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Mucinous adenocarcinoma

MedGen UID:
2844
•Concept ID:
C0007130
•
Neoplastic Process
Synonyms: Adenocarcinoma of the appendix; Colonic type adenocarcinoma; Nonmucinous adenocarcinoma
SNOMED CT: Mucinous adenocarcinoma (72495009); Mucous carcinoma (72495009); Mucinous carcinoma (72495009); Colloid adenocarcinoma (72495009); Colloid carcinoma (72495009); Gelatinous adenocarcinoma (72495009); Gelatinous carcinoma (72495009); Mucoid adenocarcinoma (72495009); Mucoid carcinoma (72495009); Mucous adenocarcinoma (72495009); Pseudomyxoma peritonei with unknown primary site (72495009)
 
Monarch Initiative: MONDO:0004957

Definition

An invasive adenocarcinoma composed of malignant glandular cells which contain intracytoplasmic mucin. Often, the infiltrating glandular structures are associated with mucoid stromal formation. It may arise from the large and small intestine, appendix, stomach, lung, ovary, breast, corpus uteri, cervix, vagina, and salivary gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMucinous adenocarcinoma

Professional guidelines

PubMed

Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma.
Ebisudani T, Hamamoto J, Togasaki K, Mitsuishi A, Sugihara K, Shinozaki T, Fukushima T, Kawasaki K, Seino T, Oda M, Hanyu H, Toshimitsu K, Emoto K, Hayashi Y, Asakura K, Johnson TA, Terai H, Ikemura S, Kawada I, Ishii M, Hishida T, Asamura H, Soejima K, Nakagawa H, Fujii M, Fukunaga K, Yasuda H, Sato T
Cell Rep 2023 Mar 28;42(3):112212. Epub 2023 Mar 6 doi: 10.1016/j.celrep.2023.112212. PMID: 36870059
Colonic mucinous adenocarcinoma in a tufted deer: differential diagnosis and literature review.
Gonzalez-Astudillo V, Navarro MA, Moore J, Uzal FA
J Vet Diagn Invest 2022 Nov;34(6):983-989. Epub 2022 Sep 2 doi: 10.1177/10406387221123007. PMID: 36056527Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article

Recent clinical studies

Etiology

Mucin-rich salivary gland tumors.
Bishop JA
Semin Diagn Pathol 2024 Jul;41(4):165-172. Epub 2024 Jun 8 doi: 10.1053/j.semdp.2024.06.001. PMID: 38853124
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Salivary Glands.
Skálová A, Hyrcza MD, Leivo I
Head Neck Pathol 2022 Mar;16(1):40-53. Epub 2022 Mar 21 doi: 10.1007/s12105-022-01420-1. PMID: 35312980Free PMC Article
Mucinous breast cancer: A narrative review of the literature and a retrospective tertiary single-centre analysis.
Marrazzo E, Frusone F, Milana F, Sagona A, Gatzemeier W, Barbieri E, Bottini A, Canavese G, Rubino AO, Eboli MG, Rossetti CM, Testori A, Errico V, De Luca A, Tinterri C
Breast 2020 Feb;49:87-92. Epub 2019 Nov 11 doi: 10.1016/j.breast.2019.11.002. PMID: 31783314Free PMC Article
Mucinous Ovarian Tumors.
Mills AM, Shanes ED
Surg Pathol Clin 2019 Jun;12(2):565-585. doi: 10.1016/j.path.2019.01.008. PMID: 31097115
Cervical Glandular Neoplasia: Classification and Staging.
Turashvili G, Park KJ
Surg Pathol Clin 2019 Jun;12(2):281-313. doi: 10.1016/j.path.2019.01.002. PMID: 31097105

Diagnosis

Colonic mucinous adenocarcinoma in a tufted deer: differential diagnosis and literature review.
Gonzalez-Astudillo V, Navarro MA, Moore J, Uzal FA
J Vet Diagn Invest 2022 Nov;34(6):983-989. Epub 2022 Sep 2 doi: 10.1177/10406387221123007. PMID: 36056527Free PMC Article
Mucinous Ovarian Tumors.
Mills AM, Shanes ED
Surg Pathol Clin 2019 Jun;12(2):565-585. doi: 10.1016/j.path.2019.01.008. PMID: 31097115
Mucinous Ovarian Carcinoma.
Morice P, Gouy S, Leary A
N Engl J Med 2019 Mar 28;380(13):1256-1266. doi: 10.1056/NEJMra1813254. PMID: 30917260
Mucinous and secondary tumors of the prostate.
Osunkoya AO
Mod Pathol 2018 Jan;31(S1):S80-S95. doi: 10.1038/modpathol.2017.132. PMID: 29297488
Trousseau syndrome.
Fujikawa T, Tokuda Y
BMJ Case Rep 2017 Mar 7;2017 doi: 10.1136/bcr-2017-219249. PMID: 28270400Free PMC Article

Therapy

Mucinous Ovarian Carcinoma.
Morice P, Gouy S, Leary A
N Engl J Med 2019 Mar 28;380(13):1256-1266. doi: 10.1056/NEJMra1813254. PMID: 30917260
Early stage mucinous ovarian cancer: A review.
Crane EK, Brown J
Gynecol Oncol 2018 Jun;149(3):598-604. Epub 2018 Feb 9 doi: 10.1016/j.ygyno.2018.01.035. PMID: 29429591
Mucinous epithelial ovarian carcinoma.
Perren TJ
Ann Oncol 2016 Apr;27 Suppl 1:i53-i57. doi: 10.1093/annonc/mdw087. PMID: 27141073
Mucinous ovarian cancer: A therapeutic review.
Xu W, Rush J, Rickett K, Coward JI
Crit Rev Oncol Hematol 2016 Jun;102:26-36. Epub 2016 Mar 19 doi: 10.1016/j.critrevonc.2016.03.015. PMID: 27083591
Mucinous ovarian cancer.
Harrison ML, Jameson C, Gore ME
Int J Gynecol Cancer 2008 Mar-Apr;18(2):209-14. Epub 2007 Jul 11 doi: 10.1111/j.1525-1438.2007.01022.x. PMID: 17624989

Prognosis

Postoperative LAMN surveillance recommendations.
Gupta AR, Brajcich BC, Merkow RP
J Surg Oncol 2022 Mar;125(3):546-547. Epub 2021 Oct 31 doi: 10.1002/jso.26724. PMID: 34719030
Long-term Risk of Malignancy in Branch-Duct Intraductal Papillary Mucinous Neoplasms.
Oyama H, Tada M, Takagi K, Tateishi K, Hamada T, Nakai Y, Hakuta R, Ijichi H, Ishigaki K, Kanai S, Kogure H, Mizuno S, Saito K, Saito T, Sato T, Suzuki T, Takahara N, Morishita Y, Arita J, Hasegawa K, Tanaka M, Fukayama M, Koike K
Gastroenterology 2020 Jan;158(1):226-237.e5. Epub 2019 Aug 29 doi: 10.1053/j.gastro.2019.08.032. PMID: 31473224
Advanced Mucinous Colorectal Cancer: Epidemiology, Prognosis and Efficacy of Chemotherapeutic Treatment.
Ott C, Gerken M, Hirsch D, Fest P, Fichtner-Feigl S, Munker S, Schnoy E, Stroszczynski C, Vogelhuber M, Herr W, Evert M, Reng M, Schlitt HJ, Klinkhammer-Schalke M, Teufel A
Digestion 2018;98(3):143-152. Epub 2018 Jun 5 doi: 10.1159/000487710. PMID: 29870979
Mucinous epithelial ovarian carcinoma.
Perren TJ
Ann Oncol 2016 Apr;27 Suppl 1:i53-i57. doi: 10.1093/annonc/mdw087. PMID: 27141073
Clinicopathological characteristics and prognosis of mucinous breast carcinoma.
Zhang M, Teng XD, Guo XX, Zhao JS, Li ZG
J Cancer Res Clin Oncol 2014 Feb;140(2):265-9. Epub 2013 Dec 5 doi: 10.1007/s00432-013-1559-1. PMID: 24305754

Clinical prediction guides

Role of colectomy in the management of appendiceal tumors: a retrospective cohort study.
Marks VA, Kerekes D, Butensky S, Ahuja N, Johnson C, Turaga K, Khan SA
BMC Gastroenterol 2023 Nov 17;23(1):398. doi: 10.1186/s12876-023-03019-4. PMID: 37978348Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Development and Validation of a Multi-institutional Preoperative Nomogram for Predicting Grade of Dysplasia in Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas: A Report from The Pancreatic Surgery Consortium.
Attiyeh MA, Fernández-Del Castillo C, Al Efishat M, Eaton AA, Gönen M, Batts R, Pergolini I, Rezaee N, Lillemoe KD, Ferrone CR, Mino-Kenudson M, Weiss MJ, Cameron JL, Hruban RH, D'Angelica MI, DeMatteo RP, Kingham TP, Jarnagin WR, Wolfgang CL, Allen PJ
Ann Surg 2018 Jan;267(1):157-163. doi: 10.1097/SLA.0000000000002015. PMID: 28079542Free PMC Article
A Consensus for Classification and Pathologic Reporting of Pseudomyxoma Peritonei and Associated Appendiceal Neoplasia: The Results of the Peritoneal Surface Oncology Group International (PSOGI) Modified Delphi Process.
Carr NJ, Cecil TD, Mohamed F, Sobin LH, Sugarbaker PH, González-Moreno S, Taflampas P, Chapman S, Moran BJ; Peritoneal Surface Oncology Group International
Am J Surg Pathol 2016 Jan;40(1):14-26. doi: 10.1097/PAS.0000000000000535. PMID: 26492181
The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: Definition of Grading Patterns and Proposal for a New Grading System.
Epstein JI, Egevad L, Amin MB, Delahunt B, Srigley JR, Humphrey PA; Grading Committee
Am J Surg Pathol 2016 Feb;40(2):244-52. doi: 10.1097/PAS.0000000000000530. PMID: 26492179

Recent systematic reviews

Prognostic factors for invasive mucinous adenocarcinoma of the lung: systematic review and meta-analysis.
Zhao T, Yi J, Luo D, Liu J, Fan X, Wu Q, Wang W
World J Surg Oncol 2024 Feb 2;22(1):41. doi: 10.1186/s12957-024-03326-4. PMID: 38303008Free PMC Article
Incidence rate and histology of appendiceal neoplasms in complicated versus uncomplicated appendicitis: A meta-analysis and systematic review.
Solis-Pazmino P, Oka K, La K, Termeie O, Figueroa LA, Pilatuna E, Solis-Pazmino D, Harnegie MP, Cohen J, Barnajian M, Nasseri Y
Langenbecks Arch Surg 2023 Nov 9;408(1):432. doi: 10.1007/s00423-023-03164-0. PMID: 37940770Free PMC Article
Systematic review of challenging issues in pathology of intraductal papillary mucinous neoplasms.
Wood LD, Adsay NV, Basturk O, Brosens LAA, Fukushima N, Hong SM, Kim SJ, Lee JW, Luchini C, Noë M, Pitman MB, Scarpa A, Singhi AD, Tanaka M, Furukawa T
Pancreatology 2023 Nov;23(7):878-891. Epub 2023 Aug 11 doi: 10.1016/j.pan.2023.08.002. PMID: 37604731
Primary cutaneous mucinous carcinoma: a systematic review and meta-analysis of outcomes after surgery.
Kamalpour L, Brindise RT, Nodzenski M, Bach DQ, Veledar E, Alam M
JAMA Dermatol 2014 Apr;150(4):380-4. doi: 10.1001/jamadermatol.2013.6006. PMID: 24452370
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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