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Appendix carcinoma

MedGen UID:
196398
•Concept ID:
C0728951
•
Neoplastic Process
Synonyms: Appendiceal Cancer; Appendix Cancer; Appendix Carcinoma; appendix carcinoma; Ca appendix; Carcinoma of Appendix; carcinoma of appendix; Carcinoma of the Appendix; carcinoma of the appendix; carcinoma of vermiform appendix; vermiform appendix carcinoma
 
Monarch Initiative: MONDO:0003196

Definition

A malignant epithelial neoplasm arising from the appendix. The vast majority of the cases are adenocarcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAppendix carcinoma

Professional guidelines

PubMed

Appendiceal Mucinous Neoplasms: Diagnosis and Management.
Shaib WL, Assi R, Shamseddine A, Alese OB, Staley C 3rd, Memis B, Adsay V, Bekaii-Saab T, El-Rayes BF
Oncologist 2017 Sep;22(9):1107-1116. Epub 2017 Jun 29 doi: 10.1634/theoncologist.2017-0081. PMID: 28663356Free PMC Article

Recent clinical studies

Etiology

Prolonged Survival in Peritoneal Metastatic Appendiceal Carcinoma Patients Treated With Combined Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.
Acs M, Gerken M, Zustin J, Blaj S, Isgandarova S, Piso P
J Surg Res 2023 Mar;283:839-852. Epub 2022 Dec 6 doi: 10.1016/j.jss.2022.10.083. PMID: 36915011
Differential expression of Chitinase 3-Like 1 protein in appendicitis and appendix carcinomas.
Zhang Y, Li Y, Li F, Li L, Wang C, Wang H, Chen Y, Zhang C, Zhang Y, Wang W
J Clin Lab Anal 2022 Dec;36(12):e24790. Epub 2022 Nov 29 doi: 10.1002/jcla.24790. PMID: 36447423Free PMC Article
Indications and outcomes for repeat cytoreductive surgery and heated intra-peritoneal chemotherapy in peritoneal surface malignancy.
Sutton PA, O'Dwyer ST, Barriuso J, Aziz O, Selvasekar CR, Renehan AG, Wilson MS
Surg Oncol 2021 Sep;38:101572. Epub 2021 Apr 20 doi: 10.1016/j.suronc.2021.101572. PMID: 33915487
Appendiceal Mucinous Neoplasms: Diagnosis and Management.
Shaib WL, Assi R, Shamseddine A, Alese OB, Staley C 3rd, Memis B, Adsay V, Bekaii-Saab T, El-Rayes BF
Oncologist 2017 Sep;22(9):1107-1116. Epub 2017 Jun 29 doi: 10.1634/theoncologist.2017-0081. PMID: 28663356Free PMC Article
Should we remove the normal-looking appendix during operations for borderline mucinous ovarian neoplasms?: A retrospective study of 129 cases.
Ozcan A, Töz E, Turan V, Sahin C, Kopuz A, Ata C, Sancı M
Int J Surg 2015 Jun;18:99-103. Epub 2015 Apr 20 doi: 10.1016/j.ijsu.2015.04.043. PMID: 25907325

Diagnosis

Appendiceal adenocarcinoma is associated with better prognosis than cecal adenocarcinoma: a population-based comparative survival study.
Chen G, Chen K, Sahyoun L, Zaman S, Protiva P
BMJ Open Gastroenterol 2023 Feb;10(1) doi: 10.1136/bmjgast-2022-001045. PMID: 36822658Free PMC Article
The caecal mucus sign.
Behary J, Hui JM
Gut 2018 Feb;67(2):298. Epub 2017 Jan 10 doi: 10.1136/gutjnl-2016-313248. PMID: 28073893
Appendiceal Mucinous Neoplasms: Diagnosis and Management.
Shaib WL, Assi R, Shamseddine A, Alese OB, Staley C 3rd, Memis B, Adsay V, Bekaii-Saab T, El-Rayes BF
Oncologist 2017 Sep;22(9):1107-1116. Epub 2017 Jun 29 doi: 10.1634/theoncologist.2017-0081. PMID: 28663356Free PMC Article
Should we remove the normal-looking appendix during operations for borderline mucinous ovarian neoplasms?: A retrospective study of 129 cases.
Ozcan A, Töz E, Turan V, Sahin C, Kopuz A, Ata C, Sancı M
Int J Surg 2015 Jun;18:99-103. Epub 2015 Apr 20 doi: 10.1016/j.ijsu.2015.04.043. PMID: 25907325
Appendix carcinoma invading the urinary bladder.
Dahms SE, Hohenfellner M, Eggersmann C, Lampel A, Golz R, Thüroff JW
Urol Int 1997;58(2):124-7. doi: 10.1159/000282967. PMID: 9096277

Therapy

Prolonged Survival in Peritoneal Metastatic Appendiceal Carcinoma Patients Treated With Combined Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.
Acs M, Gerken M, Zustin J, Blaj S, Isgandarova S, Piso P
J Surg Res 2023 Mar;283:839-852. Epub 2022 Dec 6 doi: 10.1016/j.jss.2022.10.083. PMID: 36915011
Indications and outcomes for repeat cytoreductive surgery and heated intra-peritoneal chemotherapy in peritoneal surface malignancy.
Sutton PA, O'Dwyer ST, Barriuso J, Aziz O, Selvasekar CR, Renehan AG, Wilson MS
Surg Oncol 2021 Sep;38:101572. Epub 2021 Apr 20 doi: 10.1016/j.suronc.2021.101572. PMID: 33915487

Prognosis

Prolonged Survival in Peritoneal Metastatic Appendiceal Carcinoma Patients Treated With Combined Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.
Acs M, Gerken M, Zustin J, Blaj S, Isgandarova S, Piso P
J Surg Res 2023 Mar;283:839-852. Epub 2022 Dec 6 doi: 10.1016/j.jss.2022.10.083. PMID: 36915011
Appendiceal adenocarcinoma is associated with better prognosis than cecal adenocarcinoma: a population-based comparative survival study.
Chen G, Chen K, Sahyoun L, Zaman S, Protiva P
BMJ Open Gastroenterol 2023 Feb;10(1) doi: 10.1136/bmjgast-2022-001045. PMID: 36822658Free PMC Article
Differential expression of Chitinase 3-Like 1 protein in appendicitis and appendix carcinomas.
Zhang Y, Li Y, Li F, Li L, Wang C, Wang H, Chen Y, Zhang C, Zhang Y, Wang W
J Clin Lab Anal 2022 Dec;36(12):e24790. Epub 2022 Nov 29 doi: 10.1002/jcla.24790. PMID: 36447423Free PMC Article
Indications and outcomes for repeat cytoreductive surgery and heated intra-peritoneal chemotherapy in peritoneal surface malignancy.
Sutton PA, O'Dwyer ST, Barriuso J, Aziz O, Selvasekar CR, Renehan AG, Wilson MS
Surg Oncol 2021 Sep;38:101572. Epub 2021 Apr 20 doi: 10.1016/j.suronc.2021.101572. PMID: 33915487
Should we remove the normal-looking appendix during operations for borderline mucinous ovarian neoplasms?: A retrospective study of 129 cases.
Ozcan A, Töz E, Turan V, Sahin C, Kopuz A, Ata C, Sancı M
Int J Surg 2015 Jun;18:99-103. Epub 2015 Apr 20 doi: 10.1016/j.ijsu.2015.04.043. PMID: 25907325

Clinical prediction guides

Differential expression of Chitinase 3-Like 1 protein in appendicitis and appendix carcinomas.
Zhang Y, Li Y, Li F, Li L, Wang C, Wang H, Chen Y, Zhang C, Zhang Y, Wang W
J Clin Lab Anal 2022 Dec;36(12):e24790. Epub 2022 Nov 29 doi: 10.1002/jcla.24790. PMID: 36447423Free PMC Article
Should we remove the normal-looking appendix during operations for borderline mucinous ovarian neoplasms?: A retrospective study of 129 cases.
Ozcan A, Töz E, Turan V, Sahin C, Kopuz A, Ata C, Sancı M
Int J Surg 2015 Jun;18:99-103. Epub 2015 Apr 20 doi: 10.1016/j.ijsu.2015.04.043. PMID: 25907325

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