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Malignant Inner Ear Neoplasm

MedGen UID:
1757413
•Concept ID:
C2837942
•
Neoplastic Process

Definition

A malignant neoplasm that affects the inner ear. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Inner Ear Neoplasm

Professional guidelines

PubMed

The Future of Vestibular Schwannoma Management.
Moore LS, Stankovic KM
Otolaryngol Clin North Am 2023 Jun;56(3):611-622. Epub 2023 Apr 3 doi: 10.1016/j.otc.2023.02.018. PMID: 37019772
Prenatal diagnosis of vermian cyst: a new type of posterior fossa cyst.
Chanclud J, Valence S, Perre SV, Guilbaud L, Moutard ML, Jouannic JM, Ducou Le Pointe H, Blondiaux E, Garel C
Pediatr Radiol 2023 Mar;53(3):461-469. Epub 2022 Oct 24 doi: 10.1007/s00247-022-05531-3. PMID: 36274068
Clinical features and treatment of endolymphatic sac tumor.
Bae SH, Kim SS, Kwak SH, Jung JS, Choi JY, Moon IS
Acta Otolaryngol 2020 Jun;140(6):433-437. Epub 2020 Feb 18 doi: 10.1080/00016489.2020.1722855. PMID: 32068496

Recent clinical studies

Etiology

MRI can help differentiate Ménière's disease from other menieriform diseases.
Li J, Li L, Jin X, Hu N, Kong X, Wang L, Li X, Dou W, Sun L, Li C, Gong R
Sci Rep 2023 Dec 6;13(1):21527. doi: 10.1038/s41598-023-49066-5. PMID: 38057393Free PMC Article
von Hippel-Lindau disease: Updated guideline for diagnosis and surveillance.
Louise M Binderup M, Smerdel M, Borgwadt L, Beck Nielsen SS, Madsen MG, Møller HU, Kiilgaard JF, Friis-Hansen L, Harbud V, Cortnum S, Owen H, Gimsing S, Friis Juhl HA, Munthe S, Geilswijk M, Rasmussen ÅK, Møldrup U, Graumann O, Donskov F, Grønbæk H, Stausbøl-Grøn B, Schaffalitzky de Muckadell O, Knigge U, Dam G, Wadt KA, Bøgeskov L, Bagi P, Lund L, Stochholm K, Ousager LB, Sunde L
Eur J Med Genet 2022 Aug;65(8):104538. Epub 2022 Jun 13 doi: 10.1016/j.ejmg.2022.104538. PMID: 35709961
SOX10: 20 years of phenotypic plurality and current understanding of its developmental function.
Pingault V, Zerad L, Bertani-Torres W, Bondurand N
J Med Genet 2022 Feb;59(2):105-114. Epub 2021 Oct 19 doi: 10.1136/jmedgenet-2021-108105. PMID: 34667088Free PMC Article
Aminoglycoside- and Cisplatin-Induced Ototoxicity: Mechanisms and Otoprotective Strategies.
Kros CJ, Steyger PS
Cold Spring Harb Perspect Med 2019 Nov 1;9(11) doi: 10.1101/cshperspect.a033548. PMID: 30559254Free PMC Article
Radiotherapy-induced ear toxicity.
Jereczek-Fossa BA, Zarowski A, Milani F, Orecchia R
Cancer Treat Rev 2003 Oct;29(5):417-30. doi: 10.1016/s0305-7372(03)00066-5. PMID: 12972360

Diagnosis

MRI can help differentiate Ménière's disease from other menieriform diseases.
Li J, Li L, Jin X, Hu N, Kong X, Wang L, Li X, Dou W, Sun L, Li C, Gong R
Sci Rep 2023 Dec 6;13(1):21527. doi: 10.1038/s41598-023-49066-5. PMID: 38057393Free PMC Article
The Vestibulocochlear Nerve: Anatomy and Pathology.
Corrêa DG, Hygino da Cruz LC Jr, Freddi TAL
Semin Ultrasound CT MR 2023 Apr;44(2):81-94. Epub 2023 Mar 22 doi: 10.1053/j.sult.2023.03.007. PMID: 37055143
Intralabyrinthine schwannomas.
Frisch CD, Eckel LJ, Lane JI, Neff BA
Otolaryngol Clin North Am 2015 Jun;48(3):423-41. Epub 2015 Apr 9 doi: 10.1016/j.otc.2015.02.004. PMID: 25863567
Endolymphatic sac tumors.
Wick CC, Manzoor NF, Semaan MT, Megerian CA
Otolaryngol Clin North Am 2015 Apr;48(2):317-30. Epub 2015 Jan 31 doi: 10.1016/j.otc.2014.12.006. PMID: 25650230
Intralabyrinthine schwannomas.
Neff BA, Willcox TO Jr, Sataloff RT
Otol Neurotol 2003 Mar;24(2):299-307. doi: 10.1097/00129492-200303000-00028. PMID: 12621348

Therapy

Circulating IL-17 reduces the risk of cisplatin-induced hearing loss in children: a bidirectional two-sample Mendelian randomization study.
Xu Y, Huang C, Liu J, Xu Y, Yang H
Sci Rep 2023 Nov 2;13(1):18957. doi: 10.1038/s41598-023-46299-2. PMID: 37919361Free PMC Article
In vivo delivery of CRISPR-Cas9 genome editing components for therapeutic applications.
Huang K, Zapata D, Tang Y, Teng Y, Li Y
Biomaterials 2022 Dec;291:121876. Epub 2022 Oct 28 doi: 10.1016/j.biomaterials.2022.121876. PMID: 36334354Free PMC Article
Aminoglycoside- and Cisplatin-Induced Ototoxicity: Mechanisms and Otoprotective Strategies.
Kros CJ, Steyger PS
Cold Spring Harb Perspect Med 2019 Nov 1;9(11) doi: 10.1101/cshperspect.a033548. PMID: 30559254Free PMC Article
Radiation therapy and hearing loss.
Bhandare N, Jackson A, Eisbruch A, Pan CC, Flickinger JC, Antonelli P, Mendenhall WM
Int J Radiat Oncol Biol Phys 2010 Mar 1;76(3 Suppl):S50-7. doi: 10.1016/j.ijrobp.2009.04.096. PMID: 20171518Free PMC Article
Medical audiology.
Sataloff J, Vassallo L
Arch Otolaryngol 1970 Feb;91(2):208-11. doi: 10.1001/archotol.1970.00770040278023. PMID: 4905384

Prognosis

Growth rate of vestibular schwannoma.
Paldor I, Chen AS, Kaye AH
J Clin Neurosci 2016 Oct;32:1-8. Epub 2016 Jul 20 doi: 10.1016/j.jocn.2016.05.003. PMID: 27450283
Multisession Radiosurgery for Hearing Preservation.
Rashid A, Karam SD, Rashid B, Kim JH, Pang D, Jean W, Grimm J, Collins SP
Semin Radiat Oncol 2016 Apr;26(2):105-11. Epub 2015 Nov 25 doi: 10.1016/j.semradonc.2015.11.004. PMID: 27000506
Primary inner ear schwannomas: a case series and systematic review of the literature.
Van Abel KM, Carlson ML, Link MJ, Neff BA, Beatty CW, Lohse CM, Eckel LJ, Lane JI, Driscoll CL
Laryngoscope 2013 Aug;123(8):1957-66. Epub 2013 Jan 18 doi: 10.1002/lary.23928. PMID: 23335152
NeuroD: the predicted and the surprising.
Chae JH, Stein GH, Lee JE
Mol Cells 2004 Dec 31;18(3):271-88. PMID: 15650322
Radiotherapy-induced ear toxicity.
Jereczek-Fossa BA, Zarowski A, Milani F, Orecchia R
Cancer Treat Rev 2003 Oct;29(5):417-30. doi: 10.1016/s0305-7372(03)00066-5. PMID: 12972360

Clinical prediction guides

Burden of serious harms from diagnostic error in the USA.
Newman-Toker DE, Nassery N, Schaffer AC, Yu-Moe CW, Clemens GD, Wang Z, Zhu Y, Saber Tehrani AS, Fanai M, Hassoon A, Siegal D
BMJ Qual Saf 2024 Jan 19;33(2):109-120. doi: 10.1136/bmjqs-2021-014130. PMID: 37460118Free PMC Article
MRI can help differentiate Ménière's disease from other menieriform diseases.
Li J, Li L, Jin X, Hu N, Kong X, Wang L, Li X, Dou W, Sun L, Li C, Gong R
Sci Rep 2023 Dec 6;13(1):21527. doi: 10.1038/s41598-023-49066-5. PMID: 38057393Free PMC Article
SOX10: 20 years of phenotypic plurality and current understanding of its developmental function.
Pingault V, Zerad L, Bertani-Torres W, Bondurand N
J Med Genet 2022 Feb;59(2):105-114. Epub 2021 Oct 19 doi: 10.1136/jmedgenet-2021-108105. PMID: 34667088Free PMC Article
Intralabyrinthine schwannomas.
Neff BA, Willcox TO Jr, Sataloff RT
Otol Neurotol 2003 Mar;24(2):299-307. doi: 10.1097/00129492-200303000-00028. PMID: 12621348
von Hippel-Lindau disease.
Singh AD, Shields CL, Shields JA
Surv Ophthalmol 2001 Sep-Oct;46(2):117-42. doi: 10.1016/s0039-6257(01)00245-4. PMID: 11578646

Recent systematic reviews

Pre-habilitation with intratympanic gentamicin in vestibular schwannomas: a systematic review.
Potdar T, Kontorinis G
J Laryngol Otol 2023 Sep;137(9):985-991. Epub 2023 Apr 26 doi: 10.1017/S0022215123000725. PMID: 37185086
Transcanal Transpromontorial Approaches to the Internal Auditory Canal: A Systematic Review.
Palmisciano P, Doyle EJ 3rd, Hoz SS, Cass D, Samy RN, Andaluz N, Zuccarello M
Laryngoscope 2023 Nov;133(11):2856-2867. Epub 2023 Apr 20 doi: 10.1002/lary.30703. PMID: 37078512
Symptoms and clinical features in patients affected by endolymphatic sac tumor: a systematic review and meta-analysis.
Gioacchini FM, Kaleci S, Chiarella G, Viola P, Pisani D, Scarpa A, Tulli M, Pace A, Iannella G, Re M
Eur Arch Otorhinolaryngol 2022 Nov;279(11):5081-5088. Epub 2022 Jun 15 doi: 10.1007/s00405-022-07469-6. PMID: 35704074
Indications and contraindications of auditory brainstem implants: systematic review and illustrative cases.
Merkus P, Di Lella F, Di Trapani G, Pasanisi E, Beltrame MA, Zanetti D, Negri M, Sanna M
Eur Arch Otorhinolaryngol 2014 Jan;271(1):3-13. Epub 2013 Feb 13 doi: 10.1007/s00405-013-2378-3. PMID: 23404468
Primary inner ear schwannomas: a case series and systematic review of the literature.
Van Abel KM, Carlson ML, Link MJ, Neff BA, Beatty CW, Lohse CM, Eckel LJ, Lane JI, Driscoll CL
Laryngoscope 2013 Aug;123(8):1957-66. Epub 2013 Jan 18 doi: 10.1002/lary.23928. PMID: 23335152

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