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Penis verrucous carcinoma

MedGen UID:
234477
•Concept ID:
C1336955
•
Neoplastic Process
Synonyms: Penile Verrucous Carcinoma; penis verrucous carcinoma; Squamous Carcinoma of Penis, Verrucous Type; squamous carcinoma of penis, verrucous type; Squamous Carcinoma of the Penis, Verrucous Type; squamous carcinoma of the penis, verrucous type; Verrucous Carcinoma of Penis; verrucous carcinoma of penis; Verrucous Carcinoma of the Penis; verrucous carcinoma of the penis; Verrucous Penile Carcinoma; verrucous penile carcinoma; Verrucous Penile Squamous Carcinoma; verrucous penile squamous carcinoma; verrucous penile squamous cell carcinoma; Verrucous Squamous Carcinoma of Penis; verrucous squamous carcinoma of penis; Verrucous Squamous Carcinoma of the Penis; verrucous squamous carcinoma of the penis
 
Monarch Initiative: MONDO:0003698

Definition

A slow growing, locally recurring, very well differentiated papillary squamous cell carcinoma that arises from the penis. It is characterized by the presence of acanthosis and hyperkeratosis. The neoplastic infiltrate extends into the underlying stroma with a pushing border. Koilocytotic atypia is not present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPenis verrucous carcinoma

Professional guidelines

PubMed

Optimal treatment for penile verrucous carcinoma: a systematic literature review.
Jo DI, Han SH, Kim SH, Kim HY, Chung H, Kim HS
BMC Urol 2021 Jan 29;21(1):13. doi: 10.1186/s12894-020-00777-1. PMID: 33514369Free PMC Article
Treatment of verrucous carcinoma in penis with topical aminolevulinic acid photodynamic therapy: An effective and safe treatment method.
He X, Zhang J, Tan L, Wang W, Song Y, Wang H, Zhang X, Kou H, Lu Y
Photodiagnosis Photodyn Ther 2018 Dec;24:232-236. Epub 2018 Sep 8 doi: 10.1016/j.pdpdt.2018.08.015. PMID: 30205190
Papillary squamous cell carcinoma, not otherwise specified (NOS) of the penis: clinicopathologic features, differential diagnosis, and outcome of 35 cases.
Chaux A, Soares F, Rodríguez I, Barreto J, Lezcano C, Torres J, Velazquez EF, Cubilla AL
Am J Surg Pathol 2010 Feb;34(2):223-30. doi: 10.1097/PAS.0b013e3181c7666e. PMID: 20061934

Recent clinical studies

Etiology

WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Tumor lesions of penis and scrotum according to WHO classification 2022.
Michalová K, Beniač P, Kacerovská D
Cesk Patol 2022 Fall;67(4):192-197. PMID: 36513504
Papillary squamous cell carcinoma, not otherwise specified (NOS) of the penis: clinicopathologic features, differential diagnosis, and outcome of 35 cases.
Chaux A, Soares F, Rodríguez I, Barreto J, Lezcano C, Torres J, Velazquez EF, Cubilla AL
Am J Surg Pathol 2010 Feb;34(2):223-30. doi: 10.1097/PAS.0b013e3181c7666e. PMID: 20061934
HPV infection and immunochemical detection of cell-cycle markers in verrucous carcinoma of the penis.
Stankiewicz E, Kudahetti SC, Prowse DM, Ktori E, Cuzick J, Ambroisine L, Zhang X, Watkin N, Corbishley C, Berney DM
Mod Pathol 2009 Sep;22(9):1160-8. Epub 2009 May 22 doi: 10.1038/modpathol.2009.77. PMID: 19465901
The detection of human papillomavirus deoxyribonucleic acid in intraepithelial, in situ, verrucous and invasive carcinoma of the penis.
Cupp MR, Malek RS, Goellner JR, Smith TF, Espy MJ
J Urol 1995 Sep;154(3):1024-9. PMID: 7637047

Diagnosis

Optimal treatment for penile verrucous carcinoma: a systematic literature review.
Jo DI, Han SH, Kim SH, Kim HY, Chung H, Kim HS
BMC Urol 2021 Jan 29;21(1):13. doi: 10.1186/s12894-020-00777-1. PMID: 33514369Free PMC Article
Genital verruciform xanthoma: lessons from a contemporary multi-institutional series.
Wang G, Mochel MC, Randall MB, Gandhi JS, Udager AM, Chan MP, Patel RM, Amin MB, Osunkoya AO, Smith SC
Histopathology 2020 Nov;77(5):841-846. Epub 2020 Sep 15 doi: 10.1111/his.14198. PMID: 32598505
Diagnostic problems in precancerous lesions and invasive carcinomas of the penis.
Chaux A, Cubilla AL
Semin Diagn Pathol 2012 May;29(2):72-82. doi: 10.1053/j.semdp.2011.08.002. PMID: 22641956
Penile squamous cell carcinoma: anatomic, pathologic and viral studies in Paraguay (1993-2007).
Velazquez EF, Cubilla AL
Anal Quant Cytol Histol 2007 Aug;29(4):185-98. PMID: 17879626
Verrucous carcinoma of the skin and mucosa.
Schwartz RA
J Am Acad Dermatol 1995 Jan;32(1):1-21; quiz 22-4. doi: 10.1016/0190-9622(95)90177-9. PMID: 7822496

Therapy

Treatment of verrucous carcinoma in penis with topical aminolevulinic acid photodynamic therapy: An effective and safe treatment method.
He X, Zhang J, Tan L, Wang W, Song Y, Wang H, Zhang X, Kou H, Lu Y
Photodiagnosis Photodyn Ther 2018 Dec;24:232-236. Epub 2018 Sep 8 doi: 10.1016/j.pdpdt.2018.08.015. PMID: 30205190
Buschke-Löwenstein tumor: squamous cell carcinoma of the anogenital region.
Turkalj I, Djilas-Ivanović D, Boskov N, Petrov B, Stajer L, Ivković-Kapicl T
Srp Arh Celok Lek 2014 May-Jun;142(5-6):356-9. doi: 10.2298/sarh1406356t. PMID: 25033595
Advanced penile verrucous carcinoma treated with intra-aortic infusion chemotherapy.
Sheen MC, Sheu HM, Jang MY, Chai CY, Wang YW, Wu CF
J Urol 2010 May;183(5):1830-5. Epub 2010 Mar 29 doi: 10.1016/j.juro.2009.12.108. PMID: 20303107
Contemporary management of penile cancer including surgery and adjuvant radiotherapy: an experience in Taiwan.
Chen MF, Chen WC, Wu CT, Chuang CK, Ng KF, Chang JT
World J Urol 2004 Apr;22(1):60-6. Epub 2003 Dec 5 doi: 10.1007/s00345-003-0383-7. PMID: 14657999
Verrucous carcinoma of the penis: report of a case and review.
Smith RB, Young HH 2nd, Chaffey BT
Br J Urol 1969 Jun;41(3):327-31. doi: 10.1111/j.1464-410x.1969.tb11892.x. PMID: 5784603

Prognosis

WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Optimal treatment for penile verrucous carcinoma: a systematic literature review.
Jo DI, Han SH, Kim SH, Kim HY, Chung H, Kim HS
BMC Urol 2021 Jan 29;21(1):13. doi: 10.1186/s12894-020-00777-1. PMID: 33514369Free PMC Article
Diagnostic problems in precancerous lesions and invasive carcinomas of the penis.
Chaux A, Cubilla AL
Semin Diagn Pathol 2012 May;29(2):72-82. doi: 10.1053/j.semdp.2011.08.002. PMID: 22641956
Penile squamous cell carcinoma: anatomic, pathologic and viral studies in Paraguay (1993-2007).
Velazquez EF, Cubilla AL
Anal Quant Cytol Histol 2007 Aug;29(4):185-98. PMID: 17879626
Verrucous carcinoma of the skin and mucosa.
Schwartz RA
J Am Acad Dermatol 1995 Jan;32(1):1-21; quiz 22-4. doi: 10.1016/0190-9622(95)90177-9. PMID: 7822496

Clinical prediction guides

Analysis of alterations adjacent to invasive squamous cell carcinoma of the penis and their relationship with associated carcinoma.
Renaud-Vilmer C, Cavelier-Balloy B, Verola O, Morel P, Servant JM, Desgrandchamps F, Dubertret L
J Am Acad Dermatol 2010 Feb;62(2):284-90. doi: 10.1016/j.jaad.2009.06.087. PMID: 20115951
Comparison of morphologic features and outcome of resected recurrent and nonrecurrent squamous cell carcinoma of the penis: a study of 81 cases.
Chaux A, Reuter V, Lezcano C, Velazquez EF, Torres J, Cubilla AL
Am J Surg Pathol 2009 Sep;33(9):1299-306. doi: 10.1097/PAS.0b013e3181a418ae. PMID: 19471153
HPV infection and immunochemical detection of cell-cycle markers in verrucous carcinoma of the penis.
Stankiewicz E, Kudahetti SC, Prowse DM, Ktori E, Cuzick J, Ambroisine L, Zhang X, Watkin N, Corbishley C, Berney DM
Mod Pathol 2009 Sep;22(9):1160-8. Epub 2009 May 22 doi: 10.1038/modpathol.2009.77. PMID: 19465901
Epithelial abnormalities and precancerous lesions of anterior urethra in patients with penile carcinoma: a report of 89 cases.
Velazquez EF, Soskin A, Bock A, Codas R, Cai G, Barreto JE, Cubilla AL
Mod Pathol 2005 Jul;18(7):917-23. doi: 10.1038/modpathol.3800371. PMID: 15920559
Squamous cell carcinoma of the penis: multivariate analysis of prognostic factors and natural history in monocentric study with a conservative policy.
Soria JC, Fizazi K, Piron D, Kramar A, Gerbaulet A, Haie-Meder C, Perrin JL, Court B, Wibault P, Théodore C
Ann Oncol 1997 Nov;8(11):1089-98. doi: 10.1023/a:1008248319036. PMID: 9426328

Recent systematic reviews

Optimal treatment for penile verrucous carcinoma: a systematic literature review.
Jo DI, Han SH, Kim SH, Kim HY, Chung H, Kim HS
BMC Urol 2021 Jan 29;21(1):13. doi: 10.1186/s12894-020-00777-1. PMID: 33514369Free PMC Article

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