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Pharynx carcinoma in situ

MedGen UID:
83851
•Concept ID:
C0347098
•
Neoplastic Process
Synonyms: Cancer in situ of pharynx; Carcinoma in situ of pharynx; Carcinoma in situ of Pharynx; carcinoma in situ of pharynx; Carcinoma in situ of the Pharynx; carcinoma in situ of the pharynx; Pharyngeal Cancer Stage 0; pharyngeal cancer stage 0; Pharyngeal Carcinoma in situ; pharyngeal carcinoma in situ; Pharynx Carcinoma in situ; pharynx carcinoma in situ; pharynx in situ carcinoma; Stage 0 Carcinoma of Pharynx; stage 0 carcinoma of pharynx; Stage 0 Carcinoma of the Pharynx; stage 0 carcinoma of the pharynx; Stage 0 Pharyngeal Cancer; stage 0 pharyngeal cancer; Stage 0 Pharyngeal Carcinoma; stage 0 pharyngeal carcinoma; stage 0 pharyngeal throat cancer; Stage 0 Pharynx Carcinoma; stage 0 pharynx carcinoma
SNOMED CT: Carcinoma in situ of pharynx (92681005); Cancer in situ of pharynx (92681005)
 
Monarch Initiative: MONDO:0000372

Definition

Stage 0 carcinoma of the pharynx according to the American Joint Committee on Cancer, 6th, 7th, and 8th editions. [from NCI]

Professional guidelines

PubMed

Epstein-Barr virus DNA load in nasopharyngeal brushings and whole blood in nasopharyngeal carcinoma patients before and after treatment.
Adham M, Greijer AE, Verkuijlen SA, Juwana H, Fleig S, Rachmadi L, Malik O, Kurniawan AN, Roezin A, Gondhowiardjo S, Atmakusumah D, Stevens SJ, Hermani B, Tan IB, Middeldorp JM
Clin Cancer Res 2013 Apr 15;19(8):2175-86. Epub 2013 Mar 14 doi: 10.1158/1078-0432.CCR-12-2897. PMID: 23493345
Adenosquamous carcinoma of the head and neck: criteria for diagnosis in a study of 12 cases.
Alos L, Castillo M, Nadal A, Caballero M, Mallofre C, Palacin A, Cardesa A
Histopathology 2004 Jun;44(6):570-9. doi: 10.1111/j.1365-2559.2004.01881.x. PMID: 15186272
Transoral CO2 laser for surgical management of glottic carcinoma in situ.
Damm M, Sittel C, Streppel M, Eckel HE
Laryngoscope 2000 Jul;110(7):1215-21. doi: 10.1097/00005537-200007000-00028. PMID: 10892699

Recent clinical studies

Etiology

HPV Infection in Squamous Cell Carcinoma of the Hypopharynx, Larynx, and Oropharynx With Multisite Involvement.
Kuga R, Yamamoto H, Jiromaru R, Hongo T, Yasumatsu R, Matsuo M, Hashimoto K, Taniguchi M, Nakagawa T, Oda Y
Am J Surg Pathol 2023 Sep 1;47(9):955-966. Epub 2023 Jun 26 doi: 10.1097/PAS.0000000000002086. PMID: 37357948
Secretory carcinoma of the sinonasal cavity and pharynx: A retrospective analysis of four cases and literature review.
Yue C, Zhao X, Ma D, Piao Y
Ann Diagn Pathol 2022 Dec;61:152052. Epub 2022 Oct 8 doi: 10.1016/j.anndiagpath.2022.152052. PMID: 36270241
Oro- and Nasopharyngeal Papillomas with Squamous and Respiratory Features: A Case Series of Schneiderian-Like Papillomas of the Pharynx.
Ababneh EI, Shah AA
Head Neck Pathol 2022 Jun;16(2):486-493. Epub 2021 Oct 25 doi: 10.1007/s12105-021-01389-3. PMID: 34694538Free PMC Article
Prevalence of High-Risk Human Papillomavirus in Tonsil Tissue in Healthy Adults and Colocalization in Biofilm of Tonsillar Crypts.
Rieth KKS, Gill SR, Lott-Limbach AA, Merkley MA, Botero N, Allen PD, Miller MC
JAMA Otolaryngol Head Neck Surg 2018 Mar 1;144(3):231-237. doi: 10.1001/jamaoto.2017.2916. PMID: 29372248Free PMC Article
Human papillomavirus and head and neck cancer: epidemiology and molecular biology.
McKaig RG, Baric RS, Olshan AF
Head Neck 1998 May;20(3):250-65. doi: 10.1002/(sici)1097-0347(199805)20:3<250::aid-hed11>3.0.co;2-o. PMID: 9570632

Diagnosis

Secretory carcinoma of the sinonasal cavity and pharynx: A retrospective analysis of four cases and literature review.
Yue C, Zhao X, Ma D, Piao Y
Ann Diagn Pathol 2022 Dec;61:152052. Epub 2022 Oct 8 doi: 10.1016/j.anndiagpath.2022.152052. PMID: 36270241
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
HPV-related carcinoma of the oropharynx: challenges on small biopsy specimens.
Palsgrove D, Bishop JA
J Am Soc Cytopathol 2020 Sep-Oct;9(5):359-368. Epub 2020 Jun 19 doi: 10.1016/j.jasc.2020.06.001. PMID: 32651129
Human papillomavirus and head and neck cancer: epidemiology and molecular biology.
McKaig RG, Baric RS, Olshan AF
Head Neck 1998 May;20(3):250-65. doi: 10.1002/(sici)1097-0347(199805)20:3<250::aid-hed11>3.0.co;2-o. PMID: 9570632
Nasopharyngeal carcinoma, with emphasis on its relationship to Epstein-Barr virus.
Vasef MA, Ferlito A, Weiss LM
Ann Otol Rhinol Laryngol 1997 Apr;106(4):348-56. doi: 10.1177/000348949710600416. PMID: 9109729

Therapy

Feasibility of transnasal flexible carbon dioxide laser surgery for laryngopharyngeal lesions.
Araki K, Tomifuji M, Uno K, Suzuki H, Tanaka Y, Tanaka S, Kimura E, Shiotani A
Auris Nasus Larynx 2019 Oct;46(5):772-778. Epub 2019 Feb 11 doi: 10.1016/j.anl.2019.01.008. PMID: 30765273
Lymphoepithelioma-like carcinoma of breast: A case report and review of the literature.
Nieto-Coronel MT, Perez-Sanchez VM, Salazar-Campos JE, Diaz-Molina R, Arce-Salinas CH
Indian J Pathol Microbiol 2019 Jan-Mar;62(1):125-128. doi: 10.4103/IJPM.IJPM_761_17. PMID: 30706876
Photodynamic therapy and the treatment of head and neck cancers.
Biel MA
J Clin Laser Med Surg 1996 Oct;14(5):239-44. doi: 10.1089/clm.1996.14.239. PMID: 9612189
Incidence of invasive cancers following carcinoma in situ of the cervix.
Levi F, Randimbison L, La Vecchia C, Franceschi S
Br J Cancer 1996 Oct;74(8):1321-3. doi: 10.1038/bjc.1996.538. PMID: 8883426Free PMC Article
Pharyngeal pouch carcinoma.
Saunders MW, Murty GE, Bradely PJ
Ear Nose Throat J 1993 Feb;72(2):149-50. PMID: 8482256

Prognosis

HPV Infection in Squamous Cell Carcinoma of the Hypopharynx, Larynx, and Oropharynx With Multisite Involvement.
Kuga R, Yamamoto H, Jiromaru R, Hongo T, Yasumatsu R, Matsuo M, Hashimoto K, Taniguchi M, Nakagawa T, Oda Y
Am J Surg Pathol 2023 Sep 1;47(9):955-966. Epub 2023 Jun 26 doi: 10.1097/PAS.0000000000002086. PMID: 37357948
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
HPV-related carcinoma of the oropharynx: challenges on small biopsy specimens.
Palsgrove D, Bishop JA
J Am Soc Cytopathol 2020 Sep-Oct;9(5):359-368. Epub 2020 Jun 19 doi: 10.1016/j.jasc.2020.06.001. PMID: 32651129
Human papillomavirus and head and neck cancer: epidemiology and molecular biology.
McKaig RG, Baric RS, Olshan AF
Head Neck 1998 May;20(3):250-65. doi: 10.1002/(sici)1097-0347(199805)20:3<250::aid-hed11>3.0.co;2-o. PMID: 9570632
Nasopharyngeal carcinoma, with emphasis on its relationship to Epstein-Barr virus.
Vasef MA, Ferlito A, Weiss LM
Ann Otol Rhinol Laryngol 1997 Apr;106(4):348-56. doi: 10.1177/000348949710600416. PMID: 9109729

Clinical prediction guides

HPV Infection in Squamous Cell Carcinoma of the Hypopharynx, Larynx, and Oropharynx With Multisite Involvement.
Kuga R, Yamamoto H, Jiromaru R, Hongo T, Yasumatsu R, Matsuo M, Hashimoto K, Taniguchi M, Nakagawa T, Oda Y
Am J Surg Pathol 2023 Sep 1;47(9):955-966. Epub 2023 Jun 26 doi: 10.1097/PAS.0000000000002086. PMID: 37357948
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
The Clinical Significance of IGF-1R and Relationship with Epstein-Barr Virus Markers: LMP1 and EBERs in Tunisian Patients with Nasopharyngeal Carcinoma.
Baizig NM, Wided BA, Amine OE, Gritli S, ElMay M
Ann Otol Rhinol Laryngol 2020 Oct;129(10):1011-1019. Epub 2020 May 29 doi: 10.1177/0003489420929362. PMID: 32468823
Prevalence of human papillomavirus (HPV) in oral cavity and oropharynx.
Castro TP, Bussoloti Filho I
Braz J Otorhinolaryngol 2006 Mar-Apr;72(2):272-82. doi: 10.1016/s1808-8694(15)30068-9. PMID: 16951865Free PMC Article
Squamous cell carcinoma in situ at oropharyngeal and hypopharyngeal mucosal sites.
Muto M, Nakane M, Katada C, Sano Y, Ohtsu A, Esumi H, Ebihara S, Yoshida S
Cancer 2004 Sep 15;101(6):1375-81. doi: 10.1002/cncr.20482. PMID: 15368325

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