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Localized Esophageal Carcinoma

MedGen UID:
1711643
•Concept ID:
C5237751
•
Neoplastic Process
Synonym: Non-Metastatic Esophageal Carcinoma

Definition

Esophageal carcinoma that is confined to the site in which it initially manifested without evidence of spread to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocalized Esophageal Carcinoma

Professional guidelines

PubMed

Health-related quality of life during neoadjuvant treatment and surgery for localized esophageal carcinoma.
Blazeby JM, Sanford E, Falk SJ, Alderson D, Donovan JL
Cancer 2005 May 1;103(9):1791-9. doi: 10.1002/cncr.20980. PMID: 15779022
Combined modality radiotherapy and chemotherapy in nonsurgical management of localized carcinoma of the esophagus: a practice guideline.
Wong RK, Malthaner RA, Zuraw L, Rumble RB; Cancer Care Ontario Practice Guidelines Initiative Gastrointestinal Cancer Disease Site Group
Int J Radiat Oncol Biol Phys 2003 Mar 15;55(4):930-42. doi: 10.1016/s0360-3016(02)04278-5. PMID: 12605971

Recent clinical studies

Etiology

Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer.
Vellayappan BA, Soon YY, Ku GY, Leong CN, Lu JJ, Tey JC
Cochrane Database Syst Rev 2017 Aug 22;8(8):CD010511. doi: 10.1002/14651858.CD010511.pub2. PMID: 28829911Free PMC Article
WITHDRAWN. Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus.
Wong RK, Malthaner R
Cochrane Database Syst Rev 2010 Jan 20;2010(1):CD002092. doi: 10.1002/14651858.CD002092.pub3. PMID: 20091530Free PMC Article
Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus.
Wong R, Malthaner R
Cochrane Database Syst Rev 2006 Jan 25;(1):CD002092. doi: 10.1002/14651858.CD002092.pub2. PMID: 16437440
Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus.
Rebecca WO, Richard MA
Cochrane Database Syst Rev 2003;(1):CD002092. doi: 10.1002/14651858.CD002092. PMID: 12535428
Concurrent radiation therapy and chemotherapy followed by esophagectomy for localized esophageal carcinoma.
Bates BA, Detterbeck FC, Bernard SA, Qaqish BF, Tepper JE
J Clin Oncol 1996 Jan;14(1):156-63. doi: 10.1200/JCO.1996.14.1.156. PMID: 8558191

Diagnosis

WITHDRAWN. Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus.
Wong RK, Malthaner R
Cochrane Database Syst Rev 2010 Jan 20;2010(1):CD002092. doi: 10.1002/14651858.CD002092.pub3. PMID: 20091530Free PMC Article
Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus.
Wong R, Malthaner R
Cochrane Database Syst Rev 2006 Jan 25;(1):CD002092. doi: 10.1002/14651858.CD002092.pub2. PMID: 16437440
Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus.
Rebecca WO, Richard MA
Cochrane Database Syst Rev 2003;(1):CD002092. doi: 10.1002/14651858.CD002092. PMID: 12535428
Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus.
Wong R, Malthaner R
Cochrane Database Syst Rev 2001;(2):CD002092. doi: 10.1002/14651858.CD002092. PMID: 11406033
Concurrent radiation therapy and chemotherapy followed by esophagectomy for localized esophageal carcinoma.
Bates BA, Detterbeck FC, Bernard SA, Qaqish BF, Tepper JE
J Clin Oncol 1996 Jan;14(1):156-63. doi: 10.1200/JCO.1996.14.1.156. PMID: 8558191

Therapy

Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer.
Vellayappan BA, Soon YY, Ku GY, Leong CN, Lu JJ, Tey JC
Cochrane Database Syst Rev 2017 Aug 22;8(8):CD010511. doi: 10.1002/14651858.CD010511.pub2. PMID: 28829911Free PMC Article
WITHDRAWN. Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus.
Wong RK, Malthaner R
Cochrane Database Syst Rev 2010 Jan 20;2010(1):CD002092. doi: 10.1002/14651858.CD002092.pub3. PMID: 20091530Free PMC Article
Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus.
Wong R, Malthaner R
Cochrane Database Syst Rev 2006 Jan 25;(1):CD002092. doi: 10.1002/14651858.CD002092.pub2. PMID: 16437440
Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus.
Rebecca WO, Richard MA
Cochrane Database Syst Rev 2003;(1):CD002092. doi: 10.1002/14651858.CD002092. PMID: 12535428
Concurrent radiation therapy and chemotherapy followed by esophagectomy for localized esophageal carcinoma.
Bates BA, Detterbeck FC, Bernard SA, Qaqish BF, Tepper JE
J Clin Oncol 1996 Jan;14(1):156-63. doi: 10.1200/JCO.1996.14.1.156. PMID: 8558191

Prognosis

Incidence of Brain Metastasis as First Event in Patients with Esophageal Carcinoma: a Report from Three Prospective Alliance Clinical Trials.
Smith RS, Foster NR, Jatoi A, Thomé SD, Miller RC
J Gastrointest Cancer 2023 Sep;54(3):846-854. Epub 2022 Oct 17 doi: 10.1007/s12029-022-00871-7. PMID: 36251211Free PMC Article
The role of qualitative and quantitative analysis of F18-FDG positron emission tomography in predicting pathologic response following chemoradiotherapy in patients with esophageal carcinoma.
Klayton T, Li T, Yu JQ, Keller L, Cheng J, Cohen SJ, Meropol NJ, Scott W, Xu-Welliver M, Konski A
J Gastrointest Cancer 2012 Dec;43(4):612-8. doi: 10.1007/s12029-012-9412-3. PMID: 22777832
Is combined chemotherapy and radiation therapy equally effective as surgical resection in localized esophageal carcinoma?
Chan A, Wong A
Int J Radiat Oncol Biol Phys 1999 Sep 1;45(2):265-70. doi: 10.1016/s0360-3016(99)00199-6. PMID: 10487544
Concurrent radiation therapy and chemotherapy followed by esophagectomy for localized esophageal carcinoma.
Bates BA, Detterbeck FC, Bernard SA, Qaqish BF, Tepper JE
J Clin Oncol 1996 Jan;14(1):156-63. doi: 10.1200/JCO.1996.14.1.156. PMID: 8558191
Results of surgery in multimodality therapy of esophageal cancer.
Schlag P
Onkologie 1991 Feb;14(1):13-4, 16, 18-20. doi: 10.1159/000216939. PMID: 2057171

Clinical prediction guides

The role of qualitative and quantitative analysis of F18-FDG positron emission tomography in predicting pathologic response following chemoradiotherapy in patients with esophageal carcinoma.
Klayton T, Li T, Yu JQ, Keller L, Cheng J, Cohen SJ, Meropol NJ, Scott W, Xu-Welliver M, Konski A
J Gastrointest Cancer 2012 Dec;43(4):612-8. doi: 10.1007/s12029-012-9412-3. PMID: 22777832
Health-related quality of life during neoadjuvant treatment and surgery for localized esophageal carcinoma.
Blazeby JM, Sanford E, Falk SJ, Alderson D, Donovan JL
Cancer 2005 May 1;103(9):1791-9. doi: 10.1002/cncr.20980. PMID: 15779022
Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus.
Rebecca WO, Richard MA
Cochrane Database Syst Rev 2003;(1):CD002092. doi: 10.1002/14651858.CD002092. PMID: 12535428
Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus.
Wong R, Malthaner R
Cochrane Database Syst Rev 2001;(2):CD002092. doi: 10.1002/14651858.CD002092. PMID: 11406033
Concurrent radiation therapy and chemotherapy followed by esophagectomy for localized esophageal carcinoma.
Bates BA, Detterbeck FC, Bernard SA, Qaqish BF, Tepper JE
J Clin Oncol 1996 Jan;14(1):156-63. doi: 10.1200/JCO.1996.14.1.156. PMID: 8558191

Recent systematic reviews

Chemoradiotherapy versus chemoradiotherapy plus surgery for esophageal cancer.
Vellayappan BA, Soon YY, Ku GY, Leong CN, Lu JJ, Tey JC
Cochrane Database Syst Rev 2017 Aug 22;8(8):CD010511. doi: 10.1002/14651858.CD010511.pub2. PMID: 28829911Free PMC Article
WITHDRAWN. Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus.
Wong RK, Malthaner R
Cochrane Database Syst Rev 2010 Jan 20;2010(1):CD002092. doi: 10.1002/14651858.CD002092.pub3. PMID: 20091530Free PMC Article
Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus.
Wong R, Malthaner R
Cochrane Database Syst Rev 2006 Jan 25;(1):CD002092. doi: 10.1002/14651858.CD002092.pub2. PMID: 16437440
Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus.
Rebecca WO, Richard MA
Cochrane Database Syst Rev 2003;(1):CD002092. doi: 10.1002/14651858.CD002092. PMID: 12535428
Combined chemotherapy and radiotherapy (without surgery) compared with radiotherapy alone in localized carcinoma of the esophagus.
Wong R, Malthaner R
Cochrane Database Syst Rev 2001;(2):CD002092. doi: 10.1002/14651858.CD002092. PMID: 11406033

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