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Multicentric Breast Carcinoma

MedGen UID:
458890
•Concept ID:
C2986664
•
Neoplastic Process

Definition

A breast carcinoma characterized by the presence of multiple cancerous tumors that originate from different clones and are usually located in different quadrants of the breast. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMulticentric Breast Carcinoma

Professional guidelines

PubMed

Radical tumor excision and cosmetic balance in the surgical treatment of breast carcinoma: biquadrantectomy.
Garofalo R, Borioni R, Garofalo RL, Lavanga G, Mathé G
Biomed Pharmacother 1992;46(9):401-4. doi: 10.1016/0753-3322(92)90044-8. PMID: 1292651

Recent clinical studies

Etiology

Axillary lymph node status and prognosis in multifocal and multicentric breast carcinoma.
Duraker N, Caynak ZC
Breast J 2014 Jan-Feb;20(1):61-8. Epub 2013 Nov 18 doi: 10.1111/tbj.12205. PMID: 24438065
Preliminary results: double lumpectomies for multicentric breast carcinoma.
Kapoor NS, Chung A, Huynh K, Giuliano AE
Am Surg 2012 Dec;78(12):1345-8. PMID: 23265123
Accuracy of sentinel lymph node biopsy in large and multifocal/multicentric breast carcinoma--a systematic review.
Spillane AJ, Brennan ME
Eur J Surg Oncol 2011 May;37(5):371-85. Epub 2011 Feb 3 doi: 10.1016/j.ejso.2011.01.011. PMID: 21292433
Clinicopathological feature and long-term prognosis of apocrine carcinoma of the breast in Japanese women.
Takeuchi H, Tsuji K, Ueo H, Kano T, Maehara Y
Breast Cancer Res Treat 2004 Nov;88(1):49-54. doi: 10.1007/s10549-004-9495-z. PMID: 15538045
Multicentric mammary carcinoma: evidence of monoclonal proliferation.
Middleton LP, Vlastos G, Mirza NQ, Eva S, Sahin AA
Cancer 2002 Apr 1;94(7):1910-6. doi: 10.1002/cncr.10452. PMID: 11932891

Diagnosis

Accuracy of sentinel lymph node biopsy in large and multifocal/multicentric breast carcinoma--a systematic review.
Spillane AJ, Brennan ME
Eur J Surg Oncol 2011 May;37(5):371-85. Epub 2011 Feb 3 doi: 10.1016/j.ejso.2011.01.011. PMID: 21292433
Sensitivity of imaging for multifocal-multicentric breast carcinoma.
Bozzini A, Renne G, Meneghetti L, Bandi G, Santos G, Vento AR, Menna S, Andrighetto S, Viale G, Cassano E, Bellomi M
BMC Cancer 2008 Sep 30;8:275. doi: 10.1186/1471-2407-8-275. PMID: 18826585Free PMC Article
Clinicopathological feature and long-term prognosis of apocrine carcinoma of the breast in Japanese women.
Takeuchi H, Tsuji K, Ueo H, Kano T, Maehara Y
Breast Cancer Res Treat 2004 Nov;88(1):49-54. doi: 10.1007/s10549-004-9495-z. PMID: 15538045
Multicentric mammary carcinoma: evidence of monoclonal proliferation.
Middleton LP, Vlastos G, Mirza NQ, Eva S, Sahin AA
Cancer 2002 Apr 1;94(7):1910-6. doi: 10.1002/cncr.10452. PMID: 11932891
Pathologic analysis of tumor size and lymph node status in multifocal/multicentric breast carcinoma.
Andea AA, Wallis T, Newman LA, Bouwman D, Dey J, Visscher DW
Cancer 2002 Mar 1;94(5):1383-90. doi: 10.1002/cncr.10331. PMID: 11920492

Therapy

Accuracy of sentinel lymph node biopsy in large and multifocal/multicentric breast carcinoma--a systematic review.
Spillane AJ, Brennan ME
Eur J Surg Oncol 2011 May;37(5):371-85. Epub 2011 Feb 3 doi: 10.1016/j.ejso.2011.01.011. PMID: 21292433

Prognosis

Integrating anatomy, radiology, pathology, and surgery: An alternative approach in resecting multifocal and multicentric breast carcinoma.
Tan MP, Ong EM, Amy D, Tot T
Breast J 2017 Nov;23(6):663-669. Epub 2017 Aug 22 doi: 10.1111/tbj.12891. PMID: 28833864
Multifocal and Multicentric Breast Carcinoma: A Significantly More Aggressive Tumor than Unifocal Breast Cancer.
Lang Z, Wu Y, Li C, Li X, Wang X, Qu G
Anticancer Res 2017 Aug;37(8):4593-4598. doi: 10.21873/anticanres.11858. PMID: 28739757
Axillary lymph node status and prognosis in multifocal and multicentric breast carcinoma.
Duraker N, Caynak ZC
Breast J 2014 Jan-Feb;20(1):61-8. Epub 2013 Nov 18 doi: 10.1111/tbj.12205. PMID: 24438065
Preliminary results: double lumpectomies for multicentric breast carcinoma.
Kapoor NS, Chung A, Huynh K, Giuliano AE
Am Surg 2012 Dec;78(12):1345-8. PMID: 23265123
Clinicopathological feature and long-term prognosis of apocrine carcinoma of the breast in Japanese women.
Takeuchi H, Tsuji K, Ueo H, Kano T, Maehara Y
Breast Cancer Res Treat 2004 Nov;88(1):49-54. doi: 10.1007/s10549-004-9495-z. PMID: 15538045

Clinical prediction guides

Integrating anatomy, radiology, pathology, and surgery: An alternative approach in resecting multifocal and multicentric breast carcinoma.
Tan MP, Ong EM, Amy D, Tot T
Breast J 2017 Nov;23(6):663-669. Epub 2017 Aug 22 doi: 10.1111/tbj.12891. PMID: 28833864
Pathologic analysis of tumor size and lymph node status in multifocal/multicentric breast carcinoma.
Andea AA, Wallis T, Newman LA, Bouwman D, Dey J, Visscher DW
Cancer 2002 Mar 1;94(5):1383-90. doi: 10.1002/cncr.10331. PMID: 11920492
Patient selection for breast conservation therapy with magnification mammography.
Morrow M, Schmidt R, Hassett C
Surgery 1995 Oct;118(4):621-6. doi: 10.1016/s0039-6060(05)80027-3. PMID: 7570314

Recent systematic reviews

Accuracy of sentinel lymph node biopsy in large and multifocal/multicentric breast carcinoma--a systematic review.
Spillane AJ, Brennan ME
Eur J Surg Oncol 2011 May;37(5):371-85. Epub 2011 Feb 3 doi: 10.1016/j.ejso.2011.01.011. PMID: 21292433

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