID: 30018486Free PMC Article

Therapy

A Prognostic Model for Survival in Patients with Gastric Signet Ring Cell Carcinoma.
Shao XX, Li XC, Lin ZJ, Ruan YJ, Lu GR, Wang WZ, Huang H
Dig Dis 2024;42(3):221-229. Epub 2024 Feb 9 doi: 10.1159/000536454. PMID: 38342087
A Prognostic Model for Patients With Gastric Signet Ring Cell Carcinoma.
Guo Q, Wang Y, An J, Wang S, Dong X, Zhao H
Technol Cancer Res Treat 2021 Jan-Dec;20:15330338211027912. doi: 10.1177/15330338211027912. PMID: 34190015Free PMC Article
Nomograms to Predict Overall and Cancer-Specific Survival in Gastric Signet-Ring Cell Carcinoma.
Chen CL, Xue DX, Chen HH, Liang MZ, Lin DZ, Yu M, Chen JX, Wu WL
J Surg Res 2021 Oct;266:13-26. Epub 2021 May 9 doi: 10.1016/j.jss.2021.03.053. PMID: 33979736
Crohn's Disease Following Rituximab Treatment for Follicular Lymphoma in a Patient with Synchronous Gastric Signet Ring Cells Carcinoma: A Case Report and Literature Review.
Cavalcanti E, Armentano R, Lolli I
Cancer Res Treat 2020 Oct;52(4):1291-1295. Epub 2020 Jul 13 doi: 10.4143/crt.2020.406. PMID: 32683839Free PMC Article
The Proportion of Signet Ring Cell Component in Patients with Localized Gastric Adenocarcinoma Correlates with the Degree of Response to Pre-Operative Chemoradiation.
Charalampakis N, Nogueras González GM, Elimova E, Wadhwa R, Shiozaki H, Shimodaira Y, Blum MA, Rogers JE, Harada K, Matamoros A Jr, Sagebiel T, Das P, Minsky BD, Lee JH, Weston B, Bhutani MS, Estrella JS, Badgwell BD, Ajani JA
Oncology 2016;90(5):239-47. Epub 2016 Apr 6 doi: 10.1159/000443506. PMID: 27046280Free PMC Article

Prognosis

Clinicopathological characteristics of early onset colorectal cancer.
Vuik FER, Nieuwenburg SAV, Nagtegaal ID, Kuipers EJ, Spaander MCW
Aliment Pharmacol Ther 2021 Dec;54(11-12):1463-1471. Epub 2021 Oct 12 doi: 10.1111/apt.16638. PMID: 34637541Free PMC Article
A Prognostic Model for Patients With Gastric Signet Ring Cell Carcinoma.
Guo Q, Wang Y, An J, Wang S, Dong X, Zhao H
Technol Cancer Res Treat 2021 Jan-Dec;20:15330338211027912. doi: 10.1177/15330338211027912. PMID: 34190015Free PMC Article
Prognostic Nomograms for Nonelderly Adults with Gastric Signet Ring Cell Carcinoma.
Wang H, Peng Y, Huang Q, Wu J, Zhang M
Biomed Res Int 2021;2021:1274527. Epub 2021 Mar 24 doi: 10.1155/2021/1274527. PMID: 33834061Free PMC Article
Signet Ring Cell Gastric Carcinoma: Clinical Epidemiology and Outcomes in a Predominantly Latino County Hospital Population.
Fung BM, Patel M, Patel N, Brown AF, Ostrzega NL, Tabibian JH
Dig Dis Sci 2021 Apr;66(4):1240-1248. Epub 2020 May 24 doi: 10.1007/s10620-020-06341-z. PMID: 32448921Free PMC Article
Mucinous and signet-ring cell colorectal cancers differ from classical adenocarcinomas in tumor biology and prognosis.
Nitsche U, Zimmermann A, Späth C, Müller T, Maak M, Schuster T, Slotta-Huspenina J, Käser SA, Michalski CW, Janssen KP, Friess H, Rosenberg R, Bader FG
Ann Surg 2013 Nov;258(5):775-82; discussion 782-3. doi: 10.1097/SLA.0b013e3182a69f7e. PMID: 23989057Free PMC Article

Clinical prediction guides

Single-Cell Profiling of Tumor Immune Microenvironment Reveals Immune Irresponsiveness in Gastric Signet-Ring Cell Carcinoma.
Chen J, Liu K, Luo Y, Kang M, Wang J, Chen G, Qi J, Wu W, Wang B, Han Y, Shi L, Wang K, Han X, Ma X, Liu W, Ding Y, Wang L, Liang H, Wang L, Chen J
Gastroenterology 2023 Jul;165(1):88-103. Epub 2023 Mar 14 doi: 10.1053/j.gastro.2023.03.008. PMID: 36921674
Clinicopathological Characteristics and Prognostic Factors of Primary Bladder Signet Ring Cell Carcinoma.
Liu L, Wang Q, Yuan H
J Healthc Eng 2022;2022:3224616. Epub 2022 Sep 5 doi: 10.1155/2022/3224616. PMID: 36105716Free PMC Article
Nomograms to Predict Overall and Cancer-Specific Survival in Gastric Signet-Ring Cell Carcinoma.
Chen CL, Xue DX, Chen HH, Liang MZ, Lin DZ, Yu M, Chen JX, Wu WL
J Surg Res 2021 Oct;266:13-26. Epub 2021 May 9 doi: 10.1016/j.jss.2021.03.053. PMID: 33979736
Appendix Tumor Microenvironment.
Roncati L, Gasparri P, Gallo G, Bernardelli G, Zanelli G, Manenti A
Adv Exp Med Biol 2020;1226:87-95. doi: 10.1007/978-3-030-36214-0_7. PMID: 32030678
Gastric adenocarcinoma of fundic gland type with signet-ring cell carcinoma component: A case report and review of the literature.
Kai K, Satake M, Tokunaga O
World J Gastroenterol 2018 Jul 14;24(26):2915-2920. doi: 10.3748/wjg.v24.i26.2915. PMID: 30018486Free PMC Article

Recent systematic reviews

Clinicopathological Features and Prognostic-Related Risk Factors of Gastric Signet Ring Cell Carcinoma: A Meta-Analysis.
Guo Y, Wang Q, Tian Q, Bo C, Li N, Zhang S, Li P
Comput Math Methods Med 2022;2022:3473445. Epub 2022 Aug 5 doi: 10.1155/2022/3473445. PMID: 36035278Free PMC Article
The Molecular Associations of Signet-Ring Cell Carcinoma in Colorectum: Meta-Analysis and System Review.
Liu X, Huang L, Liu M, Wang Z
Medicina (Kaunas) 2022 Jun 21;58(7) doi: 10.3390/medicina58070836. PMID: 35888555Free PMC Article
Overall Survival in Phase 3 Clinical Trials and the Surveillance, Epidemiology, and End Results Database in Patients With Metastatic Colorectal Cancer, 1986-2016: A Systematic Review.
Shen C, Tannenbaum D, Horn R, Rogers J, Eng C, Zhou S, Johnson B, Kopetz S, Morris V, Overman M, Parseghian C, Chang GJ, Lopez-Olivo MA, Kanwal R, Ellis LM, Dasari A
JAMA Netw Open 2022 May 2;5(5):e2213588. doi: 10.1001/jamanetworkopen.2022.13588. PMID: 35608860Free PMC Article
Histological and mutational profile of diffuse gastric cancer: current knowledge and future challenges.
Garcia-Pelaez J, Barbosa-Matos R, Gullo I, Carneiro F, Oliveira C
Mol Oncol 2021 Nov;15(11):2841-2867. Epub 2021 May 2 doi: 10.1002/1878-0261.12948. PMID: 33724653Free PMC Article
Japanese Gastric Cancer Association Task Force for Research Promotion: clinical utility of ¹⁸F-fluoro-2-deoxyglucose positron emission tomography in gastric cancer. A systematic review of the literature.
Shimada H, Okazumi S, Koyama M, Murakami K
Gastric Cancer 2011 Mar;14(1):13-21. Epub 2011 Feb 18 doi: 10.1007/s10120-011-0017-5. PMID: 21331531

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Gastric Cancer, 2023

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...