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Metastatic Cutaneous Melanoma

MedGen UID:
272113
•Concept ID:
C1321872
•
Neoplastic Process

Definition

A melanoma that arises from the skin and has metastasized to another anatomic site. [from NCI]

Professional guidelines

PubMed

Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of melanoma, version 3.0.
Pavlick AC, Ariyan CE, Buchbinder EI, Davar D, Gibney GT, Hamid O, Hieken TJ, Izar B, Johnson DB, Kulkarni RP, Luke JJ, Mitchell TC, Mooradian MJ, Rubin KM, Salama AK, Shirai K, Taube JM, Tawbi HA, Tolley JK, Valdueza C, Weiss SA, Wong MK, Sullivan RJ
J Immunother Cancer 2023 Oct;11(10) doi: 10.1136/jitc-2023-006947. PMID: 37852736Free PMC Article
Systemic Therapy for Melanoma: ASCO Guideline Update.
Seth R, Agarwala SS, Messersmith H, Alluri KC, Ascierto PA, Atkins MB, Bollin K, Chacon M, Davis N, Faries MB, Funchain P, Gold JS, Guild S, Gyorki DE, Kaur V, Khushalani NI, Kirkwood JM, McQuade JL, Meyers MO, Provenzano A, Robert C, Santinami M, Sehdev A, Sondak VK, Spurrier G, Swami U, Truong TG, Tsai KK, van Akkooi A, Weber J
J Clin Oncol 2023 Oct 20;41(30):4794-4820. Epub 2023 Aug 14 doi: 10.1200/JCO.23.01136. PMID: 37579248
In-transit metastatic cutaneous melanoma: current management and future directions.
Patel A, Carr MJ, Sun J, Zager JS
Clin Exp Metastasis 2022 Feb;39(1):201-211. Epub 2021 May 17 doi: 10.1007/s10585-021-10100-3. PMID: 33999365

Recent clinical studies

Etiology

Prognostic and predictive biomarkers in melanoma.
Maher NG, Vergara IA, Long GV, Scolyer RA
Pathology 2024 Mar;56(2):259-273. Epub 2023 Dec 20 doi: 10.1016/j.pathol.2023.11.004. PMID: 38245478
Efficacy of adoptive therapy with tumor-infiltrating lymphocytes and recombinant interleukin-2 in advanced cutaneous melanoma: a systematic review and meta-analysis.
Dafni U, Michielin O, Lluesma SM, Tsourti Z, Polydoropoulou V, Karlis D, Besser MJ, Haanen J, Svane IM, Ohashi PS, Kammula US, Orcurto A, Zimmermann S, Trueb L, Klebanoff CA, Lotze MT, Kandalaft LE, Coukos G
Ann Oncol 2019 Dec 1;30(12):1902-1913. doi: 10.1093/annonc/mdz398. PMID: 31566658
Overall survival in patients with BRAF-mutant melanoma receiving encorafenib plus binimetinib versus vemurafenib or encorafenib (COLUMBUS): a multicentre, open-label, randomised, phase 3 trial.
Dummer R, Ascierto PA, Gogas HJ, Arance A, Mandala M, Liszkay G, Garbe C, Schadendorf D, Krajsova I, Gutzmer R, Chiarion Sileni V, Dutriaux C, de Groot JWB, Yamazaki N, Loquai C, Moutouh-de Parseval LA, Pickard MD, Sandor V, Robert C, Flaherty KT
Lancet Oncol 2018 Oct;19(10):1315-1327. Epub 2018 Sep 12 doi: 10.1016/S1470-2045(18)30497-2. PMID: 30219628
Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF-mutant melanoma (COLUMBUS): a multicentre, open-label, randomised phase 3 trial.
Dummer R, Ascierto PA, Gogas HJ, Arance A, Mandala M, Liszkay G, Garbe C, Schadendorf D, Krajsova I, Gutzmer R, Chiarion-Sileni V, Dutriaux C, de Groot JWB, Yamazaki N, Loquai C, Moutouh-de Parseval LA, Pickard MD, Sandor V, Robert C, Flaherty KT
Lancet Oncol 2018 May;19(5):603-615. Epub 2018 Mar 21 doi: 10.1016/S1470-2045(18)30142-6. PMID: 29573941
Systemic treatments for metastatic cutaneous melanoma.
Pasquali S, Hadjinicolaou AV, Chiarion Sileni V, Rossi CR, Mocellin S
Cochrane Database Syst Rev 2018 Feb 6;2(2):CD011123. doi: 10.1002/14651858.CD011123.pub2. PMID: 29405038Free PMC Article

Diagnosis

Prognostic and predictive biomarkers in melanoma.
Maher NG, Vergara IA, Long GV, Scolyer RA
Pathology 2024 Mar;56(2):259-273. Epub 2023 Dec 20 doi: 10.1016/j.pathol.2023.11.004. PMID: 38245478
Blocking Genomic Instability Prevents Acquired Resistance to MAPK Inhibitor Therapy in Melanoma.
Dharanipragada P, Zhang X, Liu S, Lomeli SH, Hong A, Wang Y, Yang Z, Lo KZ, Vega-Crespo A, Ribas A, Moschos SJ, Moriceau G, Lo RS
Cancer Discov 2023 Apr 3;13(4):880-909. doi: 10.1158/2159-8290.CD-22-0787. PMID: 36700848Free PMC Article
Pleural Melanoma Metastasis.
D'Ambrosio AE, Albonico G, Enide I, Mordà O, Maisano M, Mondello B
Ann Thorac Surg 2021 Aug;112(2):e103-e105. Epub 2021 Jan 7 doi: 10.1016/j.athoracsur.2020.09.088. PMID: 33421399
Efficacy of adoptive therapy with tumor-infiltrating lymphocytes and recombinant interleukin-2 in advanced cutaneous melanoma: a systematic review and meta-analysis.
Dafni U, Michielin O, Lluesma SM, Tsourti Z, Polydoropoulou V, Karlis D, Besser MJ, Haanen J, Svane IM, Ohashi PS, Kammula US, Orcurto A, Zimmermann S, Trueb L, Klebanoff CA, Lotze MT, Kandalaft LE, Coukos G
Ann Oncol 2019 Dec 1;30(12):1902-1913. doi: 10.1093/annonc/mdz398. PMID: 31566658
Immunotherapy in managing metastatic melanoma: which treatment when?
Amaral T, Meraz-Torres F, Garbe C
Expert Opin Biol Ther 2017 Dec;17(12):1523-1538. Epub 2017 Sep 17 doi: 10.1080/14712598.2017.1378640. PMID: 28891339

Therapy

Systemic Therapy for Melanoma: ASCO Guideline Update.
Seth R, Agarwala SS, Messersmith H, Alluri KC, Ascierto PA, Atkins MB, Bollin K, Chacon M, Davis N, Faries MB, Funchain P, Gold JS, Guild S, Gyorki DE, Kaur V, Khushalani NI, Kirkwood JM, McQuade JL, Meyers MO, Provenzano A, Robert C, Santinami M, Sehdev A, Sondak VK, Spurrier G, Swami U, Truong TG, Tsai KK, van Akkooi A, Weber J
J Clin Oncol 2023 Oct 20;41(30):4794-4820. Epub 2023 Aug 14 doi: 10.1200/JCO.23.01136. PMID: 37579248
Tebentafusp, A TCR/Anti-CD3 Bispecific Fusion Protein Targeting gp100, Potently Activated Antitumor Immune Responses in Patients with Metastatic Melanoma.
Middleton MR, McAlpine C, Woodcock VK, Corrie P, Infante JR, Steven NM, Evans TRJ, Anthoney A, Shoushtari AN, Hamid O, Gupta A, Vardeu A, Leach E, Naidoo R, Stanhope S, Lewis S, Hurst J, O'Kelly I, Sznol M
Clin Cancer Res 2020 Nov 15;26(22):5869-5878. Epub 2020 Aug 18 doi: 10.1158/1078-0432.CCR-20-1247. PMID: 32816891Free PMC Article
Efficacy of adoptive therapy with tumor-infiltrating lymphocytes and recombinant interleukin-2 in advanced cutaneous melanoma: a systematic review and meta-analysis.
Dafni U, Michielin O, Lluesma SM, Tsourti Z, Polydoropoulou V, Karlis D, Besser MJ, Haanen J, Svane IM, Ohashi PS, Kammula US, Orcurto A, Zimmermann S, Trueb L, Klebanoff CA, Lotze MT, Kandalaft LE, Coukos G
Ann Oncol 2019 Dec 1;30(12):1902-1913. doi: 10.1093/annonc/mdz398. PMID: 31566658
Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF-mutant melanoma (COLUMBUS): a multicentre, open-label, randomised phase 3 trial.
Dummer R, Ascierto PA, Gogas HJ, Arance A, Mandala M, Liszkay G, Garbe C, Schadendorf D, Krajsova I, Gutzmer R, Chiarion-Sileni V, Dutriaux C, de Groot JWB, Yamazaki N, Loquai C, Moutouh-de Parseval LA, Pickard MD, Sandor V, Robert C, Flaherty KT
Lancet Oncol 2018 May;19(5):603-615. Epub 2018 Mar 21 doi: 10.1016/S1470-2045(18)30142-6. PMID: 29573941
Systemic treatments for metastatic cutaneous melanoma.
Pasquali S, Hadjinicolaou AV, Chiarion Sileni V, Rossi CR, Mocellin S
Cochrane Database Syst Rev 2018 Feb 6;2(2):CD011123. doi: 10.1002/14651858.CD011123.pub2. PMID: 29405038Free PMC Article

Prognosis

Uveal melanoma immunogenomics predict immunotherapy resistance and susceptibility.
Leonard-Murali S, Bhaskarla C, Yadav GS, Maurya SK, Galiveti CR, Tobin JA, Kann RJ, Ashwat E, Murphy PS, Chakka AB, Soman V, Cantalupo PG, Zhuo X, Vyas G, Kozak DL, Kelly LM, Smith E, Chandran UR, Hsu YS, Kammula US
Nat Commun 2024 Apr 16;15(1):2863. doi: 10.1038/s41467-024-46906-4. PMID: 38627362Free PMC Article
Prognostic and predictive biomarkers in melanoma.
Maher NG, Vergara IA, Long GV, Scolyer RA
Pathology 2024 Mar;56(2):259-273. Epub 2023 Dec 20 doi: 10.1016/j.pathol.2023.11.004. PMID: 38245478
Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of melanoma, version 3.0.
Pavlick AC, Ariyan CE, Buchbinder EI, Davar D, Gibney GT, Hamid O, Hieken TJ, Izar B, Johnson DB, Kulkarni RP, Luke JJ, Mitchell TC, Mooradian MJ, Rubin KM, Salama AK, Shirai K, Taube JM, Tawbi HA, Tolley JK, Valdueza C, Weiss SA, Wong MK, Sullivan RJ
J Immunother Cancer 2023 Oct;11(10) doi: 10.1136/jitc-2023-006947. PMID: 37852736Free PMC Article
Cutaneous and uveal melanoma: two different cancers in therapeutic needs.
Bertolotto C
C R Biol 2021 Nov 15;344(3):219-231. doi: 10.5802/crbiol.63. PMID: 35786627
Systemic treatments for metastatic cutaneous melanoma.
Pasquali S, Hadjinicolaou AV, Chiarion Sileni V, Rossi CR, Mocellin S
Cochrane Database Syst Rev 2018 Feb 6;2(2):CD011123. doi: 10.1002/14651858.CD011123.pub2. PMID: 29405038Free PMC Article

Clinical prediction guides

Uveal melanoma immunogenomics predict immunotherapy resistance and susceptibility.
Leonard-Murali S, Bhaskarla C, Yadav GS, Maurya SK, Galiveti CR, Tobin JA, Kann RJ, Ashwat E, Murphy PS, Chakka AB, Soman V, Cantalupo PG, Zhuo X, Vyas G, Kozak DL, Kelly LM, Smith E, Chandran UR, Hsu YS, Kammula US
Nat Commun 2024 Apr 16;15(1):2863. doi: 10.1038/s41467-024-46906-4. PMID: 38627362Free PMC Article
Prognostic and predictive biomarkers in melanoma.
Maher NG, Vergara IA, Long GV, Scolyer RA
Pathology 2024 Mar;56(2):259-273. Epub 2023 Dec 20 doi: 10.1016/j.pathol.2023.11.004. PMID: 38245478
Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of melanoma, version 3.0.
Pavlick AC, Ariyan CE, Buchbinder EI, Davar D, Gibney GT, Hamid O, Hieken TJ, Izar B, Johnson DB, Kulkarni RP, Luke JJ, Mitchell TC, Mooradian MJ, Rubin KM, Salama AK, Shirai K, Taube JM, Tawbi HA, Tolley JK, Valdueza C, Weiss SA, Wong MK, Sullivan RJ
J Immunother Cancer 2023 Oct;11(10) doi: 10.1136/jitc-2023-006947. PMID: 37852736Free PMC Article
Metastatic Melanoma to a Neurofibroma.
Ireland A, Williams B, Rijhumal A, Mesbah Ardakani N
Am J Dermatopathol 2022 Sep 1;44(9):683-686. Epub 2022 Apr 11 doi: 10.1097/DAD.0000000000002199. PMID: 35475788
Tebentafusp, A TCR/Anti-CD3 Bispecific Fusion Protein Targeting gp100, Potently Activated Antitumor Immune Responses in Patients with Metastatic Melanoma.
Middleton MR, McAlpine C, Woodcock VK, Corrie P, Infante JR, Steven NM, Evans TRJ, Anthoney A, Shoushtari AN, Hamid O, Gupta A, Vardeu A, Leach E, Naidoo R, Stanhope S, Lewis S, Hurst J, O'Kelly I, Sznol M
Clin Cancer Res 2020 Nov 15;26(22):5869-5878. Epub 2020 Aug 18 doi: 10.1158/1078-0432.CCR-20-1247. PMID: 32816891Free PMC Article

Recent systematic reviews

Systemic Therapy for Melanoma: ASCO Guideline Update.
Seth R, Agarwala SS, Messersmith H, Alluri KC, Ascierto PA, Atkins MB, Bollin K, Chacon M, Davis N, Faries MB, Funchain P, Gold JS, Guild S, Gyorki DE, Kaur V, Khushalani NI, Kirkwood JM, McQuade JL, Meyers MO, Provenzano A, Robert C, Santinami M, Sehdev A, Sondak VK, Spurrier G, Swami U, Truong TG, Tsai KK, van Akkooi A, Weber J
J Clin Oncol 2023 Oct 20;41(30):4794-4820. Epub 2023 Aug 14 doi: 10.1200/JCO.23.01136. PMID: 37579248
Preferentially Expressed Antigen in Melanoma (PRAME) and Human Malignant Melanoma: A Retrospective Study.
Cazzato G, Mangialardi K, Falcicchio G, Colagrande A, Ingravallo G, Arezzo F, Giliberti G, Trilli I, Loizzi V, Lettini T, Scarcella S, Annese T, Parente P, Lupo C, Casatta N, Maiorano E, Cormio G, Resta L, Ribatti D
Genes (Basel) 2022 Mar 19;13(3) doi: 10.3390/genes13030545. PMID: 35328098Free PMC Article
Efficacy of adoptive therapy with tumor-infiltrating lymphocytes and recombinant interleukin-2 in advanced cutaneous melanoma: a systematic review and meta-analysis.
Dafni U, Michielin O, Lluesma SM, Tsourti Z, Polydoropoulou V, Karlis D, Besser MJ, Haanen J, Svane IM, Ohashi PS, Kammula US, Orcurto A, Zimmermann S, Trueb L, Klebanoff CA, Lotze MT, Kandalaft LE, Coukos G
Ann Oncol 2019 Dec 1;30(12):1902-1913. doi: 10.1093/annonc/mdz398. PMID: 31566658
WITHDRAWN: Systemic treatments for metastatic cutaneous melanoma.
Crosby T, Fish R, Coles B, Mason M
Cochrane Database Syst Rev 2018 Feb 7;2(2):CD001215. doi: 10.1002/14651858.CD001215.pub2. PMID: 29411867Free PMC Article
Systemic treatments for metastatic cutaneous melanoma.
Pasquali S, Hadjinicolaou AV, Chiarion Sileni V, Rossi CR, Mocellin S
Cochrane Database Syst Rev 2018 Feb 6;2(2):CD011123. doi: 10.1002/14651858.CD011123.pub2. PMID: 29405038Free PMC Article

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