U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Locally Advanced Malignant Mesothelioma

MedGen UID:
1780272
•Concept ID:
C5446863
•
Neoplastic Process

Definition

Malignant mesothelioma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Malignant Mesothelioma

Professional guidelines

PubMed

FDG PET/CT for Primary Staging of Lung Cancer and Mesothelioma.
Kandathil A, Subramaniam RM
Semin Nucl Med 2022 Nov;52(6):650-661. Epub 2022 Jun 20 doi: 10.1053/j.semnuclmed.2022.04.011. PMID: 35738910
Advances in treatment of mesothelioma.
Maggioni C, Barletta G, Rijavec E, Biello F, Gualco E, Grossi F
Expert Opin Pharmacother 2016 Jun;17(9):1197-205. Epub 2016 Apr 21 doi: 10.1080/14656566.2016.1176145. PMID: 27055148
Management of malignant pleural mesothelioma: have we made any progress?
Hiddinga BI, Surmont VF, Van Meerbeeck JP
Panminerva Med 2013 Jun;55(2):157-73. PMID: 23676957

Recent clinical studies

Etiology

Pembrolizumab in paediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumour or lymphoma (KEYNOTE-051): interim analysis of an open-label, single-arm, phase 1-2 trial.
Geoerger B, Kang HJ, Yalon-Oren M, Marshall LV, Vezina C, Pappo A, Laetsch TW, Petrilli AS, Ebinger M, Toporski J, Glade-Bender J, Nicholls W, Fox E, DuBois SG, Macy ME, Cohn SL, Pathiraja K, Diede SJ, Ebbinghaus S, Pinto N
Lancet Oncol 2020 Jan;21(1):121-133. Epub 2019 Dec 4 doi: 10.1016/S1470-2045(19)30671-0. PMID: 31812554
Peritoneal Carcinomatosis of Gastric Origin - Treatment Possibilities.
Hoskovec D, Krška Z, Dytrych P, Vočka M
Klin Onkol 2019 Fall;32(5):345-348. doi: 10.14735/amko2019345. PMID: 31610666
Malignant Pleural Mesothelioma: Diagnosis, Staging, Pitfalls and Follow-up.
Odisio EG, Marom EM, Shroff GS, Wu CC, Benveniste APA, Truong MT, Benveniste MF
Semin Ultrasound CT MR 2017 Dec;38(6):559-570. Epub 2017 Aug 2 doi: 10.1053/j.sult.2017.07.006. PMID: 29179896
Clinical and pathologic predictors of clinical outcome of malignant pleural mesothelioma.
Berardi R, Fiordoliva I, De Lisa M, Ballatore Z, Caramanti M, Morgese F, Savini A, Rinaldi S, Torniai M, Tiberi M, Ferrini C, Onofri A, Cascinu S
Tumori 2016 Mar-Apr;102(2):190-5. Epub 2016 Feb 12 doi: 10.5301/tj.5000418. PMID: 26893272
Malignant pleural mesothelioma.
Kindler HL
Curr Treat Options Oncol 2000 Oct;1(4):313-26. doi: 10.1007/s11864-000-0047-4. PMID: 12057157

Diagnosis

Target Therapy in Malignant Pleural Mesothelioma: Hope or Mirage?
Borea F, Franczak MA, Garcia M, Perrino M, Cordua N, Smolenski RT, Peters GJ, Dziadziuszko R, Santoro A, Zucali PA, Giovannetti E
Int J Mol Sci 2023 May 23;24(11) doi: 10.3390/ijms24119165. PMID: 37298116Free PMC Article
The 2021 WHO Classification of Tumors of the Pleura: Advances Since the 2015 Classification.
Sauter JL, Dacic S, Galateau-Salle F, Attanoos RL, Butnor KJ, Churg A, Husain AN, Kadota K, Khoor A, Nicholson AG, Roggli V, Schmitt F, Tsao MS, Travis WD
J Thorac Oncol 2022 May;17(5):608-622. Epub 2022 Jan 10 doi: 10.1016/j.jtho.2021.12.014. PMID: 35026477
Advances in treatment of mesothelioma.
Maggioni C, Barletta G, Rijavec E, Biello F, Gualco E, Grossi F
Expert Opin Pharmacother 2016 Jun;17(9):1197-205. Epub 2016 Apr 21 doi: 10.1080/14656566.2016.1176145. PMID: 27055148
Surgery for malignant pleural mesothelioma.
Sugarbaker DJ, Wolf AS
Expert Rev Respir Med 2010 Jun;4(3):363-72. doi: 10.1586/ers.10.35. PMID: 20524919
Malignant gonadal mesothelioma.
Gupta NP, Kumar R
Curr Treat Options Oncol 2002 Oct;3(5):363-7. doi: 10.1007/s11864-002-0001-8. PMID: 12194801

Therapy

Target Therapy in Malignant Pleural Mesothelioma: Hope or Mirage?
Borea F, Franczak MA, Garcia M, Perrino M, Cordua N, Smolenski RT, Peters GJ, Dziadziuszko R, Santoro A, Zucali PA, Giovannetti E
Int J Mol Sci 2023 May 23;24(11) doi: 10.3390/ijms24119165. PMID: 37298116Free PMC Article
Pembrolizumab in paediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumour or lymphoma (KEYNOTE-051): interim analysis of an open-label, single-arm, phase 1-2 trial.
Geoerger B, Kang HJ, Yalon-Oren M, Marshall LV, Vezina C, Pappo A, Laetsch TW, Petrilli AS, Ebinger M, Toporski J, Glade-Bender J, Nicholls W, Fox E, DuBois SG, Macy ME, Cohn SL, Pathiraja K, Diede SJ, Ebbinghaus S, Pinto N
Lancet Oncol 2020 Jan;21(1):121-133. Epub 2019 Dec 4 doi: 10.1016/S1470-2045(19)30671-0. PMID: 31812554
Advances in treatment of mesothelioma.
Maggioni C, Barletta G, Rijavec E, Biello F, Gualco E, Grossi F
Expert Opin Pharmacother 2016 Jun;17(9):1197-205. Epub 2016 Apr 21 doi: 10.1080/14656566.2016.1176145. PMID: 27055148
Photodynamic therapy for lung cancer and malignant pleural mesothelioma.
Simone CB 2nd, Cengel KA
Semin Oncol 2014 Dec;41(6):820-30. Epub 2014 Oct 7 doi: 10.1053/j.seminoncol.2014.09.017. PMID: 25499640Free PMC Article
Emerging drugs for mesothelioma.
Scagliotti GV, Selvaggi G
Expert Opin Emerg Drugs 2007 Mar;12(1):127-37. doi: 10.1517/14728214.12.1.127. PMID: 17355218

Prognosis

Immunotherapy for non-small cell lung cancer.
Kagamu H
Respir Investig 2024 Mar;62(2):307-312. Epub 2024 Feb 3 doi: 10.1016/j.resinv.2024.01.011. PMID: 38310751
Target Therapy in Malignant Pleural Mesothelioma: Hope or Mirage?
Borea F, Franczak MA, Garcia M, Perrino M, Cordua N, Smolenski RT, Peters GJ, Dziadziuszko R, Santoro A, Zucali PA, Giovannetti E
Int J Mol Sci 2023 May 23;24(11) doi: 10.3390/ijms24119165. PMID: 37298116Free PMC Article
The 2021 WHO Classification of Tumors of the Pleura: Advances Since the 2015 Classification.
Sauter JL, Dacic S, Galateau-Salle F, Attanoos RL, Butnor KJ, Churg A, Husain AN, Kadota K, Khoor A, Nicholson AG, Roggli V, Schmitt F, Tsao MS, Travis WD
J Thorac Oncol 2022 May;17(5):608-622. Epub 2022 Jan 10 doi: 10.1016/j.jtho.2021.12.014. PMID: 35026477
Pembrolizumab in paediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumour or lymphoma (KEYNOTE-051): interim analysis of an open-label, single-arm, phase 1-2 trial.
Geoerger B, Kang HJ, Yalon-Oren M, Marshall LV, Vezina C, Pappo A, Laetsch TW, Petrilli AS, Ebinger M, Toporski J, Glade-Bender J, Nicholls W, Fox E, DuBois SG, Macy ME, Cohn SL, Pathiraja K, Diede SJ, Ebbinghaus S, Pinto N
Lancet Oncol 2020 Jan;21(1):121-133. Epub 2019 Dec 4 doi: 10.1016/S1470-2045(19)30671-0. PMID: 31812554
Advances in treatment of mesothelioma.
Maggioni C, Barletta G, Rijavec E, Biello F, Gualco E, Grossi F
Expert Opin Pharmacother 2016 Jun;17(9):1197-205. Epub 2016 Apr 21 doi: 10.1080/14656566.2016.1176145. PMID: 27055148

Clinical prediction guides

Immunotherapy for non-small cell lung cancer.
Kagamu H
Respir Investig 2024 Mar;62(2):307-312. Epub 2024 Feb 3 doi: 10.1016/j.resinv.2024.01.011. PMID: 38310751
FDG PET/CT for Primary Staging of Lung Cancer and Mesothelioma.
Kandathil A, Subramaniam RM
Semin Nucl Med 2022 Nov;52(6):650-661. Epub 2022 Jun 20 doi: 10.1053/j.semnuclmed.2022.04.011. PMID: 35738910
Pembrolizumab in paediatric patients with advanced melanoma or a PD-L1-positive, advanced, relapsed, or refractory solid tumour or lymphoma (KEYNOTE-051): interim analysis of an open-label, single-arm, phase 1-2 trial.
Geoerger B, Kang HJ, Yalon-Oren M, Marshall LV, Vezina C, Pappo A, Laetsch TW, Petrilli AS, Ebinger M, Toporski J, Glade-Bender J, Nicholls W, Fox E, DuBois SG, Macy ME, Cohn SL, Pathiraja K, Diede SJ, Ebbinghaus S, Pinto N
Lancet Oncol 2020 Jan;21(1):121-133. Epub 2019 Dec 4 doi: 10.1016/S1470-2045(19)30671-0. PMID: 31812554
Management of malignant pleural mesothelioma: have we made any progress?
Hiddinga BI, Surmont VF, Van Meerbeeck JP
Panminerva Med 2013 Jun;55(2):157-73. PMID: 23676957
Malignant pleural mesothelioma.
Kindler HL
Curr Treat Options Oncol 2000 Oct;1(4):313-26. doi: 10.1007/s11864-000-0047-4. PMID: 12057157

Recent systematic reviews

Disease-Related Outcomes and Toxicities of Intensity Modulated Radiation Therapy After Lung-Sparing Pleurectomy for Malignant Pleural Mesothelioma: A Systematic Review.
Patel R, Ludmir EB, Miccio JA, Menon H, Barsky AR, Mesko SM, Kodali M, Lautenschlaeger T, Adeberg S, Simone CB 2nd, Verma V
Pract Radiat Oncol 2020 Nov-Dec;10(6):423-433. Epub 2020 Feb 20 doi: 10.1016/j.prro.2020.02.007. PMID: 32088429
Benign multicystic mesothelioma and peritoneal inclusion cysts: are they the same clinical and histopathological entities? A systematic review to find an evidence-based management.
Rapisarda AMC, Cianci A, Caruso S, Vitale SG, Valenti G, Piombino E, Cianci S
Arch Gynecol Obstet 2018 Jun;297(6):1353-1375. Epub 2018 Mar 6 doi: 10.1007/s00404-018-4728-2. PMID: 29511797
Randomized Trials of Systemic Medically-treated Malignant Mesothelioma: A Systematic Review.
Blomberg C, Nilsson J, Holgersson G, Edlund P, Bergqvist M, Adwall L, Ekman S, Brattström D, Bergström S
Anticancer Res 2015 May;35(5):2493-501. PMID: 25964522
Intensity-modulated radiotherapy after extrapleural pneumonectomy in the combined-modality treatment of malignant pleural mesothelioma.
Chi A, Liao Z, Nguyen NP, Howe C, Gomez D, Jang SY, Komaki R
J Thorac Oncol 2011 Jun;6(6):1132-41. doi: 10.1097/JTO.0b013e3182199819. PMID: 21532502

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...