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Diffuse type adenocarcinoma

MedGen UID:
87207
•Concept ID:
C0334280
•
Neoplastic Process
Synonyms: Adenocarcinoma - diffuse type; Adenocarcinoma, diffuse type; Carcinoma - diffuse type; Carcinoma, diffuse type; Diffuse Type Adenocarcinoma; diffuse type adenocarcinoma; Diffuse Type Carcinoma; diffuse type carcinoma
SNOMED CT: Adenocarcinoma - diffuse type (24505004); Carcinoma - diffuse type (24505004); Carcinoma, diffuse type (24505004); Adenocarcinoma, diffuse type (24505004)
 
Monarch Initiative: MONDO:0021652

Definition

An adenocarcinoma characterized by the presence of a diffuse cellular infiltrate which is composed of poorly cohesive cells with minimal or no glandular formations. Representative example is the gastric diffuse adenocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDiffuse type adenocarcinoma

Professional guidelines

PubMed

Helicobacter pylori genotypes determine risk of non-cardia gastric cancer and intestinal- or diffuse-type GC in Ardabil: A very high-risk area in Northwestern Iran.
Abdi E, Latifi-Navid S, Zahri S, Yazdanbod A, Safaralizadeh R
Microb Pathog 2017 Jun;107:287-292. Epub 2017 Apr 5 doi: 10.1016/j.micpath.2017.04.007. PMID: 28390977

Recent clinical studies

Therapy

Helicobacter pylori Infection Facilitates the Expression of Resistin-like Molecule Beta in Gastric Carcinoma and Precursor Lesions.
Li HJ, Fang EH, Wang JQ, Zheng LD, Tong QS
Curr Med Sci 2020 Feb;40(1):95-103. Epub 2020 Mar 13 doi: 10.1007/s11596-020-2151-y. PMID: 32166670
Geospatial analyses identify regional hot spots of diffuse gastric cancer in rural Central America.
Dominguez RL, Cherry CB, Estevez-Ordonez D, Mera R, Escamilla V, Pawlita M, Waterboer T, Wilson KT, Peek RM, Tavera G, Williams SM, Gulley ML, Emch M, Morgan DR
BMC Cancer 2019 Jun 7;19(1):545. doi: 10.1186/s12885-019-5726-x. PMID: 31174492Free PMC Article
A phase III trial comparing oral S-1/cisplatin and intravenous 5-fluorouracil/cisplatin in patients with untreated diffuse gastric cancer.
Ajani JA, Abramov M, Bondarenko I, Shparyk Y, Gorbunova V, Hontsa A, Otchenash N, Alsina M, Lazarev S, Feliu J, Elme A, Esko V, Abdalla K, Verma U, Benedetti F, Aoyama T, Mizuguchi H, Makris L, Rosati G; DIGEST Study Group
Ann Oncol 2017 Sep 1;28(9):2142-2148. doi: 10.1093/annonc/mdx275. PMID: 28911091
Leptomeningeal carcinomatosis associated with gastric cancer.
Tomita H, Yasui H, Boku N, Nakasu Y, Mitsuya K, Onozawa Y, Fukutomi A, Yamazaki K, Machida N, Taku K, Todaka A, Taniguchi H, Tsushima T
Int J Clin Oncol 2012 Aug;17(4):361-6. Epub 2011 Aug 17 doi: 10.1007/s10147-011-0301-8. PMID: 21847535
Dietary antioxidant intake and the risk of cardia cancer and noncardia cancer of the intestinal and diffuse types: a population-based case-control study in Sweden.
Ekström AM, Serafini M, Nyrén O, Hansson LE, Ye W, Wolk A
Int J Cancer 2000 Jul 1;87(1):133-40. PMID: 10861464

Prognosis

Multimodal Therapy Versus Primary Surgery for Gastric and Gastroesophageal Junction Diffuse Type Carcinoma, with a Focus on Signet Ring Cell Carcinoma: A Nationwide Study.
Gertsen EC, van der Veen A, Brenkman HJF, Brosens LAA, van der Post RS, Verhoeven RHA, Luijten JCHBM, Vissers PAJ, Vegt E, van Hillegersberg R, Siersema PD, Ruurda JP
Ann Surg Oncol 2024 Mar;31(3):1760-1772. Epub 2023 Dec 21 doi: 10.1245/s10434-023-14690-y. PMID: 38127213
A deep learning model for gastric diffuse-type adenocarcinoma classification in whole slide images.
Kanavati F, Tsuneki M
Sci Rep 2021 Oct 14;11(1):20486. doi: 10.1038/s41598-021-99940-3. PMID: 34650155Free PMC Article
A population-based study on intestinal and diffuse type adenocarcinoma of the oesophagus and stomach in the Netherlands between 1989 and 2015.
van der Kaaij RT, Koemans WJ, van Putten M, Snaebjornsson P, Luijten JCHBM, van Dieren JM, Cats A, Lemmens VEPP, Verhoeven RHA, van Sandick JW
Eur J Cancer 2020 May;130:23-31. Epub 2020 Mar 11 doi: 10.1016/j.ejca.2020.02.017. PMID: 32171106
Tumor Budding and Prognosis in Gastric Adenocarcinoma.
Kemi N, Eskuri M, Ikäläinen J, Karttunen TJ, Kauppila JH
Am J Surg Pathol 2019 Feb;43(2):229-234. doi: 10.1097/PAS.0000000000001181. PMID: 30334831
Helicobacter pylori genotypes determine risk of non-cardia gastric cancer and intestinal- or diffuse-type GC in Ardabil: A very high-risk area in Northwestern Iran.
Abdi E, Latifi-Navid S, Zahri S, Yazdanbod A, Safaralizadeh R
Microb Pathog 2017 Jun;107:287-292. Epub 2017 Apr 5 doi: 10.1016/j.micpath.2017.04.007. PMID: 28390977

Clinical prediction guides

Expression of HER2/neu in gastric adenocarcinoma and its correlation with serum HER2/neu level and E-cadherin expression.
Pandey I, Misra V, Pandey AT, Verma A
Indian J Pathol Microbiol 2022 Jan-Mar;65(1):35-41. doi: 10.4103/ijpm.ijpm_133_21. PMID: 35074963
Helicobacter pylori Infection Facilitates the Expression of Resistin-like Molecule Beta in Gastric Carcinoma and Precursor Lesions.
Li HJ, Fang EH, Wang JQ, Zheng LD, Tong QS
Curr Med Sci 2020 Feb;40(1):95-103. Epub 2020 Mar 13 doi: 10.1007/s11596-020-2151-y. PMID: 32166670
Helicobacter pylori genotypes determine risk of non-cardia gastric cancer and intestinal- or diffuse-type GC in Ardabil: A very high-risk area in Northwestern Iran.
Abdi E, Latifi-Navid S, Zahri S, Yazdanbod A, Safaralizadeh R
Microb Pathog 2017 Jun;107:287-292. Epub 2017 Apr 5 doi: 10.1016/j.micpath.2017.04.007. PMID: 28390977
Leptomeningeal carcinomatosis associated with gastric cancer.
Tomita H, Yasui H, Boku N, Nakasu Y, Mitsuya K, Onozawa Y, Fukutomi A, Yamazaki K, Machida N, Taku K, Todaka A, Taniguchi H, Tsushima T
Int J Clin Oncol 2012 Aug;17(4):361-6. Epub 2011 Aug 17 doi: 10.1007/s10147-011-0301-8. PMID: 21847535
Expression of MUC2 in gastric carcinomas and background mucosae.
Lee HW, Yang DH, Kim HK, Lee BH, Choi KC, Choi YH, Park YE
J Gastroenterol Hepatol 2007 Aug;22(8):1336-43. Epub 2007 Jun 7 doi: 10.1111/j.1440-1746.2007.04939.x. PMID: 17559374

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